The MYC gene is frequently activated in cancer. It encodes a transcription factor that controls gene expression programs regulating numerous aspects of cellular behavior, including cell proliferation,
Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed theenormous progress in our understanding of the nature and behavior of chromosomes during the life cy
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed theenormous progress in our understanding of the nature and behavior of chromosomes during the life cy
Cilia and flagella are protrusive structures on the surface of cells that perform a variety of functions. The beating of flagella and motile cilia, for example, can be used to propel cells or move mat
The 80th Cold Spring Harbor Symposium was held to mark the 150th anniversary of Gregor Mendel's landmark 1865 presentation of his paper "Experiments on Plant Hybridization", which laid the groundwork
Prevail Through Knowledge: A History of Cold Spring Harbor Laboratory is published to mark the Laboratory's 125th anniversary. Written by historian Jan Witkowski, Executive Director of the Laboratory'
"The skin is a continually renewing organ that acts as a protective barrier isolating us from the external environment. This book examines the cells that make up the skin and their functions, as well
Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mito
DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding
Life arose on Earth more than three billion years ago. How the first self-replicating systems emerged from prebiotic chemistry and evolved into primitive cell-like entities is an area of intense rese
Based on a popular course at Cold Spring Harbor Laboratory, this new manual assembles cutting-edge protocols, helpful hints, and lecture notes to teach researchers from a variety of disciplines the e
Grounds for Knowledge is an engaging and knowledgeable guide to CSH Laboratory's buildings both historic and new, and to the 150 species of trees that surround them. The superb color photography and d
The Yeast Genetics & Genomics course is a modern, state of the art, laboratory course designed to teach the full repertoire of genetic approaches needed to dissect complex problems in the yeas
Nineteen chapters review the process and regulation of protein synthesis as understood through recent research. Among the topics are new insights and challenges in the mechanism of eukaryotic translat
Electronic devices can now be used to analyse and modulate the electrical activity within the nervous system. This book explores how development of these devices is leading to new diagnostics and trea
Correct folding of proteins is critical for cell function, and accumulation of misfolded proteins is a feature of a number of neurodegenerative conditions. This book examines the mechanisms that ensur
Complex molecular machinery within the cells of the inner ear allow it to sense sounds of different frequencies and relay information to the brain. This volume examines the nature of this machinery, t
Next-generation sequencing technology allows rapid sequencing of a patient's DNA. This book introduces the technology and describes how it may be used in personalized medicine to diagnose diseases su
RNA (ribonucleic acid) molecules drive much of cellular action. Messenger RNA (mRNA) relays genetic information from DNA to ribosomes to direct the formation of proteins. At the same time, noncoding R
Lab Dynamics is a unique guide to the interpersonal side of scientific research and management. The book provides practical solutions to some of the toughest problems that working scientists and scien
Viruses that are transmitted via the fecal-oral route and may cause liver damage are known as enteric hepatitis viruses. These viruses, which include the hepatitis A and E viruses (HAV and HEV, respec
Translation converts the genetic code in messenger RNA molecules copied from DNA into a specific sequence of amino acids in a protein. It occurs on ribosomes in the cell cytoplasm and is one of the mo
In this provocative work, the historian Elof Carlson explores how new fields of the life sciences emerge. Some scientists describe new theories, experiments, discoveries, or the use of new technology
Ras proteins are critical molecular switches in signaling mechanisms that control cell behavior and are frequently mutated in cancer. This volume examines the functions of Ras, how its activation lead
This book features drawings by Lewis Miller of those who have played a role in the mapping of the human genome paired with short biographies written by prominent scientists.--
Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the myelin sheaths that surround nerve cells, producing a variety of neurological symptoms such as limb weakness and
Prostate cancer is the second most common type of cancer and affects millions of individuals worldwide. This volume reviews our understanding of the disease, its progression, and new therapeutic appro
Our daily routines and physiological functions-and those of virtually all living organisms-are synchronized with the Earth's rotation about its axis. These include sleep patterns, hormone secretion, b
One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various de
The ability to grow new tissue and organs is an important goal of regenerative medicine. This book discusses new research in which cells are grown on artificial scaffolds to build replacement tissue t
The adaptive immune system ensures that our bodies remember pathogens so that we can rapidly mount an immune response if they are encountered again, without succumbing to infection. This volume examin
Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes
