Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Magical Unicorn is perfect for children who love fantasy creatures. Features shaped pieces that can be placed in die cut spaces within the book or used for pretend play. Over a million copies sold to

Dino Explorer is a must have for dinosaur fans. Features shaped pieces that can be placed in die cut spaces within the book or used for pretend play. Over a million copies sold to date of the bestsell

Have fun assembling two-piece puzzles, then read the rhyming story in the board book. You’ll learn all about opposites!• Fantastic gift package for 2-year-olds.• A new way to learn basic concepts abou

Thirty-six masterpieces are up for auction. Are they bargains to be snapped up or over-hyped drains on your finances? You'll never know unless you bid! In this board game for up to six players, you tr

Celebrate the art of Studio Ghibli, the beloved Japanese animation film studio, with this extensive collection of 100 full-color postcards showcasing final frames from all their feature-length films—from Nausicaa of the Valley of the Wind (1984) to When Marnie Was There (2014). Housed in a keepsake box with a lifting ribbon, these gorgeously detailed images will delight Studio Ghibli and animation fans of every age.© 2001 Studio Ghibli – NDDTM

Shake, stir - or shuffle? Step up to the bar and order your favourite drinks in this cheerful game of cocktails. Collect illustrated cards of 52 iconic drinks and group them into sets of four to win.

☆結合故事情境，孩子更能融入遊戲。☆加入編序教學的概念，引導孩子完成遊戲任務。☆簡易的玩法指引，孩子看圖也能自已玩。學習比你想像的更有趣1書 × 1玩具 = SMART BOX擴充版SMART BOX × SMART BOX擴充版 = 遊戲加值．思考加深【SMART BOX專注力擴充版】內容介紹《內容物》遊戲書1本、六角積木《遊戲重點》專注力是許多基礎技巧的累積而形成的一種訓練，包括了視覺、聽覺、操作、社交等面向，遊戲書中將透過增加的六角積木，使堆疊難度提高、造型變化更豐富，經由分階學習任務，穩固孩子的專注力、激發更多創意。《分階遊戲任務》階段Ⅰ 積木堆疊〉小積木疊高練習，增加小肌肉的穩定度、協調性。階段Ⅱ 創作表達〉仿拼各種動物、花草的外型特徵，激發創意。家長不仿也讓孩子用大小積 木拼組其他造型。階段Ⅲ 解決問題〉思考加一個積木，穩固結構的方法。了解物體的平衡關鍵。【產品特色】☆結合故事情境，孩子更能融入遊戲。☆加入編序教學的概念，引導孩子完成遊戲任務。☆簡易的玩法指引，孩子看圖也能自已玩。【SMART BOX擴充版系列產品簡介】《SMART BOX》系列原有5盒，而《SMART BOX擴充版》系列依照每盒的學習重點，共擴充設計有5盒的內容。每1盒都有其玩樂的重點，多種遊戲類型，啟發孩子的多元能力，你會發現學習比你想像的更有趣。‧S－Skill『專注力UP』‧M－Math『數學力UP』‧A－Art『美感力UP』‧R－Read『語文力UP』‧T－Think『思考力UP』　《SMART BOX擴充版》每一盒遊戲盒裡都有「1書」+「1玩具」，書中的主角《阿布》一樣會隨著故事情節化身成不同的角色，如：船長、建築師，孩子玩遊戲時，就會更有認同感，更加投入。《SMART BOX擴充版》分階遊戲歷程：建議孩子先使用過SMART BOX系列產品後，再使用本系列產品，並透過家長在旁引導，等孩子了解遊戲模式後，即可自己挑戰；書中還提供親子同樂的玩法建議，一套遊戲有多重功能，讓孩子越玩越聰明！家長透過故事邀請孩子一起當故事的主角。孩子熟悉遊戲模式後，開始進行分階挑戰，讓孩子享受玩遊戲任務的樂趣。提供多人玩法，全家一起玩遊戲，促進親子情感。【同系列產品】SMART BOX專注力擴充版SMART BOX數學力擴充版SMART BOX美感力擴充版SMART

