Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Go on an amazing journey of discovery with the Very Hungry Caterpillar and learn about ocean wonders, from sharks to seamounts.Take a tour of the blue planet and discover everything you need to know about ocean geography and the animals that live beneath the waves.Topics range from individual sea creatures and their habitats, to how tides work and the ways in which we can look after the oceans. Bite-size chunks of information are complemented by captivating illustrations in Eric Carle's unique style, eye-catching photography, and simple how-it-works diagrams, while pull-out images and facts provide extra nuggets of interest. Young learners can find out all about marine mammals, deep sea fish, ocean zones, currents, islands, exploration, pollution, and much more in this one-of-a-kind introduction to oceans.For lovers ofThe Very Hungry Caterpillarand all bright young minds, this is the ultimate must-have oceans encyclopedia.

From Bolivia's bustling markets to the massive and scorching Sahara Desert, see the world with this beautifully illustrated atlas. Children's Illustrated World Atlas is divided into six main sections, each devoted to a continent. Within each continent, a country or a region is explored in detail through stunning maps showcasing cities, towns, rivers, mountain ranges, and other geographical features. Apart from the geography of a region, Children's Illustrated World Atlas also provides interesting information about the people, their traditions, politics, and economics through spectacular images and snippets of facts. Take a trip around the world with Children's Illustrated World Atlas, from the majestic Himalayas to the Carnival of Venice. This colorful and comprehensive book is the perfect addition to every book shelf at home or school.

Go on an amazing journey of discovery with the Very Hungry Caterpillar and learn fascinating facts about animals. Take a tour of the animal kingdom and discover everything you need to know about creatures from elephants to ants in this colorful and charming first animal reference book. Different chapters focus on different animal types, with a new critter every time you turn the page. Bite-size chunks of information are complemented by captivating illustrations by the World of Eric Carle, eye-catching photography, and simple how-it-works diagrams, while pull-out images and facts provide extra nuggets of interest. Young learners can find out all about koalas, armadillos, eagles, penguins, turtles, frogs, sharks, and butterflies and many, many more in this one-of-a-kind introduction to nature. For lovers of The Very Hungry Caterpillar and all bright young minds, this is the ultimate must-have animal encyclopedia.

Understand the rules of English grammar with this fun, fully illustrated reference book for children aged 5–9 who are studying English as a foreign language.Make learning grammar fun with this clear, simple and visual guide for children learning English as a foreign language or English as a second language (ESL). Young learners of English will be captivated and engaged by the dynamic visual approach that sets English for Everyone Junior: English Grammar apart from other language materials for children. Attractive illustrations, clear layouts, and simple explanations present and explain the rules of the English language in a way that is easy for younger learners to understand and digest. The grammar covered in this reference book will help children to describe the world around them, talk about their likes and dislikes, ask questions, and form negative sentences. Grammar is first presented in a realistic scene, and then broken down into small chunks that are easy to unders

A fun sticker activity book for kids to accompany the release of Disney’s WishFollow Princess Asha and her goat Valentino on an epic starlit adventure in Disney’s Wish with this book packed with stickers.This fun activity sticker book features images and artwork from Disney’s movie Wish. Wish upon a star and celebrate Disney’s 100th year with all the key characters, locations, and moments and relieve the movie magic with more than 100 stickers.Disney Wish: The Ultimate Sticker Book will help kids relive the wonder of Disney’s newest movie. Fun stickering activities will keep kids aged 5–7 entertained for hours, and, with more than 100 stickers, there are plenty of extra stickers, too.

Kids will be able to say, "I can do that!" after reading this value-packed resource dedicated to learning independent life skills."Really great. I've been waiting for a book like this for a very long time with photos and illustrations that can be understood by a child who can't read yet. My children love to reproduce what they see and not what I tell them, so it's perfect!" (customer review of the French edition).In I Can Do That, photos and illustrations combine to produce a value-packed resource for families preparing for their child’s big life stages. Young readers can learn how to lace up their shoes, put on a sweater, go to the toilet, peel fruit, count to 100, and brush their teeth. Step by step instructions sit alongside more than 700 fun and helpful photos and illustrations to help children practice and learn.The short and practical text will help your child learn to be independent. As they grow up, they will be able to say, "I can do that!" every time they turn the page. Perfe

