Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Discover the Earth’s most explosive volcanoes and what an earthquake feels like with this picture-led guide exploring the hot spots of the world.This book tells you everything you need to know about the Earth’s most extraordinary natural forces – from active volcanoes, including Kilauea in Hawaii and Etna in Italy, to devastating earthquakes that have hit San Francisco and Japan. Discover how the eruption of Mount Vesuvius devastated the cities of Pompeii and Herculaneum, but left in its wake remarkably preserved treasures. Find out, too, how dogs can search for survivors in the aftermath of a huge quake.Eyewitness Volcano & Earthquake explores how tectonic plates collide, what causes magma to escape from deep inside Earth, and why eruptions affect our weather. Learn how scientists predict and measure the magnitude of earthquakes, and find out what a volcanologist does. Packed with striking full-color photographs and illustrations of lava flows, pyroclastic clouds, rocks and precious s

Discover how we got to where we are, in this multidisciplinary approach to 13.8 billion years of human and cosmic history.With the Big Bang as its starting point, Big History places humans in the contextof our Universe, revealing how and why we got to where we are today. From the formation of our Universe and the dawn of time to the present day, a series of major events has changed the nature and course of life on the planet we call home. With trademark clarity – and the support of the Big History Institute –DK unites ideas and concepts of multiple disciplines, from physics to sociology, to create a visual account of 13.8 billion years of history. By taking us right back to our origins in the stars, and exploring how a unique series of events led to and then impacted human existence, Big History gives us a deeper understanding of the world we live in now.

A book-and-card collection of 50 fun outdoor challenges to make any family camping trip one to remember, whatever the weather.Ranging from the silly to the sublime, once you’ve tried any of the 50 challenges in this brilliant book-and-card set, it will become a must-pack for all family camping trips.Featuring 50 boredom-busting ideas, never struggle for something to do on your next camping break with this collection of brilliant challenges. Not only will the cards keep the kids active, engaged, and laughing day or night and whatever the weather, the games are fun for grown-ups to play, too. Challenge themes covered include look-and-find, creative, active, LOL, and more, with each one only ever needing equipment regularly taken on a camping trip or items you can easily find in nature. So whether it’s going on a creepy crawly hunt, taking part in the sleeping bag triathlon, or trying to sing your favorite song around the campfire with eight marshmallows shoved in your mouth, kids and adu

This stunning visual guide explores and explains the defining eras, key moments, and outstanding people that have made history. In the same series as the New Children’s Encyclopedia and DK Visual Encyclopedias of Science, Art, and Geography (among others), this brand new history encyclopedia will help children, parents, and educators grasp the events, personalities, and inventions that have changed the world. From the earliest civilizations in Mesopotamia and India to the rise of populism in the US and China’s growth as a global power, this book gives you the facts about all major historical periods.Illustrated with over 1,500 photographs, artifacts, and maps, History: A Visual Encyclopedia is a way in to understanding the diversity of world history, from the African kingdoms that predated colonialism and the cultures of the pre-Colombian Americas to the dynasties that have ruled China for thousands of years and the many empires that have come and gone over the centuries in Asia and Eu

This stunning visual guide explores and explains the defining eras, key moments, and outstanding people that have made history.In the same series as the New Children’s Encyclopedia and DK Visual Encyclopedias of Science, Art, and Geography (among others), this brand new history encyclopedia will help children, parents, and educators grasp the events, personalities, and inventions that have changed the world. From the earliest civilizations in Mesopotamia and India to the rise of populism in the US and China’s growth as a global power, this book gives you the facts about all major historical periods.Illustrated with over 1,500 photographs, artifacts, and maps, History: A Visual Encyclopedia is a way in to understanding the diversity of world history, from the African kingdoms that predated colonialism and the cultures of the pre-Colombian Americas to the dynasties that have ruled China for thousands of years and the many empires that have come and gone over the centuries in Asia and Eur

Classic Dutch language course, now revised and updated with a new audio app Learn to speak Dutch in just three months with this practical and comprehensive self-study language course. Whether you're a complete beginner or want to refresh your knowledge, DK's Hugo Dutch in 3 Months will have you speaking Dutch fluently in just 12 weeks. With a fresh new look and an accompanying audio app, the latest edition of this classic self-study course provides all the resources needed to speak, read, and write in Dutch. The 12 weekly chapters contain lessons on the key grammatical structures and present a range of useful vocabulary, along with exercises to reinforce your learning. The essentials of Dutch grammar are clearly explained and tested in conversational exercises, giving you the authentic feel of the language. In addition to a written "imitated pronunciation" guide, which replaces Dutch sounds with English syllables you're already familiar with, the new audio app also allows you to perfec

The diversity and drama of the bird world brought to breathtaking life in an encyclopedic new editionUnrivaled in scope for a single-volume reference work, this photographic guide to every bird order

