A comprehensive guide to cutting-edge tools in ADME researchThe last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology too
An irresistible comedy of manners about three generations of a Chicago restaurant family and the deep-fried, beer-battered, cream cheese-frosted love that feeds them all.Here are the three things the Sullivan family knows to be true: the Chicago Cubs will always be the underdogs; historical progress is inevitable; and their grandfather, Bud, founder of JP Sullivan’s, will always make the best burgers in Oak Park. But when, over the course of three strange months, the Cubs win the World Series, Trump is elected president, and Bud drops dead, suddenly everyone in the family finds themselves doubting all they hold dear. Take Gretchen for example, lead singer for a ’90s cover band who has been flirting with fame for a decade but is beginning to wonder if she’s too old to be chasing a childish dream. Or Jane, Gretchen’s older sister, who is starting to suspect that her fitness-obsessed husband who hides the screen of his phone isn’t always “working late.” And then there’s Teddy, their stead
The last 20 years have seen an explosion of research and development in the neurosciences. Indeed, some have called this first decade of the 21st century 'the decade of the mind'. An all-encompassing term, the neurosciences cover such fields as biology, psychology, neurology, psychiatry and philosophy and include anatomy, physiology, molecular biology, genetics and behaviour. It is now a major industry with billions of dollars of funding invested from both public and private sectors. Huge progress has been made in our understanding of the brain and its functions. However, with progress comes controversy, responsibility and dilemma. The New Brain Sciences: Perils and Prospects examines the implications of recent discoveries in terms of our sense of individual responsibility and personhood. With contributing chapters from respected and influential names in neuroscience, law, psychology, philosophy and sociology, The New Brain Sciences should kick-start a discussion of where neuroscience
This volume presents the lectures of the nineteenth Canary Islands Winter School, dedicated to the Cosmic Microwave Background (CMB). This relict radiation from the very early Universe provides a fundamental tool for precision cosmology. Prestigious researchers in the field present a comprehensive overview of current knowledge of the CMB, reviewing the theoretical foundations, the main observational results and the most advanced statistical techniques used in this discipline. The lectures give coverage from the basic principles to the most recent research results, reviewing state of the art observational and statistical analysis techniques. The impact of new experiments and the constraints imposed on cosmological parameters are emphasized and put into the broader context of research in cosmology. This is an important resource for both graduate students and experienced researchers, revealing the spectacular progress that has been made in the study of the CMB within the last decade.
Including an overview of progress made in the field over the past decade, Neural Stem Cell Assays provides a detailed and comprehensive review of the basic methods for neural stem cell cultures.
For the first time in one collected volume, mainstream and critical human rights scholars together examine the empirical and normative debates around the future of human rights. They ask what makes human rights effective, what strategies will enhance the chances of compliance, what blocks progress, and whether the hope for human rights is entirely misplaced in a rapidly transforming world. Human Rights Futures sees the world as at a crucial juncture. The project for globalizing rights will either continue to be embedded or will fall backward into a maelstrom of nationalist backlash, religious resurgence and faltering Western power. Each chapter talks directly to the others in an interactive dialogue, providing a theoretical and methodological framework for a clear research agenda for the next decade. Scholars, graduate students and practitioners of political science, history, sociology, law and development will find much to both challenge and provoke them in this innovative book.
Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate thes
Superconductors are entering a new age where they will be much more commonplace. High-temperature superconductors (HTS) are currently in the marketplace for rf filter applications and are coming into power applications as wires for cables, fault current limiters and motors/generators. Critical to enabling these developments are the great advances over the last decade-and-a-half in preparation of high-quality materials. Equally exciting, new superconductors are emerging and a better understanding of the cuprates is evolving. The three-year-old MgB2 superconductor appears to be now moving on to the applications arena as well. This book offers a diverse collection of timely presentations on these new frontiers in superconducting materials. Topics include: developments in second-generation HTS wire, known as coated conductors; progress in first-generation HTS wire towards better performance and manufacturing; MgB2 materials developments, especially thin films and wires; rf applications; a
For the first time in one collected volume, mainstream and critical human rights scholars together examine the empirical and normative debates around the future of human rights. They ask what makes human rights effective, what strategies will enhance the chances of compliance, what blocks progress, and whether the hope for human rights is entirely misplaced in a rapidly transforming world. Human Rights Futures sees the world as at a crucial juncture. The project for globalizing rights will either continue to be embedded or will fall backward into a maelstrom of nationalist backlash, religious resurgence and faltering Western power. Each chapter talks directly to the others in an interactive dialogue, providing a theoretical and methodological framework for a clear research agenda for the next decade. Scholars, graduate students and practitioners of political science, history, sociology, law and development will find much to both challenge and provoke them in this innovative book.
Algebraic geometers have renewed their interest in the interplay between algebraic vector bundles and projective embeddings. New methods have been developed for questions such as: what is the geometric content of syzygies and of bundles derived from them? how can they be used for giving good compactifications of natural families? which differential techniques are needed for the study of families of projective varieties? Such problems have often been reformulated over the last decade; often the need for a deeper analysis of the works of classical algebraic geometers was recognised. These questions were addressed at successive conferences held in Trieste and Bergen. New results, work in progress, conjectures and modern accounts of classical ideas were presented. This collection represents a development of the work conducted at the conferences; the Editors have taken the opportunity to mould the papers into a cohesive volume.
Reshaping Life is an authoritative yet easy-to-read description of modern molecular biology and genetics, and the ethical implications of genetic engineering. Now in its third edition, it has been fully revised and updated, taking advantage of a decade of progress in genetics and biotechnology. No other book straddles the scientific and the social dimensions of genetics as lucidly. It offers a concise working knowledge of DNA science and of those aspects of cell biology needed to understand such issues as animal cloning, genetically modified food, and gene therapy. It examines the debates on the sociological and ethical issues surrounding modern technology, laying out the issues for the reader, while urging a rational approach. Reshaping Life is well suited to general readers interested in science and medicine, as well as undergraduate and graduate students across a broad band of disciplines within the life sciences.
