Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A looking searching puzzle book with many layers and a fantastic read-aloud, as 18 colourful animals do something new on every page - look carefully!Who's hiding? Who's crying? Who's backwards? The answers to these questions are not as simple as they appear. In this sturdy board book edition of bestseller Who's Hiding? 18 colourful animals stand in a row. Something small changes on every double page: animals disappear, turn around, cry or sleep.Young children love spotting the changes and, at the same time, get to know animal names, colours, expressions, emotions and how to count.

In this pithy board book series, an overenthusiastic, impulsive lion tests his daily routines to their limit—in Lionel Poops, cheerfully trying all sorts of places to poop before ending up proudly on the potty.Lionel is bouncing on his trampoline when all of a sudden he needs to poop. Where will he do it? On some cows! No, Lionel, no! On some wildcats! No, Lionel! Lionel thinks of many inappropriate places but eventually poops on his potty. Well done, Lionel! But wait—that’s not all…Cheeky toddler lion Lionel learns about looking after his own body. His mischievous grin puts the reader instantly on his side, and the tolerant voice of his adult helper provides an amused commentary. Ideal to read to a child while they are on a potty.Series includes Lionel Eats All By Himself.From the author of Encyclopedia of Grannies…“A completely bonkers, gleefully silly guide to grandmothers of all stripes.” School Library Journal…and My Pictures after the Storm (3 starred reviews)“A terrific little b

Have you ever wondered what's under the ground? A fascinating world lies hidden there. In an exciting journey into the Earth, young children can lift flaps and peep into holes to find ants and bunnies, pipes and trains, fossils and even lava!

Introducing an exciting new multi-sensory board book series written by Camilla Reid, with illustrations from acclaimed collage artist Clare Youngs!All pre-schoolers will adore Clare Youngs' friendly animals with their high-contrast collage artwork, decorative foil highlights and signature animal noises - but there's a tiny creature to find behind a tuggable felt flap on each spread, too! In this book, you'll meet Baa Baa Sheep, Cluck Cluck Hen, Oink Oink Pig and Moo Moo Cow herself.With a final 'recap' animal noises page, and the question, "But what noise do YOU make?", little readers will enjoy lifting the last flap and saying 'hello' to themselves in the surprise mirror!Visually gorgeous and with a genuinely engaging hide-and-seek narrative, this is the launch of a stunning new series from the author behind some of Nosy Crow's bestselling pre-school books: Felt Flaps Where's Mr/Mrs?, Pip and Posy, Bizzy Bear and Peekaboo. Also available: Look, It's Roar Roar Lion!

Introducing an exciting new multi-sensory board book series written by Camilla Reid, with illustrations from acclaimed collage artist Clare Youngs!All pre-schoolers will adore Clare Youngs' friendly animals with their high-contrast collage artwork, decorative foil highlights and signature animal noises - but there's a tiny creature to find behind a tuggable felt flap on each spread, too! In this book, you'll meet Clip Clop Zebra, Ooo Ooo Monkey, Munch Munch Hippo and Roar Roar Lion himself. With a final 'recap' animal noises page, and the question, "But what noise do YOU make?", little readers will enjoy lifting the last flap and saying 'hello' to themselves in the surprise mirror!Visually gorgeous and with a genuinely engaging hide-and-seek narrative, this is the launch of a stunning new series from the author behind some of Nosy Crow's bestselling pre-school books: Felt Flaps Where's Mr/Mrs?, Pip and Posy, Bizzy Bear and Peekaboo. Also available: Look, It's Moo Moo Cow!

Just how many things can one be? One box of crayons. One batch of cookies. One world. One family. In this unabridged board book edition of the beloved picture book, One Family, author George Shannon and artist Blanca Gomez craft a playful, interactive story that shows how a family can be big or small and comprised of people of a range of genders and races.

Follow the adventures of Little Bunny through the sunny meadow in this quirky board book that's full of flaps to lift and sliders to slide! This quirky board book follows the adventures of Little Bunny on a journey through the meadow on a sunny day. Little Bunny stops to smell some flowers and sees Butterfly and Ladybug. Then Little Bunny continues into the forest and finds Squirrel and Bird. Next, Little Bunny heads to the pond and watches Frog, Duck, and the ducklings in the water. And at the end of the day, Little Bunny sees bees and Bear hiding behind the beehive, and then hops home to bed. Features flaps to lift and sliders to slide throughout.

