Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Learn all about the fascinating world of insects--from bees, to butterflies, beetles, and more. Grab your magnifying glass and head out to discover all about insects-- their different types, body structures, and behaviors. Filled with eye-catching images and bite-sized information, every young nature enthusiast will marvel at the mind-boggling facts about these adaptable creatures. The book covers the seven major insect groups and includes profiles for more than 40 amazing insects, such as the stag beetle, monarch butterfly, and honeybee. Dive into their brilliant world and learn how some insects blend in with their surroundings. Discover how some can survive in different environments, while others can defend themselves against predators using clever tactics. Explore the many ways in which insects help humans, and the crucial role they play in pollination and maintaining a balance in the ecosystem. My Book of Bugs is a wonderful introduction to insects and their many incredible feature

A visually stimulating practice book to accompany English for Everyone Junior: Beginner's Course English for Everyone Junior: Beginner's Practice Book is a clearly structured and beautifully illustrated workbook for children ages 6-9, which offers extra practice for those beginning their journey of learning English as a foreign language. Following the same unit-by-unit structure as English for Everyone Junior: Beginner's Course, this workbook provides your child with all the support they need to build their confidence when using the language skills they have learned in the course book. Featuring hundreds of exercises, this practice book tests all the vocabulary and grammar structures taught within English for Everyone Junior: Beginner's Course, making use of a range of both familiar and new exercise mechanisms. Although best used to accompany English for Everyone Junior: Beginner's Course, this practice book can also be used independently by children or teachers who are in need of addi

Grab your Spidey-Suit and explore the Spider-Verse in this first-ever LEGO® Marvel Spider-Man™ book!Discover a vast multiverse of spidery Super Heroes and their unique worlds in this fun and engaging guide to the world of LEGO Marvel Spider-Man. Learn about the vehicles and locations and meet amazing superstars like Peter Parker, Miles Morales and Gwen Stacy – as well as lesser-known characters like Pork Grind and Scarlet Spider.Swing into action with LEGO Spider-Man as you explore the Spider-Verse:Features LEGO sets based on the Marvel Comics and films, showcasing a range of fan-favourite Spider-Man characters, vehicles, and locationsExplore LEGO Spider-Man’s world, gadgets and suits as you find out more about the web-slinging hero and his friendsAdd to your LEGO collection with an exclusive Spider-Man minifigure insideA wonderful gift for younger kids who love LEGO, Spider-Man, or both!This entry point to the Spider-Man multiverse is the perfect gift for young fans eager to know more

Speak English with confidence in a wide range of everyday situations, from making small talk to booking a trip abroad. With more than 1,500 of the most useful phrases and common expressions, English for Everyone: Everyday English gives you all the English conversation skills you need to get by in the real world. This engaging and accessible book covers a wide range of real-life topics and scenarios - from everyday activities, such as going to the supermarket and making appointments, to key communication skills, such as comforting someone and dealing with conflict. You'll learn how to welcome visitors, ask for directions, give a presentation at work, find somewhere to live, order a meal out, and much, much more. Each short unit uses memorable, true-to-life dialogues to introduce a new topic, followed by practice exercises to reinforce the new words and phrases that you have learned. The dialogues are accompanied by attractive illustrations and brought to life by animated videos and audi

From Bolivia's bustling markets to the massive and scorching Sahara Desert, see the world with this beautifully illustrated atlas. Children's Illustrated World Atlas is divided into six main sections, each devoted to a continent. Within each continent, a country or a region is explored in detail through stunning maps showcasing cities, towns, rivers, mountain ranges, and other geographical features. Apart from the geography of a region, Children's Illustrated World Atlas also provides interesting information about the people, their traditions, politics, and economics through spectacular images and snippets of facts. Take a trip around the world with Children's Illustrated World Atlas, from the majestic Himalayas to the Carnival of Venice. This colorful and comprehensive book is the perfect addition to every book shelf at home or school.

