Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A first novelty book telling the story of the Nativity, with push, pull and slide mechanisms.Busy Nativity introduces young children to the wonderful story of the First Christmas. Push, pull and turn the tabs to join Mary and Joseph on their long journey to Bethlehem, marvel as a host of angels appear and see beautiful baby Jesus in his crib.The perfect gift for toddlers with inquisitive fingers and minds, they will love playing with the easy-to-handle mechanisms in this bright and colourful board book with gentle rhyming text and magical illustrations by Emily Bolam.Listen along to an audio recording of this story by scanning the QR code on the back cover.Keep little ones busy with more festive favourites, like Busy Christmas and Can You Find Santa?.

Fingers become wiggly ghost arms in this interactive rhyming story.Little children and their grown-ups can stick their fingers through the holes to become the arms of two friendly but easily scared little ghosts who go trick or treating on Halloween night. There are surprises along the way as they float through the spooky forest towards a creepy little house which is surrounded by pumpkins, broomsticks, bats and cats...A gentle and engaging introduction to Halloween for little children.Rhyming text is fun to read out loud.Helps children develop fine motor skills as they interact with the die-cut pages.

From crust to core, dig down and uncover the amazing things deep inside the Earth.This book takes you on a fascinating journey deep inside the Earth. From the rocky, moving plates that make up the surface, to the core hotter than the Sun, lift the flaps to discover what explodes out of volcanoes, how nearly everything we use each day comes from under the ground, how digging down can take you back in time, and even where the water we drink comes from.

Join Stick Man on a flip-the-flap adventure! Lift the colourful, chunky card flaps in this fun board book, perfect for small hands. With a gentle opposites theme, this board book will also help increase hand-eye co-ordination, develop speech and aid learning through repetition. Story based on the bestselling book Stick Man by Julia Donaldson and Axel Scheffler, creators of The Gruffalo, and Zog Stick Man is also a fabulous BBC TV production with superstars Martin Freeman and Hugh Bonneville Learn about opposites with fun, sturdy & interactive flaps Look out forJonty Gentoo, Julia Donaldson and Axel Scheffler's latest picture book

You'd better not tickle the dragon, because it might just roar if you do... but that soft patch is ever so tempting! This magical novelty book combines touchy-feely patches with sounds to create an irresistible treat for babies and toddlers. As well as the dragon, there's a troll, a sea monster and a griffon to be tickled, before they all join in with a foot-stomping musical finale guaranteed to get everyone dancing.

Selected as one of Oprah’s Favorite Things 2023 As Oprah says on OprahDaily.com – 'Created for kids, these little books pair famous artworks (Gauguin! Kerry James Marshall!) with read-aloud text ("Love is... soft snuggles... and tender nuzzles").So special – adults will want them, too.' This keepsake children’s book celebrates adventure in a new and accessible way: through art Featuring a bright stylish cover and sturdy colorful pages, My Art Book of Adventure pairs 35 famous artworks with joyful read-aloud text, illustrating the many feelings that come with big milestones. A beautiful gift for babies, toddlers, and young children, as well as new and expecting parents, My Art Book of Adventure presents vibrant paintings, drawings, and sculptures by a diverse array of artists – from Edward Hopper and Henri Matisse to Amy Sherald and Yinka Shonibare. With its elegant design and heartwarming descriptions, My Art Book of Adventure will be treasured by little ones and grown-ups alike. Part

Lift the felt flaps to find the magical friends in this chunky board book - with a surprise mirror ending!Who is hiding behind each flap?Play peekaboo with your baby and say hello to some magical friends with this colourful felt flaps book. With bright and playful characters to spot behind each soft felt flap, and a surprise mirror finale, this chunky board book is the perfect first book to share together with your baby. From tummy time to bath time, the bestselling Baby Touch series contains the perfect first books to support key milestones.Illustrated by Lemon Ribbon Studio

