Chemosensitivity—In Vivo Models, Imaging, And Molecular Regulators

In this second of a two-volume set, researchers working in academia and biotech companies describe state-of-the-art laboratory methods for assessing the cellular effects of anti-cancer drugs in vitro and in vivo. In introducing 26 contributions, Blumenthal (Garden State Cancer Center, Belleville, NJ) overviews problems associated with patient drug sensitivities and resistance mechanisms in response to chemotherapy, and efforts to assess parameters modulating tumor chemosensitivity in customizing therapy. This volume contains detailed protocols, including genomic and proteomic approaches, for classifying tumors into response categories by measuring DNA damage, regulators of cytotoxicity, and animal modeling. Color plates and other illustrations enhance the text. Annotation c2004 Book News, Inc., Portland, OR (booknews.com)