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Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials – and controversies and future challenges – are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an internat

Computational biology drives discovery through its use of high-throughput informatics approaches. This book provides a road map of the current drug development process and how computational biology approaches play a critical role across the entire drug discovery pipeline. Through the use of previously unpublished, real-life case studies the impact of a range of computational approaches are discussed at various phases of the pipeline. Additionally, a focus section provides innovative visualisation approaches, from both the drug discovery process as well as from other fields that utilise large datasets, recognising the increasing use of such technology. Serving the needs of early career and more experienced scientists, this up-to-date reference provides an essential introduction to the process and background of drug discovery, highlighting how computational researchers can contribute to that pipeline.

As societies become more complex and interconnected, the global risk for catastrophic disasters is increasing. Demand for expertise to mitigate the human suffering and damage these events cause is also high. A new field of disaster medicine is emerging, offering innovative approaches to optimize disaster management. Much of the information needed to create the foundation for this growing specialty is not objectively described or is scattered among multiple different sources. This definitive work brings together a coherent and comprehensive collection of scientific observations and evidence-based recommendations with expert contributors from around the globe. This book identifies essential subject matter, clarifies nomenclature, and outlines necessary areas of proficiency for healthcare professionals handling mass casualty crises. It also describes in-depth strategies for the rapid diagnosis and treatment of victims suffering from blast injuries or exposure to chemical, biological, and

Reason, Revelation, and Devotion argues that immersion in religious reading traditions and their associated spiritual practices significantly shapes our emotions, desires, intuitions, and volitional commitments; these in turn affect our construction and assessments of arguments for religious conclusions. But far from distorting the reasoning process, these emotions and volitional and cognitive dispositions can be essential for sound reasoning on religious and other value-laden subject matters. And so western philosophy must rethink its traditional antagonism toward rhetoric. The book concludes with discussions of the implications of the earlier chapters for the relation between reason and revelation, and for the role that the concept of mystery should play in philosophy in general, and in the philosophy of religion and philosophical theology in particular.

Teaching and Digital Technologies: Big Issues and Critical Questions helps both pre-service and in-service teachers to critically question and evaluate the reasons for using digital technology in the classroom. Unlike other resources that show how to use specific technologies – and quickly become outdated, this text empowers the reader to understand why they should (or should not) use digital technologies, when it is appropriate (or not), and the implications arising from these decisions. The text directly engages with policy, the Australian Curriculum, pedagogy, learning and wider issues of equity, access, generational stereotypes and professional learning. The contributors to the book are notable figures from across a broad range of Australian universities, giving the text a unique relevance to Australian education while retaining its universal appeal. Teaching and Digital Technologies is an essential contemporary resource for early childhood, primary and secondary pre-service and in

Reason, Revelation, and Devotion argues that immersion in religious reading traditions and their associated spiritual practices significantly shapes our emotions, desires, intuitions, and volitional commitments; these in turn affect our construction and assessments of arguments for religious conclusions. But far from distorting the reasoning process, these emotions and volitional and cognitive dispositions can be essential for sound reasoning on religious and other value-laden subject matters. And so western philosophy must rethink its traditional antagonism toward rhetoric. The book concludes with discussions of the implications of the earlier chapters for the relation between reason and revelation, and for the role that the concept of mystery should play in philosophy in general, and in the philosophy of religion and philosophical theology in particular.

Paul Craig's analysis of UK, EU and global administrative law examines the challenges facing each system and reveals the commonalities in and differences between their foundational assumptions. The challenges which they face may be particular to that legal order, endemic to any legal system of administrative law or the result of interaction between the three systems. The inter-relationship between the three levels is important. The legal and practical reality is that developments at one level can have an impact on the other two. Legal doctrine fashioned at the national level may therefore inform developments in EU and global administrative law. The doctrine thus created may then function symbiotically, shaping developments within a domestic legal order. The inter-relationship is equally marked from the regulatory perspective, since many such provisions originate at the global or EU level.

