Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A powerful debut novel charting the faultlines that open in a farming family in North Wales as they wait for their son to return from the Iraq War'Beautiful and unflinching, Cloudless is a phenomenal debut' ANNA HOPE, author of Albion‘Attends to the bonds we have to family, landscape, global politics with uncommon attention, extraordinary depth and lightness of touch’ ELIZABETH O'CONNOR, author of Whale FallIt is autumn 2004 and in a farmhouse on the hills outside Llandudno, Catrin and John endure the agonizing wait for their older son to return from Iraq. His decision to join up has left them reeling, yet there are other battles at home: the working of the land that has been theirs for generations and what to do with their troubled younger son.Catrin’s childhood sweetheart comes back to their small town, forcing the boys’ doting mother to confront the life she might have had. And John, desperate to keep farm and family together, turns to ever riskier methods to stay afloat.As each mem

在櫻花盛開的河畔橋邊，隱身林間的「Marble Cafe」靜靜佇立。一位總是點熱可可的女子，在筆記本上書寫日常；年輕的侍者默默為她準備熟悉的滋味。彼此不曾真正交談，卻在心裡猜想對方的人生，也觀察著來來往往的客人。本書以十二個彼此相連的生活片段，描繪散步、煎玉子燒、塗指甲油這些微小瞬間，如何在不經意間改變他人的命運。故事溫柔細膩，如一杯暖熱可可，緩緩滲入心底，提醒我們——在各自的孤單與喜悅之中，人與人始終悄悄相互照亮。THE GLOBAL BESTSELLERBy the multi-million copy author of What You Are Looking For Is in the LibraryFor fans of Before the Coffee Gets ColdReaders love Hot Chocolate on Thursday:‘Slipped into my heart and warmed me, just like a cup of cocoa’ ★★★★★‘I definitely recommend this book!’ ★★★★★‘Thursday is the beginning of the second half of the week. I felt restored reading this’ ★★★★★‘Reminds you that everyone is living their own daily joy and pain. Heartwarming’ ★★★★★‘This made me realise how we magically influence each other’s lives without realising it’ ★★★★★Across a bridge, in view of cherry blossom lies the Marble Cafe,where a woman writes in a notebookand a young waiter prepares her favourite hot drink.Both wonder about each other,and about the other lives of the clientelewho fre

A FORGOTTEN EGYPTIAN GODDESS. A FAMILY IN DANGER. Victorian Egyptologist Clemmie’s dark talents have torn her family apart. Now she has one chance to atone for the past.‘Brilliant… I loved it.’ Santa MontefioreA FORGOTTEN EGYPTIAN GODDESS. A FAMILY IN DANGER.Victorian Egyptologist Clemmie’s dark talents have torn her family apart. Now she has one chance to atone for the past.Clemmie’s gift for reading hieroglyphs shines at the Egyptian relic parties which have made her father the toast of Victorian society. But at one party, the words she interprets from an unusual amulet strike fear into her heart. The childhood game she used to play about the immortal sisters, Isis and Nephthys, takes on a devastating resonance and it is only by following Nephthys' story back to Egypt that she can undo the mistakes of the past.‘An irresistible page-turner’ Susan Stokes-Chapman, author Pandora‘An intoxicating tale of adventure and obsession’ Emilia Hart, author of Weyward‘A joy of a book’ Fiza Saeed M

**FROM THE AUTHOR OF 2024 BOOKER PRIZE WINNING ORBITAL**It''s Jake''s birthday. He has lost his wife, his son is in prison and he is about to lose his past. Jake has Alzheimer''s.As the disease takes hold of him, the key events of his life shift, and what until recently seemed solid fact melts into surreal imaginings. Is his daughter alive or long dead? And why exactly is his son in prison? There was a cherry tree once, and a yellow dress, but what do they mean? Is there anything he''ll be able to salvage from the wreckage?From the first sentence to the last, The Wilderness holds us in its grip. This is writing of extraordinary power and beauty.

