Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Have you got a plant problem and don’t know how to fix it? This complete, practical guide has all the answers you need. Drawing on the expertise and authority of the RHS, RHS Pests and Diseases has been carefully conceived to help you make a correct diagnosis – and find the most effective cure. This brand new, updated edition includes helpful new entries detailing how to cope with the latest prevalent problems, and how to keep your garden healthy while respecting the environment.Look up possible ailments in the plant-by-plant listings; make a visual identification from the extensive gallery of symptoms; then follow detailed advice in the A-Z directory to remedy the issue. With a focus on growing for food and an emphasis on sustainable solutions, RHS Pests and Diseases will help your garden stay productive, attractive, and in the best of health while caring for the planet.

A transformative and philosophical investigation into how we ask questions, full of practical advice on how we can harness the power of questions for ourselvesWe live in a world that wants answers. Answers provide solutions to our problems, teach us about the world, and help us navigate our lives. But we rush toward answers forgetting, that it is questions that set the course.Questions are a form of power, as well as a vital, everyday tool. After all, if you don’t ask the right questions, you won’t get the right answers. InQ, philosopher Lani Watson examines the history of question-asking, analyzes our answer-oriented present, and offers a path forward toward a question-oriented future. Along the way, she asks us to consider what a question is, why we ask the questions we do, when we first start asking questions, and where we want our questions to take us.The shift from prioritizing answers to focusing on questions is not easy, and it requires careful attention and practice.Qalso inclu

The new hilarious, glamorous and heartwarming rom-com full of sparkle and charm – the perfect escapist read for 2026!Crushing it online…crashing in real life'What a treat!' DAWN FRENCHThe brand-new heartwarming and escapist rom-com from Rosie Nixon. Perfect for fans of Sophie Kinsella and Alexandra Potter!Following an eventful stint styling Manhattan’s elite, Amber Green is back in London and ready to style her biggest client yet.Superstar influencer Mandy Sykes is all-American and all-wrong for her new Surrey surroundings. Desperate to endear herself to the British upper crust, and to win likes from a new fanbase, the brash celebrity tasks Amber with providing all the smoke and mirrors she might need.With only twelve weeks to prove her worth – and to earn the bonus which will secure her dream flat with her steady boyfriend, Rob – Amber’s biggest challenge is to keep her flats firmly on the ground.But when your new boss has a private life as colourful as her designer wardrobe, and a br

★ 每天一頁超萌動物漫畫，療癒日常從翻頁開始！★ Liz Climo 經典幽默風格，暖心又爆笑★ 可撕式桌曆設計，陪你365天微笑生活這不只是一款桌曆，而是一種與日常相處的方式。用一頁一笑，療癒每一天。這款桌曆以 Liz Climo 經典動物漫畫為核心，結合幽默與溫暖，讓日常生活多了一份輕盈與共鳴。不論自用或送禮，都能成為陪伴整年的可愛存在。This charming day-to-day calendar features adorable animal comics by bestselling author Liz Climo.With a different illustration on each page, this day-to-day desk calendar features Liz Climo's short and sweet comics based on her quirky, funny, and almost human-like animal kingdom. Sweet, adorable, and all too relatable, this calendar captures life's everyday eccentricities with lighthearted wit, humor, and wisdom, making it an irresistible self-buy and a unique, affordable gift for fans of Liz Climo and animal lovers everywhere.6 x 5 x 1 1/2 inches316 tear-away pagesGREAT GIFT: Easy to display at home or in an office, this is a must-have for Liz Climo fans, a perfect present for animal lovers, and a unique treat for moms, dads, aunts, grandmas, and more. RELATABLE AND FUNNY CONTENT: This calendar is filled with short

