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Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

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Statistical Methods For Dose-Finding Experiments
90 折
出版日:2006/04/13 作者:Chevret  出版社:John Wiley & Sons Inc  裝訂:精裝
Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. Used appro
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Exposure-response Modeling ― Methods and Practical Implementation
90 折
出版日:2015/07/29 作者:Jixian Wang  出版社:Taylor & Francis  裝訂:精裝
Discover the Latest Statistical Approaches for Modeling Exposure-Response RelationshipsWritten by an applied statistician with extensive practical experience in drug development,Exposure-Response Mode
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Batch Effects And Noise In Microarray Experiments - Sources And Solutions
90 折
出版日:2009/10/28 作者:Scherer  出版社:John Wiley & Sons Inc  裝訂:精裝
Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whi
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Integrating Omics Data
90 折
出版日:2015/05/31 作者:George Tseng  出版社:Cambridge Univ Pr  裝訂:精裝
In most modern biomedical research projects, application of high-throughput genomic, proteomic, and transcriptomic experiments has gradually become an inevitable component. Popular technologies include microarray, next generation sequencing, mass spectrometry and proteomics assays. As the technologies have become mature and the price affordable, omics data are rapidly generated, and the problem of information integration and modeling of multi-lab and/or multi-omics data is becoming a growing one in the bioinformatics field. This book provides comprehensive coverage of these topics and will have a long-lasting impact on this evolving subject. Each chapter, written by a leader in the field, introduces state-of-the-art methods to handle information integration, experimental data, and database problems of omics data.
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Regression With Social Data: Modeling Continuous And Limited Response Variables
90 折
出版日:2004/08/27 作者:Demaris  出版社:John Wiley & Sons Inc  裝訂:精裝
An accessible introduction to the use of regression analysis in the social sciencesRegression with Social Data: Modeling Continuous and Limited Response Variables represents the most complete and full
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Handbook for Applied Modeling ─ Non-Gaussian and Correlated Data
90 折
出版日:2017/07/31 作者:Jamie D. Riggs  出版社:Cambridge Univ Pr  裝訂:精裝
Designed for the applied practitioner, this book is a compact, entry-level guide to modeling and analyzing non-Gaussian and correlated data. Many practitioners work with data that fail the assumptions of the common linear regression models, necessitating more advanced modeling techniques. This Handbook presents clearly explained modeling options for such situations, along with extensive example data analyses. The book explains core models such as logistic regression, count regression, longitudinal regression, survival analysis, and structural equation modelling without relying on mathematical derivations. All data analyses are performed on real and publicly available data sets, which are revisited multiple times to show differing results using various modeling options. Common pitfalls, data issues, and interpretation of model results are also addressed. Programs in both R and SAS are made available for all results presented in the text so that readers can emulate and adapt analyses for
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Analyzing Financial Data and Implementing Financial Models Using R
90 折
出版日:2015/04/14 作者:Clifford S. Ang  出版社:Springer Verlag  裝訂:精裝
This book is a comprehensive introduction to financial modeling that teaches advanced undergraduate and graduate students in finance and economics how to use R to analyze financial data and implement
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Modeling Atmospheric And Oceanic Fluid Flow: Insights From Laboratory Experiments And Numerical Simulations
90 折
出版日:2014/11/14 作者:Von Larcher  出版社:John Wiley & Sons Inc  裝訂:精裝
Modeling Atmospheric and Oceanic Flows: Insights from Laboratory Experiments and Numerical Simulations provides a broad overview of recent progress in using laboratory experiments and numerical simula
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Modeling Count Data
90 折
出版日:2014/06/30 作者:Joseph M. Hilbe  出版社:Cambridge Univ Pr  裝訂:精裝
This entry-level text offers clear and concise guidelines on how to select, construct, interpret, and evaluate count data. Written for researchers with little or no background in advanced statistics, the book presents treatments of all major models using numerous tables, insets, and detailed modeling suggestions. It begins by demonstrating the fundamentals of modeling count data, including a thorough presentation of the Poisson model. It then works up to an analysis of the problem of overdispersion and of the negative binomial model, and finally to the many variations that can be made to the base count models. Examples in Stata, R, and SAS code enable readers to adapt models for their own purposes, making the text an ideal resource for researchers working in health, ecology, econometrics, transportation, and other fields.