Paul Craig's analysis of UK, EU and global administrative law examines the challenges facing each system and reveals the commonalities in and differences between their foundational assumptions. The challenges which they face may be particular to that legal order, endemic to any legal system of administrative law or the result of interaction between the three systems. The inter-relationship between the three levels is important. The legal and practical reality is that developments at one level can have an impact on the other two. Legal doctrine fashioned at the national level may therefore inform developments in EU and global administrative law. The doctrine thus created may then function symbiotically, shaping developments within a domestic legal order. The inter-relationship is equally marked from the regulatory perspective, since many such provisions originate at the global or EU level.

Fully revised, this new edition reviews the most up-to-date and clinically relevant information on the mental health and behavioral problems of people with intellectual, developmental and learning disabilities, also previously known as mental retardation. Providing the latest evidence base from the literature and embracing clinical experience, it covers the essential facts and concepts relating to coexisting medical and psychiatric disorders, with new and updated chapters on mental health and epilepsy, schizophrenia spectrum disorders, personality disorders, and mental health problems in people with autism and related disorders. The disorder-based chapters are complemented by chapters on carer and family perspectives, possible future developments and contributions highlighting the principles of assessment, management and services from global and historical perspectives. This is essential hands-on practical advice for psychiatrists, psychologists and all other mental health professional

This book describes and proposes an unusual integrative approach to human perception that qualifies as both an ecological and a phenomenological approach at the same time. Thomas Natsoulas shows us how our consciousness - in three of six senses of the word that the book identifies - is involved in our activity of perceiving the one and only world that exists, which includes oneself as a proper part of it, and that all of us share together with the rest of life on earth. He makes the case that our stream of consciousness - in the original Jamesian sense minus his mental/physical dualism - provides us with firsthand contact with the world, as opposed to our having such contact instead with theorist-posited items such as inner mental representations, internal pictures, or sense-image models, pure figments and virtual objects, none of which can have effects on our sensory receptors.

Definitive guide to modern organic electro-optic and photonic technologies, from basic theoretical concepts to practical applications in devices and systems.

Law and medicine can be caught in a tight embrace. They both play a central role in the politics of harm, making decisions regarding what counts as injury and what might be the most suitable forms of redress or remedy. But where do law and medicine converge and diverge in their responses to and understandings of harm and suffering? Using empirical case studies from Europe, the Americas and Africa, The Clinic and the Court brings together leading medical and legal anthropologists to explore this question.

'Ethnolinguistics' is the study of how language relates to culture and ethnicity. This book offers an original approach to ethnolinguistics, discussing how abstract concepts such as truth, love, hate and war are expressed across cultures and ethnicities. James W. Underhill seeks to situate these key cultural concepts within four languages (English, French, Czech and German). Not only do these concepts differ from language to language, but they go on changing over time. The book explores issues such as how far meaning is politically and culturally influenced, how far language shapes the thought of ethnic groups and how far their thought shapes language, and the role of individuals in the consolidation of cultural concepts. It offers a clear and thought-provoking account of how concepts are understood and will be welcomed by those working in the fields of sociolinguistics, linguistic anthropology, discourse analysis, semantics and pragmatics.

Silverberg's Principles and Practice of Surgical Pathology and Cytopathology is one of the most durable reference texts in pathology. Thoroughly revised and updated, this state-of-the-art new edition encompasses the entire fields of surgical pathology and cytopathology in a single source. Its practice-oriented format uniquely integrates these disciplines to present all the relevant features of a particular lesion, side by side. Over 4000 color images depict clinical features, morphological attributes, histochemical and immunohistochemical findings, and molecular characteristics of all lesions included. This edition features new highly experienced and academically accomplished editors, while chapters are written by the leading experts in the field (several new to this edition, bringing a fresh approach). Dr Steven Silverberg's practical approach to problem solving has been carefully preserved. The print book is packaged with access to a secure, electronic copy of the book, providing qui

How have research agendas on race and ethnic relations changed over the past two decades and what new developments have emerged? Theories of Race and Ethnicity provides a comprehensive and cutting-edg

How have research agendas on race and ethnic relations changed over the past two decades and what new developments have emerged? Theories of Race and Ethnicity provides a comprehensive and cutting-edg