This volume presents a selection of the philosophical papers which Richard Rorty has written over the past decade, and complements three previous volumes of his papers: Objectivity, Relativism, and Truth, Essays on Heidegger and Others and Truth and Progress. Topics discussed include the changing role of philosophy in Western culture over the course of recent centuries, the role of the imagination in intellectual and moral progress, the notion of 'moral identity', the Wittgensteinian claim that the problems of philosophy are linguistic in nature, the irrelevance of cognitive science to philosophy, and the mistaken idea that philosophers should find the 'place' of such things as consciousness and moral value in a world of physical particles. The papers form a rich and distinctive collection which will appeal to anyone with a serious interest in philosophy and its relation to culture.
Physics at Surfaces is a unique graduate-level introduction to the physics and chemical physics of solid surfaces, and atoms and molecules that interact with solid surfaces. A subject of keen scientific inquiry since the last century, surface physics emerged as an independent discipline only in the late 1960s as a result of the development of ultra-high vacuum technology and high speed digital computers. With these tools, reliable experimental measurements and theoretical calculations could at last be compared. Progress in the last decade has been truly striking. This volume provides a synthesis of the entire field of surface physics from the perspective of a modern condensed matter physicist with a healthy interest in chemical physics. The exposition intertwines experiment and theory whenever possible, although there is little detailed discussion of technique. This much-needed text will be invaluable to graduate students and researchers in condensed matter physics, physical chemistry
African regional trade integration has grown exponentially in the last decade. This book is the first comprehensive analysis of the legal framework within which it is being pursued. It will fill a huge knowledge gap and serve as an invaluable teaching and research tool for policy makers in the public and private sectors, teachers, researchers and students of African trade and beyond. The author argues that African Regional Trade Agreements (RTAs) are best understood as flexible legal regimes particularly given their commitment to variable geometry and multiple memberships. He analyzes the progress made toward trade liberalization in each region, how the RTAs are financed, their trade remedy and judicial regimes, and how well they measure up to Article XXIV of GATT. The book also covers monetary unions as well as intra-African regional integration, and examines free trade agreements with non-African regions including the Economic Partnership Agreements with the European Union.
This volume presents a selection of the philosophical papers which Richard Rorty has written over the past decade, and complements three previous volumes of his papers: Objectivity, Relativism, and Truth, Essays on Heidegger and Others and Truth and Progress. Topics discussed include the changing role of philosophy in Western culture over the course of recent centuries, the role of the imagination in intellectual and moral progress, the notion of 'moral identity', the Wittgensteinian claim that the problems of philosophy are linguistic in nature, the irrelevance of cognitive science to philosophy, and the mistaken idea that philosophers should find the 'place' of such things as consciousness and moral value in a world of physical particles. The papers form a rich and distinctive collection which will appeal to anyone with a serious interest in philosophy and its relation to culture.
Singularity theory is not a field in itself, but rather an application of algebraic geometry, analytic geometry and differential analysis. The adjective 'singular' in the title refers here to singular points of complex-analytic or algebraic varieties or mappings. A tractable (and very natural) class of singularities to study are the isolated complete intersection singularities, and much progress has been made over the past decade in understanding these and their deformations.
The last 20 years have seen an explosion of research and development in the neurosciences. Indeed, some have called this first decade of the 21st century 'the decade of the mind'. An all-encompassing term, the neurosciences cover such fields as biology, psychology, neurology, psychiatry and philosophy and include anatomy, physiology, molecular biology, genetics and behaviour. It is now a major industry with billions of dollars of funding invested from both public and private sectors. Huge progress has been made in our understanding of the brain and its functions. However, with progress comes controversy, responsibility and dilemma. The New Brain Sciences: Perils and Prospects examines the implications of recent discoveries in terms of our sense of individual responsibility and personhood. With contributing chapters from respected and influential names in neuroscience, law, psychology, philosophy and sociology, The New Brain Sciences should kick-start a discussion of where neuroscience
This textbook provides graduate students with a thorough and up-to-date introduction to inflationary cosmology. Enormous progress has been made in this area in the last few years and this book is the first to provide a modern and unified overview. It covers all aspects of inflationary cosmology and carefully compares predictions with the latest observations, including those of the cosmic microwave background, the clustering and velocities of galaxies and the epoch of structure formation. Problems are included throughout to help the student to develop a thorough understanding. With the host of international experiments currently being performed and planned for the near future (including NASA's MAP satellite, and the European Space Agency's Planck mission), inflationary cosmology promises to be one of the most exciting and fruitful topics of research in science in the next decade. This book provides graduate students with the ideal introduction.
Since the classification of finite simple groups was announced in 1980 the subject has continued to expand opening many new areas of research. This volume contains a collection of papers, both survey and research, arising from the 1990 Durham conference in which the excellent progress of the decade was surveyed and new goals considered. The material is divided into eight sections: sporadic groups; moonshine; local and geometric methods in group theory; geometries and related groups; finite and algebraic groups of Lie type; finite permutation groups; further aspects of Lie groups; related topics. The list of contributors is impressive and the subjects covered include many of the fascinating developments in group theory that have occurred in recent years. It will be an invaluable document for mathematicians working in group theory, combinatorics and geometry.
An analysis of how a decade of military rule in Venezuela produced a dominant ideology of progress so meticulously crafted that to this day audacious Modernist art and architecture and dictatorship ar
