Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Mehar, a young bride in rural 1929 Punjab, is trying to discover the identity of her new husband. She and her sisters-in-law, married to three brothers in a single ceremony, spend their days hard at work in the family's 'china room', sequestered from contact with the men. When Mehar develops a theory as to which of them is hers, a passion is ignited that will put more than one life at risk.Spiralling around Mehar's story is that of a young man who in 1999 travels from England to the now-deserted farm, its 'china room' locked and barred.In enforced flight from the traumas of his adolescence - his experiences of addiction, racism, and estrangement from the culture of his birth - he spends a summer in painful contemplation and recovery, before finally finding the strength to return 'home'.

Join in a super-silly Christmas celebration based on an all-new LEGO(R) holiday song!The holiday season can get a little kooky--especially when LEGO(R) friends come to visit. Get ready for Christmas w

Bullshit isn't what it used to be. Now, two science professors give us the tools to dismantle misinformation and think clearly in a world of fake news and bad data. "A modern classic . . . a straight-talking survival guide to the mean streets of a dying democracy and a global pandemic."--Wired Misinformation, disinformation, and fake news abound and it's increasingly difficult to know what's true. Our media environment has become hyperpartisan. Science is conducted by press release. Startup culture elevates bullshit to high art. We are fairly well equipped to spot the sort of old-school bullshit that is based in fancy rhetoric and weasel words, but most of us don't feel qualified to challenge the avalanche of new-school bullshit presented in the language of math, science, or statistics. In Calling Bullshit, Professors Carl Bergstrom and Jevin West give us a set of powerful tools to cut through the most intimidating data. You don't need a lot of technical expertise to call out problems

A thought-provoking examination of competitive parenting, which can lead to teen suicide, eating disorders, depression, and drug use, delves into the factors that drive parents to pressure their child

Oft quoted but seldom credited,Charles Dudley Warner’s My Summer in a Garden is a classic of American garden writing and was a seminal early work in the then fledgling genre of American nature writing

Here is a superb collection of recipes from across the Indian subcontinent. Each step in preparing Indian food is explained, in a simple manner that will produce delicious results. Recipes from many r

The bold and boundlessly original debut novel from the Oscar®-winning screenwriter of Being John Malkovich, Adaptation, Eternal Sunshine of the Spotless Mind, and Synecdoche, New York.B. Rosenberger R

By the New York Times bestselling author of The Bone Clocks and Cloud Atlas | A Publishers Weekly Literary Fiction Top 10 Pick for Fall 2015Keep your eyes peeled for a small black iron door.Down the r

#1 New York Times bestselling author Tami Hoag returns with her second thriller in the Deeper than the Dead microseries, exploring the early days of forensic investigation, the characteristics of inno

The author describes his early life as a young Jew amid the Christian society surrounding him in the Deep South during the civil rights era, his recognition of his differences among the other children

Offers advice on using food processors and provides recipes for a variety of soups, salads, main dishes, and desserts that make full use of the appliance's capabilities

In her first novel since winning the Newbery Medal for When You Trap a Tiger, Tae Keller offers a gripping and emotional story about a girl who is alienated by her friends . . . for believing in aliens. Sometimes middle school can make you feel like you're totally alone in the universe...but what if we aren't alone at all? Thanks to her best friend, Reagan, Mallory Moss knows the rules of middle school. The most important one? You have to fit in to survive. But then Jennifer Chan moves in across the street, and that rule doesn't seem to apply. Jennifer doesn't care about the laws of middle school, or the laws of the universe. She believes in aliens--and she thinks she can find them.Then Jennifer goes missing. Using clues from Jennifer's journals, Mallory goes searching. But the closer she gets, the more Mallory has to confront why Jennifer might have run . . . and face the truth within herself.Tae Keller lights up the sky with this insightful story about shifting friendships, right and

A clear-eyed account of learning how to lead in a chaotic world, by General Jim Mattis--the former Secretary of Defense and one of the most formidable strategic thinkers of our time--and Bing West, a former assistant secretary of defense and combat Marine.Call Sign Chaos is the account of Jim Mattis's storied career, from wide-ranging leadership roles in three wars to ultimately commanding a quarter of a million troops across the Middle East. Along the way, Mattis recounts his foundational experiences as a leader, extracting the lessons he has learned about the nature of warfighting and peacemaking, the importance of allies, and the strategic dilemmas--and short-sighted thinking--now facing our nation. He makes it clear why America must return to a strategic footing so as not to continue winning battles but fighting inconclusive wars.Mattis divides his book into three parts: direct leadership, executive leadership, and strategic leadership. In the first part, Mattis recalls his early e