☆結合故事情境，孩子更能融入遊戲。☆加入編序教學的概念，引導孩子完成遊戲任務。☆簡易的玩法指引，孩子看圖也能自已玩。學習比你想像的更有趣1書 × 1玩具 = SMART BOX擴充版SMART BOX × SMART BOX擴充版 = 遊戲加值．思考加深【SMART BOX數學力擴充版】內容介紹《內容物》遊戲書1本、冰山圖卡、角色圖卡《遊戲重點》數學力範圍很廣，在幼兒階段，SMART BOX希望透過遊戲，建立孩子對空間的感知，前後、左右的相對位置，藉此培養孩子對數學力中的立體空間有基本認識。擴充版中增加了數量點數、合成分解、集合分類等、邏輯判斷的概念，增加遊戲內容的廣度。《分階遊戲任務》階段Ⅰ 數量分合〉對照遊戲書，運用數量分解的概念，用冰山圖卡露出指定的企鵝數量。階段Ⅱ 上下空間策略〉將圖案分成3層，運用上、中、下，以及前後關係，練習遮檔。 階段Ⅲ 左右空間策略〉圖卡上有方向及顏色兩種條件，在缺乏規則性位置的條件，進行遮檔。 階段Ⅳ 條件推理〉依照指定條件下，運用邏輯推理，找出指定的雪人，並進行遮檔遊戲。【SMART BOX擴充版系列產品簡介】《SMART BOX》系列原有5盒，而《SMART BOX擴充版》系列依照每盒的學習重點，共擴充設計有5盒的內容。每1盒都有其玩樂的重點，多種遊戲類型，啟發孩子的多元能力，你會發現學習比你想像的更有趣。‧S－Skill『專注力UP』‧M－Math『數學力UP』‧A－Art『美感力UP』‧R－Read『語文力UP』‧T－Think『思考力UP』　《SMART BOX擴充版》每一盒遊戲盒裡都有「1書」+「1玩具」，書中的主角《阿布》一樣會隨著故事情節化身成不同的角色，如：船長、建築師，孩子玩遊戲時，就會更有認同感，更加投入。《SMART BOX擴充版》分階遊戲歷程：建議孩子先使用過SMART BOX系列產品後，再使用本系列產品，並透過家長在旁引導，等孩子了解遊戲模式後，即可自己挑戰；書中還提供親子同樂的玩法建議，一套遊戲有多重功能，讓孩子越玩越聰明！家長透過故事邀請孩子一起當故事的主角。孩子熟悉遊戲模式後，開始進行分階挑戰，讓孩子享受玩遊戲任務的樂趣。提供多人玩法，全家一起玩遊戲，促進親子情感。【同系列產品】SMART BOX專注力擴充版SMART BOX數學力擴充版SMART BOX美感力擴充版SMART BOX語文力擴充版S

☆結合故事情境，孩子更能融入遊戲。☆加入編序教學的概念，引導孩子完成遊戲任務。☆簡易的玩法指引，孩子看圖也能自已玩。學習比你想像的更有趣1書 × 1玩具 = SMART BOX擴充版SMART BOX × SMART BOX擴充版 = 遊戲加值．思考加深【SMART BOX美感力擴充版】內容介紹《內容物》遊戲書1本、印章DIY工具組《遊戲重點》美感力的範圍很廣，在幼兒階段，SMART BOX希望透過遊戲，建立孩子空間、形狀、顏色的選擇與搭配，藉此培養孩子圖像整合的概念與美感創意發想。《分階遊戲任務》階段Ⅰ DIY印章〉用矽膠黏土自己做印章，玩蓋印，體驗自由創作的樂趣。階段Ⅱ 色彩變化〉運用印泥進行色彩重疊蓋印，發現顏色變化的原理，感受顏色細微差異的趣味性。階段Ⅲ 形狀聯想〉運用印章形狀的組合，學習觀察視覺影像，將複雜的圖案簡單化，進行形狀的聯想。階段Ⅳ 蓋印變化〉學習印章蓋印的技巧，發現創作工具的各種可能性，豐富創作的靈感。【SMART BOX擴充版系列產品簡介】《SMART BOX》系列原有5盒，而《SMART BOX擴充版》系列依照每盒的學習重點，共擴充設計有5盒的內容。每1盒都有其玩樂的重點，多種遊戲類型，啟發孩子的多元能力，你會發現學習比你想像的更有趣。‧S－Skill『專注力UP』‧M－Math『數學力UP』‧A－Art『美感力UP』‧R－Read『語文力UP』‧T－Think『思考力UP』　《SMART BOX擴充版》每一盒遊戲盒裡都有「1書」+「1玩具」，書中的主角《阿布》一樣會隨著故事情節化身成不同的角色，如：船長、建築師，孩子玩遊戲時，就會更有認同感，更加投入。《SMART BOX擴充版》分階遊戲歷程：建議孩子先使用過SMART BOX系列產品後，再使用本系列產品，並透過家長在旁引導，等孩子了解遊戲模式後，即可自己挑戰；書中還提供親子同樂的玩法建議，一套遊戲有多重功能，讓孩子越玩越聰明！家長透過故事邀請孩子一起當故事的主角。孩子熟悉遊戲模式後，開始進行分階挑戰，讓孩子享受玩遊戲任務的樂趣。提供多人玩法，全家一起玩遊戲，促進親子情感。【同系列產品】SMART BOX專注力擴充版SMART BOX數學力擴充版SMART BOX美感力擴充版SMART BOX語文力擴充版SMART BOX思考力擴充版

