Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The world is filled with curious objects made by plants, animals, and even by the Earth itself. Dive into this collection of more than 100 intriguing items from the natural world and discover the stories behind them. Learn how huge whales eat tiny animals from looking at their bristly teeth, why butterflies shine and glitter in the sunlight from seeing their minute wing scales, how plants transport water and food around from examining a delicate leaf skeleton, and what makes every snowflake unique from admiring their miniature, branching crystals of ice. Birds' eggs, a lump of coal, a glass sponge skeleton, a cacao pod, a mermaid's purse, a fossil human footprint, an ear of corn, a pine cone, an owl pellet, and a chrysalis--all tell a story. Arranged by animal, vegetable, or mineral, objects are shown with truly stunning photography and colorful illustrations to help explain the science behind them. The lively descriptions by best-selling nature writer Ben Hoare explore the remarkable

Explore the everyday miracle of the microscopic world With spectacular macro photography and microscope images, this book reveals a hidden, living world full of intricate structures beyond the naked eye. Included are the tiniest insects and spiders; but looking deeper, you will discover truly microscopic creatures--even bacteria and viruses. Earth is home to more microbes, and more different types of microbes, than any other living organism. Bacteria on Earth outweigh humans by 1,100 to 1; and without them, all world ecosystems would collapse. This book reveals this vital, unseen realm, but it includes large life-forms too, in extreme close-up, so that you can wonder at the beauty of a pollen grain, a butterfly egg, the spore of a fungus, and the nerve cell of a human. The spectacular imagery in Micro Life exploits cutting-edge technology, such as focus-stacked macro photographs, as well as micrographs (microscope images) including scanning electron micrographs. Illustrations nearby ex

This exciting introduction to oceans is brimming with curious creatures, beautiful homes, and incredible adventures. From the spectacular seabirds soaring over Earth's vast oceans, to the tiny creatures lurking on the ocean floor, get ready for an adventure into the great unknown... Dive in and explore forgotten shipwrecks, swim with fantastic fish, and other awesome underwater animals, and weave your way through secret deepsea homes. You'll travel back in time to meet plundering pirates and explorers who changed the course of history, then it's time to learn about lots of very important underwater jobs and how you can help to protect Earth's precious oceans. Packed with fun facts and colorful illustrations, My Encyclopedia of Very Important Oceans will feed your imagination and quench your thirst for knowledge.

A bumper book for little learners that's bursting with fascinating facts about life on and under the wavesThis exciting introduction to oceans is brimming with curious creatures, beautiful homes, and incredible adventures.Dive in and explore forgotten shipwrecks, swim with fabulous fish and other awesome underwater animals, and weave your way through secret deepsea homes. You'll travel back in time to meet plundering pirates, scientists, and explorers who changed the course of history, then it's time to learn about lots of very important underwater jobs and how you can help to protect Earth's precious oceans.Packed with fun facts and colourful illustrations, My Encyclopedia of Very Important Oceans will feed your imagination and quench your thirst for knowledge.

Explore the social and cultural history of 100 of the world's most important cities. From the first towns in Mesopotamia to today's global metropolises, cities have marked the progress of civilisation

The Metropolitan Museum of Art is jam-packed with treasures from around the world... Now they're leaping out of the museum and onto your sticker book pages!This is your chance to create your very own art gallery! From dancers to dragons, masks to mummies and much, much more, your Met Sticker Book will be bursting with awesome art, curated by you.Discover The Met's collection of spectacular paintings, amazing artefacts, and world-famous sculptures, and choose which gallery to display them in. Where will you hang the modern-art installations or the ancient suits of armour? Along the way, learn fun facts about artists, history, and the stories behind some of the most famous objects from across the globe.Developed in partnership with The Metropolitan Museum of Art, this is the perfect introduction to the art world for any budding art lover.© The Metropolitan Museum of Art, New York

