Handbook for Critical Cleaning：Applications, Processes, and Controls, Second Edition

Applications, Processes, and Controls is the second volume in the Handbook for Critical Cleaning, Second Edition.

Should you clean your product during manufacturing? If so, when and how? Cleaning is essential for proper performance, optimal quality, and increased sales. Inadequate cleaning of product elements can lead to catastrophic failure of the entire system and serious hazards to individuals and the general public.

Gain a competitive edge with proven cleaning and contamination-control strategies

A decade after the bestselling original, the Handbook for Critical Cleaning, Second Edition helps manufacturers meet today’s challenges, providing practical information and perspective about cleaning chemistries, equipment, processes, and applications. With 90% new or revised chapters plus supplementary online material, the handbook has grown into two comprehensive volumes: Cleaning Agents and Systems, and Applications, Processes, and Controls.

Helping manufacturers become more efficient and productive, these books:


Show how to increase profitability and meet both existing and expected product demand


Clarify the sea of print and Internet information about cleaning chemistries and techniques


Address challenges of performance, miniaturization, and cost, as well as regulatory and supply chain pressures


Offer clearly written guidance from the viewpoints of more than 70 leading industry contributors in technical, management, academic, and regulatory disciplines


Overview chapters by the editors, industry icons Barbara and Ed Kanegsberg, meld the different viewpoints and compile and critique the options. The result is a complete, cohesive, balanced perspective that helps manufacturers better select, implement, and maintain a quality, value-added cleaning process.
The second volume, Handbook for Critical Cleaning: Applications, Processes, and Controls, addresses how to implement, validate, monitor, and maintain a critical cleaning process. Topics include cleanrooms, materials compatibility, worker safety, sustainability, and environmental constraints. The book shows readers how to draw from diverse disciplines—including aerospace, art conservation, electronics, food, life sciences, military, optics, and semiconductors—to achieve superior productivity.

Barbara Kanegsberg is president of BFK Solutions LLC, Pacific Palisades, California, an independent consulting company established in 1994. BFK Solutions is the industry leader in critical cleaning. As a recognized consultant in the areas of critical cleaning, contamination control, surface quality, and process validation, she helps companies optimize manufacturing cleaning processes, improve yield, resolve regulatory issues, and maintain trouble-free production. She has participated in projects that include aerospace/military equipment, electronics assembly, medical devices, engineered coatings, metals, pump repair, and optical and nanotechnological devices. She has also participated in a number of product development- and intellectual property-related projects for manufacturers of cleaning chemicals and industrial equipment. Barbara is a recipient of the U.S. EPA Stratospheric Ozone Protection Award for her achievements in implementing effective, environment-friendly manufacturing processes. She has numerous publications to her credit in the areas of surface preparation, contamination control, critical cleaning, method validation, analytical techniques, and regulatory issues.

Ed Kanegsberg is the vice president of BFK Solutions, Pacific Palisades, California. He is also a chemical physicist and engineer who troubleshoots and solves manufacturing production problems. Ed is a recognized advisor and consultant in the areas of industrial cleaning process design and process performance. He uses his four decades of practical experience along with his background in physics and engineering to help companies solve production problems and optimize their cleaning and contamination control processes.

Part I: Process Implementation and Control
Evaluating, Choosing, and Implementing the Process: How to Get Vendors to Work with You, B. Kanegsberg
Cleaning Agent Balancing Act, B. Kanegsberg
Blunders, Disasters, Horror Stories, and Mistakes You Can Avoid, A. Gillman
Cleaning Practices and Pollution Prevention, M.S. Callahan
Basis of Design for Life Science Cleanroom Facilities, S.E. Mackler
Validating and Monitoring the Cleanroom, K. O’Donoghue
Cleanroom Management, Validation of a Cleanroom Garment System, and Gowning Procedure, J. Eudy
Principles of Wiping and Cleaning Validation, K.F. Bonnell and H. Siegerman
Overview to Analytical and Monitoring Techniques, E. Kanegsberg
Practical Aspects of Analyzing Surfaces, B. Schiefelbein
How Clean Is Clean? Measuring Surface Cleanliness and Defining Acceptable Levels of Cleanliness, M.K. Chawla
Cleaning Validations Using Extraction Techniques, K. Andrascik
Biomedical Applications: Testing Methods for Verifying Medical Device Cleanliness, D.E. Albert
Material Compatibility, E. Eichinger


Part II: Applications
Clean Critically: An Overview of Cleaning Applications, B. Kanegsberg
Cleaning Validation of Reusable Medical Devices: An Overview of Issues in Designing, Testing, and Labeling of Reusable Devices, J.E. Broad and D.A.B. Smith
Critical Cleaning for Pharmaceutical Applications, P. Lopolito
Cleaning in the Food Processing Industry, H.A. Timmerman
Electronic Assembly Cleaning Process Considerations, M. Bixenman
Precision Cleaning in the Electronics Industry: Surfactant-Free Aqueous Chemistries, H. Wack
Contamination-Induced Failure of Electronic Assemblies, H. Schweigart
Surface Cleaning: Particle Removal, A.A. Busnaina
Cleaning Processes for Semiconductor Wafer Manufacturing (Aluminum Interconnect), S. Sahbari, M. Toofan, and J. Chu
Advanced Cleaning Processes for Electronic Device Fabrication (Copper Interconnect and Particle Cleaning), S. Sahbari and M. Toofan
The Cleaning of Paintings, R.C. Wolbers and C. Stavroudis
Road Map for Cleaning Product Selection for Pollution Prevention, J. Marshall
Wax Removal in the Aerospace Industry, B. Breault, J. Soma, and C. Fouts
Implementation of Environmentally Preferable Cleaning Processes for Military Applications, W. Ziegler and T. Torres


Part III: Safety and Regulations
Worker Protection and the Environment: Current Editorial Observations, B. Kanegsberg
Health and Safety, J.L. Unmack
Critical Cleaning and Working with Regulators: From a Regulator’s Viewpoint, M. Balagopalan
Momentum from the Phaseout of Ozone-Depleting Solvents Drives Continuous Environmental Improvement, S.O. Andersen and M. Sheppard
Screening Techniques for Environmental Impact of Cleaning Agents, D.J. Wuebbles

Glossary of Terms and Acronyms