Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. Used appro

Discover the Latest Statistical Approaches for Modeling Exposure-Response RelationshipsWritten by an applied statistician with extensive practical experience in drug development,Exposure-Response Mode

This jam-packed collection of fun and simple science experiments for kids is perfect for the classroom or home. Stir up some sticky slime, build a solar system with rubber bands, power a speed boat using soap, and construct an erupting volcano, all with Home Activity Lab, which offers exciting experiments for budding scientists. Including a foreword by Professor Robert Winston, this stunning book includes 28 brilliant science projects using simple step-by-step instructions, everyday ingredients that can be found around the house, and amazing photography to guide you from start to finish. Each experiment describes the science behind the project, highlighting STEM facts with STEM icons pointing out the key science, technology, engineering, and math learning involved in each project. "Take it further" panels encourage young readers to experiment and take their projects to the next level, developing their independence, initiative, and creative thinking skills. Perfect for budding scientist

Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whi

In most modern biomedical research projects, application of high-throughput genomic, proteomic, and transcriptomic experiments has gradually become an inevitable component. Popular technologies include microarray, next generation sequencing, mass spectrometry and proteomics assays. As the technologies have become mature and the price affordable, omics data are rapidly generated, and the problem of information integration and modeling of multi-lab and/or multi-omics data is becoming a growing one in the bioinformatics field. This book provides comprehensive coverage of these topics and will have a long-lasting impact on this evolving subject. Each chapter, written by a leader in the field, introduces state-of-the-art methods to handle information integration, experimental data, and database problems of omics data.

An accessible introduction to the use of regression analysis in the social sciencesRegression with Social Data: Modeling Continuous and Limited Response Variables represents the most complete and full

繼電影《魔戒三部曲》之後，亞馬遜重啟開拍全新影集。透過《小人物大夢想》繪本認識這部奇幻史詩的作者J. R. R.托爾金。從南非搬到英國大城市，受困於水泥叢林進而使想像力的種子萌芽，成為當代奇幻文壇巨擘。In this book from the highly acclaimed Little People, BIG DREAMS series, discover the incredible life of J. R. R. Tolkien, author and forefather of the fantasy genre. Little John experienced lots of change in his life from a young age. Moving from South Africa to a big city in England, he longed for the nature he grew up around. After the death of both of his parents, John found comfort in telling stories and building imaginary worlds with his friends. And he continued to tell stories for the rest of his life, creating epic tales of hobbits, dwarves, elves, and wizards as J. R. R. Tolkien. This inspiring book features stylish and quirky illustrations and extra facts at the back, including a biographical timeline with historical photos and a detailed profile of the writer's life. Little People, BIG DREAMS is a bestselling series of books and educational games that explore the lives of ou

Data Science and Analytics with Python is designed for practitioners in data science and data analytics in both academic and business environments. The aim is to present the reader with the main conce

Designed for the applied practitioner, this book is a compact, entry-level guide to modeling and analyzing non-Gaussian and correlated data. Many practitioners work with data that fail the assumptions of the common linear regression models, necessitating more advanced modeling techniques. This Handbook presents clearly explained modeling options for such situations, along with extensive example data analyses. The book explains core models such as logistic regression, count regression, longitudinal regression, survival analysis, and structural equation modelling without relying on mathematical derivations. All data analyses are performed on real and publicly available data sets, which are revisited multiple times to show differing results using various modeling options. Common pitfalls, data issues, and interpretation of model results are also addressed. Programs in both R and SAS are made available for all results presented in the text so that readers can emulate and adapt analyses for

This book is a comprehensive introduction to financial modeling that teaches advanced undergraduate and graduate students in finance and economics how to use R to analyze financial data and implement

Modeling Atmospheric and Oceanic Flows: Insights from Laboratory Experiments and Numerical Simulations provides a broad overview of recent progress in using laboratory experiments and numerical simula

This entry-level text offers clear and concise guidelines on how to select, construct, interpret, and evaluate count data. Written for researchers with little or no background in advanced statistics, the book presents treatments of all major models using numerous tables, insets, and detailed modeling suggestions. It begins by demonstrating the fundamentals of modeling count data, including a thorough presentation of the Poisson model. It then works up to an analysis of the problem of overdispersion and of the negative binomial model, and finally to the many variations that can be made to the base count models. Examples in Stata, R, and SAS code enable readers to adapt models for their own purposes, making the text an ideal resource for researchers working in health, ecology, econometrics, transportation, and other fields.

