Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy.

The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters, leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems.

Through clear descriptions and color images, this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field, the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.

Dara L. Kraitchman, VMD, PhD, FACC, is an associate professor in the Department of Radiology and Department of Molecular and Comparative Pathobiology at Johns Hopkins University. Her research interests include noninvasive imaging and minimally invasive treatment of cardiovascular disease.
Joseph C. Wu, MD, PhD, is an associate professor in the Department of Medicine (Cardiology) and Department of Radiology at Stanford University School of Medicine. His research interests include stem cell biology, gene therapy, genomics, and molecular imaging.

Introduction: Stem Cell Types Overview and Rationale for Labeling for Imaging, Dara L. Kraitchman and Joseph Wu

Human Embryonic Stem Cells, Richard P. Davis, Edouard G. Stanley, and Christine L. Mummery

Mesenchymal Stem Cells from Bone Marrow, Mark F. Pittenger

Hematopoietic Stem Cells, David C. Weksberg, Megan T. Baldridge, Emmanuel J. Volanakis, and Margaret A. Goodell

Adipose-Derived Adult Stem Cells, Deepak M. Gupta, Nicholas J. Panetta, and Michael T. Longaker

Umbilical Cord Stem Cells, Suzanne Kadereit

Induced Pluripotent Stem Cells, Timothy J. Nelson, Satsuki Yamada, Robert J. McDonald, Almudena Martinez-Fernandez, Carmen Perez-Terzic, Yasuhiro Ikeda, and Andre Terzic

Radionuclide Approaches to Imaging Stem Cells and Their Biological Effects on the Myocardium, Fiona See and Lynne L. Johnson

Fluorescence Imaging of Stem Cells In Vivo: Evolving Technologies and Applications, David E. Sosnovik

Ultrasound Imaging Basics, Howard Leong-Poi

MRI Basics and Principles for Cellular Imaging, Lisa M. Gazdzinski, Paula J. Foster, Eddy S.M. Lee, and Brian K. Rutt

X-Ray Imaging Basics, Jochen Cammin and Katsuyuki Taguchi

Radionuclide Cell-Labeling Methods, Rong Zhou and Hui Qiao

Principles of Bioluminescence Imaging and Its Application In Vivo, Maarten A. Lijkwan, Ernst Jan Bos, and Joseph C. Wu

Quantum Dot Labeling Methods, A.B.R. Kontorovich, G.R. Gaudette, M.R. Rosen, P.R. Brink, and I.S. Cohen

Magnetic Resonance Imaging Cell-Labeling Methods, Ali S. Arbab and Joseph A. Frank

Ultrasound Cell-Labeling Methods, Flordeliza S. Villanueva

X-Ray-Guided Delivery and Tracking of Cells, Jeff W.M. Bulte and Aravind Arepally

Multimodality/Fusion Imaging toward Imaging of Structure and Function, Jason M. Criscione, Albert J. Sinusas, and Tarek M. Fahmy

Other Non-Stem Cell Therapies for Cellular Tracking—Inflammatory Cell Tracking, Yijen L. Wu, Qing Ye, Haosen Zhang, T. Kevin Hitchens, and Chien Ho

Bioluminescence, MRI, and PET Imaging Modalities of Stem Cell-Based Therapy for Neurological Disorders, Marcel M. Daadi, Raphael Guzman, and Gary K. Steinberg

Clinical Application of Noninvasive Molecular Imaging in Cancer Cell Therapy: The First Reporter Gene-Based Imaging Clinical Trial, Shahriar S. Yaghoubi and Sanjiv S. Gambhir

Clinical Cardiology Stem Cell Applications, Anthony J. White, Rachel Ruckdeschel Smith, Raj Makkar, and Eduardo Marbán

Musculoskeletal Clinical Applications of Stem Cells, Antonio J. Machado, John A. Carrino, and Lew C. Schon
Regulatory Hurdles to Translation, Adrian D. Nunn


Index