There are so many ways to spend a sunny summer day. Join The Very Hungry Caterpillar and explore everything the season has to offer!Celebrate summer with The Very Hungry Caterpillar and his friends in this exploration of the season. Young readers can learn all about seasonal sensory experiences, like listening to noisy bugs, feeling the warm sunshine, smelling the yummy scents of a cookout, and so much more!

Part of the Let's Look at... series of board books from best-selling author and illustrator Marion Deuchars, this book is the perfect introduction to the wonders of nature. From green grass and fluffy white clouds to pebbles and shells on the seashore, the bright colours and sweet characters will take your little one on a mini adventure in the natural world.Also available in the Let's Look at... series: Let's Look at...Numbers, Let's Look at...Shapes, Let's Look at...Animals and Let's Look at...Colours. Marion Deuchars is the award-winning and best-selling author of the Let's Make Some Great Art series.Other titles, also published by Laurence King, include Bob the Artist, Bob's Blue Period and Bob Goes Pop, beautiful picture books about friendship, art, dealing with emotions and working together.

Part of the Let's Look at... series of board books from best-selling author and illustrator Marion Deuchars, this book is the perfect introduction to the world of opposites. From up and down penguins to hot and cold aardvarks, the charming characters and bright colours will have your little ones exploring opposites in no time.Also available in the Let's Look at... series: Let's Look at...Numbers, Let's Look at...Shapes, Let's Look at...Animals and Let's Look at...Colours. Marion Deuchars is the award-winning and best-selling author of the Let's Make Some Great Art series.Other titles, also published by Laurence King, include Bob the Artist, Bob's Blue Period and Bob Goes Pop, beautiful picture books about friendship, art, dealing with emotions and working together.

Push, pull and slide the scenes to celebrate Father's Day in I Love My Daddy! From making up silly games to learning to ride a bike, every day's an adventure with Dad by your side!Young children will love playing with this bright and colourful board book with gentle rhyming text and wonderful illustrations by Louise Forshaw. Part of the popular Busy Book series, I Love My Daddy is the perfect gift to share on Father's Day, and is endorsed and recommended by Dr Amanda Gummer's Good Play Guide. Discover more of the Busy Book series with titles such as Busy Party, Busy Bikes and I Love My Mummy.

Peppa and her friends are taking part in the playgroup song contest - but will Peppa remember the words?It's the playground song contest and everyone is very excited to show off their musical skills!Peppa is nervous - what if she isn't loud enough or she can't remember the words? Luckily her friends are there to give her the support she needs!This thick board book is a lovely story about confidence, support, friendship and singing as loud as you can!

You can do it too with Ladybird's It's Time to...!This interactive novelty board book is filled with sliders and flaps to help little ones mimic the adult behaviours they see every day. In It's Time to... Clean Up! the moving sliders and transformative flaps on every page allow toddlers to perform the tasks in the simple text - they can vacuum the floor, wash the dishes and even hang up the washing!The It's Time to...series:Boosts motor skillsEncourages imaginative playRecommended for children aged 3+Also available:It's Time to... Fix It!

Push, pull and slide the tabs to enjoy a day out at the Busy Park! Visit the playground, spots lots of different animals and have a picnic. Young children will love playing with this bright and colourful board book with a gentle rhyme and wonderful illustrations by Louise Forshaw, which is part of the Busy Book series. Busy Park has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.Discover more in the Busy Book series: Busy Zoo, Busy Airport and Busy Farm.

Push, pull and slide the tabs to hop aboard in Busy Trains! Enjoy watching the steam puff out of an engine, going through a crossing and chugging along the railway. Young children will love playing with this bright and colourful board book with a gentle rhyme and wonderful illustrations by Jo Byatt. Busy Trains has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.Discover more of the Busy Book series: Busy Fire Station, Busy Airport and Busy Bikes.

Push, pull and slide the tabs to learn all about life on the Busy Farm! Meet all the different animals, help the farmer bale the hay and join in rounding up the sheep at bedtime. Young children will love playing with this bright and colourful board book with a gentle rhyme and wonderful illustrations by Louise Forshaw, which is part of the Busy Book series. Busy Farm has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.Discover more of the Busy Book series: Busy Zoo, Busy Pets and Busy Park.

Push, pull and slide the tabs to be a part of the Busy Fire Station! Join in with the firefighters as they slide down the pole, drive the fire engine and put out a fire while everyone cheers. Young children will love playing with this bright and colourful board book with lots to spot, a gentle rhyme and wonderful illustrations by Jo Byatt. Busy Fire Station has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.Discover more of the Busy Book series: Busy Bikes, Busy Airport and Busy Trains.

