Most animal cells are polarized, with structurally and functionally distinct regions. This polarization facilitates processes such as differentiation and morphogenesis, directional cell migration, ner
Cilia and flagella are protrusive structures on the surface of cells that perform a variety of functions. The beating of flagella and motile cilia, for example, can be used to propel cells or move mat
Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting t
Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mito
DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed theenormous progress in our understanding of the nature and behavior of chromosomes during the life cy
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed theenormous progress in our understanding of the nature and behavior of chromosomes during the life cy
The Yeast Genetics & Genomics course is a modern, state of the art, laboratory course designed to teach the full repertoire of genetic approaches needed to dissect complex problems in the yeas
"Fungal infections affect millions of individuals worldwide. They a particular danger to immunocompromised individuals, such as those with HIV/AIDS, and invasive infections often have a mortality rate
"The skin is a continually renewing organ that acts as a protective barrier isolating us from the external environment. This book examines the cells that make up the skin and their functions, as well
Nineteen chapters review the process and regulation of protein synthesis as understood through recent research. Among the topics are new insights and challenges in the mechanism of eukaryotic translat
Life arose on Earth more than three billion years ago. How the first self-replicating systems emerged from prebiotic chemistry and evolved into primitive cell-like entities is an area of intense rese
Next-generation sequencing technology allows rapid sequencing of a patient's DNA. This book introduces the technology and describes how it may be used in personalized medicine to diagnose diseases su
Translation converts the genetic code in messenger RNA molecules copied from DNA into a specific sequence of amino acids in a protein. It occurs on ribosomes in the cell cytoplasm and is one of the mo
In this provocative work, the historian Elof Carlson explores how new fields of the life sciences emerge. Some scientists describe new theories, experiments, discoveries, or the use of new technology
Bone plays far more than just a structural role in our bodies. It actively communicates with our brains, kidneys, and other organs, releasing and responding to signaling molecules that regulate biolog
Ras proteins are critical molecular switches in signaling mechanisms that control cell behavior and are frequently mutated in cancer. This volume examines the functions of Ras, how its activation lead
This book features drawings by Lewis Miller of those who have played a role in the mapping of the human genome paired with short biographies written by prominent scientists.--
Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the myelin sheaths that surround nerve cells, producing a variety of neurological symptoms such as limb weakness and
One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various de
The ability to grow new tissue and organs is an important goal of regenerative medicine. This book discusses new research in which cells are grown on artificial scaffolds to build replacement tissue t
Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes
Prions are best known as the agents of mad cow and related diseases, and a growing number of proteins with prion-like properties have been implicated in diseases such as Parkinson's. But some recently
The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlyingscience can drive improvements in diagnostic, prognostic, and therapeutic approaches was a majo
The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlyingscience can drive improvements in diagnostic, prognostic, and therapeutic approaches was a majo
Ion channels convey ions such as potassium, sodium and calcium across cellular membranes and play critical roles in normal physiology. This laboratory manual is based on the popular Cold Spring Harbor
Defined in the broadest sense, Glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in nature in all li
Ion channels convey ions such as potassium, sodium and calcium across cellular membranes and play critical roles in normal physiology. This laboratory manual is based on the popular Cold Spring Harbor
Studies of fission yeast were instrumental in revealing the fundamental mechanisms that control cell division in organisms from yeast to humans, and fission yeast such as Schizosaccahromyces pombe con
Studies of fission yeast were instrumental in revealing the fundamental mechanisms that control cell division in organisms from yeast to humans, and fission yeast such as Schizosaccahromyces pombe con
Malaria affects hundreds of millions of people every year, killing several hundred thousand. This book examines the biology of the Plasmodium parasites responsible, the way the disease is transmitted
CRISPR/Cas-based techniques are revolutionizing the way geneticists and molecular biologists modify DNA sequences and modulate gene expression in cells and organisms. This laboratory manual presents s
p53 is a critical tumor suppressor protein that controls cell division and is often mutated in cancer. This volume examines the structure and function of the p53 protein, its regulation of DNA repair,
The machinery that controls how DNA is packaged and genes are activated plays an important role in cancer. This book examines the functions of components of this machinery, how they can be dysregulate
Our brains learn and remember information by modifying synaptic connections in neuronal networks. These changes occur in different circuits and regions of the brain, depending on the occasion. The und
Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. Written and edited by experts in the field, this collection fromCold Spring Harbor Perspectives in
Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. Written and edited by experts in the field, this collection fromCold Spring Harbor Perspectives in
Size is a primary feature of living things. From egg to adult, the various organs, tissues, cells, and subcellular structures that make up an organism grow to appropriate sizes so that they effectivel
