Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Shark lovers will enjoy hunting down the TRUTH about their favorite ocean predators in this innovative new Science Reader series.Baby sharks are toothless at first, right? That's a LIE! The TRUTH is,

車子怎麼跑起來的？油門踩下去後，裡面發生了什麼事？讀者將穿越汽車的發展歷史，從蒸汽車、內燃機，到電動車的崛起，一探汽車如何改變世界！這本圖像科普漫畫不僅拆解汽車構造，也揭開動力來源的祕密，像是汽油如何燃燒驅動活塞，或電池怎麼轉換成能量驅動馬達。知識點豐富，畫風生動，滿足讀者的好奇心！Every volume of Science Comics offers a complete introduction to a particular topic—dinosaurs, the solar system, robots, and more. Whether you're a fourth grader doing a natural science unit at school or a thirty year old with a secret passion for airplanes, these books are for you!In this Science Comics: Cars, you'll learn where cars came from and how they work. When you pop the hood, what are you looking at? How does gasoline—or electric batteries, or even steam—make a car move? Rev up your motor and take look at the combustible history of the automobile and its explosive effects on our modern lives.

What with his friend Bear’s snoring, and a BANG! BANG! BANG! noise from up in the tree, Rabbit knows that Something Simply Has To Be Done. But high in the branches, perhaps Bear can show Rabbit how to see the world from a different perspective. A story of friendship, wisdom, and how to be REALLY NOISY, this delightful and hilarious illustrated chapter book is another fun read for Rabbit & Bear fans.

The clothes don't make the bunny in this new picture book from New York Times-bestselling author Deborah Underwood, illustrated by T. L. McBeth.When Ogilvy moves to a new town, the possibilities feel

A definitive guide to the dress, weapons and accruements of the infantry elements of the most famous formation of the Napoleonic Wars.From its origins as the Consular Guard of the French Republic, and as Napoleon’s personal bodyguard, the Imperial Guard developed into a force of all arms numbering almost 100,000 men. Used by Napoleon as his principal tactical reserve, the Guard was engaged only sparingly, being deployed at the crucial moment of battle to turn the tide of victory in favor of the Emperor of the French.Naturally, the Imperial Guard has been the subject of numerous books over many decades, yet there has never been a publication that has investigated the uniforms and equipment of the infantry of the Imperial Guard in such detail and with such precision. The author has collected copies of almost all the surviving documents relating to the Guard, which includes a vast amount of material regarding the issuing of dress items, in some instances down to company level.This informa

WHY DO WE FIND SEXUALITY SO, WELL ... SCARY?Comedian Mae Martin investigates in this hilarious and intelligent guide to 21st century sexuality. Covering everything from the pros and cons of labels, to

A new board book for the youngest fans of Leo Lionni--inspired by his bestselling classics!Discover a world full of color in this delightful board book inspired by the works of legendary children's bo

When her mami meets someone new, Juana worries that everything will change in a humorous, heartwarming follow-up to the Pura Belpré Award–winning Juana & Lucas.Juana’s life is j

從Arundel莊園的那個夏天起，Penderwick家姊妹的故事陪伴無數讀者走過童年與青春。如今系列最終集回到原點──隨著Lydia的視角，我們重新踏上那片熟悉的草地，見證一場不只是婚禮的重聚。家人從四方歸來，每個人都變了，也都沒變。幽默依舊、感情更深，這本書為整個系列畫下完美句點，也為Lydia與下一段Penderwick傳奇開啟新的旅程。The finale you've all been waiting for: The Penderwicks at Last is the final, flawless installment in the modern classic series from National Book Award winner and New York Times bestselling author Jeanne Birdsall!Nine years, five older siblings, a few beloved dogs, and an endless array of adventures--these are the things that have shaped Lydia's journey since readers first met her in The Penderwicks in Spring.Now it's summertime, and eleven-year-old Lydia is dancing at the bus stop, waiting for big sister Batty to get home from college. This is a very important dance and a very important wait because the two youngest sisters are about to arrive home to find out that the Penderwicks will all be returning to Arundel this summer, the place where it all began. And better still is the occasion: a good old-fashioned, hom

