Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Miffy visits the gallery and sees lots of beautiful works of art. Feeling inspired, she uses her pencils to make her own artworks and creates her own gallery at home! The sturdy and big puzzle pieces with rounded edges are suitable for small hands. The six jigsaw puzzles in the book increase in difficulty, from four to nine pieces.

Water, water, everywhere! From rain in the sky to waves under the sea, this colorful board book in the Maisy's Planet series introduces the youngest explorers to a natural resource. We all need water for drinking, washing, growing--and jumping in puddles, like Maisy! But where does it come from, and where does it go? Join the curious mouse as she explores wildlife living in ponds, drops a stick in a stream to watch it float away, and follows a stream all the way to the ocean, where she and her friends can play, swim, and snorkel. There's so much to see under the water! In the Maisy's Planet series, each sturdy board book celebrates a different feature of the natural world, with bold colors, clear language, and a fun spread to open out at the end. Kids love to love our planet with Maisy!

Come and explore with the Moomins in this brand-new story in a book shaped like the Moominhouse. Moomintroll is searching the Moominhouse for a string for his kite. He spots a red string .. . but where does it lead? Join Moomintroll as he follows the string past Snufkin playing a tune, Snorkmaiden swinging on a trapeze and Little My sliding down the stairs.Along the way, lift the flaps to explore rooms, peek into cupboards and peer behind doors. There are all kinds of wonderful things to find!With simple text, things to spot and flaps to lift on every page, In the Moominhouse is the perfect introduction for little ones to Tove Jansson's world of Moominvalley. If you like this book, join Moomintroll as he tiptoes through rooms in In the Lighthouse, the next lift-the-flap shaped board book in this series!

Come and explore with the Moomins in this brand-new story in a book shaped like the Moomin Lighthouse. Moomintroll has found a trail of mysterious footprints in the Lighthouse . .. but where do they end? Join Moomintroll as he follows the footprints through dark rooms and spooky corridors, past Sniff, Snufkin and even a group of fizzing Hattifatteners. Along the way, lift the flaps to explore rooms, peek into cupboards and peer behind doors.There are all kinds of amazing things to find!With simple text, things to spot and flaps to lift on every page, In the Lighthouse is the perfect introduction for little ones to Tove Jansson's world of Moominvalley. If you like this book, don't forget to join Moomintroll in In the Moominhouse, the first lift-the-flap board book in this series!

Join in and help the busy zookeeper in this playful, interactive flap book!Can you help the busy zookeeper to look after the animals? Join in and use the flaps to feed the chimpanzees, clean the elephant house, and feed the baby aardvark. With interactive action-flaps, you can do it, too!Each clever flap provides an action or scene-change to encourage children to actively engage and explore. The playful flaps are perfect for little hands to develop fine motor skills and hand-eye coordination.Original concept and illustration by Dan GreenThe Busy Day series:Introduces the worldBoosts motor skillsRecommended for children aged 2+Also available in the Busy Day series:AstronautAthleteBuilderChefDoctorFarmerFather ChristmasFirefighterFootballerMechanicPolice OfficerTeacherTrain DriverVet

It's bathtime in the bear household... but the little bears aren't quite ready for a wash! Behind each fluffy flap in this cute book you'll find a mischievous bear cub making a great big mess... before all the bears are revealed together in the bath on the last page. With adorable illustrations and lots of fun surprises, this is a perfect book to share with babies and toddlers.