Mix-and-match new farm animals by spinning the wheel! With five touch-and-feel options to choose from, these books are packed full of fun and giggles for the youngest child.Which farm animal is your favourite?Children will love spinning the wheel to create their very own farm friends! This chunky board book features a built-in wheel containing different touch-and-feel panels for little hands to explore - perfect for developing hand-eye coordination. With five touch-and-feel options to mix-and-match, this book will give hours of fun to any little one!Also available: Don't Mix Up My Dinosaur, Don't Mix Up My Puppy, Don't Mix Up My Shark

Move the sliders back and forth to hear the different vehicles zooming along in this unique and exciting sound book. When you move a slider one way you'll see and hear one vehicle... and when you move it back the other way you'll see and hear another one.There are planes, trains, cars, motorbikes and buses to discover, all driven by Ailie Busby's charming animal characters.

Christmas is one of the most special times of the year for the young narrator and her brother—and it’s even more special when they spend it with Nana and Grandpa! From playing with the train under the tree to baking delicious Christmas treats, Christmas with Nana and Grandpa is magical.Christmas is one of the most special times of the year for the young narrator and her brother—and it’s even more special when they spend it with Nana and Grandpa! The children help to shovel the snow on the sidewalk in front of Nana and Grandpa’s house, where they admire the colorful Christmas lights on the house and the icicles on the roof’s edges. They spend time making a snowman, and then when they get too cold, it’s time to go inside and sit by the fireplace drinking hot chocolate. Grandpa shows the children his train that runs around the Christmas tree, and then everyone sits down to enjoy a delicious Christmas feast. The children help Nana make special Christmas cookies, and they leave out a few fo

Bizzy Bear 每天的幼兒園生活充滿節奏與驚喜。《Nursery Time 上學去》有五種推拉機關，參與刷牙、上課、遊戲等熟悉日常，活潑的押韻句子和插畫細節引導孩子觀察、建立生活節奏。Robust, busy board books to entertain babies and toddlersFive easy-to-use sliders, a rhyming story and lots to spot and say in this series of bright, interactive board books for toddlers!This story needs YOU! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life! The high level of interaction builds confidence and engagement with books, which is a key stepping-stone to reading for toddlers.Illustrated by multi-award-winning Benji Davies, illustrator of The Storm Whale, and Grandad’s IslandCollect the whole series; other title available include: Bizzy Bear: Breakdown Truck, Bizzy Bear: Fire Rescue, Bizzy Bear: Racing Driver and lots, lots more!

Easy-to-use peekaboo sliders, a funny rhyming text, and surprise mirror ending combine in this interactive board book packed full of Halloween fun!Ingela P. Arrhenius’s unmistakable, enchanting artwork combined with an ingenious slider mechanism on every page make this a totally irresistible board book for toddlers. Young children will be captivated by the peekaboo concept as they look for Halloween-themed items. With something to push, pull, or turn on every spread, they won’t be able to put it down!

Spend a day at school with The Very Hungry Caterpillar!It's a busy day at school with The Very Hungry Caterpillar! From greeting the teacher to reading a book, get ready to celebrate learning in this tabbed board book with easy-to-flip tabs, easy-to-read text, and easy-to-love Eric Carle art.

When babies and toddlers touch the soft patches in this irresistible novelty book, the sea creatures come to life with hilarious and charming sounds. As well as tickling the shark, they can also tickle a dolphin, a sea lion and a seagull, before all the animals gather at the end for a musical finale guaranteed to get everyone dancing!

Nibbles the book monster is back in a brand new board book full of first shapes!There are circles, squares and stars to spot. And maybe one final, extra-special shape from him to you . . . A fun, rhyming, first introduction to SHAPES with Nibbles’ book-munching twist. Babies and toddlers will love peeping through die-cuts and lifting flaps as they follow Nibbles on his exciting, shape-filled journey. Nibbles Shapes is perfect for fans of Shapes by Xavier Deneux, Shapes with Little Fish by Lucy Cousins and Circles by Yusuke Yonezu.