Marsha Linehan tells the story of her journey from suicidal teenager to world-renowned developer of the life-saving behavioral therapy DBT, using her own struggle to develop life skills for others. "This book is a victory on both sides of the page."--Gloria Steinem "Are you one of us?" a patient once asked Marsha Linehan, the world-renowned psychologist who developed Dialectical Behavior Therapy. "Because if you were, it would give all of us so much hope." Over the years, DBT had saved the lives of countless people fighting depression and suicidal thoughts, but Linehan had never revealed that her pioneering work was inspired by her own desperate struggles as a young woman. Only when she received this question did she finally decide to tell her story. In this remarkable and inspiring memoir, Linehan describes how, when she was eighteen years old, she began an abrupt downward spiral from popular teenager to suicidal young woman. After several miserable years in a psychiatric institute, L

Explore Hawkins with fan-favorite character Eleven in a novel based on the iconic Netflix series Stranger Things. It's summer vacation, and everyone in Hawkins has plans--everyone except Eleven. She feels trapped by her overprotective father and wants to break out and find a normal teen life like she sees in her magazines. Luckily, Eleven's not alone. Her friend Max needs to flee a troubling home life and an increasingly dangerous older brother. They decide to escape together, and in Hawkins in the summer of 1985, there is only one place to go: the all-new Starcourt Mall. Will midnight movies and an overnight party in the food court be the solution to their problems? Or will Eleven and Max discover that a little freedom can lead to a lot of trouble, and that the ghosts of the past are never far away? Filled with details from Netflix's series Stranger Things, this novel explores Hawkins--and Eleven's place in it--like never before.

A classic Dr. Seuss story about the difficulty of making up one's mind! From the beloved author of How the Grinch Stole Christmas and The Lorax--this is the perfect book to inspire children to overcome indecision and gain confidence in their choices!It's awfully awfully awfulWhen you can't make up your mind!Do you want to kick a football?Or sit there on your behind?Do you want to go out skating?Fly a kite? Or climb a tree?Do you want to eat a pizza?Take a bath? Or watch TV? Dr. Seuss adds his signature spin to the age-old dilemma of indecisiveness in his rhyming picture-book classic Hunches in Bunches. Whether readers have a "four-way hunch," a "nowhere hunch," or an "up hunch," Dr. Seuss and his unmistakable one-of-a-kind advice will ensure that they won't get "ga-fluppted" when choosing what to do! Now available in the same size as other classic Dr. Seuss books like How the Grinch Stole Christmas and The Lorax!

WELCOME TO WEST ARCHER ACADEMY. It's an elite boarding school where a group of kids are searching for the secret to their immortality. From the award-winning author of The Miscalculations of Lightning Girl comes a magically mysterious story about a group of kids who have been alive for hundreds of years. WHAT IF YOU COULD LIVE FOREVER? The secret lies with a group of kids who call themselves the Evers. They claim to have been alive for hundreds of years. They hide among the rest of the students, their immortality a complete secret...until now. IVY is driven and ambitious, with plans to keep her head down and focus on graduating early. Then she discovers the Evers and graduation doesn't seem like the most important thing anymore. ABIGAIL is Ivy's roommate; she is also an Ever. She's searching for her long-lost best friend, whom Ivy bears an uncanny resemblance to. RONAN is a laid-back cool kid who is incredibly intelligent. When he inherits his family's psychic powers, he can suddenly t

童年時期因遊戲結緣的Sadie和Sam，長大後再次相遇，攜手投身電玩創作，讓玩家能暫時遠離現實，投向數位虛擬世界的懷抱，兩人合作設計出的遊戲一舉獲得空前成功，但隨之而來的金錢與名利浪潮，是否已準備將兩人沖散？'A gem of a novel' ERIN MORGENSTERNThis is not a romance, but it is about loveTwo kids meet in a hospital gaming room in 1987. One is visiting her sister, the other is recovering from a car crash. The days and months are long there.Their love of video games becomes a shared world -- of joy, escape and fierce competition. But all too soon that time is over, fades from view.When the pair spot each other eight years later in a crowded train station, they are catapulted back to that moment. The spark is immediate, and together they get to work on what they love - making games to delight, challenge and immerse players, finding an intimacy in digital worlds that eludes them in their real lives.Their collaborations make them superstars.This is the story of the perfect worlds Sadie and Sam build, the imperfect world they live in, and of everything that comes after success: Money. Fame. Dupli