Understand the rules of English grammar with this fun, fully illustrated reference book for children aged 5–9 who are studying English as a foreign language.Make learning grammar fun with this clear, simple and visual guide for children learning English as a foreign language or English as a second language (ESL). Young learners of English will be captivated and engaged by the dynamic visual approach that sets English for Everyone Junior: English Grammar apart from other language materials for children. Attractive illustrations, clear layouts, and simple explanations present and explain the rules of the English language in a way that is easy for younger learners to understand and digest. The grammar covered in this reference book will help children to describe the world around them, talk about their likes and dislikes, ask questions, and form negative sentences. Grammar is first presented in a realistic scene, and then broken down into small chunks that are easy to unders

Delve beneath the surface of the Earth with this pictorial atlas and discover the secrets of our planet.How did planet Earth form? What’s under the surface, and how can we see it? Why do volcanoes erupt? What do coasts and caves have in common? What’s so important about rocks and soil? All these questions and more are answered in The Earth Atlas – a lavishly illustrated guide to our planet. From oceans to ice regions to deserts, this book takes you on a trip around Earth’s features, explaining how they formed and what impact they have on us even today, supporting life and literally shaping the world with every tectonic movement.Richard Bonson’s hand-drawn illustrations allow you to see parts of the planet that can’t be shown in photographs, with diagrams clearly annotated to help explain what’s going on.

This book is full of stories highlighting how philosophy over the ages has impacted the way we think and behave today. Travel down the road of wisdom to discover how philosophers have puzzled over the meaning of life, the human experience, and existence itself. Why is philosophy important? What's so great about it? Take a leap into the world of philosophy and have all your questions answered while discovering the unexpectedly interesting history of philosophy and its many schools of thought. Philosophical ideas affect our day-to-day lives in ways that you might not expect. But understanding these ideas can be daunting--even for adults! If you want to learn how to improve your thinking, make Aristotelian friends, visit Plato in his famous cave, or discuss women's rights with Mary Wollstonecraft, What's the Point of Philosophy? is the place to start. By telling interesting stories to unpack complex theories, What's the Point of Philosophy? allows you to connect with philosophers of the p

About Queen ElizabethAn official Platinum Jubilee souvenir that explores the incredible life and legacy of Queen Elizabeth and how her historic reign has shaped the world.In honour of Queen Elizabeth's Platinum Jubilee 2022, this once in a lifetime history book for kids tells the story of a young princess who grew up to become our longest reigning monarch, and celebrates the achievements, people and places that have become part of her remarkable legacy.There is a treasure box hidden away in Great Granny Joyce's home, bursting with all kinds of things... A photo of a young woman wearing a crown, a map of the world, newspaper clippings, and so much more that reveal the great wonders of the last 70 years. There is so much to look at that little Isabella doesn't even know where to begin! Did you know that Princess Elizabeth was only 27 when she became Queen? Or that she made an appearance at the opening ceremony of the 2010 London Olympics alongside James Bond? And that the most astonishin

《English for Everyone Junior: English Dictionary》專為6至9歲設計，收錄1,000個基礎詞彙，並以A-Z排列，搭配全頁插圖，讓孩子同時熟悉字母與單字。每個詞都置於情境插圖與對話中，幫助理解並強化記憶。隨書附有免費音檔與App，涵蓋單字、片語與歌曲，方便孩子練習正確發音。每個字母單元皆呈現大小寫，強化字母辨識；書中還設有有趣小知識與補充短語，增加學習趣味。書末另含數字、時間與形狀等主題，功能完整，是孩子英語啟蒙的理想工具書。亮點：收錄1,000個必備詞彙插圖與情境設計，學習更直觀免費音檔與App，發音練習便利額外主題補充，延伸實用性Learning new vocabulary is as easy as ABC with this beautifully illustrated dictionary for children aged 6-9. Featuring 1,000 essential first words and a free audio app, this book is perfect for children who are starting to read and speak English as a second language. Every word in English for Everyone Junior: English Dictionary is illustrated and arranged A-Z to help your child build their vocabulary and learn the English alphabet.Audio for all the words, phrases, and songs featured in the book is available online and via the accompanying app, so children can listen and perfect their pronunciation. At the start of each section, the upper-case and lower-case version of each letter is presented to he