今天，Suki Cat 穿上太空衣，準備飛向月球！剛降落，她便發現一位遇到麻煩的外星人被困在飛船裡，需要幫助。Suki 能否運用勇氣與智慧，順利完成救援？本書以厚頁搭配耐用滑軌設計，孩子可透過推、拉、旋轉機關推進情節，親手參與太空冒險。色彩鮮明的插圖與韻律感十足的文字適合大聲朗讀，不僅提升閱讀趣味，也能在互動中培養專注力與手眼協調能力。Meet Suki Cat – a brand new preschool character starring in a series of action-packed stories with easy-to-use sliders!Who will Suki be today? Peek inside the box and play! Toddlers will love discovering who Suki Cat will become at the start of each story, before joining in with her dressing-up adventure – where she always saves the day! In Astronaut, Suki Cat puts on her spacesuit and zooms to the moon! But as she lands, she spots an alien in trouble. He’s stuck in his spaceship and needs help! Can Suki come to the rescue?From astronaut to dancer, this interactive series of vibrant board books with robust mechanisms is perfect for developing motor skills and inspiring imaginative play. Toddlers will enjoy pushing, pulling and turning the chunky sliders to take part in the story and bring the action to life! The narrati

Explore the enchanting animal kingdom with a twist in this magical book. Children will discover lots of fun facts about fascinating animals in this interactive book. Simply spin the wheel on each right-hand side page and reveal the cutest animal families. A great first introduction to the animal world!

Explore the enchanting animal kingdom with a twist in this magical book. Children will discover lots of fun facts about fascinating animals in this interactive book. Simply spin the wheel on each right-hand side page and reveal the cutest animal families. A great first introduction to the animal world!

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Mrs Elephant?, you're on the look out for Mr Cheetah, Mrs Hippo, Mr Ostrich and Mrs Elephant herself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Other titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun. Ingela Arrhenius' illustrations are a real

A new title in this bestselling board book series!Bizzy Bear has sold millions of copies around the world. In this new title, Bizzy Bear and his friends are going on a camping trip together. There's lots for them to see and on their outdoor adventure as they hike in the hills, canoe down the river and sing at the campsite.A robust book with sturdy sliders that can withstand in the most excited of little hands.And in this book Bizzy Bear needs YOU! Toddlers will love pushing and pulling the sliders to join in all the action!Other titles in the series: Ship's Captain, Fire Rescue, Chinese New Year and Vet's Clinic.

Help the baby dinosaurs find their way home in this fun sliding counter series!Meet T-rex, stegosaurus, pterodactyl and triceratops - four adorable baby dinosaurs who are lost in the wild! With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby dinosaurs home in this robust, satisfying board book. Scan the Stories Aloud QR code on the back cover to read along with the story!Other titles in the series include: Let's Go Home, Baby Rabbit, Let's Go Home, Baby Tiger, Let's Go Home, Baby Shark and Let's Go Home, Baby Lion

Zany slider books from Aya Watanabe!Bugs take unexpected forms in this joyful novelty book from rising talent Aya Watanabe.If you use a little imagination, the world is a wondrous place: butterflies become bows; beetles hang out the laundry and beehives become beautiful cathedrals.Lift, slide, push, pull and spin the wheels in this gloriously interactive book for babies and toddlers, that's practically bursting with colour and humour. Don't forget to find the ant hiding on every page!Also in the series: Veggies!, Fruits! and Flowers!

Spend a day at the beach with The Very Hungry Caterpillar!It's time for some fun in the sun! Play with beach toys, collect seashells, and splash in the water in this tabbed board book with easy-to-flip tabs, easy-to-read text, and easy-to-love Eric Carle art featuring The Very Hungry Caterpillar.

9781803706443 Roarr! Slider Sound BooksEach time you move one of the sliders in this unique novelty book, a jungle animal springs into view and makes a fun sound. But there's more! Move the same slider back again, and you'll see and hear a completely different animal. Babies and toddlers will love moving the sliders back and forth to enjoy all the jungle animals in this delightfully illustrated book - the first in an exciting new series.9781803707358 Vroom! Slider Sound BooksMove the sliders back and forth to hear the different vehicles zooming along in this unique and exciting sound book. When you move a slider one way you'll see and hear one vehicle... and when you move it back the other way you'll see and hear another one.There are planes, trains, cars, motorbikes and buses to discover, all driven by Ailie Busby's charming animal characters.9781805314578 Slider Sound Books: Rummble!Move the sliders back and forth in this unique sound book to hear the building site com

Read and learn over 300 words with Pip and Posy in this chunky, lift-the-flap book!With multiple flaps to lift, ten engaging scenes, and hundreds of images, this book has loads to name, discover and talk about. Every page has a thumb-tab to make turning the pages easy and the chunky pages are designed to withstand even the most enthusiastic of toddlers.Look out for other titles in the Pip and Posy series, including Pip and Posy Felt Flaps: In the Garden, At the Seaside, At Christmas, In the Park and At the Party.