Niamh Dunne undertakes a systematic exploration of the relationship between competition law and economic regulation as legal mechanisms of market control. Beginning from a theoretical assessment of these legal instruments as discrete mechanisms, the author goes on to address numerous facets of the substantive interrelationship between competition law and economic regulation. She considers, amongst other aspects, the concept of regulatory competition law; deregulation, liberalisation and 'regulation for competition'; the concurrent application of competition law in regulated markets; and relevant institutional aspects including market study procedures, the distribution of enforcement powers between competition agencies and sector regulators, and certain legal powers that demonstrate a 'hybridised' quality lying between competition law and economic regulation. Throughout her assessment, Dunne identifies and explores recurrent considerations that inform and shape the optimal relationship

This book pivots around two principal concerns in the modern world: the nature and practice of human rights in relation to religion, and the role of religion in perennial issues of war and peace. It articulates a vision for achieving a liberal peace and a just society firmly grounded in respect for human rights, while working in tandem with the constructive roles that religion can play even amid cultural difference. It explores topics including the status and justification of human rights; the meaning and significance of religious liberty; whether human rights protections ought to be extended to other species; how the comparative study of religious ethics ought to proceed; and the nature, limits, and future development of just war thinking. Featuring a group of distinguished contributors, this is a distinctive contribution that shows a multifaceted and original exploration of cutting edge issues with regards to the aforementioned themes.

Innovative forums that integrate citizen deliberation into policy making are revitalizing democracy in many places around the world. Yet controversy abounds over whether these forums ought to be seen as authentic sources of public opinion and how they should fit with existing political institutions. How can civic forums include less powerful citizens and ensure that their perspectives are heard on equal terms with more privileged citizens, officials, and policy experts? How can these fragile institutions communicate citizens' policy preferences effectively and legitimately to the rest of the political system? Deliberation, Democracy, and Civic Forums proposes creative solutions for improving equality and publicity, which are grounded in new theories about democratic deliberation, a careful review of research and practice in the field, and several original studies. This book speaks to scholars, practitioners, and sponsors of civic engagement, public management and consultation, and deli

Does science have limits? Where does order come from? Can we understand consciousness? Written by Nobel Laureate Leon N. Cooper, this book places pressing scientific questions in the broader context of how they relate to human experience. Widely considered to be a highly original thinker, Cooper has written and given talks on a large variety of subjects, ranging from the relationship between art and science, possible limits of science, to the relevance of the Turing test. These essays and talks have been brought together for the first time in this fascinating book, giving readers an opportunity to experience Cooper's unique perspective on a range of subjects. Tackling a diverse spectrum of topics, from the conflict of faith and science to whether understanding neural networks could lead to machines that think like humans, this book will captivate anyone interested in the interaction of science with society.

Emergency departments around the world may differ, but many of the problems they face are the same. Written by an international panel of experienced emergency department leaders Emergency Department Leadership and Management provides the latest knowledge and advice to improve your personal leadership skills. The book will assist emergency department leaders in overcoming common management and operational problems including overcrowding, risk management, implementing the right triage system, electronic and IT solutions, improving clinical teamwork, education of emergency department staff, improving patient flow, care pathways and leading during times of change. Example cases are included to allow leaders to compare common cases to the problems which they face in their own departments. Information on designing emergency medicine specialty residency programs is also provided. It is the official text of the International Emergency Department Leadership Institute (IEDLI) and has been endors

This book offers a comparative and historical analysis of foreign direct investment (FDI) liberalization in China and India and explains how the return of these countries' diasporas affects such liberalization. It examines diasporic investment from Western FDIs and finds that diasporas, rather than Western nations, have fueled globalization in the two Asian giants. In China, diasporas contributed the lion's share of FDI inflows. In India, returned diasporas were bridges for, and initiators of, Western investment at home. Min Ye illustrates that diasporic entrepreneurs helped to build China into the world's manufacturing powerhouse and that Indian diasporas facilitated their homeland's success in software services development.

Sudden changes, opportunities, or revelations have always carried a special significance in Western culture, from the Greek and later the Christian kairos to Evangelical experiences of conversion. This fascinating book explores the ways in which England, under the influence of industrializing forces and increased precision in assessing the passing of time, attached importance to moments, events that compress great significance into small units of time. Sue Zemka questions the importance that modernity invests in momentary events, from religion to aesthetics and philosophy. She argues for a strain in Victorian and early modern novels critical of the values the age invested in moments of time, and suggests that such novels also offer a correction to contemporary culture and criticism, with its emphasis on the momentary event as an agency of change.