本書延續《The Subtle Art of Not Giving A F*ck》的犀利風格，作者 Mark Manson 以直白又充滿黑色幽默的筆調，探討在物質極大豐富的當下，為何我們仍陷於焦慮與無望之中。從心理學研究到哲學思辨，他剖析宗教與政治的相似之處，並檢視我們與金錢、娛樂、網路的複雜關係，指出「太多美好」反而可能侵蝕心理健康。這不是安慰性的勵志書，而是一次直面現實的思考之旅，提醒讀者重新定義希望與自由的意義。From the author of the international mega-bestseller The Subtle Art of Not Giving A F*ck comes a counterintuitive guide to the problems of hope. We live in an interesting time. Materially, everything is the best it’s ever been—we are freer, healthier and wealthier than any people in human history. Yet, somehow everything seems to be irreparably and horribly f*cked—the planet is warming, governments are failing, economies are collapsing, and everyone is perpetually offended on Twitter. At this moment in history, when we have access to technology, education and communication our ancestors couldn’t even dream of, so many of us come back to an overriding feeling of hopelessness. What’s going on? If anyone can put a name to our current malaise and help fix it, it’s Mark Manson. In 20

There are lots of animals on the farm. Where are they hiding and what are they doing? In this innovative lift-the-flap book, little ones can pore over the beautiful collaged pages and explore behind b

It’s mayhem at the science fair! A squishy goo monster is a challenge for the Princess in Black — but luckily some science-loving princesses are on hand to help.Princess Magnolia is excited. Excited a

Some people are boys. Some people are girls. Some people are both, neither, or somewhere in between. This sweet, straightforward exploration of gender identity will give children a fuller understanding of themselves and others. With child-friendly language and vibrant art, It Feels Good to Be Yourself provides young readers and parents alike with the vocabulary to discuss this important topic with sensitivity.

The second in an introductory series to fine art, curated for young children as never before: by themeFor children everywhere, sleep is part of their every day... and now, part of their first art coll

Paws is tired. He just wants to rest. And to dream about the days when he used to chase rabbits. He still walks with Edward to the park twice a day, but only because Edward needs the fresh air. Until one day, Paws decides he doesn't want to go for another walk. He just wants to lie in Edward's bed. ?Paws has walked and walked. His paws are heavy. Paws doesn't have to walk anymore. Paws doesn't have to do anything anymore.? And Paws falls asleep one last time, leaving Edward to dream of the days when Paws used to chase rabbits. Espen Dekko's gently heartbreaking and heart-lifting story hits the perfect note as it explores death in an accessible, child-friendly, and nonfrightening way. By writing from the dog's perspective, Dekko makes it easier for children to understand and accept Paws's decline and death. Beginning with Paws dreaming of chasing rabbits and ending with Edward dreaming of Paws chasing rabbits, the story has a circular structure that is satisfying and reassuring, as it c

Another spot-on story of middle school drama and friendship from Terri Libenson, national bestselling author of Invisible Emmie and Positively Izzy.Friends. Frenemies. Middle school...The last day of seventh grade has Jaime and Maya wondering who their real friends are.Jaime knows something is off with her friend group. They’ve started to exclude her and make fun of the way she dresses and the things she likes. At least she can count on her BFF, Maya, to have her back . . . right?Maya feels more and more annoyed with Jaime, who seems babyish compared to the other girls in their popular group. It’s like she has nothing in common with Jai anymore. Are their days as BFFs numbered . . . ?Perfect for fans of Raina Telgemeier and Jennifer L. Holm.

#1 New York Times bestselling author John Flanagan returns to the world of Ranger's Apprentice, continuing the story arc that began in The Royal Ranger: A New Beginning, starring fan favorites Will an

Toy Story 4: The Junior Novelization retells the exciting new Disney/Pixar movie hitting theaters June 21, 2019!Disney/Pixar's Toy Story 4 opens a new chapter in the lives of Woody, Buzz Lightyear, an

The instant #1 New York Times bestseller! Stephanie Garber’s limitless imagination takes flight once more in the colorful, mesmerizing, and immersive sequel to the bestselling breakout debut CaravalA

See if you have what it takes to survive the monster-zombie apocalypse in this interactive guided journal from the New York Times bestselling Last Kids on Earth series, soon to be a Netflix original a

Learn how the United States ended up fighting for twenty years in a remote country on the other side of the world.The Vietnam War was as much a part of the tumultuous Sixties as Flower Power and the C

