The Third Histamine Receptor: Selective Ligands As Potential Therapeutic Agents in Cns Disorders

Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders
The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon.
The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases.



Presents Several Disease-Specific Chapters
Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.

INTRODUCTION
H3 Receptor Target: Past, Present, and Future
Perspectives from Worldwide H3 Experts, D. Vohora and S. Celanire
The Third Histamine Receptor: From Discovery to Clinics, a Long- Lasting Love Story at INSERM and Bioprojet, J.-C. Schwartz
Histamine as a Neurotransmitter, O. Selbach and H.L. Haas

THE THIRD HISTAMINE RECEPTOR
Phylogeny, Gene Structure, Expression, and Signaling, P. Panula, C. Jin, K. Karlstedt, and R.A. Bakker
Drug Discovery: From Hits to Clinical Candidates, S. Celanire, F. Lebon, and H. Stark
Peripheral Actions and Therapeutic Potential in Periphery, G. Coruzzi and M. Adami
THERAPEUTIC POTENTIAL IN CENTRAL NERVOUS SYSTEM DISORDERS
Cognitive Functions, Attention-Deficit Hyperactivity Disorders, and Alzheimer’s Disease, M.B. Passani, P. Blandina, K.E. Browman, and G.B. Fox

Sleep Disorders, J.E. Shelton, T.W. Lovenberg, and C. Dugovic
Obesity, T.A. Esbenshade, M.E. Brune, and M.I. Strakhova
Epilepsy, D. Vohora and K.K. Pillai
Schizophrenia, K.E. Browman, M. Zhang, G.B. Fox, and L.E. Rueter
Other Central Nervous System Disorders, P.L. Chazot and F.C. Shenton