Learn English with this fun course for complete beginners. Simple exercises and lively audio will have you speaking and reading more than 500 words in no time!The perfect introduction to English vocab

You may not realize it, but math controls just about everything in our world.From cracking codes to winning game shows, from predicting comets to solving crimes, this unique book reveals where our mos

Ideal for anyone who wants to learn English to native-speaker standard and prepare for major English exams including IELTS, TOEIC, and TOEFL, this fun and engaging visual guide to the most common and useful English idioms and phrases will help you understand and remember English idiomatic expressions and their meanings, making your English more fluent and natural.English for Everyone: English Idioms combines an innovative visual teaching method with the best of DK design to make one of the most difficult aspects of learning English as a foreign language incredibly easy. Hundreds of expressions are presented in context, with crystal-clear definitions and attractive illustrations that show each idiom's literal and idiomatic meaning. The book also covers English collocations and commonly confused words, helping you avoid the kind of mistakes that native English speakers would never make. Each teaching module is followed by tightly focused practice exercises to help you remember what you h

Stir up some sticky slime, build a Solar System with rubber bands, power a speed boat using soap, and construct an erupting volcano, all with Home Lab, exciting experiments for budding scientists. Inc

An exciting project-packed book of crafts, activities, and experiments for curious children who love to make, play, and explore. With clear step-by-step instructions and photos, children will learn ab

Discover the wonders of our rocky planet!This amazing deck of cards welcomes you to Earth's extraordinary minerals and gems, from sparkling emeralds to igneous rocks formed deep inside the Earth’s molten core. Stunning pictures and fast facts enable you to grasp a wealth of knowledge in a fun way. Each card contains snappy and accessible information, displaying each rock or mineral in dazzling detail. The front of the card shows the rock with a clue of what it is. The back reveals the answer, plus a dataset of essential information, ensuring you can recognize sedimentary from sandstone, metamorphic from marble, and pyrite from pearl. You’ll discover the unique qualities of each material, together with how it is used in art, industry, architecture, and science. You can use the cards to test your own knowledge, or how about using them to play a guessing game, quiz, or competitive comparison game with a friend? Our World in Pictures: Rocks & Minerals Flash Cards are packed with informat

The simplest guide to astronomy and stargazing!Grasping astronomy has never been easier. The awe of the night sky will soon turn into knowledge of the constellations, planets, and astrological phenomena!Bold graphics and easy-to-understand text make this visual guide the perfect introduction to astronomy and stargazing for those who have little time but a big thirst for knowledge. Inside you'll find:- Simple, easy-to-understand graphics that help to explain astronomy, space, and the night sky in a clear, visual way- The latest astronomical information on black holes, gravitational waves, the origin of the Universe, and the planets of the Solar System- User-friendly star-charts that guide you through the sky using brighter stars as "signposts" to locate harder-to-see objects- Essential advice on the practicalities of stargazing - from observing with the naked eye to using telescopesEach pared-back entry covers the essentials more clearly than ever before.

Explore the magic of holidays at Hogwarts Features Harry Potter minifigure in Yule Ball robes. Enter the festive world of LEGO(R) Harry Potter(TM) and visit Hogwarts for a spellbinding winter holiday. Celebrate the season with your favorite LEGO Harry Potter minifigures and join them for a feast in the Great Hall. Admire the castle's decorations and get ready to hit the dance floor at the Yule Ball. Head to the Gryffindor common room to play a game of wizard chess, warm up in front of a roaring log fire, and join Harry as he exchanges gifts with friends. Sprinkled with festive scenes and the latest LEGO Advent Calendars, sets, and minifigures, this is the perfect gift for young LEGO Harry Potter fans. LEGO Harry Potter: Holidays At Hogwarts comes with a Harry Potter minifigure in Yule Ball robes. (c) & (TM) Warner Bros. Entertainment Inc. Publishing Rights (c) JKR. (s20). (c)2020 The LEGO Group.