Learn all the essential facts about our solar system and beyond in this illustrated, interactive, and educational activity book for kids. How old is the universe? How was the Earth formed? What lies beyond our solar system? Active Learning: Stars & Planets covers all these questions and more! Children will have fun learning through doing, with dozens of different activity types to fully engage with and explore the stars and planets in outer space. Kids aged 8-12 will be occupied for hours as they pore over the information-packed pages in this space activity book and tackle the wide range of puzzles - including mazes and tangles, code-breakers, matching games, anagrams, word searches, logic games, classification and identification games, quizzes, sudoku, odd one out, drawing, and colouring.This exciting stars and planets activity book for children includes: - Detailed, high-quality illustrations and photography alongside informative text to engage children aged 8-12 with learning. -

Dive into a world of gross facts and discover the secret science of everything icky and sticky. This irresistibly disgusting book for children will teach you all you need to know about all kinds of animal and human waste and goo - what it's for, how it's made, where it goes, and lots more. Did you know that the global population produces more than a million tons of poo every day? Or that the ancient Egyptians used animal excrement in their medicine? That sea cucumbers can vomit their sticky insides when threatened, yet still survive? Children aged 9+ will love all these facts and more, presented either with jaw-dropping CGI illustrations or eye-popping photography - plus additional boxes feature diagrams that make information easy to understand. Celebrate your child's curiosity as they explore: 1,000 jaw-dropping, mind-blowing facts that will be sure to wow family and friends. Stunning CGI graphics, fun visual comparisons, and diagrams make stats and facts easy to understand.Science bo

Customise Barbie's outfits for every occasion with the Barbie Dress Up Ultimate Sticker Collection, packed with more than 1,000 colourful stickers. Dress Barbie in a whole range of exciting outfits and discover looks from her various careers, fun hobbies, and high fashion style! Add cool accessories and friendly pets to complete the look. Meet Barbie's friends and dress them in their own unique styles, too.This fun-filled sticker collection encourages imagination, expression and discovery through play. ©2023 Mattel. All rights reserved.

Delve beneath the surface of the Earth with this pictorial atlas and discover the secrets of our planet.How did planet Earth form? What’s under the surface, and how can we see it? Why do volcanoes erupt? What do coasts and caves have in common? What’s so important about rocks and soil? All these questions and more are answered in The Earth Atlas – a lavishly illustrated guide to our planet. From oceans to ice regions to deserts, this book takes you on a trip around Earth’s features, explaining how they formed and what impact they have on us even today, supporting life and literally shaping the world with every tectonic movement.Richard Bonson’s hand-drawn illustrations allow you to see parts of the planet that can’t be shown in photographs, with diagrams clearly annotated to help explain what’s going on.

This book is full of stories highlighting how philosophy over the ages has impacted the way we think and behave today. Travel down the road of wisdom to discover how philosophers have puzzled over the meaning of life, the human experience, and existence itself. Why is philosophy important? What's so great about it? Take a leap into the world of philosophy and have all your questions answered while discovering the unexpectedly interesting history of philosophy and its many schools of thought. Philosophical ideas affect our day-to-day lives in ways that you might not expect. But understanding these ideas can be daunting--even for adults! If you want to learn how to improve your thinking, make Aristotelian friends, visit Plato in his famous cave, or discuss women's rights with Mary Wollstonecraft, What's the Point of Philosophy? is the place to start. By telling interesting stories to unpack complex theories, What's the Point of Philosophy? allows you to connect with philosophers of the p

A comprehensive and accessible visual history of music – from prehistory to the present.Why did jazz go Latin? And how did blues influence rock? Find out how music has shaped the world from prehistory to the present.Classical or rock, everyone has their favorite music style, but how did your top choice come about? Music is a compelling and richly illustrated history of the most unifying art form in the world. Explore the roots of all genres, from chants of the middle ages through the grandeur of the classical period to the modern rhythm of blues, jazz, hip-hop, and pop. Music includes illustrated histories of instruments and listening suggestions for each musical genre. Spectacular galleries display families of instruments from around the world, while special features showcase the evolution of key instruments, such as the piano and the guitar, and profile iconic innovators such as Mozart, Billie Holiday, and David Bowie. Charting every musical revolution, from bone flutes to electronic