'A powerful and haunting tale of a young woman's will to live, of love flowering in defiance of tyranny. It will twine like a dark forest around your heart.' Samantha Shannon on The Wolf and the WoodsmanFrom the Sunday Times bestselling author of The Wolf and the Woodsman comes a gothic retelling of The Juniper Tree, where a young witch seeks to discover her identity and escape the domination of her abusive wizard father. Perfect for fans of Angela Carter, Catherynne M. Valente and Shirley Jackson_________________________________A gruesome curse. A city in upheaval. A monster with unquenchable appetites.As the last true witches living in a city shifting from magic to industry, Marlinchen and her two sisters are little more than tourist traps as they treat their clients with archaic remedies and beguile them with nostalgic charm.Marlinchen spends her days divining secrets in exchange for rubles and trying to placate their tyrannical, xenophobic wizard father, who keeps his daughters seq

A stirring meditation on Black performance in America from the New York Times bestselling author of Go Ahead in the Rain “Whether heralding unsung entertainers or reexamining legends, Hanif Abdurraqib weaves together gorgeous essays that reveal the resilience, heartbreak, and joy within Black performance. I read this book breathlessly.”—Brit Bennett, author of The Vanishing HalfAt the March On Washington in 1963, Josephine Baker was 57 years old, well beyond her most prolific days. But in her speech at the march, she was in a mood to consider her life, her legacy, her departure from the country she was now triumphantly returning to. "I was a devil in other countries, and I was a little devil in America, too," she told the crowd. From those few words, Hanif Abdurraqib has written a profound and lasting reflection on how black performance is inextricably woven into the fabric of American culture. Each moment in every performance he examines--whether it's the 27 seconds in "Gi

Vivid accounts of life in a Soviet prison camp by the author of Inhuman Land.Interned with thousands of Polish army officers and a handful of civilians in the Soviet prisoner-of-war camp at Starobiels

A fearless writer confronts grief and transforms it into art, in a book of transforming power and love.In this imagined dialogue between mother and child in a timeless world, Yiyun Li meets life’s dee

NEW YORK TIMES BESTSELLER • Ali Wong’s heartfelt and hilarious letters to her daughters (the two she put to work while they were still in utero) cover everything they need to know in life, like the un

A lonely young woman gets too close to her charismatic female student in a propulsive debut culminating in a dangerously debauched Midsommar's Eve--for readers of Julie Buntin's Marlena and Emily Frid

NEW YORK TIMES BESTSELLER • In this powerful and uplifting novel, a mother and her daughter-in-law bravely leave their troubled marriages and face the challenge of starting over. Leaning on each

A man named Mohammed sits in a cafe in Vienna, about to propose a deal to a Colombian. Mohammed has a strong network of agents and sympathizers throughout Europe and the Middle East, and the Colombian

A big-hearted, boundary-vaulting novel that heralds a remarkable new talent: set in 1970s New York, a story outsized in its generosity, warmth, and ambition, its deep feeling for its characters, its e

This fall, Lisbeth Salander and Mikael Blomkvist return in the highly anticipated follow-up to Stieg Larsson’s THE GIRL WHO KICKED THE HORNET’S NEST In this adrenaline-charged thriller, genius-ha

From #1 New York Times bestselling author Debbie Macomber comes the first book in a new series set in the beloved Pacific Northwest town of Cedar Cove. Also from Debbie Macomber: watch the new origi

The disturbing fate of a runaway older sister is gradually revealed in a tale told from the perspectives of the Hurst family, including a teen girl whose hallucinogen use has landed her in a mental wa

Frequently mistaken for one another in spite of very different natures, brothers Subhash and Udayan Mitra pursue respective lives in rebellion-torn 1960s Calcutta until a shattering tragedy compels Su

Internationally acclaimed crime writer Jo Nesbo’s antihero police investigator, Harry Hole, is back: in a bone-chilling thriller that will take Hole to the brink of insanity. Oslo in November. The fir

Tom Kedrick earned his stripes during the Civil War, fought Apaches, and even soldiered overseas. But in the high desert country of New Mexico, the battle-hardened Kedrick is entangled in a different

Loop me in, odd one. The words, spoken in the deep of night by a sleeping child, chill the young man watching over her. For this was a favorite phrase of Stormy Llewellyn, his lost love, and Stormy is

In July 2004, Barack Obama electrified the Democratic National Convention with an address that spoke to Americans across the political spectrum. One phrase in particular anchored itself in listeners’

In a sometimes troubling memoir, the best-selling author of Hitler's Pope describes his own teenage sojourn at Cotton College, a Catholic seminary for boys in the remote West Midlands countryside, des

In this classic sixth novel in the award-winning Myron Bolitar series, # 1 New York Times bestselling author Harlan Coben delivers a riveting, powerhouse thriller featuring one of the most fascinating

In his triumphant fictional debut, Stephen Carter combines a large-scale, riveting novel of suspense with the saga of a unique family. The Emperor of Ocean Park is set in two privileged worlds: the u