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Dopamine-Glutamate Interactions in the Basal Ganglia
  • Dopamine-Glutamate Interactions in the Basal Ganglia

  • ISBN13:9781420088793
  • 出版社:CRC Press UK
  • 作者:Edited by Susan Jones
  • 裝訂/頁數:精裝/284頁
  • 版次:1
  • 出版日:2011/12/01
定  價:NT$6175元
優惠價: 95558
可得紅利積點:166 點

無庫存,下單後進貨(採購期約45-60個工作天)

商品簡介

目次

The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is released in close proximity to glutamate. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of these two neurotransmitters, dopamine and glutamate.
Elucidating the relationship between their molecular and cellular effects and behavioural significance has been challenging, but in the past 5–10 years, improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. Dopamine–Glutamate Interactions in the Basal Ganglia synthesizes this recent researchfrom the level of receptor molecules all the way to complex behaviours and disease.
Current insights from research on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia are presented against a historical perspective. The book also discusses compromised dopamine–glutamate interaction in disorders of basal ganglia function, including Parkinson’s disease, Huntington’s disease, and drug addiction.
Metabotropic Glutamate Receptor–Dopamine Interactions in the Basal Ganglia Motor Circuit, Kari A. Johnson and P. Jeffrey ConnIonotropic Glutamate Receptors in the Basal Ganglia, Susan Jones, Shona L.C. Brothwell, Isabel Huang-Doran, and James HallettDopamine Receptors and their Interactions with NMDA Receptors, Alasdair J. Gibb and Huaxia TongSynaptic Triad in the Neostriatum: Dopamine, Glutamate, and the MSN, Jason R. Klug, Ariel Y. Deutch, Roger J. Colbran, and Danny G. WinderDopaminergic Modulation of Glutamatergic Synaptic Plasticity in Striatal Circuits: New Insights from BAC-Transgenic Mice, D. James Surmeier, Weixing Shen, Tracy S. Gertler, and C. Savio ChanStriatal Acetylcholine–Dopamine Crosstalk and the Dorsal–Ventral Divide, Sarah Threlfell and Stephanie J. CraggElectrophysiology of the Corticostriatal Network In Vivo, Morgane Pidoux, Séverine Mahon, and Stéphane CharpierFunctional Organization of the Midbrain Substantia Nigra, Jennifer BrownStriatal Dopamine and Glutamate in Action: The Generation and Modification of Adaptive Behavior, Henry H. Yin and Rui M. CostaImpaired Dopamine–Glutamate Receptor Interactions in Some Neurological Disorders, Miriam A. Hickey and Carlos CepedaIndex

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