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Data-Driven Modeling ― Using Matlab in Water Resources and Environmental Engineering
90 折
出版日:2013/11/30 作者:Shahab Araghinejad  出版社:Springer Verlag  裝訂:精裝
“Data-Driven Modeling: Using MATLABR in Water Resources and Environmental Engineering” provides a systematic account of major concepts and methodologies for data-driven models and presents a unified f
優惠價: 9 3375
無庫存
出版日:2013/04/03 作者:Tshilidzi Marwala  出版社:Springer-Verlag New York Inc  裝訂:精裝
Economic Modeling Using Artificial Intelligence Methods examines the application of artificial intelligence methods to model economic data. Traditionally, economic modeling has been modeled in the lin
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Spatial Data Analysis in Ecology and Agriculture Using R
90 折
出版日:2012/03/09 作者:Richard E. Plant  出版社:CRC Press UK  裝訂:精裝
Assuming no prior knowledge of R, Spatial Data Analysis in Ecology and Agriculture Using R provides practical instruction on the use of the R programming language to analyze spatial data arising from
優惠價: 9 3392
無庫存
Early Drug Development: Strategies And Routes To First-In-Human Trials
90 折
出版日:2010/06/24 作者:Cayen  出版社:John Wiley & Sons Inc  裝訂:精裝
The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials gu
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出版日:2010/03/30 作者:Sridar V. Chittur (EDT)  出版社:Springer Verlag  裝訂:精裝
While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital ap
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Uncertainty Modeling In Dose Response: Bench Testing Environmental Toxicity
90 折
出版日:2009/06/23 作者:Cooke  出版社:John Wiley & Sons Inc  裝訂:精裝
A valuable guide to understanding the problem of quantifying uncertainty in dose response relations for toxic substances In today's scientific research, there exists the need to address the topic of
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出版日:2006/05/01 作者:Edited by Rajesh Krishna  出版社:CRC Press UK  裝訂:精裝
This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and
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Data Science Using Python And R
90 折
出版日:2019/03/22 作者:Larose  出版社:John Wiley & Sons Inc  裝訂:精裝
Learn data science by doing data science! Data Science Using Python and R will get you plugged into the world’s two most widespread open-source platforms for data science: Python and R.Data scien
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Panel Data Econometrics With R
90 折
出版日:2018/08/29 作者:Croissant  出版社:John Wiley & Sons Inc  裝訂:精裝
Panel Data Econometrics with R provides a tutorial for using R in the field of panel data econometrics. Illustrated throughout with examples in econometrics, political science, agriculture and epidemi
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A Data Scientist'S Guide To Acquiring, Cleaning And Managing Data In R
滿額折
出版日:2017/10/16 作者:Buttrey  出版社:John Wiley & Sons Inc  裝訂:精裝
The only how-to guide offering a unified, systemic approach to acquiring, cleaning, and managing data in R Every experienced practitioner knows that preparing data for modeling is a painstaking, time-
優惠價: 9 3179
無庫存
出版日:2017/01/06 作者:Rui Sarmento; Vera Costa  出版社:Information Science Reference  裝訂:精裝
For readers who may not be statisticians or data analysts, Sarmento and Costa explain how to analyze data using the Python and R languages. They have particularly in mind, students and researchers
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出版日:2016/04/06 作者:Pietro Hiram Guzzi (EDT)  出版社:Humana Pr Inc  裝訂:精裝
This volume covers a large area, from the description of methodologies for data analysis to the real application. Chapters focus on methodologies for preprocessing of microarray data, a survey of miRN
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Structural Equation Modeling: Applications Using Mplus ─ Methods and Applications
90 折
出版日:2012/09/14 作者:WANG  出版社:JOHN WILEY & SONS;LTD  裝訂:精裝
A reference guide for applications of SEM using MplusStructural Equation Modeling: Applications Using Mplus is intended as both a teaching resource and a reference guide. Written in non-mathematical terms, this book focuses on the conceptual and practical aspects of Structural Equation Modeling (SEM). Basic concepts and examples of various SEM models are demonstrated along with recently developed advanced methods, such as mixture modeling and model-based power analysis and sample size estimate for SEM. The statistical modeling program, Mplus, is also featured and provides researchers with a flexible tool to analyze their data with an easy-to-use interface and graphical displays of data and analysis results.Key features:Presents a useful reference guide for applications of SEM whilst systematically demonstrating various advanced SEM models, such as multi-group and mixture models using Mplus.Discusses and demonstrates various SEM models using both cross-sectional and longitudinal data wi
出版日:2011/03/07 作者:Ying Kuen Cheung  出版社:Chapman & Hall  裝訂:精裝
As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, t
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出版日:2011/03/04 作者:Yizeng Liang; Qing-song Xu  出版社:CRC Press UK  裝訂:精裝
Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While
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Pharmaceutical Data Mining: Approaches And Applications For Drug Discovery
90 折
出版日:2009/11/23 作者:Balakin  出版社:John Wiley & Sons Inc  裝訂:精裝
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and ap