Meet the little bear who's always hungry for honey and find 5 pop-up surprises inside! Join Pooh as he searches The Hundred Acre Wood for his friends: Piglet, Eeyore, Tigger, and Roo, and share with your toddler a character that you loved too. The lively, read-aloud rhymes encourage literacy and early learning, while the surprise pop-up scenes will delight curious preschoolers. With the help of parents and caregivers, toddlers will have fun turning the sturdy board book pages, guessing what's hiding under each flap, and then lifting the flaps to reveal Winnie and his friends, and play peekaboo! Ideal for interactive preschool play, Disney Winnie the Pooh Pop-up Peekaboo! will appeal to both parents and children and is certain to keep little ones entertained time and time again!

Join Mister Seahorse and his ocean friends in this touch-and-feel adventure!Greet a new friend with each turn of the page as you explore the ocean with Mister Seahorse. Interactive text encourages young readers to feel and think about each texture they encounter, and Eric Carle's colorful art sets each delightful scene. Classic characters come to life in this sensational story--perfect for little hands!

A study little board book full of gardening fun for babies and toddlers.Five easy-to-use sliders, a rhyming story and lots to spot and say in this new title in the internationally bestselling Bizzy Bear series.Each busy spread is full of little details to spot and talk about, and in this charming garden story Bizzy Bear needs You! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life!The high level of interaction builds confidence and engagement with books from a young age, and this is a key stepping stone to reading for toddlers and preschoolers.Illustrated by multi-award-winning Benji Davies, the creator of The Storm Whale, and Grandad's Island.Collect more in the Bizzy Bear series: Vet's Clinic, Ship's Captain, Fire Rescue, Farmyard Fun and lots more.

Learn all about bees with Maisy in this brand-new series celebrating our planet!Maisy is finding out about the bees in her garden and learning why they are so important for our planet. What do bees do all day? Where do they live? Little ones will discover the answers to these questions and many more in this colourful board book. Open out the final scene to see Maisy and the busy bees at work!Maisy’s Planet books are perfect for little nature-lovers aged from 18 months. Each sturdy, toddler-friendly board book celebrates a different feature of the natural world with bright colours, simple language and a fun open-out spread.

Join Bluey and Bingo as they search for Easter eggs in this lift-the-flap adventure!Bluey and Bingo are going on an Easter egg hunt following the clues left by the Easter bunny.Will they find their eggs? Lift the flaps to find out!Join Bluey and Bingo in this brilliant lift-the-flap adventure!Want more Bluey? Also available:Bluey: EasterBluey: Easter Fun ActivityBluey: More Easter Fun

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Mr Tractor?, you're on the look out for Mr Farmer, Mrs Combine Harvester, Mrs Sheepdog and Mr Tractor himself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Other titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun. Ingela Arrhenius' illustrations ar

Join Bizzy Bear on the building site in this chunky new board book with sliding counters. Bizzy Bear is helping the builders build a house today. There are lots of jobs to do and he needs your help! Push the rubble, build the walls and get the garden ready with four easy-to-use moving counters.Learn farm vocabulary with simple first words and helpful text prompts to encourage talking. Then push Bizzy Bear along 4 different tracks with a moving counter on every spread, plus an extra one on the cover! The perfect book for children who love things that go, busy building sites and love being in control of the story!Other titles in the series include: On the Farm, At the Zoo and In Space.