Get the facts about how our planet's climate is changing and what the consequences will be. This essential guide explores Earth's climate, past and present, giving you the facts and figures behind one of today's most urgent issues, and investigates what we can all do to make a difference. Eyewitness Climate Change explains why human activities are making the planet heat up--and how we know for sure that this is the case. The book explores the effects of the changing climate, from more frequent hurricanes and wildfires to melting ice caps and rising sea levels. It shows how scientists predict how the climate will change in the future and what actions we can all take to combat climate change. Stunning photographs offer a unique eyewitness view of the dramatic changes that are affecting the weather, the environment, and the way we lead our lives. With a groundbreaking visual approach and clear, child-friendly text, Eyewitness books have been trusted favorites of parents, teachers, and sch

A vibrant vocabulary workbook aimed for children--teaches and tests Spanish, five words at a time. Your first 1,000 Spanish words--five words a day. Over the course of a year, Five Words a Day: Spanish teaches new vocabulary to children who are starting to learn Spanish. Presenting 20 new words between Monday and Thursday, the final day of each week's teaching allows the child to practice the vocabulary they have just learned. A mix of nouns and verbs are taught through beautifully illustrated scenes, with each new word clearly labeled. Five Words a Day first encourages the child to copy out the words before covering them with the flaps on the jacket and testing their new knowledge. Accompanying audio means that children are also able to practice their Spanish pronunciation as many times as they want. With over 1,000 Spanish words, Five Words a Day is a colorful, clear, and comprehensive workbook that will lay the foundations for your child's journey in learning and understanding Spani

Help your child master Spanish vocabulary - five words at a time! Learn 1000 Spanish words over a year with this Spanish workbook for beginners! It's an essential vocabulary builder for young children who are starting to learn their first Spanish words. Discover the perfect introduction to Spanish for children aged 6-9. It's the ultimate Spanish lesson for kids! It includes:- Beautifully illustrated scenes that teach and test five words at a time.New vocabulary is practised again at the end of each week in two pages of exercises- Clever flaps on the jacket that cover the scene so your child can practise what they have just learned- Uses the effective rote-learning method to teach new vocabulary- Teaches a range of nouns and verbs that are useful in everyday life; audio is available online and via a handy app to help with pronunciationThis unique Spanish teaching guide contains everything your child needs to acquire a firm grasp of the Spanish language in a fun and interactive way! Each

Help your child master Italian vocabulary - five words at a time! Learn 1000 Italian words over a year with this Italian workbook for beginners! It's an essential vocabulary builder for young children who are starting to learn their first Italian words. Discover the perfect introduction to Italian for children aged 6-9. It's the ultimate Italian lesson book for kids! It includes:- Beautifully illustrated scenes that teach and test five words at a time.New vocabulary is practised again at the end of each week in two pages of exercises- Clever flaps on the jacket that cover the scene so your child can practise what they have just learned- Uses the effective rote-learning method to teach new vocabulary- Teaches a range of nouns and verbs that are useful in everyday life; audio is available online and via a handy app to help with pronunciationLearning a foreign language is one of the best ways to develop your child's cognitive and language abilities. What's more, children gain insight into

Help your child master German vocabulary - five words at a time! Learn 1000 German words over a year with this German workbook for beginners! It's an essential vocabulary builder for young children who are starting to learn their first German words. Discover the perfect introduction to German for children aged 6-9. It's the ultimate German lesson for kids! It includes:- Beautifully illustrated scenes that teach and test five words at a time.New vocabulary is practised again at the end of each week in two pages of exercises- Clever flaps on the jacket that cover the scene so your child can practise what they have just learned- Uses the effective rote-learning method to teach new vocabulary- Teaches a range of nouns and verbs that are useful in everyday life; audio is available online and via a handy app to help with pronunciationThis unique German teaching guide contains everything your child needs to acquire a firm grasp of the German language in a fun and interactive way! Each week, 2