An expert author team examines in detail the theory and history behind the EU, before moving on to explore the institutions and policies at work, giving readers valuable insight into this complicated

Play the best of Bluey's games in this coloring and activity pad that comes with a 5-color stackable marker and 50+ stickers! Keepy Uppy, Fancy Restaurant, Rug Island . . . there are just too many games to choose from! Join Bluey, Bingo, and their whole family in this coloring and activity pad that is all about the fun games they play together. From made up games to awesome sports, the coloring pages show the whole Heeler gang having a blast with their friends. Solve mazes, puzzles, dot-to-dots, and so much more. Bring the fun-packed coloring pages to life with the 5-color stackable marker, then add the 50+ stickers to your favorite pages. With so much coloring and activity fun, this is the perfect gift for all Bluey fans!

Step into Muffin's World with this playful 48-page coloring and activity pad featuring Bluey's unforgettable cousin, Muffin! Step into Muffin's World with this playful 48-page coloring and activity pad featuring Bluey's unforgettable cousin, Muffin! Kids will love exploring Muffin's silly antics and unique personality through fun coloring pages, mazes, puzzles, and more. Complete with four jumbo crayons and 50+ stickers, this pad is perfect for young fans to dive into hours of creative fun, whether they're at home or on the go. Let the adventures begin with Bluey, Bingo, and Muffin in this playful activity pad!

Pre-order now to receive the stunning DELUXE LIMITED EDITION-- only available on the first printing while supplies last! The collector's hardcover features stenciled edges, illustrated endpapers, and jacket effects.From New York Times bestselling author Kate Quinn comes a gorgeously written fantastical adventure which poses the question: Have you ever wished you could live inside a book? Welcome to the Astral Library, where books are not just objects, but doors to new worlds, new lives, and new futures.Alexandria "Alix" Watson has learned one lesson from her barren childhood in the foster-care system: books will never let you down, unlike people. Working three dead-end jobs to make ends meet and knowing college is a pipe dream, Alix takes nightly refuge in the high-vaulted reading room at the Boston Public Library, escaping into her favorite fantasy novels and dreaming of far-off lands. Until the day she stumbles through a hidden door and meets the Librarian: the ageless, acerbic guard

A fresh and fascinating picture book biography about the iconic magician Harry Houdini, an avid book collector who lived and breathed the idea that books are magic, from the author of Caldecott Honor book The Noisy Paint Box. Houdini is the world's most beloved magician, and he became famous for all of the amazing tricks he accomplished. Houdini knew just how to captivate his audience, whether it was leaping from a bridge or freeing himself from a straitjacket. But in true magician's fashion, he kept a secret so great that not many people knew about, and that was his love for books! As a young boy in Budapest, Harry learned to read at his father's knee. After the family emigrated to America, Harry grew up to be the amazing Houdini--but never lost his love of reading. He spent the rest of his life collecting all kinds of rare and unusual books, almost entirely about magic. With warm, inviting text and astounding art with miniature models constructed from paper, this extraordinary book o

A companion book to the bestselling Go Show the World, this is another joyous picture book celebration of 13 Indigenous heroes from the past and present. We are who we are. There's strength in this too. We kept this place free, so you can be you. Author Wab Kinew expresses this essential message and continues his work from Go Show the World by celebrating the triumphs of 13 more Indigenous heroes throughout history -- and how their struggles and successes have made not just their communities but the world a better place for today's youth. From engineer Mary Golda Ross to interpreter George Bonga, from actor Chief Dan George to author Tasha Spillett, Kinew explores how each of these heroes embraced their most authentic selves (alongside gorgeous illustrations by Janine Gibbons) . . . and encourages young readers to do the same.

★ 真實歷史事件「盧西塔尼亞號沉沒」為背景的震撼冒險小說★ 《The Blackbird Girls》得獎作家 Anne Blankman 最新歷史故事★ 在戰爭與偏見之中，看見友情與勇氣的力量★ 結合歷史事件、逃亡冒險與深刻情感的動人作品以第一次世界大戰與盧西塔尼亞號沉沒為背景，本書描寫少女 Marta 在敵國獨自求生的冒險。當她隱藏德國身分、被善良家庭收留時，也開始思考戰爭與偏見的真相。這是一部結合歷史、友情與成長的動人故事。2025 SLJ Best Middle Grade BooksIn the spirit of Lauren Wolk and Ruta Sepetys comes the tale of a girl fighting her way back home after surviving the sinking of the Lusitania--and learning to think for herself rather than accept the prejudice of wartime. The year is 1915 and the world is at war. Marta and her father are passengers on the Lusitania, desperately trying to get back home to Germany. While aboard, they must keep their identities hidden or risk being mistaken for enemy spies. Then the Lusitania is attacked by a German submarine. They just make it off the sinking ship, but her father is discovered and detained. Marta suddenly finds herself alone in enemy land. To survive, Marta must draw upon a deep well of bravery she never knew she had. Fortunately, she meets C