About Queen ElizabethAn official Platinum Jubilee souvenir that explores the incredible life and legacy of Queen Elizabeth and how her historic reign has shaped the world.In honour of Queen Elizabeth's Platinum Jubilee 2022, this once in a lifetime history book for kids tells the story of a young princess who grew up to become our longest reigning monarch, and celebrates the achievements, people and places that have become part of her remarkable legacy.There is a treasure box hidden away in Great Granny Joyce's home, bursting with all kinds of things... A photo of a young woman wearing a crown, a map of the world, newspaper clippings, and so much more that reveal the great wonders of the last 70 years. There is so much to look at that little Isabella doesn't even know where to begin! Did you know that Princess Elizabeth was only 27 when she became Queen? Or that she made an appearance at the opening ceremony of the 2010 London Olympics alongside James Bond? And that the most astonishin

ABOUT ENGLISH FOR EVERYONE JUNIOR SIGHT WORDS FLASH CARDSA set of beautifully illustrated sight word flash cards for preschool children; introduces 100 first sight words. Make learning new sight words fun with this beautifully illustrated pack of 100 flash cards. All the featured words have been selected from the Dolch and Fry word lists for children aged 4–5. On one side of each card is an essential sight word (words that frequently appear in text and are best remembered by sight) in large, bold lettering for easy reading. On the reverse, the word is repeated with a simple example sentence and illustration to put the word into context. Children can use the cards to learn the meaning of sight words before memorizing the words and testing their knowledge. Five additional cards are packed with suggestions for educational games and activities. Simple to use and fun, these flash cards are made of sturdy laminated cardboard and are suitable for young hands to play with again

ABOUT ENGLISH FOR EVERYONE JUNIOR ENGLISH ALPHABET FLASH CARDSDesigned for children learning to read and speak English, this pack of flash cards introduces the alphabet and 52 essential first words through images and audio. Make learning the English alphabet fun with this beautifully illustrated pack of 52 flash cards. With lively accompanying audio, finger-tracing patterns, and fun ideas for games and activities, these flash cards are perfect for children beginning to learn English as a second language. English for Everyone Junior: English Alphabet Flash Cards have been designed for children who are starting to read and speak English. Each beautifully illustrated card introduces the upper and lowercase letters of the alphabet and an essential first word. Audio for all the letters and words featured in the pack is available online and via a handy app so young learners can memorize the sound of the letters and perfect their pronunciation. On one side of the card, both th

百科見長的DK出版社暢銷英語學習系列《English for Everyone》兒童全彩插圖字典。帶領國小階段孩子從A到Z有系統的學習千個常見單字，結合專屬APP中的歌曲、互動遊戲，輕鬆學英文。An illustrated A-Z dictionary with accompanying audio that introduces 1,000 essential words to children learning English as a foreign language. Learning new vocabulary is as easy as ABC with this beautifully illustrated dictionary for children aged 6-9. Featuring 1,000 essential first words and a free audio app, this book is perfect for children who are starting to read and speak English as a second language. Every word in English for Everyone Junior: English Dictionary is illustrated and arranged A-Z to reinforce letter recognition and help your child learn the alphabet. Audio for all the words featured in the book is available online and via an app, so children can listen and perfect their pronunciation. At the start of each section, the upper-case and lower-case version of each letter is presented, to help fix the shape and form of the letter. Charming illustrations help put each word in

《English for Everyone Junior: English Dictionary》專為6至9歲設計，收錄1,000個基礎詞彙，並以A-Z排列，搭配全頁插圖，讓孩子同時熟悉字母與單字。每個詞都置於情境插圖與對話中，幫助理解並強化記憶。隨書附有免費音檔與App，涵蓋單字、片語與歌曲，方便孩子練習正確發音。每個字母單元皆呈現大小寫，強化字母辨識；書中還設有有趣小知識與補充短語，增加學習趣味。書末另含數字、時間與形狀等主題，功能完整，是孩子英語啟蒙的理想工具書。亮點：收錄1,000個必備詞彙插圖與情境設計，學習更直觀免費音檔與App，發音練習便利額外主題補充，延伸實用性Learning new vocabulary is as easy as ABC with this beautifully illustrated dictionary for children aged 6-9. Featuring 1,000 essential first words and a free audio app, this book is perfect for children who are starting to read and speak English as a second language. Every word in English for Everyone Junior: English Dictionary is illustrated and arranged A-Z to help your child build their vocabulary and learn the English alphabet.Audio for all the words, phrases, and songs featured in the book is available online and via the accompanying app, so children can listen and perfect their pronunciation. At the start of each section, the upper-case and lower-case version of each letter is presented to he