Help your child master French vocabulary - five words at a time! Learn 1000 French words over a year with this French workbook for beginners! It's an essential vocabulary builder for young children who are starting to learn their first French words. Discover the perfect introduction to French for children aged 6-9. It's the ultimate French lesson for kids! It includes:- Beautifully illustrated scenes that teach and test five words at a time.New vocabulary is practised again at the end of each week in two pages of exercises- Clever flaps on the jacket that cover the scene so your child can practise what they have just learned- Uses the effective rote-learning method to teach new vocabulary- Teaches a range of nouns and verbs that are useful in everyday life; audio is available online and via a handy app to help with pronunciationThis unique French teaching guide contains everything your child needs to acquire a firm grasp of the French language in a fun and interactive way! Each week, 2

Meet the Secret Explorers Children will be inspired to discover the world with these character-driven adventure stories for children ages 5 to 8 years old. Learn all about volcanoes in this explosive

If you can't stand the heat, get into the kitchen! This cookbook helps children learn about making food by themselves - a skill that will last them a lifetime. The recipes in this "no-cook" cookbook w

Help your child master the English vocabulary with this beautifully illustrated dictionary!An essential vocabulary builder for young children that teaches and tests five new words each day, for five days a week, over one year. Packed full of useful everyday vocabulary, this visual reference book will capture the imagination of little learners and encourage a love for learning their first English words. The book presents your child with 5 new words to learn and practise each day for four days, then tests these words through a variety of interactive exercises on day five.Over the course of one year, your child will build up a vocabulary of more than 1000 English words. From colours, numbers, fruits and toys to animals, sports, clothes and weather, just about every subject in the English language is covered in eye-catching, illustrative detail. Incredibly easy to use, it includes daily "test yourself" activities with cleverly designed flaps which hide the words your child has just learned

Explore the intriguing answers to more than 200 questions about the human body in DK's newest biology encyclopedia for kids. What does the heart do? What are bones made of? Why do your ears pop? This

About The Aircraft BookTake an action-packed flight through the history of aircraft and the intrepid pioneers who made a dream become reality.Uncover the engineering behind more than 800 aircraft models, from military jets to commercial planes. This visual history book captures the fascinating story of aeroplanes and aviation, and how this groundbreaking discovery has influenced the 21st Century.Inside the pages of this aircraft book, you'll discover:- The history of military and commercial aircraft from all over the world, decade by decade, to the present day in stunning visual detail- Comprehensive catalogues highlighting the most important aircraft of each period along with their specifications and unique features- Showcases particularly celebrated aircraft - such as the Supermarine Spitfire and Concorde - in beautifully photographed "virtual tour" features- Tells the stories of the engineers and manufacturers that created marques like Boeing and AirbusModern flight has opened the w

Take a trip to the land down under and search for Koala in this plastic-free touch and feel book. You’ll discover beautiful endangered animals along the way!G’day, mate! Let your little explorer take

Take a first look at the watery world of X-ray fish in this beautifully illustrated non-fiction picture book for babies and toddlers. Part of DK's illustrated animal alphabet series, X is for X-ray Fi

Since the dawn of humankind, people have looked upward to the heavens and tried to understand them. This encyclopedia takes you on an expedition through time and space to discover our place in the uni

Discover the science behind wild and wonderful weather in this fact-packed book!From heatwaves and big freezes to tornadoes and fog, this science book gives your budding meteorologist a glimpse into all the action that happens in the sky. Learn about all kinds of weather and marvel at how powerful it can be!At a time when extreme weather is becoming more and more common, this eco-focused book is perfect for getting your little one clued up about the environment. Throughout the pages of this colorful and energetic STEM book, your child will discover fun facts about the weather. They will also gain insight into serious topics such as global warming and how our climate is changing.Inside the pages of this beautifully illustrated children's science book, you'll learn all about the weather, and discover:- Fascinating illustrations that introduce scientific topics in a simple and accessible way- Stand out facts, presented clearly on each spread- Easy to understand text that teach children ab

Discover the world of five adorable puppies and their friends and find out what makes each of them so special. In this charming book filled with beautiful illustrations and fun facts, little ones meet

Travel back in time to find out about the fantastical wildlife that lived on Earth before we did. From the first living cells to fearsome dinosaurs and giant mammals, take a journey through prehistory