☆結合故事情境，孩子更能融入遊戲。☆加入編序教學的概念，引導孩子完成遊戲任務。☆簡易的玩法指引，孩子看圖也能自已玩。學習比你想像的更有趣1書 × 1玩具 = SMART BOX擴充版SMART BOX × SMART BOX擴充版 = 遊戲加值．思考加深【SMART BOX語文力擴充版】內容介紹《內容物》遊戲書1本、大寫字母組合片《遊戲重點》語文力的記憶感很重要，在幼兒階段，SMART BOX希望透過生活情境，讓孩子從認識形狀開始，了解字母的構造與語言應用；同時，利用生活化的詞彙，加深孩子的語感。本次擴充版中增加大寫字母，以及題型中新增問句句型，讓孩子可以在情境中進行問答遊戲。《分階遊戲任務》階段Ⅰ 形狀認識〉了解大寫英文字的結構形狀。階段Ⅱ 認識字母〉依照故事情節，學習大寫英文字母。階段Ⅲ 單字練習〉依照故事情境，認識新的英文單字，並複習學過的單字。階段Ⅳ 語言力〉依照問句描述，回答問題。【SMART BOX擴充版系列產品簡介】《SMART BOX》系列原有5盒，而《SMART BOX擴充版》系列依照每盒的學習重點，共擴充設計有5盒的內容。每1盒都有其玩樂的重點，多種遊戲類型，啟發孩子的多元能力，你會發現學習比你想像的更有趣。‧S－Skill『專注力UP』‧M－Math『數學力UP』‧A－Art『美感力UP』‧R－Read『語文力UP』‧T－Think『思考力UP』　《SMART BOX擴充版》每一盒遊戲盒裡都有「1書」+「1玩具」，書中的主角《阿布》一樣會隨著故事情節化身成不同的角色，如：船長、建築師，孩子玩遊戲時，就會更有認同感，更加投入。《SMART BOX擴充版》分階遊戲歷程：建議孩子先使用過SMART BOX系列產品後，再使用本系列產品，並透過家長在旁引導，等孩子了解遊戲模式後，即可自己挑戰；書中還提供親子同樂的玩法建議，一套遊戲有多重功能，讓孩子越玩越聰明！家長透過故事邀請孩子一起當故事的主角。孩子熟悉遊戲模式後，開始進行分階挑戰，讓孩子享受玩遊戲任務的樂趣。提供多人玩法，全家一起玩遊戲，促進親子情感。【同系列產品】SMART BOX專注力擴充版SMART BOX數學力擴充版SMART BOX美感力擴充版SMART BOX語文力擴充版SMART BOX思考力擴充版