A new picture book from #1 New York Times bestselling author and musician Robbie Arnett about finding the music of your heart It will make you dance!It will make you sing!It's called . . .Thwistle Ping! Lennie Fling has always been good at everything. But when it comes to music, he only falls flat. So when the school's music recital is announced, Lennie must find a way to play a tune. With a little help from his groovy neighbor who dances to her own beat, Lennie learns that musical expression can take on many unexpected forms. In this rollicking tale by #1 New York Times bestselling author Robbie Arnett, Thwistle Ping! will inspire you to strum a chord, whistle a melody, and find the music of your heart.

From the Man Asian Prize-shortlisted author Rahul Bhattacharya, a breathtaking novel about a woman forging a life for herself on the railways of 20th century India. In a country rapidly modernizing after Independence, Animesh Chitol bends his caste title into a quirky surname, moves his family to the brand-new township of Bhombalpur Railway Workshop, and throws in his lot with an optimism-filled future. Then tragedy strikes. Into the empty space left by his wife's passing grows Chitol's only daughter, the middle child, Charu. As India moves from steam to diesel locomotives, through a great strike and state repression, Charu flees to Bombay, alarmed by her narrow prospects. There she quests for the means to live on her own terms. Amidst the everyday discriminations of modern India, Charu forges her own destiny, becoming a railway woman and census enumerator who keeps her heart open-sometimes guilelessly-to her country's vast possibility. Sweeping, elegiac, and at times wonderfully comic

Wab Kinew's acclaimed picture book tribute to historic and modern-day Indigenous heroes -- now available in paperback -- is sure to be shared and treasured across generations. Honoring the stories of Indigenous people across time, award-winning author Wab Kinew's celebrated picture book is now available in paperback. Featuring figures such as Crazy Horse, Net-no-kwa, former NASA astronaut John Herrington, NHL goalie Carey price and many others, Go Show the World showcases a diverse group of Indigenous people from the United States and Canada. Individually, their stories -- though briefly touched on -- are inspiring; collectively, they empower us to "show the world what people who matter can do." With breathtaking illustrations by internationally lauded artist Joe Morse, this beautiful book celebrates the potential within readers when they recognize how much they matter, and how far they can go.

A brand new spicy forced proximity action adventure romcom set on a desert island!Perfect for fans of Christina Lauren, Jo Segura and Meghan Quinn. One treasure map. Two total opposites. A romance they never saw coming... When Sydney York ends up shipwrecked on a remote island, the last thing she expects is to end up on a treasure hunt. But when she meets Hunter Holden, the island's sole inhabitant, who just happens to be searching for a legendary treasure, she ends up drawn into an adventure that leads across treacherous terrain, fighting venomous snakes and facing an enemy also searching for gold.Will the two treasure hunters find the gold they're searching for, or is it possible their unlikely partnership might turn into something more priceless?Tropes: Destination romcom Desert island location Forced proximity Chance encounter Spicy Praise for Olivia Jackson 'A fun, spicy adventure romance perfect for readers who adore puzzles and action mixed in with their love stories...