Start learning English as a second language with this visually stimulating practice book for children ages 6-9. Accompanying the English for Everyone Junior: Beginner's Course, this beautifully illustrated workbook features an abundance of vocabulary and grammar exercises for children learning English as a foreign language. When it comes to languages, practice really does make perfect! This work book guides young linguistic learners through exercises and activities to consolidate what they've learnt and build confidence in their skills.Making use of a range of both familiar and new exercise mechanisms, this practice book is an invaluable research tool to test the vocabulary and grammar structures taught in the course book. Immerse yourself in this practical ESL learning material, which includes: -Over 1,000 vocabulary and grammar exercises -Lay-flat binding, making the book easier to write in -Extensive accompanying audio resources that can be accessed via the website and the app -The

Start learning English as a second language with this visually stimulating practice book for children ages 6-9. Accompanying the English for Everyone Junior: Beginner's Course, this beautifully illustrated workbook features an abundance of vocabulary and grammar exercises for children learning English as a foreign language. When it comes to languages, practice really does make perfect! This work book guides young linguistic learners through exercises and activities to consolidate what they've learnt and build confidence in their skills.Making use of a range of both familiar and new exercise mechanisms, this practice book is an invaluable research tool to test the vocabulary and grammar structures taught in the course book. Immerse yourself in this practical ESL learning material, which includes: -Over 1,000 vocabulary and grammar exercises -Lay-flat binding, making the book easier to write in -Extensive accompanying audio resources that can be accessed via the website and the app -The

125 comprehensive, easy-to-use cards for exam preparationA fantastic aid for exam preparation, these flash cards make biology crystal clear and will have you exam-ready in no time.Make biology super simple! These handy revision cards condense everything you need to know about biology into bitesize key facts and crystal clear diagrams. Studying for exams has never been so easy. Biology is explained in simple, user-friendly language, with colorful illustrations to help you grasp difficult concepts at a glance. Whether you’re catching up on lessons, doing homework, or revising for exams, these super simple cards will make you a biology expert in no time.

125 comprehensive, easy-to-use cards for exam preparationA fantastic aid for exam preparation, these flash cards make chemistry crystal clear and will have you exam-ready in no time.Make chemistry super simple! These handy revision cards condense everything you need to know about chemistry into bitesize key facts and crystal clear diagrams. Studying for exams has never been so easy. Chemistry is explained in simple, user-friendly language, with colorful illustrations to help you grasp difficult concepts at a glance. Whether you’re catching up on lessons, doing homework, or revising for exams, these super simple cards will make you a chemistry expert in no time.

She is benevolent and nurturing, yet fierce and terrible, a warrior and a lover. She creates and gives life, is death personified, and the one who grants eternal salvation. She is the ultimate form of reality, the cosmos.The Goddess inspires deep devotion and it is not surprising to see Her being worshipped and revered across homes in India. Shakti delves into this rich tradition of the Divine Feminine as She is represented across India and the subcontinent. In Shakti, encounter the Goddess in all Her glory and numerous forms.Dive deep into Her fascinating mythology and rituals. Unravel the philosophy behind Her worship and Her adaptation within many belief systems. From the origins of the Goddess in the ancient civilization of Harappa to Her evolution and changed character in contemporary times, Shakti tells the complete story of the Goddess in a linear fashion.During the course of its narrative, it brings together the diverse threads from different cultures, regions, and traditions t

Learn to speak Dutch in just three months with this practical and comprehensive self-study language course. Whether you're a complete beginner or wanting to refresh your knowledge, Hugo: Dutch in Three Months will have you speaking Dutch fluently in just 12 weeks. With a fresh new look and an accompanying audio app, the latest edition of this classic self-study course provides all the resources needed to speak, read, and write in Dutch.The 12 weekly chapters contain lessons on the key grammatical structures and present a range of useful vocabulary, along with exercises to reinforce your learning. The essentials of Dutch grammar are clearly explained and tested in conversational exercises, giving you the authentic feel of the language. In addition to a written "imitated pronunciation" guide, which replaces Dutch sounds with English syllables you're already familiar with, the new audio app also allows you to perfect your pronunciation - at home or on the go.Whether you're learning Dutch

Learn to speak German in just three months with this practical and comprehensive self-study language course. Whether you're a complete beginner or wanting to refresh your knowledge, Hugo: German in Three Months will have you speaking German fluently in just 12 weeks. With a fresh new look and an accompanying audio app, the latest edition of this classic self-study course provides all the resources needed to speak, read, and write in German.The 12 weekly chapters contain lessons on the key grammatical structures and present a range of useful vocabulary, along with exercises to reinforce your learning. The essentials of German grammar are clearly explained and tested in conversational exercises, giving you the authentic feel of the language. In addition to a written "imitated pronunciation" guide, which replaces German sounds with English syllables you're already familiar with, the new audio app also allows you to perfect your pronunciation - at home or on the go.Whether you're learning