With the end of the 1966 dry season and the wrapping up of Operation Attleboro, General Westmoreland had both the resource and favourable weather to launch his planned series of offensives designed to push away Viet Cong and PAVN (People's Army of Vietnam) forces away from the key cities of South Vietnam. As in the previous year his focus would be the area around Saigon. Having amassed two infantry divisions, two separate brigades, and a powerful armoured cavalry regiment, he felt ready to secure the area. In this he was ably supported by General Bruce Palmer, the Commander of II Field Force, Vietnam.What followed was a constant series of offensives, including the only battalion-level combat jump made by the US military in Vietnam. These operations were large, involving multiple divisions and generating several hard-fought battles. The US and South Vietnamese forces used all the panoply of a combined arms forces with airmobile, mechanized, and infantry operations trying not only to des

The highly anticipated thriller about a serial killer's daughter and her race to solve the crimes of her family's twisted past before it's too late, from New York Times bestselling author E. Kennedy.The world is hunting for answers—but what if the truth leads straight to you?Ten years after her father—the infamous serial killer Gabriel Thorn—was caught, Ryan Shipley is back in Starling, Tennessee, trying to lay low. No one can know who she really is. No one can know the truth about her past.But as fresh eyes dig deeper into the case, old secrets refuse to stay buried. Cryptic texts, eerie coincidences, and a chilling note leave everyone wondering—does Ryan know more than she’s letting on? As the truth unravels, one thing becomes clear: in a town full of secrets, Ryan might be the biggest mystery of them all.Perfect for fans of Holly Jackson and Jeneva Rose—get ready for a thriller packed with twists you won’t see coming.

A NEW YORK TIMES NOTABLE BOOK • NEW YORK TIMES BESTSELLER • A bold, urgent appeal from the acclaimed columnist and political commentator, addressing one of the most important issues of our time“At this painful moment, Peter Beinart’s voice is more vital than ever. His reach is broad—from the tragedy of today’s Middle East to the South Africa he knows well to events centuries ago—his scholarship is deep, and his heart is big. This book is not just about being Jewish in the shadow of today’s war, but about being a person who cares for justice.” —Adam Hochschild, author of American Midnight and King Leopold’s GhostIn Peter Beinart’s view, one story dominates Jewish communal life: that of persecution and victimhood. It is a story that erases much of the nuance of Jewish religious tradition and warps our understanding of Israel and Palestine. After Gaza, where Jewish texts, history, and language have been deployed to justify mass slaughter and starvation, Beinart argues, Jews must tell a ne

From Noemi Vola, creator of The Unfortunate Life of Worms, comes a powerful story about the limits of no and the possibilities of yes.Right in the middle of whatever Spider is doing—brushing his teeth, reading a book, or watching a storm—he thinks of Frog. The strange thing is, Frog isn’t even nice. On the contrary, she’s quite rude. She never suggests going for a walk, never cares if anyone is hot or cold, and, most of all, she always says NO. And she there are all kinds of NOs:the big NO,the small NO,the baffling NO,the mysterious NO,and sometimes even the repeated NO, NO, NO.Spider keeps all these NOs tangled in his web, but when a storm sweeps everything away, it brings a new friend who helps him discover the value of YES.

Hilarious chapter books about animals with jobs, clothes and superpowers! Highly illustrated in black and white and perfect for fans of the movies Sing and Zootropolis!Bob and Archie are two hapless but enthusiastic koalas who are just getting to grips with their new superpowers. Their archenemy is Dr Colossus, a giant ostrich with grand plans to destroy Pawtonia with the help of his Zombie Chickens!Can our furry heroes thwart the feathered supervillain? Definitely, maybe…

本套組集結 Numberblocks、Alphablocks、Colourblocks 三大人氣角色，設計兼具學習與遊戲元素。孩子可以在角色陪伴下練習數數、學習拼音與聲音辨識，並認識常見顏色。套裝內容包括三本練習冊、超過 150 張貼紙、一張海報與身高表，還附有可反覆使用的練習單與專用筆，透過擦寫功能讓孩子能不斷練習。整體設計鮮明有趣，讓孩子在操作中培養專注力與基礎技能。這套產品適合學齡前至小學初階的孩子，既能啟蒙學習，也能增添親子互動的樂趣。亮點三大 Blocks 角色陪伴，提升學習興趣涵蓋數字、語音、顏色等基礎能力附 150+ 貼紙、海報、身高表擦寫式練習單，可重複使用Learn, play and explore with the Numberblocks, Alphablocks and Colourblocks. Practise counting in order, making and reading simple sounds, recognising key colours and more – all with the help of your Blocks friends! The set includes 3 workbooks, over 150 stickers, a poster, a height chart, a pen and 3 worksheets that can be used over and over again thanks to the play set’s wipe-clean plastic front.