Press-out the pieces and explore the farm with Let's Learn & Play! On the Farm from Priddy Books. This fantastic new novelty format is aimed at children aged three and over. Each of the illustrated pages is full of things for children to spot and look for as they learn about farm life from feeding the animals to shearing sheep, milking the cows and more. Packaged in a sturdy case with a magnetic fastening, there is a board book with die-cut spaces to fit in over 20 play pieces to complete the busy scenes. There are prompts on the page, as well as word labels to help children work out where to put the pieces which is a great way of encouraging hand-eye coordination, fine motor skills and problem solving. Each spread also includes simple fun facts about farms to inspire learning with different farm processes to find out about and encourage further discovery. This is a great gift as the pieces can be stored back in the clamshell and taken out and about. Perfect for entertaining on the

9781839948718 Pip and Posy, Where Are You? In the Garden (A Felt Flaps Book)9781839948343 Pip and Posy, Where Are You? At the Seaside (A Felt Flaps Book)A brand-new felt flap series, based on the bestselling picture books from Axel Scheffler and Camilla Reid.With five colourful felt flaps and rich artwork from Axel Scheffler, toddlers will love joining in a game of hide-and-seek with Pip and Posy.These robust little books will be loved by young families everywhere!

Have you ever met a snappy croc? Happy-snappy Little Croc loves to "SNAP, SNAP, SNAP!"Make story time fun with this "read-and-play" book that combines a laugh-out-loud story with a soft-to-touch hand puppet all in one book! Children will be captivated as they read the funny, rhyming story about an excitable crocodile and act out the story with the plush crocodile puppet mouth to make Little Croc go "SNAP, SNAP, SNAP" on every page.The soft, plush hand puppet mouth fits both big and little hands for read-aloud together time, and for peace of mind, the puppet is securely attached to the back of the book. Simply place your hand inside the puppet and move your fingers and thumb to act out the story and bring Little Croc to life with a "SNAP, SNAP, SNAP!"

本系列為暢銷繪本角色 Pip and Posy 所推出的全新互動操作書，由插畫名家 Axel Scheffler（《The Gruffalo》繪者）與作家 Camilla Reid 攜手打造。每本書設有五個色彩繽紛的絨布翻頁，適合幼兒小手操作，跟著 Pip 和 Posy 一起玩躲貓貓、找朋友！插畫溫馨，角色生動，場景細節豐富，是啟發觀察力與感官發展的啟蒙讀物。書本設計耐翻耐撕，圓角不傷手，特別適合嬰幼兒第一階段的「玩中學」閱讀體驗。A brand-new felt flap series, based on the bestselling picture books from Axel Scheffler and Camilla Reid.With five colourful felt flaps and rich artwork from Axel Scheffler, toddlers will love joining in a game of hide-and-seek with Pip and Posy.These robust little books will be loved by young families everywhere!看開箱影片https://youtu.be/6UkghaO4KtA?si=3fE_RLE2P_7F0YuX

這是Axel Scheffler與Camilla Reid聯手推出的全新布翻書系列，主角是深受歡迎的Pip與Posy。書中設計了五個彩色毛氈翻頁，讓孩子在遊戲中找找看角色藏在哪裡。插畫風格溫暖細緻，搭配硬頁書設計，非常適合嬰幼兒翻閱與親子共讀，是一本兼具遊戲感與美感的幼兒入門讀物。A brand-new felt flap series, based on the bestselling picture books from Axel Scheffler and Camilla Reid.With five colourful felt flaps and rich artwork from Axel Scheffler, toddlers will love joining in a game of hide-and-seek with Pip and Posy.These robust little books will be loved by young families everywhere!

Lift the lily pads and peep under the water to discover what's in a pond. From tadpoles hatching and turning into frogs, to diving beetles and even dragonfly larvae transforming into adults, this book has so much information for curious young children. Find out which fish has a nest for his babies, meet a sleepy newt and peep under a swan's wing to see her fluffy cygnets hitching a ride on her back.