“Data-Driven Modeling: Using MATLABR in Water Resources and Environmental Engineering” provides a systematic account of major concepts and methodologies for data-driven models and presents a unified f

Economic Modeling Using Artificial Intelligence Methods examines the application of artificial intelligence methods to model economic data. Traditionally, economic modeling has been modeled in the lin

Assuming no prior knowledge of R, Spatial Data Analysis in Ecology and Agriculture Using R provides practical instruction on the use of the R programming language to analyze spatial data arising from

The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials gu

While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital ap

A valuable guide to understanding the problem of quantifying uncertainty in dose response relations for toxic substances In today's scientific research, there exists the need to address the topic of

In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-dep

This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and

★ 40個「看起來像魔法」的科學實驗，讓孩子在家變身小小巫師！★ 《Ology》暢銷系列創作者 A.J. Wood 打造的奇幻科學實驗書★ 翻頁機關＋小冊子設計，每一頁都藏著驚喜探索★ 用廚房材料做出彩色藥水、結晶糖果與神奇冰淇淋結合奇幻魔法與真實科學，收錄40個簡單又充滿驚喜的實驗，讓孩子在家就能探索化學與自然的奧秘。透過翻頁機關、小冊子與互動活動，小小讀者將在魔法學院的故事情境中動手實驗，從水、空氣到能量與結晶，一步步發現科學的神奇魅力，最後獲得屬於自己的見習巫師證書。The Wizard's Guides to Magical Experimentssparks wonder and curiosity with 40 engaging real-life science experiments for wizards-in-training to try at home.The Wizard's Guides to Magical Experimentssparks wonder and curiosity with 40 engaging real-life science experiments for wizards-in-training to try at home.Welcome to the Touchwood Academy of Magical Thinking, where magical abilities are a must.Kids will discover the thrill ofthe real-life magic ofchemistry with hands-on experiments from the creator of the bestselling Ology books, A.J. Wood. As a "First Class Wizard," Wood guides wizards-in-training through dozens of magic tricks and spells that are actually wow-inducing age-appropriate science experiments.Mini-booklets and fold-out activities on e

Using the same innovative format as his Caldecott Honor winner, Mel Fell, Corey R. Tabor reimagines Aesop’s “The Dog and His Reflection” in a clever, charming tale of empathy and generosity.One day, down by the pond, Simon meets another dog just like him.And that dog has a bone just like his, only better!How will Simon ever get him to trade, when the other pup knows all the same tricks...?This is another delightfully surprising tale from the award-winning creator of Mel Fell.

Preschoolers are introduced to core science concepts with this playful format featuring 20 hands-on activities that use everyday household materials, including a vinegar volcano, a hula hoop count, and a kitchen sink or swim experiment. In this fourth book in the Busy Little Hands series, preschoolers get ready for a science adventure! Preschoolers wonder and explore with 20 hands-on experiments using everyday household objects and making daily activities such as snack time and play time into learning opportunities. Each play activity demonstrates a simple principle of physics, earth science, chemistry, or biology, including the Kitchen Sink or Float (demonstrating density), the Vinegar Volcano (pressure) and Blooming Colors (chromatography). Featuring bright, easy-to-follow photos specially designed for pre-readers, this book is packed with learning fun, plus it sets the groundwork for science success in kindergarten and beyond.