故事中，主角Jim Panzee遇到小朋友最討厭的事情「等待」，而且還是無盡的等待。Jim努力嘗試耐心等待，但因為實在太久也讓他感到非常不耐煩。雖然耐心不是一瞬間就能學會，但也讓Jim明白，生活中還是有些事情是值得等待的。本書以簡潔的文字和幽默的插畫，來幫助孩子學會等待，學會接受與面對其中的過程。非常適合學齡前幼兒和家長共讀，共同應對生活中不可避免的等待情境。In this original board book that tackles a common toddler problem, the bestselling character finds that waiting is never easy, but sometimes it is necessary.Jim Panzee is faced with something everyone hates…waiting…and waiting…and more waiting. Jim tries to be patient but he’s even impatient waiting for patience. It doesn’t happen right away, but eventually, Jim realizes that some things are worth waiting for.A simple text and humorous artwork offer parents the perfect funny book to help their toddler with waiting, even when they really don’t want to.

《Grumpy Monkey Says No!》是Suzanne Lang與Max Lang創作的情緒繪本系列，本書將探討幼兒期常見的「說不」問題。小猩猩Jim Panzee對各種提議都說「不」，像是不想散步、不想玩耍、甚至不想吃香蕉！就像許多小朋友一樣，似乎「不」是他最常使用的字。書中以簡潔的文字搭配幽默插畫，為父母提供了一本好笑又實用的書籍，幫助他們應對孩子對許多事情都說「不」的挑戰。故事傳達訊息讓孩子和家長明白，有時候說「不」並非最佳答案，鼓勵孩子嘗試更多可能。In this original board book that tackles a common toddler issue, the bestselling character finds out that “no!” isn’t always the best answer.Does Jim Panzee want to go for a walk? No! How about having a playdate? No! Not even to eat a banana? No! Grumpy Monkey just wants to say “no.” Sometimes it seems like the only word toddlers know is “no,” and Jim is no exception.A simple text and humorous artwork offer parents the perfect funny book to help when their toddler says “no” to absolutely everything.

Say hello to all sorts of unicorns in this bright, interactive touch-and-feel-book! With simple text, high-contrast colours, and an exciting touch-and-feel on every double page, this magical book engages your baby's senses as they discover different unicorns. Children will love exploring all the different textures as they touch the sparkly horn, feel the shimmery wing and stroke the furry mane! This touch-and-feel playbook:Encourages sensory developmentBoosts motor skillsRecommended for children aged 0+ Illustrated by Lemon Ribbon StudioAlso Available:Baby Touch: PetsBaby Touch: FarmBaby Touch: ColoursBaby Touch: FeelingsBaby Touch: Opposites

Introduce your little one to DINOSAURS in this bright, interactive touch-and-feel book. Packed with FLUFFY feathers, SMOOTH horns and BUMPY scales, each page has a new texture for your little one to try. With simple text, high-contrast colours and an exciting touch-and-feel on every double page, this playful book engages your baby's senses as they discover their first dinosaurs.This touch-and-feel playbook:Encourages sensory developmentBoosts motor skillsRecommended for children aged 0+Illustrated by Lemon Ribbon StudioFrom tummy time to bath time, the bestselling Baby Touch series contains the perfect first books to support key milestones. Also available:Baby Touch: PetsBaby Touch: FarmBaby Touch: My First BookBaby Touch: ColoursBaby Touch: OppositesBaby Touch: NumbersBaby Touch: WordsBaby Touch: ShapesBaby Touch: Hello, Daddy!Baby Touch: Hello, Mummy!

Little children will love joining Bunny and the other woodland animals for a game of hide and seek in this endearing flap book. Each page has a big, satisfying flap for little fingers to lift, reveali

What a Stink! is a hilarious board book about a bunch of animals in an elevator and a very stinky problem―featuring fun pull-out sliders and flaps.TOOT! What’s that smell? In this interactive board book, a group of animals enter an elevator―at each floor, one of the animals breaks wind, producing a serious stench! But who did it?As each animal exits the elevator, it slowly becomes clearer who the “tooter” is…and it’s not who you expect!This sturdy board book includes 5 double-sided pull-out sliders and 2 flaps, which reveal extra story details―whether it’s the giraffe’s incredibly long neck or the mystery stinky culprit! Bright, playful illustrations, and lovable animal characters will make What a Stink! a firm family favorite.This robust board book and its fun sliders will withstand hours of hilarious fun.