You'd better not open the flaps, because the animals might jump out! Children will love stepping into the mischievous world of this unique and hilarious pop-up book. Full of surprises that are guaranteed to cause giggles, and wittily illustrated by the brilliant Susan Batori, the book culminates in a spectacular pop-up with all the different animals springing out together.

A new title in the hit novelty series with multiple sliders and a host of safari animals!Easy-to-use peekaboo sliders, a funny rhyming text and surprise mirror ending combine in this stylish and interactive board book for babies and toddlers!With a total of 10 smooth mechanisms to push, pull or turn on every spread this beautiful book is packed full of fun!From Camilla Reid and Ingela P Arrhenius, the award-winning team behind the bestselling Felt Flaps Where's Mr? series. Connecting with faces and playing peekaboo is one of the first games that babies play. It's why the very youngest of children will love this cute safari-themed book - and want to read it again and again.Also available: Peekaboo Cow, Peekaboo Apple, Peekaboo Bear, Peekaboo Sun, Peekaboo Love, Peekaboo House, Peekaboo Moon, Peekaboo Chick and Peekaboo Baby

小手準備好，一起幫Bizzy Bear完成任務吧！這系列操作書有五個滑軌機關，拉拉門、推推窗、轉轉齒輪，每一頁都像在玩遊戲。押韻小故事唸起來朗朗上口，圖畫中還藏著好多可以一起找的東西，邊看邊說超有趣！Benji Davies溫暖又熱鬧的畫風，讓每本書都像開了一場小小歷險，陪小小孩從遊戲中愛上閱讀。Five easy-to-use sliders, a rhyming story and lots to spot and say in this series of bright, interactive board books for toddlers!An engaging little story with loads of details to spot and chat about.This story needs YOU! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life! The high level of interaction builds confidence and engagement with books, which is a key stepping-stone to reading for toddlers.Illustrated by multi-award-winning Benji Davies, illustrator of The Storm Whale, and Grandad’s IslandCollect the whole series; other title available include: Bizzy Bear: Vet’s Clinic, Bizzy Bear: Fire Rescue, Bizzy Bear: Breakdown Truck and lots, lots more!

It's normal and OK to feel sad at times. It happens to everyone, for all sorts of different reasons. We might just show it in different ways. This book uses thoughtful, engaging illustrations and gentle, friendly text to help children recognise sadness, understand why they might feel that way, find ways of coping and ways to feel happy again. Drawing on expert input from child clinical psychologist Dr Sasha Lillie Lyons, this book provides children and their grown-ups with a perfect tool to help them discuss their feelings and emotions.

A fascinating introduction to your amazing body and how it works.Whether it's walking, talking, breathing, growing, eating or excreting, your body has a LOT going on. But how does it do it? What's really going on in there? Lift the flaps to find out!

A brand-new novelty series all about things that go!All aboard the baby train, We're going on a ride today. All aboard the baby trainThe whistle PEEPS - we're on our way!Climb aboard the train in this brand-new novelty series, perfect for babies and pre-schoolers. With tabs to slide and wheels to spin, little ones will love to make the train move on every page.Seb Braun (illustrator of Spinderella by Julia Donaldson, the Daddy Grizzle books by Mark Sperring and author-illustrator of Raj and the Best Day) creates friendly, action-packed scenes, full of detail and warmth. Bursting with adorable animal characters on a special day trip, this bright and busy book will provide hours of entertainment. Also in the series: Baby on Board: Car (2023), Tractor (2024), Aeroplane (2024)

You can do it too with Ladybird's It's Time to...!This interactive novelty board book is filled with sliders and flaps to help little ones mimic the adult behaviours they see every day. In It's Time to... Bake It! the moving sliders and transformative flaps on every page allow toddlers to perform the tasks in the simple text - they can break the eggs, mix the batter and even decorate the cake!The It's Time to...series:Boosts motor skillsEncourages imaginative playRecommended for children aged 3+Also available:It's Time to... Fix It!It's Time to... Clean Up!It's Time to...Grow It!