Join Bizzy Bear on the farm in this chunky new board book with sliding counters. Bizzy Bear is helping out on the farm today. He's got lots to do and he needs your help! Visit the chickens, feed the pigs and ride a horse with four easy-to-use moving counters.Learn farm vocabulary with simple first words and helpful text prompts to encourage talking. Then push Bizzy Bear along 4 different tracks with a moving counter on every spread, plus an extra one on the cover! The perfect book for children who love animals, farms and love being in control of the story!Other titles in the series include: On the Building Site, At the Zoo and In Space.

Koala is ready for bed, but first she wants to say goodnight to all her animal friends in this magical bedtime story book. Young children will love to help Koala find her animal friends in this interactive novelty book. There's a kangaroo, a dingo, a shark, a platypus, a kookaburra, and many more popular Aussie animals waiting to be discovered in the scenes.From searching by a billabong and exploring the bush to looking at the beach, there's different habitats to search and different animals to look for on each magic page. Simply insert the included 'magic torch' between the pages to find Koala's friends in each night-time scene and watch children glow with delight as hidden pictures appear!

Beaver is ready for bed, but first he wants to say goodnight to all his animal friends in this magical bedtime story book. Young children will love to help Beaver find his animal friends in this interactive novelty book. There's a wolf, a brown bear, a racoon, a moose, a chipmunk, and many more popular North American animals waiting to be discovered in the scenes.From searching in the forest and exploring the mountains to splashing in the lake, there's different habitats to search and different animals to look for on each magic page. Simply insert the included 'magic torch' between the pages to find Beaver's friends in each night-time scene and watch children glow with delight as hidden pictures appear!

用這本超級彈跳翻翻書，讓家中的小寶貝跟著友善的蜘蛛俠一起學習幫助他人吧！ 幫助蜘蛛俠保護紐約市，逐一找到他的朋友，包括最受歡迎的角色：彌爾斯、幽靈蜘蛛、鋼鐵人、黑豹和奇異博士。翻動大的翻翻板，看到五個從書頁中彈出的突如其來的驚喜場景，並探索友誼、團隊合作和勇氣的主題。 生動的韻文鼓勵語言和早期學習，而驚喜的彈出場景，會讓學齡前兒童眼睛一亮。在父母的幫助下，孩子翻動堅固的硬紙板書頁，猜測每個翻翻板下藏著什麼，然後揭開翻翻板，揭示蜘蛛俠和他的朋友，一起玩“躲貓貓”！ 這本《彈出翻翻書！漫威蜘蛛俠和他的驚奇朋友》是互動的學齡前遊戲理想之選，既適合父母和孩子，也肯定能一次又一次地讓小寶貝開心娛樂！ Teach your little one the power of helping others with your Friendly Neighborhood Spidey in this lift-the-flap pop-up bookHelp Spidey keep New York City safe and find his friends one by one, including your little one’s favorite characters: Miles, Ghost Spider, Iron Man, Black Panther, and Ms Marvel. Little hands can lift big flaps and see five peekaboo surprises pop up from the pages, and explore themes of friendship, teamwork, and bravery.The lively, read-aloud rhymes encourage literacy and early learning, while the surprise pop-up scenes will delight curious preschoolers. With the help of parents and caregivers, children will have fun turning the sturdy board book pages

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Mrs Fox?, you're on the look out for Mr Mole, Mrs Hare, Mr Woodpecker and Mrs Fox herself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Scan the Stories Aloud QR code on the back cover to read along with the storyOther titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and fin

Lift the soft blankets in this irresistible novelty book to find four cheeky bear cubs who aren't quite ready for bed! Each page has a big soft flap to lift with a charming surprise underneath it, as the reader helps to tuck in the mischievous little baby bears. With adorable illustrations full of gentle humour, this is a perfect blend of giggles and snuggles at bedtime.

Spend a day in the snow with The Very Hungry Caterpillar! It's a winter wonderland outside! Build a snowman, admire the falling snowflakes, and enjoy more frosty fun in this tabbed board book with easy-to-flip tabs, easy-to-read text, and easy-to-love Eric Carle art featuring The Very Hungry Caterpillar.

