Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

It is Ireland in the early 1950s and for Eilis Lacey, as for so many young Irish girls, opportunities are scarce. So when her sister arranges for her to emigrate to New York, Eilis knows she must go,

Listen to audio presented by Literary Affairs: Pride and Prejudice.View our feature on Jane Austen.Few have failed to be charmed by the witty and independent spirit of Elizabeth Bennet. Her early det

Relax and unwind with this adorable colouring book, full of tiny furry friends!Penguin Books edition - updated with exclusive new drawings!Find comfort in the enchanting world of Cozy Friends, with 45 uplifting hand-drawn pages ready for you to colour in. In this book you’ll find familiar everyday activities, but with your brand new Cozy Friends – super cute animal characters!Cozy Friends has sweet and irresistible images for colouring fans, and also includes:45 hand-drawn pages ready for your creativityLarge, bold designs that are easy to colourConvenient 8 x 8-inch size, perfect for relaxing anywhereCrisp, high-resolution illustrations that bring each page to lifeSuitable for children.

Relax and unwind with this adorable colouring book, perfect for curling up with and getting cosy!Penguin Books edition - updated with exclusive new drawings!Step into the calm and comforting world of Girl Moments, with 45 unique illustrations to help you pause and take in the little joys – from a warm cup of tea in the morning to cosying up in bed with a book. Drift away into the soft, soothing vibes and rediscover the simple comforts that make every day a little brighter. Girl Moments has sweet and irresistible images for colouring fans, and also includes:45 hand-drawn pages ready for your creativityLarge, bold designs that are easy to colourConvenient 8 x 8-inch size, perfect for relaxing anywhereCrisp, high-resolution illustrations that bring each page to lifeSuitable for children.

Rafe Khatchadorian is back in the latest adventure in the bestselling Middle School seriesThings have quietened down for lovable troublemaker Rafe Khatchadorian, and after all the mishaps and adventur

The titles in this slipcase are: 1. Peppa's Circus 2. The Children's Fete 3. Peppa's Sandpit 4. Granny Pig's Purfume 5. Grampy Rabbit in Space 6. Mr Bull in a China Shop 隨書附有一張朗讀CD。CD有兩個音軌，每一個音軌都有6個相

On 22nd January 1996 Dave Schultz, Olympic gold medallist and wrestling's golden boy, was shot in the back by John E. du Pont at the famed Foxcatcher estate in Pennsylvania. That started a two day sie

In Trouble in Paradise, Slavoj Zizek, one of our most famous, most combative philosophers, explains how by drawing on the ideas of communism, we can find a way out of the crisis of capitalism. There i

The author found a radical solution to his need for freedom, one as ancient as the experiences of the hermits of old Russia: he decided to lock himself alone in a cabin in the middle taiga, on the sho

In June 2013, reporter and political commentator Glenn Greenwald published a series of reports in the Guardian which rocked the world. The reports revealed shocking truths about the extent to which th

Bloodlines: The Fiery Heart is the smouldering fourth book in the bestselling Bloodlines series by Richelle Mead, set in the world of Vampire Academy - NOW A MAJOR FILM. A pulse-pounding world of magi

The Book of Souls is James Oswald's second electrifying thriller in the Detective Inspector McLean series. Every year for ten years, a young woman's body was found in Edinburgh at Christmas time: naked, throat slit, body washed clean. Ten years, ten women. The final victim, Kirsty Summers, was Detective Constable Tony McLean's fiancée. But the Christmas Killer made a mistake. In a cellar under a shop, McLean found a torture chamber and put an end to the brutal killing spree. Twelve years later, and a fellow prisoner has just murdered the incarcerated Christmas Killer. But with the arrival of the festive season comes a body. A young woman: naked, washed, her throat cut. Is this a copycat killer? Was the wrong man behind bars all this time? Or is there a more sinister, frightening explanation? McLean must revisit the most disturbing case of his life and discover what he missed before the killer strikes again . . . The Book of Souls is the second in the Detective Inspector Mclean series.

The sizzling third book in the New York Times bestselling Crossfire Trilogy following Bared to You and Reflected in You!

Eva and Gideon return in Reflected in You, the second novel in the erotic romance Crossfire series by Sylvia Day, following on from the blockbuster international bestseller Bared to You. Gideon Cross

Jojo Harvey is a dead ringer for Jessica Rabbit and the most ferocious literary agent in town. A former NYPD cop, she now lives in London making million-dollar book deals while trying to make partner

Bared to You by Sylvia Day is the first in the Crossfire trilogy featuring Gideon and Eva, two wounded souls who come together in an explosion of lust and passion as intoxicating as it is devastating

《加薩危機》由知名政治評論家諾姆・喬姆斯基與以色列歷史學者伊蘭・帕佩共同撰寫，深入剖析以巴衝突的歷史脈絡與現實困局。從以色列在「鑄鉛行動」中對學校、醫院的攻擊，到使用白磷彈所引發的國際關注，本書不僅回顧事件經過，更將其置於以色列長期對巴勒斯坦政策的歷史背景中探討。內容詳實、立場清晰，是了解當前中東政治與人道危機的重要讀物，適合關心國際局勢、公義與和平議題的讀者深入閱讀與反思。Co-authored by two leading voices in the struggle to liberate Palestine, a clear-sighted and essential analysis of the political context around this region at a desperate impasseFrom the targeting of schools and hospitals, to the indiscriminate use of white phosphorus, Israel's conduct in 'Operation Cast Lead' has rattled even some of its most strident supporters. In Gaza in Crisis, Noam Chomsky and Ilan Pappé survey the fallout from that devastation, and place the massacre in Gaza in the context of Israel's long-standing war against the Palestinians. It is a rigorous, historically informed and much-needed analysis of the situation and will be welcomed by all those eager for Chomsky's and Pappé's insights into yet another political catastrophe.'Noam Chomsky is a global phenomenon . . .he may be the m