Since the beginnings of the GATT and the Bretton Woods institutions, and on to the creation of the WTO, states have continued to develop institutions and legal infrastructure to promote global interdependence. International lawyers are experts in understanding how these institutions operate in practice, but they tend to uncritically accept comparative advantage as the principal normative criterion to justify these institutions. In contrast, moral and political philosophers have developed accounts of global justice, but these accounts have had relatively little influence on international legal scholarship and on institutional design. This volume reflects the results of a symposium held at Tillar House, the American Society of International Law headquarters in Washington, DC, in November 2008, which brought together philosophers, legal scholars and economists to discuss the problems of understanding international economic law from the standpoints of rights and justice, in particular from

Originally published in 1916, this book presents a selection from the Jatakas translated into English. The selection was made 'with the purpose of bringing together the Jataka stories of most interest, both intrinsically, and also from the point of view of the folklorist.' Notes and illustrative figures are also included. This book will be of value to anyone with an interest in the Jataka tales and Indian literature.

Due to the unique cultural capital of his works, Shakespeare has long been the test subject for new methods and digital advances in arts scholarship. Shakespeare sits at the forefront of the digital humanities - in archiving, teaching, performance and editing - impacting on scholars, theatres and professional organisations alike. The pace at which new technologies have developed is unprecedented (and the pressure to keep up is only growing). This book offers seventeen new essays that assess the opportunities and pitfalls presented by the twenty-first century for the ongoing exploration of Shakespeare. Through contributions from a broad range of scholars and practitioners, including case studies from those working in the field, the collection engages with the impact of the digital revolution on Shakespeare studies. By assessing and mediating this sometimes controversial digital technology, the book is relevant to those interested in the digital humanities as well as to Shakespeare schol

Due to the unique cultural capital of his works, Shakespeare has long been the test subject for new methods and digital advances in arts scholarship. Shakespeare sits at the forefront of the digital humanities - in archiving, teaching, performance and editing - impacting on scholars, theatres and professional organisations alike. The pace at which new technologies have developed is unprecedented (and the pressure to keep up is only growing). This book offers seventeen new essays that assess the opportunities and pitfalls presented by the twenty-first century for the ongoing exploration of Shakespeare. Through contributions from a broad range of scholars and practitioners, including case studies from those working in the field, the collection engages with the impact of the digital revolution on Shakespeare studies. By assessing and mediating this sometimes controversial digital technology, the book is relevant to those interested in the digital humanities as well as to Shakespeare schol

Written in D. H. Lawrence's most productive period, 'Psychoanalysis and the Unconscious' (1921) and 'Fantasia of the Unconscious' (1922) were undertaken initially in response to psychoanalytic criticism of his novel Sons and Lovers. They soon developed more generally to propose an alternative to what Lawrence perceived as the Freudian psychoanalytic theory of the unconscious and the incest motive. The essays also develop his ideas about the upbringing and education of children, about marriage, and about social and even political action. Lawrence described them as 'this pseudo-philosophy of mine which was deduced from the novels and poems, not the reverse. The absolute need one has for some sort of satisfactory mental attitude towards oneself and things in general makes one try to abstract some definite conclusions from one's experiences as a writer and as a man'. These conclusions form an illuminating guide to his works and therein lies their peculiar value.

In his book on constitutional revolutions in the Ottoman Empire and Iran in the early twentieth century, Nader Sohrabi considers the global diffusion of institutions and ideas, their regional and local reworking and the long-term consequences of adaptations. He delves into historic reasons for greater resilience of democratic institutions in Turkey as compared to Iran. Arguing that revolutions are time-bound phenomena whose forms follow global models in vogue at particular historical junctures, he challenges the ahistoric and purely local understanding of them. Furthermore, he argues that macro-structural preconditions alone cannot explain the occurrence of revolutions, but global waves, contingent events and the intervention of agency work together to bring them about in competition with other possible outcomes. To establish these points, the book draws on a wide array of archival and primary sources that afford a minute look at revolutions' unfolding.

