Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

In this book, the Zhou-Yi and its Divination Process are reviewed from mathematical perspectives which provide a completely new understanding of its meaning and operation features. The highlights are:

The untold story of how hereditary data in mental hospitals gave rise to the science of human heredityIn the early 1800s, a century before there was any concept of the gene, physicians in insane asylu

This volume highlights the interaction between public policy and innovation. The first chapter documents the dramatic globalization of R&D and how this development has affected the efforts of 

With Oliver Wendell Holmes, Jr. and Legal Logic, Frederic R. Kellogg examines the early diaries, reading, and writings of Justice Oliver Wendell Holmes, Jr. (1841–1935) to assess his contributio

A book that finally demystifies Newton’s experiments in alchemyWhen Isaac Newton’s alchemical papers surfaced at a Sotheby’s auction in 1936, the quantity and seeming incoherence of the manuscripts wa

In her authoritative new book, Maite Conde introduces readers to the crucial early years of Brazilian cinema. Focusing on silent films released during the First Republic (1889-1930), Foundational

Beyond the Pink Tide considers a wave of artistic and curatorial efforts and social movements that refuse national borders to think hemispherically. In modeling a transnational American Studies, the b

The idea of corporate culture is a much-discussed concept in today’s business world, but often it only comes into focus as a response to problems in the workplace. Business Culture Design change

This stunningly illustrated book in Sterling's 'Milestones' series chronicles the history of psychology through 250 landmark events, theories, publications, experiments and discoveries.

Extending back to the first demonstrations of 2011, No Turning Back dissects the tangle of ideologies and allegiances that make up the Syrian conflict. As protests ignited in Daraa, some citizens were brimming with a sense of possibility. A privileged young man named Suleiman posted videos of the protests online, full of hope for justice and democracy. A father of two named Mohammad, secretly radicalized and newly released from prison, saw a darker opportunity in the unrest. When violence broke out in Homs, a poet named Abu Azzam became an unlikely commander in a Free Syrian Army militia. The regime's brutal response disrupted a family in Idlib province, where a nine-year-old girl opened the door to a military raid that caused her father to flee. As the bombings increased and roads grew more dangerous, these people's lives intertwined in unexpected ways.Rania Abouzeid brings readers deep inside Assad's prisons, to covert meetings where foreign states and organizations manipulated the r

This book identifies the key rhetorical moves in academic writing. It shows students how to frame their arguments as a response to what others have said and provides templates to help them start makin

A groundbreaking history that puts early and medieval West Africa in a global contextPick up almost any book on early and medieval world history and empire, and where do you find West Africa? On the p

The volume `The Early Ottoman Peloponnese: A study in the Light of an Annotated editio princeps of the TT10-1/14662 Ottoman Taxation Cadastre (ca. 1460-1463)' is a revised version of the author's PhD

How could something as insubstantial as a ghost be made visible through the material grit of stone and paint? In this original and wide-ranging study, Patrick R. Crowley uses the figure of the ghost t

Painting with Fire shows how experiments with chemicals known to change visibly over the course of time transformed British pictorial arts of the long eighteenth century--and how they can alter our co

Although Czech scenographer and painter Jaroslav Malina (1937-2016) lived in turbulent times, he won international respect for his work. Spanning Malina's entire life--from his early years in the Nazi

We are now acutely aware, as if all of the sudden, that data matters enormously to how we live. How did information come to be so integral to what we can do? How did we become people who effortlessly

In the decades following World War II, municipal leaders and ordinary citizens embraced San Francisco’s identity as the “Gateway to the Pacific,” using it to reimagine and rebuild th

Across early modern Europe, men and women from all ranks gathered medical, culinary, and food preservation recipes from family and friends, experts and practitioners, and a wide array of printed mater

A widespread conviction in the need to rescue China’s children took hold in the early twentieth century. Amid political upheaval and natural disasters, neglected or abandoned children became a humanit

In the early years of the twenty-first century, China and India have emerged as world powers. In many respects, this is a return to the historical norm for both countries. For much of the early modern

In contemporary political discourse, it is common to denounce violent acts as “terroristic.” But this reflexive denunciation is a surprisingly recent development. In A Genealogy of Terror

In a publishing career that spanned less than a decade, Jane Austen revolutionized the literary romance, using it as a stage from which to address issues of gender politics and class-consciousness rar

We have grown accustomed to the idea that scientific theories are embedded in their place and time. But in the case of the development of mathematical physics in eighteenth-century France, the relatio

Sixty percent of humanity—some 4.3 billion people—live in debilitating poverty. The standard development narrative suggests that alleviating poverty in poor countries is a matter of getting the intern

An international bestseller, To Fight Against This Age consists of two beautifully written, cogent, and urgent essays about the rise of fascism and the ways in which we can combat it.In “The Eternal R

Made up of nine prominent scholars from three continents, The Postclassicisms Collective aims to map a space for theorizing and reflecting on the values attributed to antiquity. The product of these r

The early years of film were dominated by competition between inventors in America and France, especially Thomas Edison and the Lumiere brothers . But while these have generally been considered the fo

When people think of hackers, they usually think of a lone wolf acting with the intent to garner personal data for identity theft and fraud. But what about the corporations and government entities tha

The Board of Rites and the Making of Qing China presents a major new approach in research on the formation of the Qing empire (1636-1912) in early modern China. Focusing on the symbolic practices that

This volume features the first two novels of L. Frank Baum s classic Oz series for younger readers. In The Wonderful Wizard of Oz , young Dorothy Gale and her dog Toto are transported by a powerful cyclone to the magical land of Oz, where they team up with the Scarecrow, Tin Woodman and Cowardly Lion to seek the help of the Wizard of Oz himself. In The Marvelous Land of Oz , Tip, Jack Pumpkinhead, the Saw-Horse and the Woggle-Bug work together to help to save the Scarecrow s besieged city. Both books are illustrated in full colour with the artwork of W. W. Denslow and John R. Neill. Part of Barnes & Noble''s ''Leatherbound Classic Collection'' (or ''Collectible Editions''), this book features exquisitely designed bonded-leather binding, with distinctive gilt edging and a ribbon bookmark. Decorative, durable and collectible, the series offers hours of pleasure to readers young and old and

When we think about history, we often think about people, events, ideas, and revolutions, but what about the numbers? What do the data tell us about what was, what is, and how things changed over time

Databases have revolutionized nearly every aspect of our lives. Information of all sorts is being collected on a massive scale, from Google to Facebook and well beyond. But as the amount of informatio

Three of the formative revolutions that shook the early twentieth-century world occurred almost simultaneously in regions bordering each other. Though the Russian, Iranian, and Young Turk Revolutions

This edited collection explores the notion of agency by tracing the role and activities of consumers from the pre-internet age into the possible future. Using an overview of the historical creation of

A groundbreaking history of early America that shows how Boston built and sustained an independent city-state in New England before being folded into the United StatesIn the vaunted annals of America’

In the early modern world, the Safavid, Ottoman, and Mughal empires sprawled across a vast swath of the earth, from the Himalayas to the Mediterranean. These three polities each encompassed a wide ran

All sorts of literary encounters and exchanges took place between China and the United States in the nineteenth and early twentieth centuries, involving an unlikely array of figures including canonica

How social upheavals after the collapse of the French Empire shaped the lives and work of artists in early nineteenth-century EuropeAs the French Empire collapsed between 1812 and 1815, artists throug

A groundbreaking history of the Big Questions that dominated the nineteenth centuryIn the early nineteenth century, a new age began: the age of questions. In the Eastern and Belgian questions, as much