53*36cm。以樂高人物為主角的活動書，有超過300個活動，讓小朋友腦力激盪。Join in the LEGO(R) Iconic Christmas countdown with 24 mini books to get you in the holiday spirit Let your imagination run wild as you countdown to Christmas with this advent calendar full of exciting and engaging activities Kids get one new mini winter LEGO(R) title for each day leading up to Christmas, and with 24 activity books in all, this holiday season is sure to be fun LEGO, the LEGO logo and the Brick and Knob configurations are trademarks and/or copyrights of the LEGO Group. (c)2021 The LEGO Group. All rights reserved.Manufactured by AMEET Sp. z o.o. under license from the LEGO Group.

A valuable new edition of a standard referenceThe use of statistical methods for categorical data has increased dramatically, particularly for applications in the biomedical and social sciences. An In

The first volume in this Early Childhood Education and Care in the 21st Century: International Teaching, Family and Policy Perspectives miniseries provides a snapshot of early childhood education and

Learn data science by doing data science! Data Science Using Python and R will get you plugged into the world’s two most widespread open-source platforms for data science: Python and R.Data scien

Panel Data Econometrics with R provides a tutorial for using R in the field of panel data econometrics. Illustrated throughout with examples in econometrics, political science, agriculture and epidemi

The only how-to guide offering a unified, systemic approach to acquiring, cleaning, and managing data in R Every experienced practitioner knows that preparing data for modeling is a painstaking, time-

For readers who may not be statisticians or data analysts, Sarmento and Costa explain how to analyze data using the Python and R languages. They have particularly in mind, students and researchers

This volume covers a large area, from the description of methodologies for data analysis to the real application. Chapters focus on methodologies for preprocessing of microarray data, a survey of miRN

This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribu

A reference guide for applications of SEM using MplusStructural Equation Modeling: Applications Using Mplus is intended as both a teaching resource and a reference guide. Written in non-mathematical terms, this book focuses on the conceptual and practical aspects of Structural Equation Modeling (SEM). Basic concepts and examples of various SEM models are demonstrated along with recently developed advanced methods, such as mixture modeling and model-based power analysis and sample size estimate for SEM. The statistical modeling program, Mplus, is also featured and provides researchers with a flexible tool to analyze their data with an easy-to-use interface and graphical displays of data and analysis results.Key features:Presents a useful reference guide for applications of SEM whilst systematically demonstrating various advanced SEM models, such as multi-group and mixture models using Mplus.Discusses and demonstrates various SEM models using both cross-sectional and longitudinal data wi

As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, t

Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While

Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and ap

Collecting and presenting the latest research and development results from the leading researchers in the field of industrial database modeling, Database Modeling for Industrial Data Management: Emerg

A unique illustrated exploration of the development of finance that combines data from every part of the world and covers five thousand years of history “The book is a lot of fun. Data-fixated readers will enjoy unpicking its main content: a series of elegantly produced maps, graphs and other visualisations. These are eclectic in scope and ambitious in intent.”—Jonathan Guthrie, Financial Times From the emergence of money in the ancient world to today’s interconnected landscape of high-frequency trading and cryptocurrency, the story of finance has always taken place on an international stage.Finance is one of the most globalized and networked of human activities, and one of the most important social technologies ever invented. This volume, the first visually based book dedicated to finance, uses graphics and maps to bring the complex and abstract world of finance down to earth, showing how geography is fundamental for understanding finance, and vice versa. It illuminates the people—inc

Caldecott Medal-winner and #1 New York Times-bestselling author Kevin Henkes explores what it means to be at home in this stunning picture book. Brimming with interactive call-and-response questions,

Down where worms wriggle and microbes squirm, there's a whole world waiting to be discovered...Under Your Feet delves beneath the Earth's surface and explores the diverse wonders hidden there. Encounter creatures of the deep and marvel at the mind-boggling size of the humongous fungus - the biggest organism in the world. Learn how one handful of ordinary soil contains more organisms than there are people on Earth, and carry out experiments using dirt from your own back garden.Under Your Feet offers you the opportunity to expand your knowledge of the natural world and soil-dwelling creatures big and small. Bursting with colorful illustrations and photography, this is the perfect book for budding young plant experts, animal fanatics, and geologists, and anyone who is curious about the ground we walk on.