☆結合故事情境，孩子更能融入遊戲。☆加入編序教學的概念，引導孩子完成遊戲任務。☆簡易的玩法指引，孩子看圖也能自已玩。學習比你想像的更有趣1書 × 1玩具 = SMART BOX擴充版SMART BOX × SMART BOX擴充版 = 遊戲加值．思考加深【SMART BOX思考力擴充版】內容介紹《內容物》遊戲書1本、房子擴充積木：6個《遊戲重點》思考力是許多基礎技巧的累積，包括了空間辨識、分析判斷、邏輯推理等面向，遊戲書透過房子建築師的分階學習任務，培養孩子的思考力。《分階遊戲任務》階段Ⅰ空間辨識 觀察遊戲書上的題目，用積木蓋出一模一樣的房子。階段Ⅱ分析判斷　從遊戲書提供的提示中，判斷每個積木的位置，並蓋出指定的房子。階段Ⅲ邏輯推理　從遊戲書提供的提示中，推理未知積木的位置，並蓋出指定的房子。【SMART BOX擴充版系列產品簡介】《SMART BOX》系列原有5盒，而《SMART BOX擴充版》系列依照每盒的學習重點，共擴充設計有5盒的內容。每1盒都有其玩樂的重點，多種遊戲類型，啟發孩子的多元能力，你會發現學習比你想像的更有趣。‧S－Skill『專注力UP』‧M－Math『數學力UP』‧A－Art『美感力UP』‧R－Read『語文力UP』‧T－Think『思考力UP』　《SMART BOX擴充版》每一盒遊戲盒裡都有「1書」+「1玩具」，書中的主角《阿布》一樣會隨著故事情節化身成不同的角色，如：船長、建築師，孩子玩遊戲時，就會更有認同感，更加投入。《SMART BOX擴充版》分階遊戲歷程：建議孩子先使用過SMART BOX系列產品後，再使用本系列產品，並透過家長在旁引導，等孩子了解遊戲模式後，即可自己挑戰；書中還提供親子同樂的玩法建議，一套遊戲有多重功能，讓孩子越玩越聰明！家長透過故事邀請孩子一起當故事的主角。孩子熟悉遊戲模式後，開始進行分階挑戰，讓孩子享受玩遊戲任務的樂趣。提供多人玩法，全家一起玩遊戲，促進親子情感。【同系列產品】SMART BOX專注力擴充版SMART BOX數學力擴充版SMART BOX美感力擴充版SMART BOX語文力擴充版SMART BOX思考力擴充版

TEN hilarious and moving novels from bestselling, critically acclaimed author, David Walliams, in one TERRIFIC box-set! David Walliams精彩作品，超值收藏價！今年49歲的童書作家David Walliams，你知道他除了作者的身分，同時也是演員、編劇與節目主持人，還在

Five chunky puzzles with cute animals, numbers and colours!In this delightful game very young children can have fun and learn while putting together five simple puzzles. Each four-piece jigsaw feature

Master the language of astrology with this 45-card deck by Ruby Warrington, a popular spirituality writer and founder of The Numinous. Becoming fluent in the language of astrology can be a life

There are lots of garden creatures and objects to match in this entertaining card game for young children. There are 52 snap cards (13 matching sets of 4), with labelled pictures showing a bumblebee,

Follow fan-favorite Toy Story characters in this unique format that includes inspirational and hilarious words of wisdom from beloved Toy Story characters old and new!

Empathy fuels connections between people.But, what’s a real connection in the digital age? When do we still sit down, actively listen and engage with each other’s stories? The Empathy Game is a playfu

Robot Memory Game gives an overview of the many areas robots appear in our society. All robot domains will get a description to explain the robot on the latest developments and reason they exist. The

Have you ever wondered why your cat acts a certain way, has such an attitude, or does strange things? Now with the Phrenology Cat kit you can pin-point and label where in your cat's brain their emotio

Zen meets cats -- and kitty litter -- in this calming Zen garden kit that includes everything you need to reach ultimate enlightenment.For any cat lover looking for peace and mindfulness, this kit inc

This deck of 36 wordless storytelling cards features more than 30 games to build basic mathematics, storytelling and writing skills in children ages 3 - 10. The 12 character, 12 object and 12 setting cards invite children to create stories about mermaids, pirates and more.

Piece together the world of the genius that is Frida Kahlo in this art history jigsaw puzzle that tells the story of her life, her art and her career. Taking centre stage is Frida herself surrounded b

The Andy Warhol 500 Piece Puzzle from Galison features a print from Warhol's iconic Flowers series (1970). Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Artichoke Floral 500 Piece Puzzle features stunning image by famous foodie and photographer Sarah Phillips whose organization Ugly Produce is Beautiful is working hard to educate consumers and reduce massive food waste. With these colorful green artichokes, ruby red tomatoes and purple flowers styled against a contrasting black background, it's easy to see how beautiful food is, even if it appears imperfect in the grocery store. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Doodle Dogs and Other Mixed Breeds 500 Piece Puzzle features illustrations of 22 mixed breed dogs including the Goldendoodle, Pugapoo, and Snorkie. Mudpuppy puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.-500 pieces-Complete puzzle: 20 x 20"-Box: 8 x 8 x 2"-Puzzle greyboard contains 90% recycled paper. Packaging contains 70% recycled paper. Printed with nontoxic inks.-Ages 8-99

