商品簡介
This collection of articles by leading researchers is the first to focus on the conformational analysis of six-membered rings containing one or more sites of unsaturation, primarily by NMR and force field calculations. Such compounds provide a wealth of information regarding stereochemistry and dynamic conformational behavior.
Among the examples cited in the book are metabolites from polynuclear aromatic compounds, dihydroaromatics that play a critical role in the liquefaction of coal, and heteroatoms containing dihydroaromatics, which are important in many medications. The book also contains a considerable amount of NMR data and an appendix explaining the ins and outs of empirical force field calculations to the uninitiated.
目次
Preface
Chapter 1. Conformational Analysis of Cydohexenes
Frank A. L. Anet
Chapter 2. Conformational Analysis of Six-Membered Carbocyclic Rings with Exocyclic Double Bonds
Joseph B. Lambert
Chapter 3. Conformational Analysis of 1,3-Cyclohexadienes and Related Hydroaromatics
Peter W. Rabideau and Andrzej Sygula
Chapter 4. Conformational Analysis of 1,4-Cydohexadienes and Related Hydroaromatics
Peter W. Rabideau
Chapter 5. Use of Carbon-13 Nudear Magnetic Resonance in the Conformational Analysis of Hydroaromatic Compounds
Frederick G. Morin and David M. Grant
Chapter 6. Conformational Analysis of Partially Unsaturated Six-Membered Rings Containing Heteroatoms
Slayton A. Evans, Jr.
Chapter 7. Application of Empirical Force-Field Calculations to the Conformational Analysis of Cyclohexenes, Cyclohexadienes, and Hydroaromatics
Kenny B. Lipkowitz
Chapter 8. Conformational Analysis of Hydroaromatic Metabolites of Carcinogenic Hydrocarbons and the Relation of Conformation to Biological Activity
Ronald G. Harvey
Appendix. Empirical Force-Field Method
Kenny B. Lipkowitz
Index
