Drug Delivery to the Oral Cavity—Molecules to Market

Fourteen papers, presented by Ghosh (Office of Clinical Pharmacology and Biopharmaceutics, Federal Department of Agriculture) and Pfister (Senior Director Preclinical Affairs, NexMed Inc.), review the state of the science and innovative technologies for the pharmaceutical development of solid-state dosage for oral transmucosal drug delivery and oral mucosal drug delivery systems. After an overview of the fundamentals, contributions address such topics as preclinical assessment of oral mucosal systems; modulation of oral transmucosal permeability; oral transmucosal delivery of protein and peptide therapeutics; sublingual transmucosal delivery of organic nitrates for the treatment of angina pectoris; oral transmucosal delivery of melatonin; oral transmucosal powder injection; drug delivery systems for the treatment of periodontal and dental diseases; oral transmucosal systems for local anesthetics; quick-dispersing oral drug delivery systems; and scientific and regulatory considerations of quick-dissolving oral dosage forms. Appendixes offer reference guides to companies developing intraoral drug delivery technologies and products, and books and market research reports on such companies. Annotation c2005 Book News, Inc., Portland, OR (booknews.com)