How scientists changed the world, one breakthrough at a time. From the discovery of fire and the invention of the wheel to lunar landings and atoms, this book tells the extraordinary story of science and how it changed our world--one breakthrough at a time. Find out how history's most ingenious and daring scientists solved mysteries that had puzzled the ancient world for millennia, triggering an age of discovery that gave us telescopes, flying machines, steam engines, antibiotics, electricity, radio, space travel, and computers. Discover the amazing men and women who challenged conventional thinking and put their lives at risk to learn about everything from planetary orbits and gold to germs, gunpowder and radioactivity. What's the Point of Science? explains in super-simple terms how science really works and why it brought the world out of the dark ages. It's packed with surprising facts, tales of ingenuity and endeavor, and beautiful hand-drawn illustrations that bring the human story

A fun fact book that answers more than 50 burning questions for young Marvel fans!Discover everything you've always wanted to know about your favorite Super Heroes!How much weight can the Hulk lift? What's the farthest distance Spider-Man can sling a web? Can Iron Man fly faster than a space rocket? Young Marvel Super Hero fans want to know everything about their favorite characters from how hard Thor can slam his hammer to the size of the smallest hole Wasp can fly through―and much more.Whether they are obsessed with Marvel comic books or they've only heard about Super Heroes in the playground, young fans will love discovering the fascinating answers to wild, wacky, and wonderful questions about Marvel Super Heroes.

Learn English with this fun course for complete beginners. Simple exercises and lively audio will have you speaking and reading more than 500 words in no time!The perfect introduction to English vocab

Kids will love learning all about the animal kingdom with this spectacular sticker encyclopedia, packed with fascinating facts and more than 600 stickers! By choosing the sticker that fits in each spa

You may not realize it, but math controls just about everything in our world.From cracking codes to winning game shows, from predicting comets to solving crimes, this unique book reveals where our mos

Ideal for anyone who wants to learn English to native-speaker standard and prepare for major English exams including IELTS, TOEIC, and TOEFL, this fun and engaging visual guide to the most common and useful English idioms and phrases will help you understand and remember English idiomatic expressions and their meanings, making your English more fluent and natural.English for Everyone: English Idioms combines an innovative visual teaching method with the best of DK design to make one of the most difficult aspects of learning English as a foreign language incredibly easy. Hundreds of expressions are presented in context, with crystal-clear definitions and attractive illustrations that show each idiom's literal and idiomatic meaning. The book also covers English collocations and commonly confused words, helping you avoid the kind of mistakes that native English speakers would never make. Each teaching module is followed by tightly focused practice exercises to help you remember what you h

Find out who's sending Sheep presents in this cute baby book with flaps to lift and pop-ups to enjoy. This read-aloud children's book encourages first learning by introducing little ones to colourful

Discover a world of adorable baby dinosaurs hiding in the pages of this exciting baby book. As Baby T.rex tries to find Mummy T.rex, he discovers lots more dinky dinosaurs hiding along the way! There'

A combined reference book and workbook covering over 3,000 entries of essential words and phrases to expand your English vocabulary.Designed around the most up-to-date theories of language acquisition, English for Everyone: English Vocabulary Builder includes all the words and phrases English learners need to know. Question words, feelings, hairstyles, technology, seasons, entertainment, sports, and more are covered and illustrated, plus paired with audio in the accompanying app available for download. Readers can write their own translations and work through practice exercises to improve their English language skills. Ideal for ESL learners at all stages, from beginner to advanced.Series Overview: English for Everyone series teaches all levels of English, from beginner to advanced, to speakers of English as a second language. Innovative visual learning methods introduce key language skills, grammar, and vocabulary, which are reinforced with a variety of speaking, reading, and writing

Stir up some sticky slime, build a Solar System with rubber bands, power a speed boat using soap, and construct an erupting volcano, all with Home Lab, exciting experiments for budding scientists. Inc

