Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The incredible true story of the card-counting mathematics professor who taught the world how to beat the dealer and, as the first of the great quantitative investors, ushered in a revolution on Wall

NEW YORK TIMES BESTSELLER • An unforgettable cast of small-town characters copes with love and loss in this new work of fiction by #1 bestselling author and Pulitzer Prize winner Elizabeth Strout

The incredible true story of the decade-long quest to bring down Paul Le Roux—the creator of a frighteningly powerful Internet-enabled cartel who merged the ruthlessness of a drug lord with the techno

Imagine that Alice had walked into a bar instead of falling down the rabbit hole. In the tradition of J. R. Moehringer’s The Tender Bar and the classic reportage of Joseph Mitchell, here is an i

“A mesmerizing, head-spinning—and sometimes madcap-hilarious—take of have and have-nots.”—People (Book of the Week) NAMED ONE OF THE BEST BOOKS OF THE YEAR BY R

An intimate, deeply reported account of the women who made a shocking decision: to leave their comfortable lives behind and join the Islamic State.In early 2014, the Islamic State clinched its control

The landmark five-book investigation of uncertainty, chance, volatility, risk, and decision-making in a world we don't understand--now in a beautifully designed, cloth-bound hardcover boxed set.Nassim

In this revelatory, intimate memoir from the author of Dead Man Walking, the nation's foremost leader in efforts to abolish the death penalty shares the story of her growth as a spiritual leader, spea

A definitive statement on aesthetics, art, and modernity includes essays on specific artistic tendencies throughout the modern era, from Dresden in 1764 to New York in 1941.

The story of a legendary designer who pioneered high-end streetwear, from a storefront in Harlem to the red carpet in Hollywood, dressing everyone from Salt-N-Pepa and Eric B. & Rakim to Beyonc&ea

#1 NEW YORK TIMES BESTSELLER • Pulitzer Prize–winning author Jon Meacham helps us understand the present moment in American politics and life by looking back at critical times in our histor

In 2007, Christopher Hitchens, Richard Dawkins, Sam Harris, and Daniel Dennett filmed a landmark discussion about modern atheism. The video went viral. Now in print for the first time, the transcript

Pope Francis examines the role of millennials in the future of the Catholic Church in this urgent call to believers of all generations to work together to build a better world.Since his election in 20

A woman's disappearance shakes up a strange northern town that is stuck in the 1980s, in a wildly imaginative novel that combines elements of The Handmaid's Tale, Stranger Things and Twin Peaks.Why ca

A “riveting family saga” (Mary Karr), set in the American West, about sibling rivalry, dark secrets, and a young girl’s struggle with freedom and artistic desire In the years after W

An in-depth account of the First Battle of Ypres, a turning point in World War I—and in the history of warfare The First Battle of Ypres changed how wars are fought.

The overlooked middle sister in Jane Austen’s Pride and Prejudice casts off her prim exterior and takes center stage in this fresh retelling of the classic novel.I will tell you the story of how I kne

Pulitzer Prize–winning author Jon Meacham helps us understand the present moment in American politics and life by looking back at critical times in our history when hope overcame division and fe

A memoir of race, inequality, and the power of literature told through the life-changing friendship between an idealistic young teacher and her gifted student, jailed for murder in the Mississippi Delta“Reading with Patrick could be the most affecting book you’ll read this year.”—The Christian Science Monitor“Powerful.”—The Seattle Times“Tender.”—O: The Oprah MagazineRecently graduated from Harvard University, Michelle Kuo arrived in the rural town of Helena, Arkansas, as a Teach for America volunteer, bursting with optimism and drive. But she soon encountered the jarring realities of life in one of the poorest counties in America, still disabled by the legacy of slavery and Jim Crow. In this stirring memoir, Kuo, the child of Taiwanese immigrants, shares the story of her complicated but rewarding mentorship of one student, Patrick Browning, and his remarkable literary and personal awakening.Convinced she can make a difference in the lives of her teenaged students, Miche

A long-awaited English translation of the groundbreaking oral history of women in World War II across Europe and Russia—from the winner of the Nobel Prize in Literature“A landmark.”—Timothy Snyder, au

The tensions in a tight-knit neighborhood—and a seemingly happy marriage—are exposed by an unexpected act of violence in this provocative new novel from the #1 New York Times bestselling a

In this brilliant crime novel from the author of Missing, Presumed, a detective investigates her most personal case yet: a high-profile murder in which her own family falls under suspicion.“[Sus

Before the Corleones, before the Lannisters, there were the Borgias. One of history’s notorious families comes to life in a captivating novel from the author of The Birth of Venus. “In the

In the tradition of The Things They Carried and Redeployment, a short story collection from a U.S. Navy veteran who completed five combat tours in Iraq and Afghanistan--a remarkable portrait of the ab

True stories of sudden death in the classic collection by a master of American journalism “Reporters love murders,” Calvin Trillin writes in the introduction to Killings. “In a pinch

The never-before-told inside story of the high-stakes, four-year-long investigation into Donald Trump’s Russia ties—culminating in the Steele dossier, and sparking the Mueller report—from the founders

"Inspirational, commonsensical, and a whole lot of fun." --James PattersonEveryone deserves to shine in this sparkling new book from the New York Times bestselling author of Escape from Mr. Lemoncello

NEW YORK TIMES BESTSELLER • From Pulitzer Prize-winning author Edmund Morris comes a revelatory new biography of Thomas Alva Edison, the most prolific genius in American history.Although Thomas Alva E

A grand vision defined: The CEO of The Walt Disney Company shares the ideas and values he has used to reinvent one of the most beloved companies in the world, and inspire the people who bring the magi

Booker Prize–winning, internationally bestselling author Salman Rushdie delivers an utterly modern remake of Don Quixote with an epic love story set in the Age of Anything Can Happen.

What can we learn from the stunning rise and mysterious death of the ancient world's greatest conqueror? An acclaimed biographer reconstructs the life of Alexander the Great in this magisterial portra

#1 NEW YORK TIMES BESTSELLER. A timely and important book that challenges everything we think we know about cultivating true belonging in our communities, organizations, and culture, from the #1 bests

The New York Times bestselling author of The Tiger’s Wife returns with a stunning tale of perseverance—an epic journey across an unforgettable landscape of magic and myth. In the lawless, drought

“Ingenious . . . Mary B is a tribute not just to [Jane] Austen but to defiant women of any era.”—USA TodayThe overlooked middle sister in Pride and Prejudice casts off her

A magical love story, inspired by the legend of a woman who vanished from Grand Central Terminal, sweeps readers from the 1920s to World War II and beyond, in the spirit of The Time Traveler’s W

A riveting, urgent account of the explorers and scientists racing to understand the rapidly melting ice sheet in Greenland, a dramatic harbinger of climate change Greenland: a remote, mysterious islan

A love triangle among two college friends and a charismatic professor alters the lives of everyone involved in this razor-sharp novel from an author whose work has been hailed as “captivating&rd

“A gripping and beautiful book about the power of love in the face of unimaginable loss.” --Cheryl StrayedFor readers of The Bright Hour and When Breath Becomes Air, a moving, transcendent memoir

The stunning true story of an Alabama serial killer, and the case that obsessed the author of To Kill a Mockingbird in the years after the publication of her classic novel--a complicated and difficult

Life is a lucrative business, as long as you play by the rules.“[Joanne] Ramos’s debut novel couldn’t be more relevant or timely.”—O: The Oprah Magazine (25 Books We Can’t Wait to Read in 2019)Nestled