This book empowers children by providing an affirmation for every single day of the year from January 1 to December 31.I am strong. I am brave. I can handle anything. Using the power of positive think

Take an exclusive backstage tour of the world's most exciting museums and discover their hidden treasures.This behind-the-scenes guide showcases a huge range of incredible artifacts from history and r

Watch as Baby Bunny meets cute baby animals in this early learning lift the flap sound book. An interactive board book that contains five large and sturdy flaps, with a surprise character and sound hi

Discover how to identify flowers, where to find them, and other details about more than 100 flowers from around the world. Compact in size yet brimming with information, An Anthology of Flowers explores a vast variety of blooms, from exotic blossoms to iconic favorites. Learn to easily identify different species using detailed annotations, vivid illustrations, and unique descriptions of each flower. Featuring colorful photographs and vibrant illustrations, this book is a treasure trove for budding botanists, nature enthusiasts, and curious readers seeking an informative flower identification book. Whether you're out exploring or flipping through its pages at home, An Anthology of Flowers is sure to bring the natural world to life.

Get your paints and canvases ready for a fun-filled journey through art! Explore how artists get ideas and bring them to life, how art can affect the way we think and feel, and why people throughout history loved it so much. Why is art important? What's so great about it? In this illustrated book, you'll see the world through famous artists' eyes, and what inspired them to make art. And you'll use their techniques to produce your own masterpieces. Did you know that early humans spent a great deal of time on their cave paintings? Before cameras and smartphones were invented, people had paintings and drawings made of them to keep a record of what they looked like. Many artists, such as Vincent Van Gogh and Frida Kahlo, used art as a language to express their feelings, thoughts, and emotions in ways that words couldn't. Explore techniques you can use to create art, and you don't have to be good at drawing and painting to do it. If you want to learn why art has the power to be beautiful, s

Become an eyewitness to the high-flying world of aircraft and the history of flight. This picture-led guide will take you on a visual tour of incredible flying machines. Children can learn all about the history and science of humanity's most incredible feat: flying! Find out about how technology made flight possible, which tools pilots use, and how taking to the skies has shaped human history.Throughout the pages of this children’s guide to aviation, you can expect to find: - A fresh new look; new photographs, updated information, and a new “eyewitness” feature. - A visual tour through the topic combined with bite-sized text. - Brand new eyewitness accounts from experts in the field.Eyewitness Flight gives a detailed overview of all things aircraft for kids aged 9+, including helicopters, gliders, zeppelins, monoplanes, biplanes, and even triplanes. Using full-colour photographs of different types of aviation, including an aircraft from Leonardo da Vinci's wing machines to jet airliner

Discover the uses and symbolic meanings of flowers over the centuries and across the globe.Flowers have been depicted as objects of beauty and wonder in countless paintings and poems, exchanged as tokens of love and affection, and displayed as symbols of both celebration and remembrance - "saying it with flowers" is truly part of the human experience.But how does the significance of flowers vary across cultures and at different points in history?And what makes certain flowers special?The Secret Language of Flowers explores the meaning of more than 85 flowers, tracing their history as symbols and charting their role in folklore and mythology around the world.This fascinating book on flowers can help you to:-Unlock the meaning of flowers throughout history - from early peoples to the 19th-century.- Discover the Victorian language of flowers popular in the US, UK, and Europe.- Gain an insight into folklore and mythology in relation to different flowers.- Uncover what flowers mean in vario

Whether browsing for fun or just looking up that key fact, children will be drawn in and mesmerized by the hundreds of exciting images and surprising information in these dinosaur profiles.Dinosaur reconstructions and the latest fossil finds bring back to life the bone-crunching teeth of the Tyrannosaurus rex, the astonishingly large body of the Argentinosaurus, and the plane-size wings of the soaring Quetzalcoatlus. Page-by-page profiles on dinosaurs and other prehistoric animals reveal new facts that reflect the latest paleontological research, supported by data boxes on each animal’s size, group, habitat, time period, diet, and fossil discovery. See the fastest, largest, and fiercest creatures, browse their habitats, learn about their claws and spikes, and find out how their fossils help scientists piece together hidden clues about their lives. This must-have dinosaur book for children ages 8–12 profiles all the major types of dinosaurs as well as ancient fish, other prehistoric re

