Toxicology of the Nose and Upper Airways

Toxicology of the Nose and Upper Airways presents a culmination of knowledge as a result of both human and experimental animal studies over the past decade. The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. This book pulls all of this valuable research together, and includes:

• Contributions from internationally-recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science.
• Examines the effect of selected pollutants on the upper airways of both humans and experimental animals, while emphasizing mechanistic issues in the process.
• Epidemiologic findings from populations exposed occupationally or environmentally are reviewed, and alternative risk assessment approaches are compared and contrasted.
• Experimental data from both animal and human studies.
• Chapters organized into clear sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment and special topics.

Toxicology of the Nose and Upper Airways is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

John B. Morris is Professor and Head of Pharmaceutical Sciences and Assistant Dean for Research at the University of Connecticut. He received his Ph.D. in Toxicology at the University of Rochester in 1979 and carried out a Postdoctoral fellowship in Inhalation Toxicology at New York University. In 1981 he joined the faculty at the University of Connecticut. Dr Morris has authored over 70 peer-review articles and book chapters. He is currently on the editorial board of Inhalation Toxicology.

Dennis J. Shusterman is Professor of Clinical Medicine, Emeritus at the University of California, San Francisco (UCSF). He received his M.D. from University of California, Davis in 1978, and M.P.H. from University of California, Berkley in 1982. He currently serves as a Section Chief within the Occupational Health Branch of the California Department of Public Health, and is an attending physician in the Occupational and Environmental Medicine Clinic at UCSF. He is the author of over 70 peer-reviewed publications in the field of inhalation toxicology and occupational and environmental medicine.