Troy Litten is a unique designer, photographer, and world traveler fueled by his fascination with all forms of visual culture, communication, and expression. Snapshots of America 500 Piece Puzzle by Galison features a collage of Litten's photographs from all over the United States. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

The Frank Lloyd Wright Imperial Hotel Peacock Rug 500 Piece Foil Puzzle brings shiny new glamour to the rug design. The gold foil embellishments on this puzzle bring the luxurious deco era back to life, piece by piece. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Feathers 500 Piece Foil Puzzle features vibrant watercolor feathers from artist Margaret Berg. Gold foil accents create a stunning pattern of plumage that comes together piece by piece. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Get to know the London by working this illustrated map of city featuring the city's most famous sites and landmarks including Buckingham Palace, Trafalgar Square, Royal Albert Hall and many more. Galison's London 1000 Piece Puzzle is packaged in stylish matte-finish sturdy box, perfect for gifting, reuse, and storage.

Award-winning designer, illustrator, and creative director Michael Storrings captures the magic and lights of Broadway and the theater district of New York City. Michael Storrings The Great White Way 2000 Piece Puzzle from Galison is packaged in stylish matte-finish sturdy box, perfect for gifting, reuse, and storage.

Gray Malin's awe-inspiring aerial photographs are shot from doorless helicopters, creating playful and stunning celebrations of light, shape, and perspective, as well as summer bliss. This colorful two-sided puzzle features sunbathers basking on a white sandy beach on one side and snorklers exploring a coral reef in the sparkling blue ocean on the other side.

The Ashley Woodson Bailey 750 Piece Shaped Puzzle from Galison features the artist's signature "florography" art uniquely die-cut and contoured around this magnificent bouquet. The finished puzzle will need plenty of display time once completed! Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Cocktail Map of the USA 1000 Piece Puzzle features Anne Bentley's painting of the U.S featuring signature drinks across the 50 states. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Realist painter and former comic book artist Vincent Giaranno is well known for his urban portraits of contemporary women, and intimate interiors of New York City. Vincent Giaranno 1000 Piece Puzzle features the artist's painting Stone Street featuring a woman on the street taking a moment to use her phone. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

From Anna Marlis Burgard, author of The Beachcomber's Companion: An Illustrated Guide to Collecting and Identifying Beach Treasures, with illustrations by Jillian Ditner, comes the perfect "companion" puzzle. The Beachcomber's Companion 1000 Piece Puzzle with Shaped Pieces is a gorgeous collage of the world's shells illustrated and identified. This unique puzzle includes puzzle pieces that are die-cut in the shape of the shell! Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Phat Dog Vintage scours the earth looking for the unusual and sometimes weird objects that are undeniably meant to be. Vintage Typewriter 750 Piece Shaped Puzzle features an image of an old manual typewriter uniquely die-cut around the shape of the typewriter. The finished puzzle will need plenty of display time once completed! Galison puzzles are packaged in stylish matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Artist Ben Gilles describes his work as a composition of nature, metamorphosis, light, color, collage, collaboration, juxtaposition, repetition, excitement, evolution, manipulation, music, television, improvisation, participation and seduction. This is quite apparent in the Gilles' colorful hand-cut paper flower and butterfly collage bursting from an open book on Wonder Books 750 Piece Shaped Puzzle. The finished puzzle is a uniquely die-cut and contoured to the edges of this beautiful image. Galison puzzles are packaged in matte-finish sturdy boxes, perfect for gifting, reuse, and storage.

Rainforest 300 Piece Shaped Scene Puzzle from Mudpuppy features a colorful collage of animals from the jungle. The finished puzzle is die-cut in the shape of a wild cat adding wow-factor when complete

These award-winning readers help children develop self-control, build problem-solving skills, form healthy relationships with others, and identify feelings in themselves and others. Relevant stories e

When times are particularly difficult, and you are likely to slip into despair, some of the greatest pop songs can provide true comfort to make it through the pain. The problem with advice in general