忙碌小熊記憶配對大挑戰！集結海底世界、動物園等四種場景，尋找隱藏其中的動物。內含36個滑動機關，利用記憶配對訓練孩子手眼協調，遊戲中吸收新單字。Play and learn with Bizzy Bear! With four fun memory games and lots animal details to spot, the busy book is designed to improve memory, build vocabulary, and promote book-confidence.Discover animals in four settings: on the farm, at the zoo, under the sea and at the park!PlayWith four memory games - and three ways to play!Learn Build vocabulary with new words to learn on evey pageOn the goWith all the fun of a card matching game and none of the mess

夜晚來了，小青蛙準備要睡覺了，但他還想跟每一位動物朋友說聲晚安！這本充滿驚喜的互動繪本附有「魔法手電筒」，只要插進書頁間，就能在夜色中發現藏著的動物身影。重複押韻的句子搭配柔和插圖，幫助孩子建立節奏感，也營造出溫暖的睡前氛圍。書本設計貼心附上緞帶，讓手電筒不易遺失，是親子共讀、安撫情緒的理想睡前書。A magical bedtime story book for children.Frog is ready for bed, but first he wants to say goodnight to all his animal friends. Insert the magic torch between the pages to find Frog's friends in each night-time scene and watch children glow with delight!Repetitive, rhyming text to help young children learn rhythm and tone.Clever windows throughout reveal hidden animals when the torch is inserted.Includes a handy ribbon to keep the magic torch attached to the book.

Join The Very Hungry Caterpillar for one of his favorite meals of the day: lunch! The Very Hungry Caterpillar is very hungry . . . for lunch! With die-cut pages, a simple narrative, and beautiful artwork from Eric Carle, this interactive board book is the perfect way to introduce the midday meal. From mac and cheese and sandwiches to salads and tacos, there's something everyone will enjoy. This book will become a staple in the kitchen for even the littlest food critic in training!

9781474992145 Tree of Life (300片拼圖+16頁小書)A beautiful Tree of Life Jigsaw Puzzle accompanied by a 16pp book that explores the whole tree of life from microscopic bacteria to whole rainforest ecosystems, packed with information about how life works, what makes a living thing, and all sorts of the Earth’s amazing plants and animals.300片拼圖+16頁小書拼圖完成尺寸59*40公分9781839941191 The Tree Book (硬頁書)(英國版)Have you ever thought about all the amazing things that trees can do? How do they grow and why do they change through the seasons? How do trees help us and how can we help trees? Children will love discovering the answers with amazing see-through pages and clear, friendly text. With labelled acetate diagrams of a tree throughout the year, alongside minibeasts and animals that live in trees, this is a fantastic first look at nature for curious children everywhere.From leaves changing colour to underground root networks, The Tree Book is an exciting way to explore all the amazing things tree

Easy-to-use peekaboo sliders, super-cute faces and a surprise mirror ending combine in this stylish interactive board book for babies and toddlers! With a total of 10 ingenious mechanisms to push, pull or turn on every spread. From Camilla Reid and Ingela P Arrhenius, the award-winning team behind the bestselling Felt Flaps Where's Mr? series. Connecting with faces and playing peekaboo is one of the first games that babies play and it's why the very youngest of children will love this adorable book - and want to read it again and again! Also available: Peekaboo Cow, Peekaboo Apple, Peekaboo Bear, Peekaboo Sun, Peekaboo Love, Peekaboo Moon

Maisy is fixing Cyril's car, and she needs your help! With easy-to-use pull, slide and play tabs on every spread, little ones will love this interactive garage experience. Uh oh - Cyril's car has broken down! Luckily Maisy and her friends know just what to do. Pull, slide and play with the tabs to jack up the car, lower in a new engine, check the lights and wipers, and finally drive out of the garage.A delightful story about teamwork with exciting, interactive spreads, ideal for imaginative play!

Peep Inside翻翻小百科新書。你知道鳥類是怎麼在鳥巢裡養育寶寶嗎？企鵝不會築巢，那麼他們如何孵蛋呢？翻開機關看看從蜂鳥到紅鶴等不同的鳥類的習性吧！Peep inside a bird's nest to see her precious eggs nestled there. Lift a flap to see them hatch, and find out how a bird takes care of its young. Discover all kinds of different nests and chicks, from teeny-tiny humming birds nests to great big muddy flamingo nests, and even learn how penguins take care of their eggs in the snow without a nest at all.

Take a closer look through the seasons in this incredible board book about trees, with see-through acetate pages.Have you ever thought about all the amazing things that trees can do? How do they grow

Little Dino wants to be kind and understanding. He never wants to be a bully! Little Dino works on positive behaviors and always tries to be his best self in this encouraging board book.