A first introduction to dancing for toddlers, with push, pull, slide mechanisms.Push, pull and slide the tabs to join in with a first dance class in Busy Dancing! Pirouette in ballet class, learn how to tap dance and breakdance on stage in this first introduction to dance, perfect for fans of ballroom glitz!A perfect present for toddlers, young children will love playing with this bright and colourful board book with a gentle rhyme and wonderful illustrations by Jana Curll. Busy Dancing has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.Listen along to an audio recording of this story by scanning the QR code on the back cover.Discover more of the Busy Book series with titles such as Busy Baking, Busy Party and Busy Zoo!

Join in and help the busy doctor in this playful, interactive flap book!Can you help the busy doctor to care for their patients? Join in and use the flaps to bandage the builder's sore thumb, check Basma's earache, and give Mia some medicine. With interactive action-flaps, you can do it, too!Each clever flap provides an action or scene-change to encourage children to actively engage and explore. The playful flaps are perfect for little hands to develop fine motor skills and hand-eye coordination.Original concept and illustration by Dan Green.

An updated edition of a much-loved That's not my... classic.Meet five friendly kittens in this colourful title in the much-loved That's not my... series. Babies and toddlers love the best-selling That's not my... books with their bold illustrations, patches to stroke, and the familiar little white mouse to spot on every page.

Help the baby animals find their way home in this fun new sliding counter series!Meet lion, monkey, hippo, zebra - four adorable baby animals who are lost on the savannah! With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby animals home in this robust, satisfying board book. Scan the Stories Aloud QR code on the back cover to read along with the story!Other titles in the series include: Let's Go Home, Baby Rabbit, Let's Go Home, Baby Tiger and Let's Go Home, Baby Shark

Get to know things that go in these action-packed board books featuring sliding counters! Discover different farm vehicles in this series of interactive board books with easy-to-use moving parts. Learn vehicle vocabulary with simple first words, clear diagrams and helpful text prompts to encourage discussion. Then trace the transport around different tracks with a moving counter on every spread and the cover.The perfect book for children who love tractors and combine harvesters - and being in the driving seat! Other titles in the series include: Building Site Winner of the 2021 British Book Design and Production Awards in the 0-8 Children's Trade Category

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Mr Train?, you're on the look out for Mrs Tram, Mr Ferry, Mrs Bus and Mr Train himself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Other titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun. Ingela Arrhenius' illustrations are a real bonus.They are

Mud is so much more than squelchy brown stuff. It's why our food grows, why our forests stand tall, why our water and air are less dirty and why billions of living things have somewhere to live. This engaging new title encourages young readers and their grown-ups to delight in mud, to value it in a new way and to help protect the planet's soil for the future.

From a New York Times bestselling author comes this poignant, lyrical tale about nature's great escape artist--now in a board book edition! The octopus is happy in his undersea cave until one day, a diver captures him and takes him to live in an aquarium. The humans give him food and tests that look like toys. But every day is the same, and the octopus soon tires of captive life. And so, under the cover of darkness, he makes his daring escape... Maile Meloy and Felicita Sala bring us a story full of excitement and heart, about the thrill of hard-won freedom and the pull of home.

Dog is ready for bed, but first he wants to say goodnight to all his farm animal friends in this magical bedtime story book.Young children will love to help Dog find his farm animal friends in this interactive novelty book. Insert the included 'magic torch' between the pages to find Dog's friends in each night-time scene and watch children glow with delight!

The Very Hungry Caterpillar is playing hide and seek in the jungle! Follow the finger trails and lift the flaps to discover sleeping sloths, swooping parrots, crawling tigers and many more. A gentle rhyming narrative with a die-cut finger trail, die-cut details and a chunky flap on every page. There is so much for little hands to explore in this fun first introduction to jungle creatures and their habitat.