Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The Fault In Our Stars meets One Flew Over the Cuckoo's NestSeventeen-year-old Ivan Isaenko is a life-long resident of the Mazyr Hospital for Gravely Ill Children in Belarus. For the most part, every

Seven years earlier, France's top chef, Marc Fraysse, summoned the world's culinary press to his remote restaurant in central France to make an announcement that he said would cause shockwaves in th

Now in PaperbackWhy are we here? What is the meaning of life? What does it take to be happy? The answers to these and other life questions are gathered in Tiny Buddha: Simple Wisdom for Life’s Hard Qu

Some Americans cling desperately to the myth that we are living in a post-racial society, that the election of the first black president spelled the doom of racism. In fact, racist thought is alive an

Jigsaw Jones is back and better than ever in this brand-new chapter book mystery. Are aliens coming to Earth? Jigsaw and friends have a clue, but is there really life in outer space?

From Colleen Houck, New York Times bestselling author of The Tiger’s Curse, comes Recreated, the second book in the epic Egyptian-inspired Reawakened series, in which a seventeen-year-old must literal

When it comes to opposites, it’s all a matter of perspective! Lively text and fun retro art engage kids in the finer points of a favourite concept.Get a whole new perspective on opposites in this styl

Gina Royal is the definition of average—a shy Midwestern housewife with a happy marriage and two adorable children. But when a car accident reveals her husband’s secret life as a serial killer, she must remake herself as Gwen Proctor—the ultimate warrior mom.With her ex now in prison, Gwen has finally found refuge in a new home on remote Stillhouse Lake. Though still the target of stalkers and Internet trolls who think she had something to do with her husband’s crimes, Gwen dares to think her kids can finally grow up in peace.But just when she’s starting to feel at ease in her new identity, a body turns up in the lake—and threatening letters start arriving from an all-too-familiar address. Gwen Proctor must keep friends close and enemies at bay to avoid being exposed—or watch her kids fall victim to a killer who takes pleasure in tormenting her. One thing is certain: she’s learned how to fight evil. And she’ll never stop.

Love, secrets, and new dream world threats follow Liv Silver in the sequel to Dream A Little Dream. Things seem to be going well for Liv Silver: she's adjusting to her new home (and her new family) in

The Book of Mistakes 是一本關於「錯誤」的美麗繪本。眼睛畫歪了？原來能變成另一種神情；墨漬弄髒了畫紙？竟變成飄浮葉片。這本繪本以輕巧文字與詩意畫面，邀請讀者一同走進創作的過程，也看見容許犯錯、保留空白的力量。ZoommeetsBeautiful Oops!in this memorable picture book debut about the creative process, and the way in which "mistakes" can blossom into inspirationOne eye was bigger than the other. That was a mistake.The weird cat-cow-frog thing? Well, it made an excellent bush.And the inky smudges . . . they look as though they were always meant to be leaves floating gently across the sky.As one artist incorporates accidental splotches, spots, and misshapen things into her art, she transforms her piece in quirky and unexpected ways, taking readers on a journey through her process. Told in minimal, playful text, this story shows readers that even the biggest “mistakes” can be the source of the brightest ideas—and that, at the end of the day, we are all works in progress, too.Fans of Peter Reynolds’sIshand Patrick McDonnell’sA Perfectly Messed-Up Storywill love the funny, poignant, comple

Discover some 140 tasty restaurants and 30+ delightful hotels in the brand-new MICHELIN Guide Seoul 2017 (in English and Korean.) Seoul, a world-class dining destination, offers eclectic choices rangi

In this spare, funny picture book about diversity and friendship, a carrot in a crowd of peas just doesn’t fit in.