This Toy Story 4 Little Golden Book retells the exciting new Disney/Pixar movie, which will hit theaters June 21, 2019!Disney/Pixar's Toy Story 4 opens a new chapter in the lives of Woody, Buzz Lighty

Sleuthing duo Emily and James tackle their most challenging mystery yet set on the haunting Alcatraz Island in Book 3 of the New York Times-bestselling, middle-grade Book Scavenger series by Jennifer

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。品名：施德樓

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。品名：施德樓

When Josie goes to stay with her cousin Edith, she’s glad to be starting a new life away from the shame that has haunted her family since her brother chose not to fight in the war. But Edith’s friends

A fun, heartwarming animal story, ideal for children practising their reading at home or in school.It's Sausage's birthday and he's going to have a party with all of his friends. But the mean, jealous

A billy can't be posted, delivered on a bike, or sent in a car, truck or train. It has to be loaded on a ship with all those other Anzac billies for other soldier dads...During World War I, Australian

Elmer is enjoying his walk: smelling the flowers, watching the clouds, listening to the waterfall. But each time he points out one of these lovely things to the other animals, they all say they don't have time to stop. They're far too busy. Luckily Wilbur arrives at last and shares Elmer's enjoyment in the stars. A celebration of mindfulness from master-storyteller David McKee.

In a hot, hot country, ringed with mountains on one side and jungle on the other, lives a princess called Cinnamon. Her eyes are made of pearls, which means that she is blind. And, for reasons her par

A delightful retelling of a classic story with a twist, ideal for children practising their reading at home or in school.The little swan is not quite like his brothers and sisters. He's small and brow

From the international bestselling creator of Claude comes a brand new hero: Mr Penguin. Indiana Jones meets Hercule Poirot in this new Alex T. Smith series.Follow Mr Penguin and Colin as they crash-l

I've known you since you started.I've seen a thing or two . . .. . . or three or four or five or six!In fact, I've seen a few . . . Sometimes we are loud, sometimes we are quiet, sometimes bold and cl

A brilliantly witty introduction to comparisons and opposites, illustrated by the winner of the Sainsbury’s Children’s Book Award.These children and animals are all very different to each other. Some are big, some are small. Some are gentle, some are rough. Everyone is playful, but who’s the best at hiding? One thing’s certain: they all love a good bedtime story!Shortlisted for the Sainsbury’s Children’s Picture Book Award, this is the perfect book for little ones who are just beginning to make sense of their place in the world. Karl Newson has created a simple, funny and heart-warming text, which is perfectly matched by Kate Hindley’s charming, brilliantly witty artwork, filled with detail.Every Nosy Crow paperback picture book comes with a free “Stories Aloud” audio recording. Just scan the QR code and listen along!

From the well-loved French fairy tale, as retold by the Brothers Grimm. "Grandmother, what big eyes you have!" Little Red Riding Hood meets a wolf in the forest. He seems friendly, and he's interested

From the classic tale by the Brothers Grimm. “Rapunzel, Rapunzel, let down your long hair!” A witch keeps Rapunzel in a tall tower without a door or stairs – but she isn’t the only one visiting the lo

Sainsbury's Children's Book Awards 2019This terrific, travel-sized Where's Wally? book is full of searches, games and creative activities. Solve perplexing puzzles, personalise your travel checklist, design your own time machine and more. Plus, keep track of your own journeys with fun prompts, facts and challenges. And don’t forget to search for Wally – he's hiding in every scene! This search-and-find book also comes with a bonus sensational story card game!Fourth in a series of travel-sized Wally titles – look out for The Totally Essential Travel Collection, The Colouring Collection and Games on the Go! on your adventures!

An action-packed storytelling adventure that flips the traditional fairy tale on its head.When it’s time for Jamie’s bedtime story, his dad begins to tell an age-old fairy tale about a prince in a far

'Hilarious and charming. The most loveable duo since Frog and Toad' - Dav Pilkey, bestselling author of Dogman and Captain UnderpantsNarwhal and Jelly are back in action for a SUPER adventure - join S

2019 marks the 50th birthday of Eric Carle's beloved classic story The Very Hungry Caterpillar. In this brand new board book, The Very Hungry Caterpillar is going to a birthday party and excitement is