Bunny is almost potty trained, but pooping on the potty is still tricky. After a few hops and plops, Bunny starts to figure it out in this lighthearted board book.

夜晚入睡時，從事哪些職業的人才剛開始工作呢？從晚班醫生到博物館巡邏員、從麵包師傅到夜班火車司機，每頁包含數個小機關，搭配Ingela P. Arrhenius繽紛簡約的插畫風格，翻一翻認識你所不知道的夜間工作。Discover the amazing people that work when you’re fast asleep in this large-format board book with easy-to-lift flaps on every page!There are all kinds of people that work during the night-time, from bakers to doctors, train drivers to road workers, and out at sea or in an art gallery. Peek inside the oven at the bakery, find out if the fishing boats have caught any fish and open the doors into a busy hospital. Learn more about the world at night with this fun lift-the-flap book that’s packed with details to spot and perfect for sharing at bedtime.With a rhyming, read-aloud text from Peter Arrhenius and bold, friendly artwork from Ingela P Arrhenius, the award-winning illustrator of the bestselling Felt Flaps and Peekaboo series.

《忙碌小熊》新書，一起到遊樂園大冒險！幼兒就能輕鬆推拉的操作機關，動手玩同時聆聽充滿韻律感的音檔，更能拉進寶寶與書本的距離，建立閱讀自信。Five easy-to-use sliders, a rhyming story and lots to spot and say in this series of bright, interactive board books for toddlers!An engaging little story with loads of details to spot and chat about. This story needs YOU! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life! The high level of interaction builds confidence and engagement with books, which is a key stepping-stone to reading for toddlers. Illustrated by multi-award-winning Benji Davies, illustrator of The Storm Whale, and Grandad's Island Collect the whole series; other title available include: Bizzy Bear: Farmyard Fun, Bizzy Bear: Fire Rescue, Bizzy Bear: Breakdown Truck and lots, lots more!

The next book in the bestselling Abrams Block Book series, featuring all of your favorite Sesame Street friendsCount up to 25 with all of the friendly faces who call Sesame Street home, including Elmo

Find out what it takes to be a mechanic in this exciting board book with press-out models!Open up the garage and discover what it takes to be a mechanic. Follow the story and experience hands-on fun w

★寶寶的第一本聖誕節操作書★訓練孩子手部小肌肉★陪孩子感受溫暖的聖誕節氣氛一起跟著Magical Santa來場神奇的平安夜之旅。藉由書上的轉盤與推拉設計，並且搭配可愛溫暖的插圖與英文韻腳，讓孩子可以從遊戲中來認識聖誕老公公送禮物的過程，定感受濃濃的聖誕節氣氛。 Share Christmas Eve with the most magical Santa of all in My Magical Santa !With a sparkly foil cover wheel and push, pull and turn mechanisms, little ones will have lots of fun delivering presents with Santa and finding out just how he gets down all those chimneys!Yujin Shin's beautifully coloured illustrations are paired with gentle rhyming text to create a perfect magical world, with bright, sparkling detail and things to spot in four magical scenes.My Magical Santa is another exciting addition to the My Magical series, based on the popular Busy Book format.Enjoy more festive magical adventures with My Magical Snowman, My Magical Easter Bunny and My Magical Witch.

Join The Very Hungry Caterpillar for one of his favorite meals of the day: breakfast The Very Hungry Caterpillar is very hungry . . . for breakfast With die-cut pages, a simple narrative, and beautiful artwork from Eric Carle, this interactive board book is the perfect way to introduce the most important meal of the day. From muffins and pancakes to eggs and fruit, there's something everyone will enjoy. This book will become a staple in the kitchen for even the littlest food critic in training

Alphabet StreetThere's so much to discover in this ingenious little book! Read the story, lift the flaps, enjoy the funny rhyming text, learn the letters of the alphabet and, then, when you're finished, flip the book and have fun with the playscene on the reverse!Christmas Street This spectacular lift-the-flap Christmas alphabet story is a book, a fold-out play-scene, and a beautiful festive frieze to decorate your room!Everyone is busy on Christmas Street! Who is baking gingerbread? Who is wrapping presents? And who's that coming down the chimney? Find out in this perfect Christmas gift book, the follow-up to Alphabet Street.With bright, cheerful artwork from Ingela P Arrhenius, illustrator of the bestselling Felt Flaps and Peekaboo series, and a clever rhyming text from Jonathan Emmett.Read the rhyming story, lift the festive flaps, learn the letters of the alphabet and seasonal words and then, when you're finished, flip the book and have fun with the giant snowy concertina play-scen