New York Times bestseller Girl in Translation is Jean Kwok’s powerful story of a Chinese immigrant family in Brooklyn and their gifted daughter trying to life with no money and no English. Kimberley

A thrilling epic about an ancient clash reignited in our time- between a hidden society and heaven's darkest creatures "There were giants in the earth in those days; and also after that, when the sons

International best-seller Marian Keyes, author of Sushi for Beginners, This Charming Man and the award-winning Anybody Out There, explores love, life and secrets in The Brightest Star in the Sky. 'Ju

Hans Fallada's Alone in Berlin begins in Berlin, 1940, and the city is filled with fear. At the house on 55 Jablonski Strasse, its various occupants try to live under Nazi rule in their different ways

★ 一個登山者改變世界的真實故事，感動全球數百萬讀者★ 從攀登K2失敗，到在喜馬拉雅山區建立數十所學校★ 跨越戰爭、貧窮與文化衝突的人道教育行動《Three Cups of Tea》記錄Greg Mortenson從登山者轉變為教育行動者的真實故事。一次在巴基斯坦山區被村民救助後，他承諾為當地孩子建立學校，並展開長達十年的努力，在巴基斯坦與阿富汗偏遠地區建立數十所學校。這本書展現教育如何帶來希望，也說明一個人的信念能帶來深遠改變。"One day in 1993, high up in the world's most inhospitable mountains, Greg Mortenson wandered lost and alone, broken in body and spirit, after a failed attempt to climb K2, the world's deadliest peak. When the people of an impoverished village in Pakistan's Karakoram Himalaya took him in and nursed him back to health, Mortenson made an impulsive promise: He would return one day and build them a school. Although he was a homeless "climbing bum" living out of his aging Buick in Berkeley, California, Mortenson sold what few possessions he had to launch one of the most remarkable humanitarian campaigns of our time." "Three Cups of Tea" traces Mortenson's decade-long odyssey to build schools, especially for girls, throughout the region that gave birth to the Taliban and sanctua

Coming in Summer 2009, the major motion picture from Universal Studios"ludicrously entertaining" (Time), Public Enemies is the story of the most spectacular crime wave in American history, the two-yea

Have fun learning first words with The Very Hungry Caterpillar in this brightly coloured chunky board book. Explore familiar themes such as At Home, At the Park, At the Zoo and At the Picnic! Every spread is a colourful, engaging scene - spot The Very Hungry Caterpillar on every page and find hidden words and friendly characters under the multiple flaps.

The first volume of Steven Runciman's classic, hugely influential trilogy on the history of the Crusades 'On a February day in the year AD 638 the Caliph Omar entered Jerusalem, riding upon a white ca

There's a new fantasy phenomenon for 2014 - The Golden Cage is the third enchanting tale in J. D. Oswald's epic fantasy series, The Ballad of Sir Benfro Queen Beulah is determined to have her war, des

There's a new fantasy phenomenon for 2014 - The Rose Cord is the second enchanting tale in J.D. Oswald's epic fantasy series, The Ballad of Sir Benfro. His mother dead at the hands of Inquisitor Melyn

The multi-million copy global bestselling Crossfire series from Sylvia Day continues with Captivated by You. Gideon calls me his angel, but he's the miracle in my life. My gorgeous, wounded warrior, s

How well do you really know those you love?When a teenage girl goes missing her mother discovers she doesn't know her daughter as well as she thought in Jane Shemilt's haunting debut novel, Daught

Charlie Mortdecai from adventure to misadventure via Jersey and Moscow to a final showdown in a Buckinghamshire bungalow of unparalleled hideousness.

Art dealer and assassin Charlie Mortdecai has fled to Jersey, taking his thug Jock along with him, just in case. For now though he's had enough of secret government agencies, of stolen paintings, of t

On Guadalcanal in the south Pacific, the soldiers of C Company are about to enter the war. The men know they face their baptism of fire. But none know if they will be one of 'the lucky ones' to make i

What makes us human?How did we develop language, thought and culture?Why do we need them? The past 12,000 years represent the only time in the sweep of human history when there has been only one human

When a witch doctor appears on the Marquis de Casalduero's doorstep prophesising a plague of rabies in the Colombian seaport, he dismisses her claims - until he hears that his young daughter, Sierva M

Half Bad by Sally Green is a breathtaking debut novel about one boy's struggle for survival in a hidden society of witches.Puffin's biggest YA debut of 2014 - the hard-hitting realism of The Hunger Ga

A young man is found hanging by a rope in his Edinburgh home. A simple, sad suicide, yet Detective Inspector Tony McLean is puzzled by the curious suicide note. A second hanged man and another strange

'Can I explain why I wanted to jump off the top of a tower block?'For disgraced TV presenter Martin Sharp the answer's pretty simple: he has, in his own words, 'pissed his life away'. And on New Year'

'It would not be fair to record the adventures of Father Brown, without admitting that he was once involved in a grave scandal. There still are persons, perhaps even of his own community, who would sa

'That sort of thing may be very well for crypts and cloisters and all sorts of moonshiny places. But ghosts can't get through a closed door in an American hotel.'Father Brown, the shrewd and modest cl

Scandalous Liaisons by Sylvia Day is a trio of classic erotic romances, linking the tales of wicked rakes and the flawless aristocratic young women whose hearts - and bodies - they melt. In Stolen Pl