Myasthenia Gravis and Myasthenic Disorders

Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and the electrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseases collectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segment near the neuromuscular junction-- the syndrome of peripheral nerve hyperexcitability and the Guillain-Barri?? syndrome.

Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.

Dr. Andrew Engel is the McKnight-3M Professor of Neuroscience and Professor of Neurology, Mayo Clinic College of Medicine as well as the Director of the Neuromuscular Disease laboratory at the Mayo Clinic, Rochester, MN campus. He earned his medical degree at McGill University, was trained in Neurology at the NIH and the Mayo Clinic and in Neuropathology at Columbia University and has spent his entire professional carrier at the Mayo Clinic. Dr Engel has had a longstanding interest in neuromuscular diseases and especially those affecting neuromuscular transmission.