A fun way to learn about trees from all over the world!Discover the wonderful world of trees This amazing deck of cards welcomes you to the plant kingdom, where you can meet more than 150 species of trees, ranging from the mighty Californian redwood to the ancient banyan tree. Stunning pictures and fast facts enable you to grasp a wealth of knowledge in a fun way. Each card contains snappy and accessible information, displaying each tree in beautiful detail. The front of the card shows the tree with a clue of what it is. The back reveals the answer, plus a dataset about the tree: its size, location, and distinguishing features alongside close-up pictures of the bark, leaves, and fruit. You can use the cards to test your own knowledge; or how about using them to play a guessing game, quiz, or a competitive comparison game with a friend? Our World in Pictures: Trees of the World Flash Cards is packed with information on the world’s most amazing trees―from those that feed us to others th

An accessible guide to the world’s most popular and celebrated works of classical music, and the composers who created them.Who wrote the first true “opera”? Where did the system of musical notation come from? How do composers construct symphonies?The Classical Music Book answers these questions and more by exploring the history of classical music in clear and easy-to-follow sections. More than 90 works by famous composers are analyzed, with explanations of their music theory and impact on society. You will also explore the fascinating stories about the lives of crucial composers and performers.Covering Thomas Tallis in the early period, baroque masters like Bach and Handel, and the classical genius of Beethoven and Wagner all the way to the modern-day composers, this comprehensive book explores the key ideas underpinning the world’s greatest classical compositions and musical traditions. The importance of each composition is explained, placing them into their wider social, cultural, a

From small pets to large predators, discover how cats use their whiskers, senses, paws, claws, and more. This essential guide explores common cat characteristics and features iconic members of the cat family – find out why male lions have manes and how stripes on a tiger’s coat help it hunt. Read fascinating myths and legends of cats through history, view cat artifacts from ancient civilizations around the world, and learn how to identify domestic cat breeds as well as how to care for your pet. Eyewitness Cat introduces a much-loved pet alongside its wild family members in the animal kingdom. Using striking full-color photographs and illustrations, discover cat behavior, characteristics, big cats, domestic cat breeds, and much more along with amazing facts, infographics, and statistics to see cats as never before. Part of DK’s best-selling Eyewitness series, which is now getting an exciting makeover, this popular title has been reinvigorated for the next generation of information-seeke

More than 80 classics retold and explained, from early creation beliefs to classical hero narratives and the recurring theme of the afterlife. Who is the trickster god, Maui? What is the Mead of Poetry and what gift did it bestow on those who drank it? What did Ancient Egyptian mythology say about the Underworld? The latest title in the bestselling Big Ideas series, The Mythology Book answers these questions and more, as it explores the compelling worlds and characters depicted in myths and legends. Delve into each myth and discover the meanings behind these stories, getting to the heart of their significance to different cultures worldwide. More than just stories, myths are testament to the amazing creativity of humans striving to explain and make sense of the world around them. Here you will discover Zeus, god of the sky and ruler of the Olympian gods, Loki, the cunning trickster with a knack for causing havoc, Thor with his mighty hammer, and Hades, ruler of the underworld. Beyond t

Get better at maths and numbers by realizing which math skills you already use in daily life, and learn new ones while having fun. Did you realize how much maths you are already using when playing computer games, planning a journey, or baking a cake? This book shows how to expand the knowledge you've already got, how your brain works things out, and how you can get even better at all sorts of maths. Explore amazing algebra, puzzling primes, super sequences, and special shapes.Challenge yourself with quizzes to answer, puzzles to solve, codes to crack, and geometrical illusions to inspire you, and meet the big names and even bigger brains who made mathematical history, such as Pythagoras, Grace Hopper, and Alan Turing. Whether you're a maths mastermind, numbers nerd, or completely clueless with calculations, train your brain to come out on top. This essential book explains the basic ideas behind maths, to give young readers greater confidence in their own ability to handle numbers and m

Learn more than 10,000 of the most useful words and phrases in French with this beautifully illustrated dictionary for French-language students. Building on the success of the English for Everyone course books and the Bilingual Visual Dictionary series, the French-English Illustrated Dictionary uses crystal-clear illustrations to show the meaning of over 10,000 words of French vocabulary. The words are shown in a visual context in themed sections covering practical or everyday topics (such as shopping, food, or study), providing learners with all the vocabulary they need for work, travel, and leisure. Learning French vocabulary is even easier with this visually stunning dictionary.

