INTRODUCTION TO FLUORESCENCE IN SITU HYBRIDIZATIONPRINCIPLES AND CLINICAL APPLICATIONS

Introduction to Fluorescence in Situ Hybridization Principles and Clinical Applications Edited by Michael Andreeff, M.D., PH.D., and Daniel Pinkel, PH.D. Fluorescence In Situ Hybridization (FISH) has become an essential tool in the diagnosis and management of a variety of solid tumors and hematologic malignancies in the clinical setting, as well as an aid in the identification of particular genetic disorders. Introduction to Fluorescence In Situ Hybridization provides a solid groundwork in the basic principles and techniques of FISH and covers in detail the applications of this technology to cancer in humans, including tumorigenesis, prostate and breast tumors, myeloid leukemias, and lymphoproliferative malignancies. The final section of the book is devoted to the applications of FISH techniques to genetic analysis. This incorporates radiation biodosimetry in chromosomal aberrations, genetic toxicology, and multiprobe methods for detecting chromosomally defective sperm in humans and mice, plus rapid prenatal diagnosis of chromosomal aneuploidies and detection of fetal trisomy. Edited by two leading basic and clinical investigators in the field, with state-of-the-art contributions from expert subspecialists, and featuring over 200 color illustrations, Introduction to Fluorescence In Situ Hybridization is an essential reference for clinicians and investigators in oncology, genetics, and cytometry.

Michael Andreeff and Daniel Pinkel are the authors of Introduction to Fluorescence In Situ Hybridization: Principles and Clinical Applications, published by Wiley.

Partial table of contents: PRINCIPLES AND TECHNIQUES.

Fluorescence In Situ Hybridization (D. Pinkel).

Chromosome Microdissection (M. Bittner, et al.).

Multicolor Fluorescence In Situ Hybridization Techniques (L. Morrison & M. Legator).

APPLICATION TO HUMAN CANCER.

Fluorescence In Situ Hybridization Analysis of Prostate Cancer (J. Brown & R. Jenkins).

Interphase Cytogenetics of the HER-2/neu Onrcogene in Breast Cancer (G. Pauletti & D. Slamon).

Characterization of Multistep Tumorigenesis by In Situ Hybridization (J. Izzo & W. Hittelman).

Fluorescence In Situ Hybridization of Lymphoproliferative Malignancies (A. Younes, et al.).

Genotype and Phenotype of a Single Cell (S. Knuutila).

APPLICATION TO GENETIC ANALYSIS.

Radiation Biodosimetry Using Fluorescence In Situ Hybridization Analysis of Chromosomal Aberrations (R. Jensen).

Applications of Fluorescence In Situ Hybridization in Genetic Toxicology (M. Schuler, et al.).

Detecting Fetal Trisomy by Fluorescence In Situ Hybridization Analysis of Cells Enriched from Maternal Blood (J. Simpson, et al.).

Index.