An electrifying, propulsive novel about the rise and fall of a controversial beauty mogul and the moral gray areas at the intersections of beauty, power, and ambitionIt’s 2015 and Maxine Thomas, the founder and creative director of the cult makeup company Reveal, has just been suspended by her own Board for a scandalous transgression. Housebound in her New York City apartment, where she awaits the verdict on her future, Max recounts her version of the events that have brought her to this moment.From her start as a precocious suburban child in the eighties to her decades as a workaholic visionary, Max proselytizes a sheer, dewy look—cosmetics through a female gaze—all while battling sexist investors, the whiplash of cultural change, and the mounting pressure to keep her sexuality a secret. But when Max’s story catches up to her present, she must contend with the cost of true transparency.Told over nine intense days yet spanning a lifetime,Sheeris a gripping, incisive, and provocative ta

Protein Immobilization on Nanomaterials explores advanced technologies and methodologies for immobilizing proteins on nanomaterial surfaces, highlighting their innovative applications in biotechnology, medicine, and materials engineering. This comprehensive resource is designed to educate researchers and practitioners on the latest techniques and advances in this rapidly evolving field. The book delves into various methods of protein immobilization, including physical adsorption, covalent binding, and encapsulation, providing detailed explanations and practical examples. It also covers the characterization of protein-nanomaterial conjugates using advanced analytical techniques such as spectroscopy and microscopy. Key topics include the use of protein-nanomaterial conjugates in biosensors, diagnostic devices, drug delivery systems, and environmental monitoring. With contributions from leading experts, the book presents colorful figures and practical examples to facilitate the understand

The future of precision health care is being driven by the increasingly rapid evolution of technologies. Over the past century, health care has benefited tremendously from the steady introduction of new tools, such as imaging, vaccines, immunology, biochemical analysis, and drug development; more recently, emerging technologies have arisen rapidly, undergone swift validation, and experienced prompt application. However, these technologies and their results have uncertainties and impact all facets of precision patient management. Uncertain Precision: Managing Health Care with Personalized Technologies provides an in-depth overview of precision medicine and its relationship with new technology, examining its current scope, benefits, and limitations. While new medical technologies can identify many individual traits that establish diagnoses, predict the course of illness, and recommend therapies, the tools and their results have uncertainties that the health care professional must anticip

The first volume of the Mt. Lykaion Studies series introduces readers to the famous Arkadian sanctuaries of Zeus and Pan at Mt. Lykaion, a site renowned in antiquity as the birthplace of Zeus. First excavated in the late 19th and early 20th centuries by the Archaeological Society of Athens, the site has been the focus of renewed interest since 2004 under the Mt. Lykaion Excavation and Survey Project, a Greek-American synergasia. This volume offers an overview of the historical and contemporary campaigns, illustrating the site's immense importance from antiquity to the present through its archaeological, literary, and epigraphic evidence. A comprehensive geological study of Mt. Lykaion and the surrounding region reveals the impact of this dramatic environment on the site's development, a sacred landscape that continues to shape the activities and attitudes of residents and visitors today. The breadth of perspectives collected in this volume's nine chapters vividly illustrate the mytholo