Learn to speak Spanish in just three months with this practical and comprehensive self-study language course. Whether you're a complete beginner or wanting to refresh your knowledge, Hugo: Spanish in Three Months will have you speaking Spanish fluently in just 12 weeks. With a fresh new look and an accompanying audio app, the latest edition of this classic self-study course provides all the resources needed to speak, read, and write in Spanish.The 12 weekly chapters contain lessons on the key grammatical structures and present a range of useful vocabulary, along with exercises to reinforce your learning. The essentials of Spanish grammar are clearly explained and tested in conversational exercises, giving you the authentic feel of the language. In addition to a written "imitated pronunciation" guide, which replaces Spanish sounds with English syllables you're already familiar with, the new audio app also allows you to perfect your pronunciation - at home or on the go.Whether you're lea

Who will we meet on the farm today? Have fun spotting clues to the delightful animals, then find them hiding under peek-through flaps. Toddlers will love exploring a farm through the day, and learning all about adult and baby animals in this beautifully illustrated, read-aloud board book. The intriguing cover has a cutaway sun to feel, and inside there large flaps with peek-through holes revealing adorable animals.There are lots more exciting things to spot around the farm on every page, from insects and flowers to a big-wheeled tractor and a scarecrow. The playful, rhyming text encourages little ones to guess who's hiding. And when they lift the big flaps, they find cows in the field, a family of goats playing in their pen, pigs and piglets ready for lunch, chickens in the coop, and more!Flip Flap Find! Farm is a captivating picture book to share.A perfect gift for little animal lovers, it will spark a toddler's curiosity, stimulate their imagination, language, and literacy, and build

Learn to speak French in just three months with this practical and comprehensive self-study language course. Whether you're a complete beginner or wanting to refresh your knowledge, Hugo: French in Three Months will have you speaking French fluently in just 12 weeks. With a fresh new look and an accompanying audio app, the latest edition of this classic self-study course provides all the resources needed to speak, read, and write in French.The 12 weekly chapters contain lessons on the key grammatical structures and present a range of useful vocabulary, along with exercises to reinforce your learning. The essentials of French grammar are clearly explained and tested in conversational exercises, giving you the authentic feel of the language. In addition to a written "imitated pronunciation" guide, which replaces French sounds with English syllables you're already familiar with, the new audio app also allows you to perfect your pronunciation - at home or on the go.Whether you're learning

Learn to speak Portuguese in just three months with this practical and comprehensive self-study language course. Whether you're a complete beginner or wanting to refresh your knowledge, Hugo: Portuguese in Three Months will have you speaking Portuguese fluently in just 12 weeks. With a fresh new look and an accompanying audio app, the latest edition of this classic self-study course provides all the resources needed to speak, read, and write in Portuguese.The 12 weekly chapters contain lessons on the key grammatical structures and present a range of useful vocabulary, along with exercises to reinforce your learning. The essentials of Portuguese grammar are clearly explained and tested in conversational exercises, giving you the authentic feel of the language. In addition to a written "imitated pronunciation" guide, which replaces Portuguese sounds with English syllables you're already familiar with, the new audio app also allows you to perfect your pronunciation - at home or on the go.

Meet a magical family living in a magical home in Disney's new movie Encanto and in this fun sticker book. Travel to Colombia with this ultimate sticker book, featuring beautiful images and artwork from Disney's new movie Encanto. Discover all the key characters, including Mirabel Madrigal and her family, and encounter the magic of the Encanto. Disney Encanto Ultimate Sticker Book will help kids to relive the wonder of Disney's newest movie. Fun stickering activities will keep kids aged 5-7 entertained for hours and, with more than 100 stickers, there are plenty of extra stickers, too.

This beautifully illustrated children's book takes a close look at the life cycle of water, including how it supports all life forms, how humans harness its power, and why we need to conserve it. Water is essential for life. In fact, 60 percent of an adult human is made up of water We drink it and bathe in it, and thousands of creatures live in it. Yet our planet is running desperately low on fresh water, with less than one percent of the water on Earth available to fuel and feed the current population of 7.5 billion people. So dive into the wonderful world of water and find out how you can save this life-giving substance. From raindrops falling from the sky, to rushing rivers and vast oceans full of animals and plants, water is everywhere. Discover how it affects Earth's weather, through rainstorms, snow flurries, and cyclones, and gives life to animals, plants, and humans. Learn how it is used in growing food and in making clothing, as well as how water travels into our homes at the

