The thesis of this innovative and challenging book, first published in 2001, is that brain drug development has been restricted by the failure of adequate brain drug targeting, and that this is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author, a world leader in the study of the blood-brain barrier and its clinical implications, reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the cent
There is now a remarkably strong consensus among academics and professional economists that central banks should adopt explicit inflation targets and that all key monetary policy decisions, especially those concerning interest rates, should be made with a view to ensuring that these targets are achieved. This book provides a comprehensive review of the experience of inflation targeting since its introduction in New Zealand in 1989 and looks in detail at what we can learn from the past twenty years and what challenges we may face in the future. Written by a distinguished team of academics and professional economists from central banks around the world, the book covers a wide range of issues including many that have arisen as a result of the recent financial crisis. It should be read by anyone concerned with better understanding inflation targeting and its past, present and future role within monetary policy.
There is now a remarkably strong consensus among academics and professional economists that central banks should adopt explicit inflation targets and that all key monetary policy decisions, especially those concerning interest rates, should be made with a view to ensuring that these targets are achieved. This book provides a comprehensive review of the experience of inflation targeting since its introduction in New Zealand in 1989 and looks in detail at what we can learn from the past twenty years and what challenges we may face in the future. Written by a distinguished team of academics and professional economists from central banks around the world, the book covers a wide range of issues including many that have arisen as a result of the recent financial crisis. It should be read by anyone concerned with better understanding inflation targeting and its past, present and future role within monetary policy.
We view things from a certain position in time: in our language, thought, feelings and actions, we draw distinctions between what has happened, is happening, and will happen. Frequently, approaches to this feature of our lives - those seen in disputes between tensed and tenseless theories, between realist and anti-realist treatments of past and future, and in accounts of historical knowledge - embody serious misunderstandings of the character of the issues; they misconstrue the relation between metaphysics and ethics, and the way to characterize the kind of sense which tensed language has. David Cockburn argues that the notion of 'reasons for emotion' must have a central place in any account of meaning, and that the present should have no priority in our understanding of tense. This allows for a more satisfactory articulation of the place of past, present and future in our thought, and of the form which criticism of our thought might take.
This two-volume set provides a chronological view of the foreign policy/national security doctrines of key American presidents from Washington to Obama, framed by commentary on the historical context
The book examines the future deployment of renewable power from a normative point of view. It identifies properties characterizing the cost-optimal transition towards a renewable power system and anal
This is a case study of legal transplant, economic development, cultural adaptation and political integration. Hong Kong's journey from British entrepôt to China's international financial centre is one of the most interesting legal stories of our time. But Hong Kong's future is even more interesting: will this region with British-origin institutions survive full integration into China and become its permanent international financial centre? Does Hong Kong have the legal infrastructure to compete effectively with Shanghai and Singapore, and even New York and London? A Financial Centre for Two Empires presents Hong Kong's story, examines its corporate economy and securities market, assesses its corporate, securities and tax laws for doctrinal soundness and appropriate remedies, and evaluates the quality of their enforcement empirically. It closes with a view of Hong Kong from the perspective of developments in Beijing and Shanghai, including an examination of the important political dime
At a time when contemporary challenges seem to many to be insurmountable, this book offers an optimistic view of the future and provides a road map for societies to get there. Drawing upon extensive r
Distributed Ledger Technology (DLT) is a way of managing, storing, and sharing information over a distributed network. The position of DLT in banking can be seen as controversial as it is a rapidly evolving technology with both potential benefits and challenges. The Role of Distributed Ledger Technology in Banking presents a balanced assessment of both the opportunities and risks behind such recent innovations. Combining theory and practice, it explores the impact of DLT in the banking sector and offers the opportunity to exploit different points of view from different disciplines. It presents topics from both a theoretical and practical point of view, highlighting concrete applications. Written by a team of experts from academia and the banking sector, this book looks at DLT not as a threat but as an exciting opportunity to bring the banking/financial system in the future.
From an intuitive point of view with pictures to support the ideas, this beginner's book on analysis lays the groundwork for future work in advanced mathematics. Very detailed proofs of theorems as we
Hong Kong has remained the global metropolis for Asia since its founding in the 1840s following the Opium Wars between Britain and China. David Meyer traces its vibrant history from the arrival of the foreign trading firms, when it was established as one of the leading Asian business centres, to its celebrated handover to China in 1997. Throughout this period, Hong Kong has been prominent as a pivotal meeting place of the Chinese and foreign social networks of capital and as such has been China's window on to the world economy, dominating other financial centers such as Singapore and Tokyo. Looking into the future, the author presents an optimistic view of Hong Kong in the twenty-first century, challenging those who predict its decline under Chinese rule. This accessible and broad-ranging look at the story of Hong Kong's success will interest anyone concerned with its past, present and future.