While regulatory institutions and strategies have been the subject of increasing academic attention, there has been limited application of regulatory theories to criminal justice scholarship. This collection of essays from a range of outstanding international scholars adopts a critical, inter-disciplinary approach, providing an innovative application of regulatory theory to the practice of criminal justice and offering suggestions for further research. Part I explores the aims and values of criminal justice and other regulatory networks and the synergies and tensions between these fields; Part II examines criminal justice as a regulatory force to control 'deviant' and anti-social behaviour and Part III examines the regulation and oversight of criminal justice through the operation of prison inspectorates and explores notions of responsive justice.

This volume explores from multiple perspectives the subtle and interesting relationship between the theory of rational choice and Darwinian evolution. In rational choice theory, agents are assumed to make choices that maximize their utility; in evolution, natural selection 'chooses' between phenotypes according to the criterion of fitness maximization. So there is a parallel between utility in rational choice theory and fitness in Darwinian theory. This conceptual link between fitness and utility is mirrored by the interesting parallels between formal models of evolution and rational choice. The essays in this volume, by leading philosophers, economists, biologists and psychologists, explore the connection between evolution and rational choice in a number of different contexts, including choice under uncertainty, strategic decision making and pro-social behaviour. They will be of interest to students and researchers in philosophy of science, evolutionary biology, economics and psycholo

Why did America embrace consumer credit over the course of the twentieth century, when most other countries did not? How did American policy makers by the late twentieth century come to believe that more credit would make even poor families better off? This book traces the historical emergence of modern consumer lending in America and France. If Americans were profligate in their borrowing, the French were correspondingly frugal. Comparison of the two countries reveals that America's love affair with credit was not primarily the consequence of its culture of consumption, as many writers have observed, nor directly a consequences of its less generous welfare state. It emerged instead from evolving coalitions between fledgling consumer lenders seeking to make their business socially acceptable and a range of non-governmental groups working to promote public welfare, labor, and minority rights. In France, where a similar coalition did not emerge, consumer credit continued to be perceived

Why did America embrace consumer credit over the course of the twentieth century, when most other countries did not? How did American policy makers by the late twentieth century come to believe that more credit would make even poor families better off? This book traces the historical emergence of modern consumer lending in America and France. If Americans were profligate in their borrowing, the French were correspondingly frugal. Comparison of the two countries reveals that America's love affair with credit was not primarily the consequence of its culture of consumption, as many writers have observed, nor directly a consequences of its less generous welfare state. It emerged instead from evolving coalitions between fledgling consumer lenders seeking to make their business socially acceptable and a range of non-governmental groups working to promote public welfare, labor, and minority rights. In France, where a similar coalition did not emerge, consumer credit continued to be perceived

Based on fieldwork carried out in a Mayan village in Guatemala, this book examines local understandings of mind through the lens of language and culture. It focuses on a variety of grammatical structures and discursive practices through which mental states are encoded and social relations are expressed: inalienable possessions, such as body parts and kinship terms; interjections, such as 'ouch' and 'yuck'; complement-taking predicates, such as 'believe' and 'desire'; and grammatical categories such as mood, status and evidentiality. And, more generally, it develops a theoretical framework through which both community-specific and human-general features of mind may be contrasted and compared. It will be of interest to researchers and students working within the disciplines of anthropology, linguistics, psychology, and philosophy.

This 1864 work critiques John Stuart Mill's Utilitarianism from a Christian perspective, applying it to contemporary political and moral problems.

Divination was an important and distinctive aspect of religion in both ancient China and ancient Greece, and this book will provide the first systematic account and analysis of the two side by side. Who practised divination in these cultures and who consulted it? What kind of questions did they ask, and what methods were used to answer those questions? As well as these practical aspects, Lisa Raphals also examines divination as a subject of rhetorical and political narratives, and its role in the development of systematic philosophical and scientific inquiry. She explores too the important similarities, differences and synergies between Greek and Chinese divinatory systems, providing important comparative evidence to reassess Greek oracular divination.

"This book is an exciting new look at how archaeology has dealt with the bodily senses and offers an argument for how the discipline can offer a richer glimpse into the human sensory experience. Yanni