An interactive board book with hidden reindeer and winter animal surprises along with way! Tactile elements and delightful imagery will encourage the development of motor skills and early learning. Babies and toddlers will love lifting the big flaps to find five peekaboo surprises pop up from the pages, including Parker Polar Bear and Percy Penguin, making this board book a fun and easy story about winter animals. Pop-up Peekaboo! Reindeer provides lots of opportunities for parent-and-child interaction and hours of wintry fun.Journey through the snow and watch as a Rosie Reindeer finds each of her friends, wraps up warm and puts on her favourite boots. This winter pop-up book for 3-5 year olds includes:Hands-on play elements that build all-round learning skills. 5 flaps throughout the book to lift and find the pop-ups, helping to develop fine motor skills.Rhythmic, read-aloud text that aids language development. Rounded edges and chunky board book pages rigorously tested (and chewed) b

An interactive pop-up book that inspires hands-on learning with the help of garden creatures! Tactile elements and delightful imagery will encourage the development of motor skills and early learning.Bold, brightly coloured pictures, lift-the-flap pages and entertaining rhymes, Pop up Peekaboo: Garden provides lots of opportunities for parent-and-child interaction and hours of nature themed fun. Journey through the garden and find all the wildlife and habitats and lifecycles here!Babies and toddlers will love lifting the big flaps to find five peekaboo surprises pop up from the pages: a bright yellow sunflower growing taller and taller, busy honeybees gathering nectar and pollen, a spotty ladybird on a strawberry plant flower, a frog jumping across some waterlilies, and a cheery sparrow chirping in a cherry tree. Vocabulary about animal habitats are carefully woven throughout, making this board book a fun and easy story about gardens.Inside the pages of this adventure pop-up book, you’

About DK Super Readers Level 4 Knights and CastlesUse your reading superpowers to learn all about medieval knights and their castles - a high-quality, fun, non-fiction reader - carefully levelled to help children progress.Knights and Castles is a beautifully designed reader all about these incredible medieval fortresses.The engaging text has been carefully levelled using Lexiles so that children are set up to succeed.A motivating introduction to using essential non-fiction reading skills.Children will love to find out about why castles were built, some of the coolest castles, and medieval people's lives in and around them both in peace and wartime.

Trace India’s journey through its space program, from its early skywatchers, the myths and legends, and the dreamers in a newly independent country, to the visionaries who continue to inspire generations to look towards the stars.In 1947, a newly independent India struggled to manage its new borders, limited resources, and a burgeoning population. Almost instinctively, its leaders turned towards the skies, looking up and beyond to see how they could use technology and space to help their people. This wasn’t a new endeavour, however. Skywatchers in ancient India had always looked towards the stars, mapping them, giving them names, and building myths. So, new India turned towards the stars once again - using satellites to help with agriculture, forecast weather, and build better communication. Today, India’s space program has morphed into something larger. The country looks towards the stars―not to sustain itself, but to explore, to reach the final frontier, and to take its own place amo

Get ready for festive fun in a galaxy far, far away! Build a snow-droid. Add some festive sparkle to favourite LEGO (R) Star Wars (TM) characters, including Yoda and Darth Vader. Help Han Solo and Che

A frightfully fun LEGO (R) sticker book with more than 1000 Halloween-themed stickers. Step into the spine-chilling world of LEGO models that go bump in the night. DK's Halloween! Ultimate Sticker Co

Dive into our planet's largest and least explored world in this stunning encyclopedia of whales, waves, wrecks, wind farms, and everything oceanic!Using 3D illustrations and a level of detail you can'

Explore the laws and theories of physics in this accessible introduction to the forces that shape our Universe, our planet, and our everyday lives. Using a bold, graphic-led approach The Physics Boo

Little ones will love using their fingers to follow the glittery, bumpy shiny trails in DK's Follow the Trail Minibeasts.Help your toddler learn as they explore the lives of the butterflies, ladybirds

The amazing slime recipes in this book are sometimes gross, sometimes sparkly, sometimes smelly, but ALWAYS loads of fun. More than 30 innovative recipes, using inexpensive, accessible, and safe ingre

An exciting project-packed book of crafts, activities, and experiments for curious children who love to make, play, and explore. With clear step-by-step instructions and photos, children will learn ab

Full of hands-on activities that will tap straight into your child's natural scientific curiosity. The experiments are easy to follow and use items that most people already have tucked away at home.Lo

Little ones will love using their fingers to follow the glittery, bumpy shiny trails in DK's Follow The Trail Wild Animals. This tactile board book is packed with colourful illustrations to help encou