In his bestselling 23 Things They Don't Tell You About Capitalism, Cambridge economist Ha-Joon Chang brilliantly debunked many of the predominant myths of neoclassical economics. Now, in an entertaining and accessible primer, he explains how the global economy actually works--in real-world terms. Writing with irreverent wit, a deep knowledge of history, and a disregard for conventional economic pieties, Chang offers insights that will never be found in the textbooks.Unlike many economists, who present only one view of their discipline, Chang introduces a wide range of economic theories, from classical to Keynesian, revealing how each has its strengths and weaknesses, and why there is no one way to explain economic behavior. Instead, by ignoring the received wisdom and exposing the myriad forces that shape our financial world, Chang gives us the tools we need to understand our increasingly global and interconnected world often driven by economics. From the future of the Euro, inequality
The Open Past challenges a view of time that has dominated philosophical thought for the past two centuries. In that view, time originates from a relationship to the future, and the past can be only a
This book provides a comprehensive guide to the conceptual methodological, and epistemological problems of biology, and treats in depth the major developments in molecular biology and evolutionary theory that have transformed both biology and its philosophy in recent decades. At the same time the work is a sustained argument for a particular philosophy of biology that unifies disparate issues and offers a framework for expectations about the future directions of the life sciences. The argument explores differences between autonomist and anti-autonomist views of biology. The result is a vindication of reductionism, but one that is unexpectedly hollow. For it leaves the exponents of the autonomy of biology from physical science with as much as their view of biology really requires - and rather more than the reductionist might comfortably concede. Professor Rosenberg shows how the problems of the philosophy of biology are interconnected and how their solutions are interdependent, However,
An apocalyptic view of the future of healthcare and the world as governments turn away from the grisly art of combat and instead begin a new focus of control through the one item that nearly everyone
Astronomy is one of the oldest sciences, and one which has repeatedly led to fundamental changes in our view of the world. This book covers the history of our study of the cosmos from prehistory through to a survey of modern astronomy and astrophysics (sure to be of interest to future historians of twentieth-century astronomy). It does not attempt to cover everything, but deliberately concentrates on the important themes and topics. These include stellar astronomy in the seventeenth and eighteenth centuries, at the time subordinate to the study of the solar system, but the source of many important concepts in modern astronomy, and the Copernican revolution, which led to the challenge of ancient authorities in many areas, not just astronomy. This is an essential text for students of the history of science and for students of astronomy who require a historical background to their studies.
String theory has played a highly influential role in theoretical physics for nearly three decades and has substantially altered our view of the elementary building principles of the Universe. However, the theory remains empirically unconfirmed, and is expected to remain so for the foreseeable future. So why do string theorists have such a strong belief in their theory? This book explores this question, offering a novel insight into the nature of theory assessment itself. Dawid approaches the topic from a unique position, having extensive experience in both philosophy and high-energy physics. He argues that string theory is just the most conspicuous example of a number of theories in high-energy physics where non-empirical theory assessment has an important part to play. Aimed at physicists and philosophers of science, the book does not use mathematical formalism and explains most technical terms.
How are two or more languages learned and contained in the same mind or the same community? This handbook presents an up-to-date view of the concept of multi-competence, exploring the research questions it has generated and the methods that have been used to investigate it. The book brings together psychologists, sociolinguists, Second Language Acquisition (SLA) researchers, and language teachers from across the world to look at how multi-competence relates to their own areas of study. This comprehensive, state-of-the-art exploration of multi-competence research and ideas offers a powerful critique of the values and methods of classical SLA research, and an exciting preview of the future implications of multi-competence for research and thinking about language. It is an essential reference for all those concerned with language learning, language use and language teaching.
Tracing the path from Troy's destruction to Rome's foundation, the Aeneid explores the transition between past and future. As the Trojans struggle to found a new city and the narrator sings of his audience's often-painful history, memory becomes intertwined with a crucial leitmotif: the challenge of being part of a group that survives violence and destruction only to face the daunting task of remembering what was lost. This book offers a new reading of the Aeneid that engages with critical work on memory and questions the prevailing view that Aeneas must forget his disastrous history in order to escape from a cycle of loss. Considering crucial scenes such as Aeneas' reconstruction of Celaeno's prophecy and his slaying of Turnus, this book demonstrates that memory in the Aeneid is a reconstructive and dynamic process, one that offers a social and narrative mechanism for integrating a traumatic past with an uncertain future.
Based on a collection of statements delivered between 2003 and 2015, The Vatican in the Family of Nations provides a new understanding of the social doctrine and actions of the Catholic Church in international law and relations. These statements address contemporary issues that stir deep emotional responses, from disarmament, migrations, trade, and intellectual property to discrimination and freedom of conscience. This volume disputes irrational fears of newcomers, offers reasonable adaptations to allow for peaceful coexistence, and insists on investigating the root causes of today's conflicts and displacements. As an independent voice, the Holy See offers these reflections with the view of prioritizing the common good before confessional interests, even when their aims and ends converge. In this sense, this book is a unique collection in international literature on the intersection of theology, human rights and social issues, which opens courageous new paths for the future.