From New York Times bestselling illustrator Pete Oswald and written by acclaimed author Lucy Ruth Cummins comes a silly and sing-songy Sleepy Sheepy bedtime board book.Twinkle, twinkle, little sheep,now it's time to go to sleep . . .Crafted from the original bedtime song "Twinkle, Twinkle, Little Star," and with sturdy board book pages, this is the perfect bedtime read for little sheepies who absolutely, positively refuse to go to bed! For fans of Sandra Boynton's The Going to Bed Book and Eric Carle's Twinkle, Twinkle, Little Star and Other Nursery Rhymes.Don't miss the other books in the series:Sleepy SheepySheepy Sheepy and the SheepoverCreepy Sheepy

From one of tech’s boldest thinkers and his deputy, a sweeping indictment of the West’s culture of complacency, arguing that timid leadership, intellectual fragility, and an unambitious view of technology’s potential in Silicon Valley have made the U.S. vulnerable in an era of mounting global threats.Silicon Valley has lost its way.Our most brilliant engineering minds once collaborated with government to advance world-changing technologies. Their efforts secured the West’s dominant place in the geopolitical order. But that relationship has now eroded, with perilous repercussions.Today, the market rewards shallow engagement with the potential of technology. Engineers and founders build photo-sharing apps and marketing algorithms, unwittingly becoming vessels for the ambitions of others. This complacency has spread into academia, politics, and the boardroom. The result? An entire generation, for whom the narrow-minded pursuit of the demands of a late capitalist economy has become their c

Mars was a distant shore, and the men spread upon it in waves... Each wave different, and each wave stronger.The Martian ChroniclesRay Bradbury is a storyteller without peer, a poet of the possible, and, indisputably, one of America's most beloved authors. In a much celebrated literary career that has spanned six decades, he has produced an astonishing body of work: unforgettable novels, including Fahrenheit 451 and Something Wicked This Way Comes; essays, theatrical works, screenplays and teleplays; The Illustrated Man, Dandelion Wine, The October Country, and numerous other superb short story collections. But of all the dazzling stars in the vast Bradbury universe, none shines more luminous than these masterful chronicles of Earth's settlement of the fourth world from the sun.Bradbury's Mars is a place of hope, dreams and metaphor-of crystal pillars and fossil seas-where a fine dust settles on the great, empty cities of a silently destroyed civilization. It is here the invaders have

'Sweeping and intimate... a gorgeous meditation on roads not taken' SHELBY VAN PELT, author of Remarkably Bright Creatures'A magnificent, spellbinding love story' CLARE LESLIE HALL, author of Broken Country'A captivating debut about love, loss and the many ways in which the past bleeds into the present' J. COURTNEY SULLIVAN, author of The Cliffs_____1976, Rhode Island.Lily has two loves.There's the boy, in whom she finds a kindred spirit. And then there's Jane, her brilliant but troubled younger sister and best friend.Lily has a plan.She'll graduate, go to college, marry her high-school sweetheart and start a family of her own, her future unfolding before her as a bright, clear path.But the laws of love and logic are not as simple as Lily thinks.When one fateful night throws Lily's life on an entirely new course, she'll discover just how fragile the futures are that we so carefully plan and imagine for ourselves. Because the universe has a plan of its own - and what seems to be the end

This edition includes gorgeous black-and-whiteinterior artthat bringsThe Beastto life like never before.New York TimesandUSA Todaybestselling author Katee Robert delivers another deliciously dark enemies to lovers romance that puts a scorching twist on a classic tale.***Once upon a time, I fell in love with two men.Gaeton, with his brash charm and casual cruelty. Beast, his lust equal to his penchant for violence. Their feelings for me were matched only by their hatred for each other. Being with them was sinful and perfect in different ways.In the end, I couldn’t choose, and I lost them both.Now, my sisters have tasked me with securing our power base, no matter the cost. I will do anything for my family – even if it means agreeing to the terms set by Gaeton and Beast. The three of us. Together. But only for as long as it takes me to choose one of them once and for all. When playing games of power, happily ever after isn’t a priority. Not even for me.Especially not for me.A classic myth

FromUSA Todaybestselling author and TikTok sensation Piper CJ – author ofThe Night and Its Moon– comes the third book in the No Other Gods series: a spellbinding and deliciously dark urban fantasy romance.***It's only the end of the world...Reeling from shattered trust and caught between the truth and the love of her lifetimes, Marlow finds herself facing down the apocalypse…not as its victim, but as its very catalyst. She's ready for?the end times, and she has officially declared herself an enemy of Heaven. Gathering allies across realms and pantheons brings new, tantalising?twists and passionate nights as more and more figures step out of mythology to fight to the end.With the stakes higher than ever and every world at risk, Marlow must determine once and for all who she needs on her side?and who she can trust to stay there as she tears it all down. Enemies new and old close in, and the lines between love and hate blur. And in the end, it might just be the power of Marlow's own realm