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出版日:2007/05/03 作者:Michael J. Korenberg  出版社:Humana Pr Inc  裝訂:精裝
In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-dep
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出版日:2005/12/30 作者:Zongmin Ma (EDT)  出版社:Igi Global  裝訂:精裝
Collecting and presenting the latest research and development results from the leading researchers in the field of industrial database modeling, Database Modeling for Industrial Data Management: Emerg
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出版日:2024/11/21 作者:Robert H. Shumway  出版社:Springer Nature  裝訂:精裝
This 5th edition of this popular graduate textbook, presents a balanced and comprehensive treatment of both time and frequency domain methods with accompanying theory. It includes numerous examples using nontrivial data illustrate solutions to problems such as discovering natural and anthropogenic climate change, evaluating pain perception experiments using functional magnetic resonance imaging, and monitoring a nuclear test ban treaty. The R package 'astsa' has had major updates and the text will reflect those updates. In general, the graphics have been improved. New topics include random number generation, modeling and fitting predator-prey interactions, more emphasis on structural models, testing for linearity, discussion of EM algorithm is more extensive, Bayesian analysis of state space models and MCMC is more extensive (including new scripts in astsa), particle methods are introduced, stochastic volatility coverage is expanded, changepoint detection is introduced (new topic).The
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A Guide to Outcome Modeling in Radiotherapy and Oncology ― Listening to the Data
90 折
出版日:2018/03/06 作者:Issam El Naqa (EDT)  出版社:CRC Pr I Llc  裝訂:精裝
This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to ai
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Data Mining For Business Analytics: Concepts, Techniques, And Applications In R
90 折
出版日:2017/08/28 作者:Shmueli  出版社:John Wiley & Sons Inc  裝訂:精裝
Data Mining for Business Analytics: Concepts, Techniques, and Applications in R presents an applied approach to data mining concepts and methods, using R software for illustrationReaders will learn ho
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出版日:2017/01/31 作者:Raj K. Keservani (EDT); Anil K. Sharma (EDT); Rajesh K. Kesharwani (EDT)  出版社:Apple Academic Pr Inc  裝訂:精裝
Drug Delivery Approaches and Nanosystems, Volume 1: Novel Drug Carriers presents a full picture of the state-of-the-art research and development in drug delivery systems using nanotechnology and its a
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Microarray Image and Data Analysis ― Theory and Practice
90 折
出版日:2014/03/19 作者:Luis Rueda (EDT)  出版社:Taylor & Francis  裝訂:精裝
Computer scientists and electrical engineers present an advanced graduate textbook on the main methods, tools, and techniques for microarray image and data analysis. The topics include gridding method
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Mass Spectrometry For Drug Discovery And Drug Development
90 折
出版日:2013/01/18 作者:Korfmacher  出版社:John Wiley & Sons Inc  裝訂:精裝
This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribu
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出版日:2012/12/11 作者:Yangchang Zhao  出版社:Academic Pr  裝訂:精裝
This book introduces using R for data mining. Data mining techniques are widely used in government agencies, banks, insurance, retail, telecom, medicine and research. Recently, there is an increasing
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Statistics and Data Analysis for Microarrays Using R and Bioconductor
90 折
出版日:2011/06/26 作者:Sorin Draghici  出版社:Chapman & Hall  裝訂:精裝
Richly illustrated in color, Statistics and Data Analysis for Microarrays Using R and Bioconductor, Second Edition provides a clear and rigorous description of powerful analysis techniques and algorit
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出版日:2009/07/19 作者:Jonathan R. Pollack (EDT)  出版社:Humana Pr Inc  裝訂:精裝
In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed towa
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出版日:2009/02/28 作者:Hrishikesh D. Vinod  出版社:World Scientific Pub Co Inc  裝訂:精裝
Vinod (Fordham U.) explains modeling nonstationary equilibiria using econometrics with numerical estimation work involving computer software involving R, an object-oriented Unix type language. He uses
出版日:2008/07/14 作者:Robert Gentleman  出版社:CRC Press UK  裝訂:精裝
Due to its data handling and modeling capabilities as well as its flexibility, R is becoming the most widely used software in bioinformatics. R Programming for Bioinformatics explores the programming
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Analysis Of Microarray Data - A Network-Based Approach
90 折
出版日:2008/02/13 作者:Emmert-Streib  出版社:John Wiley & Sons Inc  裝訂:精裝
This book is the first to focus on the application of mathematical networks for analyzing microarray data. This method goes well beyond the standard clustering methods traditionally used. From the co
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出版日:2018/10/20 作者:Yinglin Xia; Jun Sun; Ding-geng Chen  出版社:Springer-Nature New York Inc  裝訂:精裝
This unique book addresses the statistical modelling and analysis of microbiome data using cutting-edge R software. It includes real-world data from the authors’ research and from the public domain, a
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