Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A Song of Ice and Fire, Book 1A NEW ORIGINAL SERIES, NOW ON HBO. Here is the first volume in George R. R. Martin’s magnificent cycle of novels that includes A Clash of Kings and A Storm of Swords. As

Acclaimed artist Arantza Sestayo gives us her vision of George R. R. Martin's epic series, the inspiration for HBO's Game of Thrones, in a calendar featuring twelve never-before-seen views of Westeros

Acclaimed artist Sam Hogg gives us her vision of George R. R. Martin’s epic series, the inspiration for HBO’s Game of Thrones, in a calendar featuring twelve never-before-seen views of Westeros and be

Publish and perish. Plumtree Press is about to launch a bombshell of a book—a fact-based novel about one of Britain’s most revered authors, Marcus Stonecypher, a member of Virginia Woolf&r

In this heartfelt novel from #1 New York Times bestselling author Danielle Steel, a young woman with an unforgettable voice fights for the freedom to pursue her dreams.Iris Cooper has been singing ever since she can remember, hitting the high notes like no one else. When she is twelve, her father convinces the owner of a bar in Lake City, Texas to let her perform, and she stuns the audience. In the ensuing years, never staying anywhere for long, father and daughter move from one dusty town to the next, her passion for music growing every time she takes the mike in another roadhouse. But it is not an easy life for Iris with her father in charge and using her income to pay for gambling, women, and booze. When she starts to tour at age eighteen, she takes on a real manager. Yet he exploits her too, and the singers and musicians she tours with are really the only family she has. It is they who give Iris the courage to finally fly free, leave the tour, and follow her dreams. After

You can’t ever know for sure what happens behind closed doors. . . . Everyone from Wakarusa, Indiana, remembers the infamous case of January Jacobs, who was discovered in a ditch hours after her family awoke to find her gone. Margot Davies was six at the time, the same age as January―and they were next-door neighbors. In the twenty years since, Margot has grown up, moved away, become a big-city journalist. But she’s always been haunted by the fear that it could’ve been her. And the worst part is, January’s killer has never been brought to justice. When Margot returns home to help care for her uncle after a diagnosis of early-onset dementia, it all feels like walking into a time capsule. Wakarusa is exactly how she remembered―genial, stifled, secretive. Then news breaks about five-year-old Natalie Clark from the next town over, who’s gone missing under eerily similar circumstances. With all the old feelings rushing back, Margot vows to find Natalie and solve January’s murder once and

A dedicated CIA agent becomes an unexpected ally to a woman haunted by the kidnapping of her family, in this thrilling novel from #1 New York Times bestselling author Danielle Steel.Theodora Morgan is fashion royalty. Founder of a wildly popular online shopping service, she is one of the most successful businesswomen in the world, although she prefers to keep a low profile, especially over the last months. It was a year ago when the unthinkable struck her family, and her husband, industry mogul Matthieu Pasquier, and their son were kidnapped and held for ransom―a nightmare that ended in tragedy. The case has gone cold, despite evidence linking the crime to Matthieu’s Russian competitors. Theo has reluctantly gone back to work running her company. On the flight to a launch party for one of her highly anticipated pop-up shops in New York City, she crosses paths with high-society networker Pierre de Vaumont. Theo politely invites him to her event―unaware that Pierre has been flagged by th

The thrilling history of the Targaryens comes to life in this masterly work, the inspiration for HBO’s upcoming Game of Thrones prequel series House of the Dragon. Now in mass market format!Centuries

A gorgeous illustrated edition of the third book in the beloved A Song of Ice and Fire series, for fans of HBO’s Game of Thrones, published in celebration of the twentieth anniversary of the book.This

The thrilling history of the Targaryens comes to life in this masterly work, the inspiration for HBO’s upcoming Game of Thrones prequel series House of the Dragon. Now in trade paperback with five new

A young woman is caught up in a dangerous double life on behalf of her country during World War II in Danielle Steel’s thrilling new novel. At eighteen, Alexandra Wickham is presented to King Geo

As part of the Louis L’Amour’s Lost Treasures series, this edition contains exclusive bonus materials! Joe Harbin hadn’t killed a man for a fortune in gold just to sit in pris

In this fast-paced mystery by Rita Mae Brown and her feline co-author Sneaky Pie Brown, Mary Minor “Harry” Haristeen and her animal friends seek to solve a whodunit rooted in eighteenth-century Virgin

NEW YORK TIMES BESTSELLER • Hailed as “a combination of Eloise and Sherlock Holmes” by The Boston Globe, Flavia de Luce returns in a Christmas mystery from award-winning author Alan Bradley. In spite

In this propulsive debut novel from the host of the #1 true crime podcast Crime Junkie, a journalist uncovers her hometown’s dark secrets when she becomes obsessed with the unsolved murder of her childhood neighbor―and the disappearance of another girl twenty years later.

