Micronutrients and Brain Health

Micronutrients and Brain Health addresses cutting-edge research related to processes of oxidative stress that affect brain function, an area of increasing significance for those concerned and involved with public health and translational medicine. Edited by four leading micronutrient researchers, the book brings together the investigative work of more than 70 leading researchers from across the world. Chapters identify brain-specific micronutrients that support function as well as the molecular mechanisms underlying their neuroprotectant activity. These explore age-related metabolic pathways, mitochondrial nutrients, neurodegeneration and micronutrients, cell signaling, and neuronal functions. General chapters are included on brain structure, function, and metabolism, while several other chapters are devoted to the role of specific micronutrients. The book explores how brain micronutrients are found to be both metabolic and redox regulators, thereby establishing a cross-talk between the major pathways involved in modulation of cell signaling and gene expression. Specific areas of research covered include:


Uses of nutritional interventions to target age-related neuronal and behavioral deficits
Effects of various micronutrients on Alzheimer’s disease, including lipoic acid, green tea, and Ginkgo biloba extracts
Nutrients specific to essential mitochondrial functions
Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age
Omega-3 fatty acids and their relation to brain function in the elderly
Challenges inherent in the development of neuroprotective-neurorescue drugs

This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress.

Neuroprotection after Cardiac Arrest by Avoiding Acute Hyperoxia and by Antioxidant Genomic Postconditioning, G. Fiskum and R.E. Rosenthal The Neuroprotective Role of Micronutrients in Parkinson’s; Kristen Malkus, Elpida Tsika, and Harry Ischiropoulos Phytoestrogens and Brain Health, L. Zhao and R. Diaz Brinton Food Antioxidants and Alzheimer’s Disease, E. Ramiro-Puig, M. Castell, A. McShea, G. Perry, M.A. Smith, and G. Casadesus Micronutrient Antioxidants, Cognition, and Neuropathology: A Longitudinal Study in the Canine Model of Human Aging, W.O. Opii and E. Head Excitatory Amino Acids, S-nitrosylation, and Protein Misfolding in Neurodegenerative Disease: Protection by Memantine and NitroMemantine at NMDA-Gated Channels, T. Nakamura and S.A. Lipton Cognitive and Behavioral Consequences of Iron Deficiency in Women of Reproductive Age, L.E. Murray-Kolb Micronutrient Needs of the Developing Brain: Priorities and Assessment, A.J. Fuglestad, S.E. Ramel, and M.K. Georgieff Therapeutics of Alzheimer’s Disease Based on Metal Bioavailability, S.S. Mok and A.I. Bush Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease, A. Maczurek, M. Krautwald, M. Steele, K. Hager, M. Kenklies, M. Sharman, R. Martins, J. Engel, D. Carlson, and G. Münch Zinc and the Cytoskeleton in Neuronal Signaling, G.G. Mackenzie and P.I. Oteiza Tocotrienol Neuroprotection: The Most Potent Biological Function of All Natural Forms of Vitamin E, C.K. Sen, S. Khanna, and S. Roy Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficits, J.A. Joseph, B. Shukitt-Hale, and L.M. Willis Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function, F.P. Maher Dietary Flavonoids as Neuroprotective Agents, J.P.E. Spencer, D. Vauzour, K. Vafeiadou, and A. Rodriguez Mateos Actions of Bioactive Phytochemicals in Cell Function and Alzheimer’s Disease Pathology, R.E. Hartman Does Ginkgo biloba Extract Exert an Effect on Alzheimer’s Disease Progression, Y. Christen Green Tea Polyphenols Protect Neurons against Alzheimer’s Disease and Parkinson’s Disease, B. Zhao Transport of Flavonoids into the Brain, P.E. Milburg Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicals, B.B. Aggarwal, K.B. Harikumar, and S. Dey Neurohormetic Properties of the Phytochemical Resveratrol, A.L. Holme and S. PervaizSirtuin and Resveratrol, A. Camins, C. Pelegri, J. Vilaplana, R. Cristofol, C. Sanfeliu, and M. Pallàs Acetyl-l-Carnitine and Ferulic Acid Action in Aging and Neurodegenerative Diseases, R.A. Sowell, C.D. Aluise, and D.A. ButterfieldEvidence Required for Causal Inferences about Effects of Micronutrient Deficiencies during Development on Brain Health: DHA, Choline, Iron, and Vitamin D, J.C. McCann and B.N. Ames Omega-3 Fatty Acids and Brain Function in Older People, R. Uauy and A.D. Dangour Iron and Monoamine Oxidase in Brain Function and Dysfunction: Development of Neuroprotective-Neurorescue Drugs, O. Weinreb, T. Amit, S. Mandel, and M.B.H. Youdim Antioxidative Defense of Brain Microglial Cells, R. Dringen and J. Hirrlinger Branched-Chain Amino Acids and Brain Metabolism, R. Murín and B. Hamprecht