Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in
The MYC gene is frequently activated in cancer. It encodes a transcription factor that controls gene expression programs regulating numerous aspects of cellular behavior, including cell proliferation,
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding
Cilia and flagella are protrusive structures on the surface of cells that perform a variety of functions. The beating of flagella and motile cilia, for example, can be used to propel cells or move mat
Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting t
Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mito
Most animal cells are polarized, with structurally and functionally distinct regions. This polarization facilitates processes such as differentiation and morphogenesis, directional cell migration, ner
DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass
"Fungal infections affect millions of individuals worldwide. They a particular danger to immunocompromised individuals, such as those with HIV/AIDS, and invasive infections often have a mortality rate
The Yeast Genetics & Genomics course is a modern, state of the art, laboratory course designed to teach the full repertoire of genetic approaches needed to dissect complex problems in the yeas
Life arose on Earth more than three billion years ago. How the first self-replicating systems emerged from prebiotic chemistry and evolved into primitive cell-like entities is an area of intense rese
"The skin is a continually renewing organ that acts as a protective barrier isolating us from the external environment. This book examines the cells that make up the skin and their functions, as well
Nineteen chapters review the process and regulation of protein synthesis as understood through recent research. Among the topics are new insights and challenges in the mechanism of eukaryotic translat
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed theenormous progress in our understanding of the nature and behavior of chromosomes during the life cy
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed theenormous progress in our understanding of the nature and behavior of chromosomes during the life cy
Neuroscientists have often pioneered the use of new visualization techniques. Imaging in Neuroscience: A Laboratory Manual provides the definitive collection of methods in use in this groundbreaking
The machinery that controls how DNA is packaged and genes are activated plays an important role in cancer. This book examines the functions of components of this machinery, how they can be dysregulate
New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visual
New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visual
Symmetry breaking events are critical for the survival of living systems. They are required for cell division, development, and movement in all organisms from single-celled species to human beings. Mo
Next-generation sequencing technology allows rapid sequencing of a patient's DNA. This book introduces the technology and describes how it may be used in personalized medicine to diagnose diseases su
Patents are an important way of protecting inventions in the pharmaceutical and biotechnology industries. However, intellectual property law reforms have not kept pace with the rapid advances in genom
Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of b
It is now clear that our risk of developing almost any disease is influenced by the genes with which we are born. One of the most important dividends of the Human Genome Project will be a much greater
Neuroscientists have often pioneered the use of new visualization techniques. Imaging in Neuroscience: A Laboratory Manual provides the definitive collection of methods in use in this groundbreaking
"It is simply amazing to me that so many of my industry coworkers stumbled upon their careers in clinical research, like I did, merely by chance. In most cases, once those opportunities were presented
This work on translational control--the central idea of which is that gene expression is regulated by the efficiency of utilization of messenger RNA in specifying protein synthesis--is a successor of
Ras proteins are critical molecular switches in signaling mechanisms that control cell behavior and are frequently mutated in cancer. This volume examines the functions of Ras, how its activation lead
Malaria affects hundreds of millions of people every year, killing several hundred thousand. This book examines the biology of the Plasmodium parasites responsible, the way the disease is transmitted
As the world of biotechnology has grown in leaps and bounds, so too have the career opportunities. But the choices can be daunting. What types of jobs are available? How do you get your foot in the do
A collection of convenient and easy to use, at the bench protocols for protein purification and further manipulations. Some of the methods describing protein purification are from Proteins and Proteo
Size is a primary feature of living things. From egg to adult, the various organs, tissues, cells, and subcellular structures that make up an organism grow to appropriate sizes so that they effectivel
Size is a primary feature of living things. From egg to adult, the various organs, tissues, cells, and subcellular structures that make up an organism grow to appropriate sizes so that they effectivel
In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. The first edition of this book was a comprehensive source of strategic, conceptual, and tech
The gene has become a cultural icon and an increasingly rich source of imagery and ideas for visual artists. Drawing on a wide range of contemporary painting and sculpture, The Molecular Gaze: Art in
Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illu
London's Imperial Cancer Research Fund laboratories at Lincoln's Inn Fields and Clare Hall (renamed The London Research Institute in 2002) were world-famous for a century. This book, published with th