Discover the Earth’s most explosive volcanoes and what an earthquake feels like with this picture-led guide exploring the hot spots of the world. This book tells you everything you need to know about the Earth’s most extraordinary natural forces – from active volcanoes, including Kilauea in Hawaii and Etna in Italy, to devastating earthquakes that have hit San Francisco and Japan. Discover how the eruption of Mount Vesuvius devastated the cities of Pompeii and Herculaneum, but left in its wake remarkably preserved treasures. Find out, too, how dogs can search for survivors in the aftermath of a huge quake. Eyewitness Volcano & Earthquake explores how tectonic plates collide, what causes magma to escape from deep inside Earth, and why eruptions affect our weather. Learn how scientists predict and measure the magnitude of earthquakes, and find out what a volcanologist does. Packed with striking full-color photographs and illustrations of lava flows, pyroclastic clouds, rocks and precious

This stunning visual guide explores and explains the defining eras, key moments, and outstanding people that have made history.In the same series as the New Children’s Encyclopedia and DK Visual Encyclopedias of Science, Art, and Geography (among others), this brand new history encyclopedia will help children, parents, and educators grasp the events, personalities, and inventions that have changed the world. From the earliest civilizations in Mesopotamia and India to the rise of populism in the US and China’s growth as a global power, this book gives you the facts about all major historical periods.Illustrated with over 1,500 photographs, artifacts, and maps, History: A Visual Encyclopedia is a way in to understanding the diversity of world history, from the African kingdoms that predated colonialism and the cultures of the pre-Colombian Americas to the dynasties that have ruled China for thousands of years and the many empires that have come and gone over the centuries in Asia and Eur

Start learning English as a second language with this visually stimulating practice book for children ages 6-9. Accompanying the English for Everyone Junior: Beginner's Course, this beautifully illustrated workbook features an abundance of vocabulary and grammar exercises for children learning English as a foreign language. When it comes to languages, practice really does make perfect! This work book guides young linguistic learners through exercises and activities to consolidate what they've learnt and build confidence in their skills.Making use of a range of both familiar and new exercise mechanisms, this practice book is an invaluable research tool to test the vocabulary and grammar structures taught in the course book. Immerse yourself in this practical ESL learning material, which includes: -Over 1,000 vocabulary and grammar exercises -Lay-flat binding, making the book easier to write in -Extensive accompanying audio resources that can be accessed via the website and the app -The

This beautifully illustrated children's book takes a close look at the life cycle of water, including how it supports all life forms, how humans harness its power, and why we need to conserve it. Water is essential for life. In fact, 60 percent of an adult human is made up of water We drink it and bathe in it, and thousands of creatures live in it. Yet our planet is running desperately low on fresh water, with less than one percent of the water on Earth available to fuel and feed the current population of 7.5 billion people. So dive into the wonderful world of water and find out how you can save this life-giving substance. From raindrops falling from the sky, to rushing rivers and vast oceans full of animals and plants, water is everywhere. Discover how it affects Earth's weather, through rainstorms, snow flurries, and cyclones, and gives life to animals, plants, and humans. Learn how it is used in growing food and in making clothing, as well as how water travels into our homes at the

Hear the stories of incredible scientists - from their corpses! - in this hilarious children’s graphic novel.Discover the incredible stories of scientists throughout history in this hilarious graphic

Slow down in southwest France.Whether you want to tour the world-famous wine country of Gironde, hop in a canoe and drift along the Dordogne river or enjoy the sweeping sandy shores of Landes, your DK

Discover two cities for the price of one.Whether you want to take a dip in mineral-rich thermal baths, step back in time on the cobbled streets of Castle Hill or enjoy cheap drinks in the city's ruin

Full of clear and detailed maps, this beautifully designed world atlas is the perfect companion to discover our planet.Originally published in 1997 and now in its 10th edition, the Essential World Atl