The book that inspired HBO’s Game of Thrones prequel series House of the Dragon, coming August 2022, now features a cover with stunning key art from the show! This thrilling history of the Targaryens contains eighty-five black-and-white illustrations, including five illustrations exclusive to the trade paperback edition.Centuries before the events of A Game of Thrones, House Targaryen—the only family of dragonlords to survive the Doom of Valyria—took up residence on Dragonstone. Fire & Blood begins their tale with the legendary Aegon the Conqueror, creator of the Iron Throne, and goes on to recount the generations of Targaryens who fought to hold that iconic seat, all the way up to the civil war that nearly tore their dynasty apart.What really happened during the Dance of the Dragons? Why was it so deadly to visit Valyria after the Doom? What were Maegor the Cruel’s worst crimes? What was it like in Westeros when dragons ruled the skies? These are but a few of the questions a

《冰與火之歌》前傳《House of the Dragon》即將上線。回到三百年前的維斯特洛，坦格利安家族倚靠巨龍出世，征服大陸。「征服者」伊耿．坦格利安登上象徵王者的鐵王座，龍族的統治就此揭開序幕。#1 NEW YORK TIMES BESTSELLER • The thrilling history of the Targaryens comes to life in this masterly work, the inspiration for HBO’s upcoming Game of Thrones prequel series House of the Dragon“The thrill of Fire & Blood is the thrill of all Martin’s fantasy work: familiar myths debunked, the whole trope table flipped.”—Entertainment WeeklyCenturies before the events of A Game of Thrones, House Targaryen—the only family of dragonlords to survive the Doom of Valyria—took up residence on Dragonstone. Fire & Blood begins their tale with the legendary Aegon the Conqueror, creator of the Iron Throne, and goes on to recount the generations of Targaryens who fought to hold that iconic seat, all the way up to the civil war that nearly tore their dynasty apart.What really happened during the Dance of the Dragons? Why was it so deadly to visit Valyria after the Doom? What were Maegor the C

Scandal and tragedy erupt against the backdrop of an exclusive Paris hotel in Danielle Steel’s riveting novel.Known for its luxurious accommodations and bespoke service, the Hotel Louis XVI has been t

An aircraft carrier adrift with a crew the size of a small town. A killer in their midst. And the disgraced Navy SEAL who must track him down…The high-octane debut thriller from New York Times bestsel

Maggie Hope is off to Hollywood to solve a crime that hits too close to home―and confront the very evil she thought she had left behind in Europe―as the acclaimed World War II mystery series from New

“For sheer adventure L’Amour is in top form.”—Kirkus Reviews Here is the kind of authentically detailed epic novel that has become Louis L’Amour’s hallmark. It

In one swift moment a fall wiped away his memory. Now all he knew for certain was that someone wanted him dead—and that he had better learn why. But everywhere he turned there seemed to be more

Rita Mae Brown and her feline co-author Sneaky Pie Brown return to Albemarle County, Virgina, as tangled mysteries past and present converge in the bestselling Mrs. Murphy series. “As fel

NEW YORK TIMES BESTSELLER • When this relentless rogue FBI agent comes knocking, her adversaries will have to answer—with their lives—in the latest thrilling Jane Hawk novel

As part of the Louis L’Amour’s Lost Treasures series, this edition contains exclusive bonus materials! He was a white man as cunning as any Indian, a brooding man who trusted in not

NEW YORK TIMES BESTSELLER • The irrepressibly charming duo of Emerson Knight and Riley Moon returns in another gripping mystery by #1 New York Times bestselling author Janet Evanovich. Buddhist m

As part of the Louis L’Amour’s Lost Treasures series, this edition contains exclusive bonus materials! It was a name that caused the most hardened gunmen to break out in a cold swea

NEW YORK TIMES BESTSELLER • Jane Hawk—fiction’s most relentless, resourceful, stunning new heroine—continues her battle against a murderous conspiracy in the riveting sequel to

#1 NEW YORK TIMES BESTSELLER • In the heart of Trenton, N.J., a killer is out to make sure someone gets his just desserts. Larry Virgil skipped out on his latest court date after he w

New York Times bestselling author Tami Hoag returns with a thriller that begins with a shocking crime scene you’ll never forget and follows two relentless detectives on a manhunt that ends in a chilli

Janet Evanovich, author of the blockbuster Stephanie Plum novels, and Lee Goldberg, writer for the Monk television show, team up once again in their rollicking, New York Times bestselling Fox and O’Ha

The bestselling author of The Power of Habit explores the science of productivity, and why, in today’s world, managing how you think—rather than what you think about—can transform your ability to do w

There is no story more distinctly American than the western and no writer as great a master of the form as Louis L’Amour. In this seventh volume of L’Amour’s collected short stories, you’ll find some

NEW YORK TIMES BESTSELLER • From the author of Star Wars: Lost Stars comes a thrilling novel set in the years before the events of Star Wars: The Force Awakens.“Unmissabl

Callaghen’s business is soldiering. For twenty years he’d fought all over the world, from China to the deserts of California; now he’s a private in the U.S. Cavalry, poorly paid, his enlistment about

#1 NEW YORK TIMES BESTSELLER • Something big is brewing in Trenton, N.J., and it could blow at any minute. Stephanie Plum might not be the world’s greatest bounty hunter, but she knows when she’s

Traversing a vivid landscape, from sunblasted hills and canyons to the nighttime streets of America’s greatest cities, some of Louis L’Amour’s most compelling fiction was set in his own time. Here are

At what point does a group of strangers become a community? When young Bendigo Shafter and a ragtag bunch of travelers settle in the rugged Wyoming mountains, they quickly come to depend on a toughnes

For twelve thousand years the Galactic Empire has ruled supreme. Now it is dying. But only Hari Sheldon, creator of the revolutionary science of psychohistory, can see into the future--to a dark age of ignorance, barbarism, and warfare that will last thirty thousand years. To preserve knowledge and save mankind, Seldon gathers the best minds in the Empire--both scientists and scholars--and brings them to a bleak planet at the edge of the Galaxy to serve as a beacon of hope for a fututre generations. He calls his sanctuary the Foundation.But soon the fledgling Foundation finds itself at the mercy of corrupt warlords rising in the wake of the receding Empire. Mankind's last best hope is faced with an agonizing choice: submit to the barbarians and be overrun--or fight them and be destroyed.

Hilariously picaresque, epic in scope, alive with the poetry and vigor of the American people, Mark Twain's story about a young boy and his journey down the Mississippi was the first great novel to sp