Grab your camera and learn everything you need to know to improve your photography in just 20 weeks. The perfect one-on-one learning programme for any aspiring photographer, Digital Photography Comp

Who will you find in the woods today? Take a wonderful woodland walk and guess the animals hiding under peek-through flaps. Toddlers will love exploring the forest through each season, finding out abo

A stunning visual celebration of the world's aircraft and the pioneers who made a dream become reality.Introducing Flight - a historical and visual exploration of awe-inspiring aviation over a period of one hundred years, from the earliest aeroplane prototypes to today's supersonic jets, this all-encompassing book about aeroplanes takes you on an action-packed flight to explore some of the greatest commercial and military aircraft ever made.So fasten your seatbelt and prepare for takeoff as DK takes you on a journey to explore:-Spectacular photographs and evocative archive images from the Smithsonian collection capture the most memorable events in the history of flight-300 profiles showcase iconic aircrafts, providing key facts-Offers a clear and compelling account of aviation history in short, self-contained episodesExplore stunning photographic galleries of planes, helicopters, and airships, each accompanied by its vital statistics. From the Wright brothers' first powered flight to C

Read all about the bloodthirsty battles of ancient Rome!Discover the deadliest fighters of the Roman Empire in this fascinating guide to the gladiators of Rome's Colosseum. Learn about the female glad

Bumbling flying elephants, the demon serpent, a brash peacock, crafty jackals, a curious leopard, and even an evil, shape-shifting jinn, all make an appearance in this delightful collection of tales f

Discover the hidden meaning of stars in this first introduction to astrology for children.Secrets of Astrology tells you all you want to know about astrology, from the meaning of zodiac signs, to how

Children will learn why they feel happy, sad, angry, and proud in this colorful collection of illustrated books.This bright box set includes five board books: How Do I Feel?, I Feel Happy, I Feel Angr

A one-stop treasure trove from the RHS that covers every aspect of gardening, from planning and planting to growing and care.Choose plants that will thrive in your space.Design a border for year-round

A gorgeously illustrated introduction to poetry for children, featuring poems about everything from science, sports, and space, to friendship, family, and feelings. This thoughtfully crafted anthology is perfect for children new to verse and for young poetry fans seeking out new favorites. Explore poetry from a diverse selection of contemporary and historical poets, covering a broad range of topics--from personal subjects like emotions and family, to the wonders of the natural environment.Carefully selected works encourage children to see the poetry in everything and to embrace the beauty of their everyday lives. Poems are complemented by detailed illustrations, timelines, and interesting facts about the topics covered, ensuring that the poems are not just entertaining, but relevant, topical, and informative. Prompts and activities inspire children to create their own poetry, and devices like rhyme, repetition, and alliteration are introduced and explained in a fun and accessible manne

A one-stop treasure trove from the RHS that covers every aspect of gardening, from planning and planting to growing and care. Choose plants that will thrive in your space. Design a border for year

Enter the enchanting world of mythical creatures and explore the history behind them in this beautifully illustrated compendium for kids aged 7 to 9. You'll meet an incredible cast of mind-boggling

Science and technology, nature, geography, culture, sports and hobbies, and history all combine in this mind-blowing visual encyclopedia. From incredible insects and musical instruments to spacecraft

Count from 10 reindeers to 1, then back to 10 again in this fun-filled, lift-the-flap Christmas board book with a playful rhyme for little ones. Beautifully illustrated by Jonny Lambert, this deligh

Does your child love cute kittens and friendly cats? This children's reading book will teach them how to read while learning amazing facts about cat breeds. In this chapter book for children, reader

Children will learn why they feel happy, sad, angry, and proud in this colourful collection of illustrated books. It is often difficult for children to articulate their emotions and to understand why

Discover the hidden meaning of stars in this first introduction to astrology for children. Secrets of Astrology tells you all you want to know about astrology, from the meaning of zodiac signs, to h

Take your toddler on a frozen adventure in this lift-the-flap baby book with pictures that pop off the page!This wintry pop-up peekaboo book follows Polly and her penguin pals as they play hide-and-se