The transplantation of organs such as the heart, kidney, and lungs is an important means of replacing seriously damaged or diseased body parts. However, a transplanted organ may fail if the recipient'
Cystic fibrosis is caused by mutations in the CFTR gene, which encodes a protein channel that regulates salt movement across the epithelial membranes of the lungs, pancreas, and other organs. In cysti
An Introduction to Nervous Systems presents the principles of neurobiology from an evolutionary perspective—from single–celled organisms to complex invertebrates such as flies—and is ideal for use as
CRISPR/Cas-based techniques are revolutionizing the way geneticists and molecular biologists modify DNA sequences and modulate gene expression in cells and organisms. This laboratory manual presents s
p53 is a critical tumor suppressor protein that controls cell division and is often mutated in cancer. This volume examines the structure and function of the p53 protein, its regulation of DNA repair,
Identified more than 100 years ago by Camillo Golgi, the Golgi is a series of flattened cisternae that acts as a critical sorting and processing station for intracellular traffic. It receives cargo in
Neighboring cells are linked to each other by multimolecular complexes such as adherens junctions, desmosomes, and gap junctions. These complexes help maintain tissue integrity, act as barriers to per
This book is a compilation of articles on significant events in the history of biochemistry, which were published in the journal "Trends in Biochemical Sciences." Editor Witkowski has selected article
Electronic devices can now be used to analyse and modulate the electrical activity within the nervous system. This book explores how development of these devices is leading to new diagnostics and trea
This book features drawings by Lewis Miller of those who have played a role in the mapping of the human genome paired with short biographies written by prominent scientists.--
Correct folding of proteins is critical for cell function, and accumulation of misfolded proteins is a feature of a number of neurodegenerative conditions. This book examines the mechanisms that ensur
Signaling by calcium ions is an important regulator of muscle contraction, nerve impulses, fertilization, and numerous other cellular processes. This book explores the experimental techniques used to
This 4th edition of the "Mouse Manual"-Manipulating the Mouse Embryo-appears 28 years after the first edition and once again is the definitive reference source on mouse development, transgenesis techn
Studies of fission yeast were instrumental in revealing the fundamental mechanisms that control cell division in organisms from yeast to humans, and fission yeast such as Schizosaccahromyces pombe con
London's Imperial Cancer Research Fund laboratories at Lincoln's Inn Fields and Clare Hall (renamed The London Research Institute in 2002) were world-famous for a century. This book, published with th
Tuberculosis (TB) is a serious infectious disease of the lungs that is usually caused by the bacterium Mycobacterium tuberculosis. Nearly one-third of the world's population is currently infected with
Prions are best known as the agents of mad cow and related diseases, and a growing number of proteins with prion-like properties have been implicated in diseases such as Parkinson's. But some recently