Join the new category of leaders who are taking a stand for a better way of working, by becoming an AI-driven leader.The difference between growing your business and going out of business is your ability to think strategically.The problem is, most leaders are stuck in the operational weeds, struggling to find the time to make better strategic decisions. This challenge is only heightened by the rise of AI. While you know AI is the future, current demands leave you with no time to explore its benefits. Meanwhile, your competition is gaining an edge by integrating AI. The time to act is now.In The AI-Driven Leader, you'll learn how to:· Escape operational overwhelm and lead with strategic clarity· Collapse the time it takes to turn data into decisions· Transform your decision-making with AI for strategic advantage· 10x the impact of every employee· Apply real-world examples and prompts to get immediate resultsYou know AI matters, but you're not using it to transform how you think, make de

Sports Law and Society: Rules of the Game, Second Edition stands out for its exceptional depth and practical approach, offering a comprehensive, concise and clear examination of the legal challenges shaping today's sports industry. Designed to engage students, it covers foundational topics like contracts, collective bargaining, and intellectual property in sports while exploring complex, evolving issues such as gender equity, the global sports ecosystem, and data analytics in performance. Each chapter provides real-world examples and cases, giving students an applied understanding of how legal principles operate within professional, college, and youth sports. By balancing established legal doctrines with emerging topics-including artificial intelligence, digital media, athlete mental health, and the future of sports-this book equips readers with both historical context and foresight, making it particularly relevant for a dynamic field.What sets this book apart is its critical focus on

Archaeological research on islands has made significant contributions to our understanding of human cultural development, with aquatic resources and maritime adaptations being increasingly recognized as having had profound effects on human evolution, worldwide dispersals, and the development of social complexity. Once thought to be marginal habitats for humans--lacking in many of the necessary dietary and raw material requirements for societies to thrive--recent research in island and coastal regions around the world has shown this to be false. In fact, the opposite appears to be true in many cases, where aquatic resources were plentiful, highly nutritious, and relatively easy to harvest. The Oxford Handbook of Island & Coastal Archaeology is the first volume to synthesize major topics in the subfield of island and coastal archaeology on a truly global scale, including methodological and theoretical advances that have positioned the subfield as central to archaeology, history, and hist

Ballet Practice and History is a complete, inclusive resource on ballet training and history for the beginning teen-adult reader. Unique in its balanced discussion of technique and history, this book guides readers through an accessible methodology of training while also presenting ballet's historical development through a culturally inclusive lens. Part One presents a progression of study guiding the reader through a series of eight scaffolded lessons, including terminology, descriptions, learning guides and lessons. Methods of learning ballet are presented in a healthy and anatomically sound approach for diverse audiences. Each chapter has a dedicated ballet class to reinforce terminology and concepts, available as a video lesson for readers to follow. Part Two presents a global survey of ballet's historical development expanding on the traditional European context to include histories in Mexico, Cuba, South America, South Africa and East-Asia. It also discusses cultural issues assoc

內容簡介 本書對28納米多晶矽柵氧邏輯技術的嵌入式鍺矽源漏外延工藝開發及相應PMOSFET器件關鍵問題進行研究，實現高質量鍺矽源漏的外延。在此基礎上開發出一種利用離子注入技術提升源漏特性的新型工藝，能夠更好地滿足28納米低功耗(射頻)芯片量產要求。同時，本書簡要介紹了適用于未來FinFET結構的鍺矽源漏外延工藝。Abstract This book investigates the development of the embedded SiGe source/drain epitaxy process and the corresponding key issues of PMOSFETs based on 28 nm logic technology with polycrystalline Si/SiON gate structure, successfully achieving high-quality SiGe source/drain epitaxy. A novel process using ion implantation technology to improve source/drain characteristics has also been developed, which can better meet the mass production requirements of 28 nm low-power (RF) chips. This book also briefly introduces the embedded SiGe source/drain epitaxy process suitable for future FinFETs.