Little readers will love playing hide-and-seek in the jungle with Jazzy the lemur and Mama JoJo! Full of vivid colours and exotic animals, with liftable flaps and die-cut windows to explore on every page! Now available as a board book for the first time.

The Earth BookTake a closer look inside Earth with this incredible board book about our planet, with see-through acetate pages. Have you ever thought about how amazing our world is? What happens deep under the Earth's surface? How do volcanoes form? And how does our planet stay a healthy place for us to live? Children will love discovering the answers with amazing see-through pages and clear, friendly text. With labelled acetate diagrams - from outer space to super soil - alongside human and animal life too, this is a fantastic first look at our world for curious children everywhere.From weather systems to the water cycle, The Earth Book is an exciting way to explore all the amazing things our planet does. Other books in the series: The Body Book and The Tree BookThe Tree Book Take a closer look through the seasons in this incredible board book about trees, with see-through acetate pages. Have you ever thought about all the amazing things that trees can do? How do they grow and why do

Take a closer look inside Earth with this incredible board book about our planet, with see-through acetate pages. Have you ever thought about how amazing our world is? What happens deep under the Earth's surface? How do volcanoes form? And how does our planet stay a healthy place for us to live? Children will love discovering the answers with amazing see-through pages and clear, friendly text. With labelled acetate diagrams - from outer space to super soil - alongside human and animal life too, this is a fantastic first look at our world for curious children everywhere.From weather systems to the water cycle, The Earth Book is an exciting way to explore all the amazing things our planet does. Other books in the series: The Body Book and The Tree Book

An adorable sing-along board book, with five robust board sliders that are easy for little hands to use. Colourful frogs and a cheerful nursery song that is full of repetition will help children begin to learn their numbers and count down from five to one in a fun and interactive way.Each board book includes a free instrumental and vocal version of the nursery song – simply click on the QR code for little ones to listen and sing along!With bright illustrations, this book makes the perfect gift this Easter and beyond. Look out for other titles in this bestselling series from Nosy Crow.

Peep! Peep! All aboard with Thomas & Friends in this All Engines Go magnetic adventure! All Engines Go! Toddlers can take a journey across the Island of Sodor and meet all the trains in this fun, magnetic book with 5 great scenes. Start the day at the Engine Sheds, visit the Farm and race down Lookout Mountain. Then create adventures of your own with the magnetic characters of Thomas, Percy, Kana, Nia, Diesel, Bruno, Sandy and Carly.Each of the 8 engines is a magnetic play piece that can be used again and again. The illustration on the front cover shows the magnets that are stored inside the book. This removes the need for a plastic holder on the front cover.There are hours of fun to be had and this is the perfect way to encourage children aged 3 and up to use their imagination and build a life-long love of books. Thomas has been teaching children lessons about life and friendship for over 75 years. He ranks alongside other beloved character such as Paddington Bear, Winnie-the-Pooh

A first book about the royal family in London, with push, pull and slide mechanisms, published for the King's Coronation and a perfect gift for toddlers.Get to know the Busy Royal Family and meet the new King!Push, pull and slide the tabs to help the King choose his outfit, enjoy a day at the races and go on a fun carriage ride. What better way to celebrate the coronation?Marion Billet's illustrations bring this adorable book, part of her popular London range, to life. Plus a fun rhyming story and lots of things to spot makes this board book a perfect present for toddlers who like to play as they read.Tiny tourists can also celebrate the coronation with The King's Coronation, The King's Coronation Sticker Book and King Charles III's Colourful Coronation!

Madame Gazelle has set up a garden at playgroup and the children love it!Everyone is having a great time growing their favourite plants and vegetables, but who will grow the biggest?Join Peppa and friends as they discover the joys of gardening in this cute little story!