Perfect for fans of Skandar and Wilderlore, this "chilling page-turner" (Publishers Weekly, starred review) follows a magical apprentice in a land of ice and snow who must uncover why strange monsters are attacking his fellow apprentices...or else suffer the tragic consequences. Tundra is the last settlement in a world of ice. Oswin Fields is its only stray--a foundling rescued from the ice who many think is a drain on scarce resources meant for Tundrans. Then Oswin is summoned to Corridor by Grandmaster Yarrow to learn magic, finally giving him a chance to prove his worth. But Oswin barely has time to embrace his new role before his fellow apprentices start being attacked by monsters. Perhaps even worse, he learns his deceased adopted uncle is considered the most infamous Tundran to ever have lived and might have left followers behind who want to destroy the settlement. Now grappling with an unwanted legacy and mysterious foes, Oswin must look deep inside himself for the strength to p

If you (and your children!) struggle with setting a nighttime routine, staying up for countless hours, and regretting it the day after--this picture book is for you! Whirby the robot is all systems go for his favorite school activity: bot battles! All that clinking, clanging, beeping, and banging makes Whirby so excited.So excited that he forgets to recharge at night. He stays up practicing his best moves and building the coolest contraptions before the big battle.But when it's finally his turn to compete...BWOMP! BZZZ! ZZT!With his battery on 0%, will Whirby find a way to still be the bot battle champion? Find out in this funny new offering from The Big Squeeze author, Molly Harris, and the illustrator of Big Bike, Little Bike, Jacob Souva! You'll love Whirby if you: need a reminder to rest and rechargeenjoyed Robobaby, Clink, Boy + Bot, Love Z and Louare a fan of stories that are pure fun and impart important life lessonslove robots, robotics, robot battles, and anything robo-related

What was school like for Grandma? What was your Great Uncle's first job? What can we find out from old photos, documents and objects? This inclusive introduction encourages young history detectives to discover more about the people, places and significant events within their own locality and family. It also provides a compact way for them to record all their findings. There are suggestions for questions to ask older members of the community and ideas for topics to explore from toys and games to clothes, hairstyles, food, transport and holidays in order to find out just how much things have changed within living memory.

Only Murders in the Building meets Escape from Mr. Lemoncello's Library in this "intriguing, fast-paced" (School Library Journal) novel about a girl pulled into a mysterious treasure hunt at her new boarding school. Ever since her mom passed away, twelve-year-old Megumi "Meg" Mizuno has been spiraling. After too many low grades and cut classes, she's been expelled from school--apparently, everyone else has moved past her grief and expects the same from her. Her dad secures her a spot at the prestigious Leland Chase Academy, a boarding school in middle-of-nowhere New York, called the Last Chance Academy by its student body. If Meg can't make it work there, she'll be forced to live with her horrible aunt. At first, Leland Chase seems like an average, if very strict, boarding school, though Meg tentatively warms up to her roommate and some of their classmates. Then, one night, a mysterious envelope appears under her door, inviting Meg and her roommate to participate in a scavenger hunt. T

Poetry and the beauty of nature combine for this breathtaking celebration of the year.In this stunning combination of wordcraft and woodcuts, readers meet the changing seasons with thirteen poems, all in different poetic structures, from award-winning Dutch author Bette Westera. Each season opens with a haiku, following with the season's months and their poems. Readers will dance into March with a rondel for a newborn lamb, wave in the August wind with a five-line tanka for a summer sunflower, snuggle in for December with a limerick for all those who stayed home instead of going south...Exquisite woodcut art from Henriette Boerendans, an artist making her US and UK debut, showcases the wonder of the natural world. Back matter offers further details about the poems' structures--offering the perfect opportunity for young writers to write their own sonnet for February or quatrain for September. Translated from the Dutch by David Colmer.Poetic types spotlighted: Haiku RondelAcrosticDouble