Copper Amine Oxidases: Structure, Catalytic Mechanism and Role in Physiopathlology

Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences of between AOs from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

History, F. Buffoni
Nomenclature and Potential Functions of Copper Amine Oxidases, S. Boyce, K. F. Tipton, M. I. O’Sullivan, G. P. Davey, M. Motherway Gildea, A. G. McDonald, A. Olivieri, and J. O’Sullivan
Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2, 4, 5-Trihydroxylphenylalanine Quinone, S. Suzuki, T. Okajima, K. Tanizawa, and M. Mure
Copper Amine Oxidases from Plants, R. Medda, A. Bellelli, P. Pec, R. Federico, A.Cona, and G. Floris
Soluble Copper Amine Oxidases from Mammals, P. Pietrangeli, L. Morpurgo, B. Mondovi, M. L. Di Paolo, and A. Rigo
Membrane-Bound Copper Amine Oxidases, A. Holt
Copper Amine Oxidase Genes, I. Frebort and H. G. Schwelberger
Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase, T. Okajima and K.Tanizawa
Copper Amine Oxidase Crystal Structures, J. Mitchell Guss, G. Zanotti, and T. A. Salminen
Plasma Amine Oxidases in Various Clinical Conditions and in Apoptosis, F. Boomsma, A. H. van den Meiracker, and A. Toninello
Copper Amine Oxidases in Intestine Diseases, W. Agnieszka Fogel, E. Toporowska-Kowalska, and A. Stasiak
Copper Amine Oxidases in Adipose Tissue-Related Disorders, C. Carpene
Copper Amine Oxidases in Adhesion Molecules in Renal Pathology and in Alzheimer’s Disease and VAP-1 in Leukocyte Migration, P. Boor, M. Unzeta, M. Salmi, and S. Jalkanen
Inhibitors of Copper Amine Oxidases: Past, Present, and Future, M. Šebela and L. M. Sayre
Pharmacological Applications of Copper Amine Oxidases, E. Masini and L. Raimondi
Copper Amine Oxidases as Antioxidant and Cardioprotective Agents, M. Alexandru Mateescu and R. Nadeau
Biotechnological Aspects of Copper Amine Oxidases, R. Stevanato
Concluding Remarks, D. M. Dooley
References