Dive into the life-cycle of water and discover how it supports all life forms, how humans harness its power, and why we need to conserve it.From snowflakes falling from the clouds and deep ocean currents to hot springs and water in space, this children's nature book showcases the beauty and power of water in the natural world.Inside the pages of this fascinating science book for kids, you'll discover:- Bite-size facts about inhabitants of freshwater and saltwater- Incredible photographs and illustrations that capture the power of water in nature- Subjects included supports STEM learning- How critical water is to the world we live in, covering national curriculum topics around biology, the natural world, geography, global warming for kids, and much moreThe wonderful world of water awaits! Water is essential for life. We drink it, bathe in it, and thousands of creatures live in it. But we are running desperately low on it. Water Cycles shows children how important keeping hydrated is for

Visit Bob and Ginger the guinea pigs in their garden and learn how they grow delicious fruits and vegetables in this colourful picture book. Bob and Ginger the guinea pigs plant delicious fruit and ve

Take a trip down under to find a koala in this plastic free touch and feel board book. In Where are You? Koala, wander through outback and woodland to meet a world of amazing Australian animals like w

Immerse yourself in the world of musicals, and fall in love all over again with the songs, stories, characters, and legendary stars from every era. From Show Boat and The Wizard of Oz to Les Miserable

Take a fascinating around-the-globe tour, with a stopover in every nation on every continent, in this picture-packed children's book. Discover the countries of the world--exploring their geography, wildlife, traditions, and arts--in this picture-packed children's book. Every country profile is full of photos, and each nation has a full-color map detailing its main cities, landscape features, and borders, and exactly where in the world they are. At-a-glance panels provide a quick reference to all the stats, and the easy-to-read text is full of fascinating, fun facts. Countries of the World shows the many unique things that make one country different from another but might also reveal surprising similarities. Did you know that Cuba's national sport is baseball, one of the most popular sports in the US? And that kids in both Japan and Chile have earthquake drills on their school schedules? Find out about anything from the spookily vibrant Day of the Dead parade in Mexico and the beautiful

Discover the inspiring story of Queen Elizabeth II, the longest-reigning monarch in British history, in this fascinating kids' biography.At just 25 years of age, Princess Elizabeth succeeded King Geor

Take a trip through the natural wonders of America's national parks in this children's guidebook, from the Great Smoky Mountains on the East Coast, to the rocky deserts of Joshua Tree in the West.The

Discover the inspiring story of Queen Elizabeth II, the longest-reigning monarch in British history, in this fascinating kids' biography.At just 25 years of age, Princess Elizabeth succeeded King Geor

Get lost in the beauty of the natural world in this captivating collection of botanical stickers. Page after page is packed with beautiful vintage drawings of ornamental flowers, tropical ferns, and

Travel back in time and share the experience of everyday thoughts and great moments in history in this fascinating compilation of diaries through the ages.Remarkable Diaries traces the history of the

Why do we need laws? What rights are protected by law? When was forensic evidence first used in court?This book explores big questions like these, explaining the laws and legal precedents, and religious, political, and moral codes that have shaped the world we live in. Written in plain English, The Law Book cuts through the legal jargon and is packed with pithy explanations of the most important milestones in legal history, with step-by-step diagrams and witty illustrations that untangle knotty concepts. From the earliest laws, such as the Code of Hammurabi, through groundbreaking legislation including Magna Carta and the Abolition of the Slave Trade Act, The Law Book offers an engaging overview of legal history across the world all the way into the 21st century with copyright in the digital age, same-sex marriage, and the "right to be forgotten".Covering the fight for universal suffrage and workers' rights, and the establishment of international legal bodies like INTERPOL and the Euro

Meet incredible endangered animals in this plastic-free touch and feel picture book series for toddlers. In Where Are You? Polar Bear wrap up warm to take a journey through a frozen world. Meet a whol

Hear the stories of incredible scientists - from their corpses! - in this hilarious children’s graphic novel.Discover the incredible stories of scientists throughout history in this hilarious graphic

Hear the stories of incredible scientists - from their corpses! - in this hilarious children’s graphic novel.Discover the incredible stories of scientists throughout history in this hilarious graphic

Build your own metropolis brick by brick with this bite-size collection of town-themed LEGO ideas.Small in size but big in inspiration, this neat 32-page volume contains a collection of projects from

Adorn and organize your room LEGO-style with this bite-sized collection of beautiful and useful LEGO ideas.Small in size but big in inspiration, this neat 32-page volume contains perfectly practical p

This bite-sized selection of activities, games, and builds will inspire you to look at your LEGO bricks in new and exciting ways.Small in size but big in inspiration, this neat 32-page volume contains

This bite-size collection of space-themed LEGO ideas will launch you into a whole new world of creativity.Small in size but big in inspiration, this neat 32-page volume contains a collection of projec

This bite-size collection of LEGO castle build ideas will whisk you back to the days when knights were bold.Small in size but big in inspiration, this neat 32-page volume contains a collection of proj