A brand new title in the Pip and Posy felt flap series for babies and toddlers. This bright, cheerful book with soft felt flaps and charming illustrations is the perfect gift for a little one celebrating a special birthday. Based on the bestselling picture books illustrated by Axel Scheffler, each spread includes rich artwork and a soft felt flap that is sturdy enough to be pulled open again (and again) to find what's hiding underneath.Pip and Posy are playing hide-and-seek at the party, but Posy can't find Pip anywhere. Can you help her find her friend?This sturdy board book is the perfect birthday gift for little hands that will love exploring (and tugging on the soft felt flaps!) while they look for Pip and Posy on every page. Other titles in the series include: In the Garden, At the Seaside, At Christmas and At the Park.

By award-winning Children's Laureate Joseph Coelho, a chunky board book special addition to the Luna Loves... series. Today is all about books, and Luna has the whole day planned...Dress up as her favourite book character: a unicorn! Meet an author and an illustrator for world book day. Buy a new book. But - disaster! - Luna the Unicorn's costume has ripped! Can Dad come to the rescue with some special book magic?A special addition to the Luna Loves...series celebrates the magic of books to bring families and friends together - and sometimes save the day!Other books in the Luna Loves... series:Luna Loves Library DayLuna Loves ArtLuna Loves DanceLuna Loves ChristmasLuna Loves Gardening

9784440450076 Usborne Lift-the-Flap First Questions and Answers系列 (共20本)包含以下書目9781474991513 What Is a Virus? (硬頁翻翻書)9781474986434 Where Does Poo Go? (硬頁翻翻書)9781474989008 How Can I Be Kind? (硬頁翻翻書)9781474940085 How Do Animals Talk? (硬頁翻翻書)9781409582137 How Do Flowers Grow? (硬頁翻翻書)9781474948180 What Are Feelings? (硬頁翻翻書)9781474995795 What Is Racism? (硬頁翻翻書)9781409598817 What Makes It Rain? (硬頁翻翻書)9781474920520 What's It Like in Space? (硬頁翻翻書)9781474982139 Where Do Animals Go In Winter? (硬頁翻翻書)9781409598824 Where Do Babies Come From? (硬頁翻翻書)9781474920537 Where Does My Food Go? (硬頁翻翻書)9781474979887 Why Do Things Die? (硬頁翻翻書)9781474948197 Why Do Tigers Have Stripes?(硬頁翻翻書)9781474917933 Why Do We Need Bees? (硬頁翻翻書)9781474996099 Why Do We Need Trees? (硬頁翻翻書)9781474948173 Why Does the Sun Shine? (硬頁翻翻書)9781803701974 Why Is It Dark at Night? (硬頁翻翻書)9781409598800 How does my body work? (硬頁翻翻書)

★ 用「俳句」玩躲貓貓！最詩意的翻翻書體驗★ 森林動物×猜謎互動，閱讀像遊戲一樣好玩★ 給孩子的第一本詩，溫柔又充滿節奏感微風吹拂，池塘熱鬧起來——滑一滑、溜一下、肚皮滑水……是誰在玩呢？翻開小機關，答案揭曉：是水獺！本書以輕巧優美的俳句，描繪森林裡悄悄出沒的小動物。每一頁都是一則充滿畫面感的詩句，引導孩子觀察、想像，再透過翻翻頁揭開答案，帶來「猜一猜、找一找」的閱讀樂趣。This poetic lift-the-flap board book features haikus about hidden woodland animals, plus flaps that reveal those animals! Warm breezes blowing, pond open for summer fun--slip, slide, belly ride!(Peek-a-boo, OTTER!) Each haiku in this lift-the-flap board book will have readers guessing the animal it describes--with the answer revealed under a flap on each page! With lovely text, sweet illustrations, and cute creatures, this lyrical and interactive book is a joy to read!

Meet the world's greatest heroes, as drawn by the world's greatest creators! Ant-Man and the Wasp are some of Earth's biggest (and smallest) heroes yet. Grow and shrink with the characters while learning all about their technology, abilities, and friends in this bright and colorful board book, with art from the classic comics. Vivid colors and three special gatefolds make for a fun-filled read that is perfect for the youngest kids and long-time Marvel fans alike.