2015 Pulitzer Prize for Fiction2015 Andrew Carnegie Medal for Excellence in FictionWinner of the Pulitzer Prize, a New York Times Book Review Top Ten Book, National Book Award finalist, more than two and a half years on the New York Times bestseller listFrom the highly acclaimed, multiple award-winning Anthony Doerr, the stunningly beautiful instant New York Times bestseller about a blind French girl and a German boy whose paths collide in occupied France as both try to survive the devastation of World War II.Marie-Laure lives in Paris near the Museum of Natural History, where her father works. When she is twelve, the Nazis occupy Paris and father and daughter flee to the walled citadel of Saint-Malo, where Marie-Laure’s reclusive great uncle lives in a tall house by the sea. With them they carry what might be the museum’s most valuable and dangerous jewel.In a mining town in Germany, Werner Pfennig, an orphan, grows up with his younger sister, enchanted by a crude radio they find that

On its first publication The Picture of Dorian Gray was regarded as dangerously modern in its depiction of fin-de-siècle decadence. In this updated version of the Faust story, the tempter is Lord Henr

In 1959 the Boston Red Sox was the last team in the Major Leagues to integrate. But when they call Elijah “Pumpsie” Green up from the minors, Bernard is overjoyed to see a black player on his beloved

In the tradition of Uni the Unicorn and Gaston, this heartwarming and adorable debut picture book tells the story of a young unicorn who was born under the sea to a family of narwhals.Growing up in th

To young James Herriot, fresh out of veterinary college, Yorkshire appears to offer an idyllic pocket of rural life in a rapidly changing world. But even life in the sleepy village of Darrowby has its

“My guardian angel is a drunk.”Evelyn Casey's life is at a standstill. She's in her mid-twenties, struggling with the dating scene in San Francisco. Nothing seems to be working out, and she’s starting

Two, four, six. Look at all the bricks!Grab a hard hat and all your tools, and get ready for a construction adventure in counting! This clever, rhyming picture book leads readers through a day in the

A follow-up to the best-selling The Storm Whale, winner of the 2014 inaugural Oscar's First Book Prize in association with the Evening Standard. It’s winter time and Noi’s island is covered in a blank

A man named Rene floats through the world of his dreams and imagination, fulfilling his desire to become a painter—of apples and hats, apple hats, apple-these and apple-thats. In his paintings, leaves are lips, baguettes are noses, the right side is never up, and the upside is never down. Award-winning author Klaas Verplancke mashes everyday objects and words together in ways that are guaranteed to make kids laugh and think. Rene Magritte (Belgian, 1898–1967), one of the world’s most beloved artists, created whimsical, subversive paintings that helped launch the popularity of surrealism. His works combined words and images in novel, thought-provoking ways, and used humor and ordinary subjects to inspire viewers to question the world around them.

In this vivid and compelling novel, Tim Murphy follows a diverse set of characters whose fates intertwine in an iconic building in Manhattan s East Village, the Christodora. The Christodora is home to

In 1960, Joy Adamson first introduced to the world the story of her life alongside Elsa - the lioness she had rescued as an orphaned cub and raised to adulthood at her home in Kenya. But, as Elsa had

A novel of social and moral themes, Hard Times is the archetypal Dickens novel, filled with family difficulties, estrangement, rotten values and unhappiness. Published in 1854, it is set in the imagin

Set in the South of France in the decade after the First World War, Tender is the Night explores the new world of moneyed leisure found by the first generation of idle-rich Americans to take refuge in

Chart an unforgettable journey in your trusty canoe down the Amazon river with this beautifully illustrated 16-panel concertina pull-out wall frieze. Learn just how unique and important this fascinating place is as you wind past colourful communities, busy jungle cities, and incredible rainforest creatures and wacky wildlife, from high up in the Andes of Peru, to the bustling city of Belem in Brazil. Then turn the frieze over to discover loads of fascinating facts about each point of interest encountered along the journey, from pink river dolphins to a disappearing tribal village.Each title in our Unfolding Journeys series has its own distinct artwork style. Unfolding Journeys - Amazon Adventure's contemporary illustrated icons are etched in black and white against the bright greens, blues and pinks that encapsulate the Amazon's history and landscape. Part of our Unfolding Journeys range Also available: Unfolding Journeys: Rocky Mountain Explorer.Collect them all! About Lonely Planet K

Challenges young readers to find named objects in busy fold-out scenes set in the city, the country, at the sea, in the mountains, and in the air.