An essential reference for practitioners and students of quantitative financeFinancial analysts and investment bankers rely greatly upon the mathematical finance (also known as computational finance) when seeking to establish the value of financial instruments. Nowhere is that more true than in the pricing of commodity and foreign exchange derivatives. While there are many guides to pricing commodity and foreign exchange derivatives, until now there were none whose focus is on making the complex mathematics involved accessible for students and practitioners. This fourth and final volume in the landmark Problems and Solutions in Mathematical Finance series does just that. Its unique problem/solution, step-by-step approach dramatically streamlines the learning process for anyone attempting to get to grips with the mathematical modeling of commodity and foreign exchange derivatives.Builds upon the ideas in the previous three volumes to school you in the essential mathematical concepts and

Across global queer activism and literature from the social sciences and humanities, the impact of empires on the regulation of sexuality and gender is an emergent theme. While there has been a considerable focus on British colonial criminal law, there is a need to investigate and compare the diverse forms of power and control adopted across the histories of European empires. In Colonialisms and Queer Politics, Sonia Corr獪, Gustavo Gomes da Costa, and Matthew Waites provide a groundbreaking comparative analysis of empires and colonialities with respect to sexuality and gender diversity. Including contributions from an international team of authors, chapters focus on eleven empires: Portuguese, Spanish, British, French, Dutch, Ottoman, Russian, Belgian, German, Italian, and United States. Starting from the fifteenth century, authors explore how colonial racial hierarchies, gender norms, and heteronormativity structured relations between colonizing and colonized societies. The chapters r

The Oxford Handbook of Ballet Pedagogy offers a comprehensive exploration of contemporary perspectives on teaching and learning ballet, emphasizing the embodied nature of dance and its role in shaping both the student sense of expression and development as an artist. The book positions ballet pedagogy as a dynamic and cross-disciplinary field that transcends traditional separation between practice and theory. It offers a holistic approach that integrates the whole body, identity, and well-being into the learning process. Through five thematic sections-focusing on the whole-dancer, embodied pedagogy, diverse teaching sites, syllabus construction, and ballet as praxis. The volume engages with critical issues such as belonging, access, rigor, syllabus, and excellence within pedagogical practices in the ballet learning space that move beyond the limitations of constructs such as race, gender, and disability. The book challenges entrenched pedagogical hierarchies, offering a vision for the

For more than a century, America's sports stadiums have evolved from modest, private ballparks into billion-dollar play-palaces for the rich-built increasingly on the backs of taxpayers. Government commitments to major-league venues are approaching $50 billion, and a looming wave of new construction threatens to double public outlays by the end of the next decade. Elected leaders justify the massive subsidies by arguing that stadiums are economic catalysts, despite overwhelming evidence that sports venues are unwise public investments. Why does this keep happening? The refrain is always the same: This one will be different. The Atlanta Braves's Truist Park in Cobb County, Georgia is the latest example. Marketed as a game-changing mixed-use development that would create a year-round economic hub, the project has fallen far short of its boosters' lofty projections-just like all the venues that came before it. In This One Will Be Different, sports economist J.C. Bradbury draws from decade

Counseling Today uses relatable, real scenarios and helpful learning aids to introduce current research, controversial topics, and authentic counseling stories. It encourages you to become a reflective practitioner, thinking about how your own personality, beliefs, values, and experiences influence how you look at the world as you consider your own development as a future professional. The 3rd Edition offers a new layout and organization, new Ethical Alerts, features to support the 2024 CACREP Professional Orientation and Ethical Practice Standards, and much more.

The Oxford Handbook of Russian Poetry brings together forty original chapters by scholars, critics, and poets from across North America, Russia, and Europe, offering a wide-ranging account of the Russian poetic tradition from the early modern period to the present. Responding to evolving critical priorities and the expanded sense of Russian poetic practice in recent decades, the Handbook aims not to settle the canon but rather to model a range of approaches to poetic history. Chapters are attentive to rupture, reinvention, and literature's changing social and institutional conditions. In particular, the volume engages with an increasingly complex understanding of Russian twentieth-century literature-one that treats, separately and together, censored, uncensored, and 幦igr?writing, and that engages with multilingualism and rapidly shifting cultural boundaries. Collectively, the contributions consider texts both well-known and newly recovered, metropolitan and diasporic, official and unde