Little children can listen to a baby bird tweeting, frogs croaking in the pond and owls hooting when they press the pages of this delightful book. Colourful pages show the garden and pond in the sun a

All legends begin somewhere, and the two novels here are where one of the world's best-loved legends began. In A Study in Scarlet, Sherlock Holmes and Dr Watson first meet and investigate a seemingly

An exciting book for all middle schoolers (6th-8th grade) who wish they had taken better notes in american history class or just want to jump to the head of the class. Each Big Fat Notebook is like getting to borrow the notebook of the best student in American history class, the one who not only writes down the important points the teacher makes—noting those crucial “you will get tested on these” facts—but also meticulously transcribes key points from the chalkboard and pastes teacher handouts into her notebook. Part “CliffsNotes,” part workbook, this study hack will help kids focus on the things they need to remember in order to rock their middle school exams and ace american history.Each notebook was written by a graduate of a prestigious university, and all the writers graduated with honors in their respective subjects.Everything You Need to Ace American History in One Big Fat Notebook is based on state standards and has been vetted by a middle school American history teacher

In the spirit of Mindy Kaling’s bestseller Is Everyone Hanging Out Without Me?or Judd Apatow’s Sick in the Head, a collection of humorous, autobiographical essays from Kunal Nayyar, best known as Raj

A picture hides a thousand words ...On a hot July day in 1967, Odelle Bastien climbs the stone steps of the Skelton gallery in London, knowing that her life is about to change forever. Having struggle

Serafina's defeat of the Man in the Black Cloak has made it impossible for her to keep hiding in the basement of Biltmore estate. No longer the secret resident and rat catcher extraordinaire who explo

**2016 Man Booker Prize Longlist In Canada in 1991, ten-year-old Marie and her mother invite a guest into their home: a young woman who has fled China in the aftermath of the Tiananmen Square protests

The final chapter in Sergei Lukyanenko's internationally bestselling Night Watch series—a revelatory urban fantasy set in contemporary Moscow.They live among us. They fight among us. They’re the Other

In the winter of 1954, in a construction camp in the remote Tasmanian highlands, when Sonja Buloh was three years old and her father was drinking too much, her mother disappeared into a blizzard never

Animals eat animals in this informative exposé of three animal food chains Three of the longest food chains of the animal kingdom are depicted in three accordion-foldout volumes, complete with stunnin

本書描寫一位小女孩親手打造自己的娃娃屋，從外牆的磚紋、室內的壁紙，到替娃娃縫製的衣服，甚至用紙杯做成的小小電梯，每個細節都來自她的想像與雙手。她對這座獨一無二的家感到驕傲，也在其中玩得不亦樂乎。直到有一天，她看見朋友 Sophie 那棟「完美」的現成娃娃屋——所有配件一應俱全，連馬桶蓋都能掀起。兩人一番比較之後，逐漸發現，真正好玩的並不是什麼都齊備，而是能自由改造、反覆想像的空間。A girl makes her own dollhouse in this picture book that celebrates creativity and imagination!A little girl proudly walks the reader through her handmade dollhouse, pointing out the bricks she painted on the outside, the wallpaper she drew on the inside, the fancy clothes she made for her dolls, and the little elevator she made out of a paper cup. She’s proud of her house and has lots of fun using her imagination to play with it—until she discovers her friend Sophie’s “perfect” storebought house. Sophie thinks her house, with everything matching and even a toilet seat that goes up and down, is pretty perfect too, until both girls discover that the narrator’s handmade dollhouse is really a lot more fun."Celebrates the best of free play, capturing what it's like to be fully engaged and inspired." —

"Shortly after her college graduation, Frances flees a painful breakup and her claustrophobic childhood home in Manhattan, which has become more airless in the aftermath of two family announcements: h

An outrageously stylish, wickedly funny novel of fashion in the digital age,The Knockoff is the story of Imogen Tate, editor in chief of Glossy magazine, who finds her twentysomething former assistant