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Palmer (pathology and infectious diseases, Washington State U.) and Azad (microbiology and immunology, U. of Maryland) offer this 14-chapter volume which assembles a group of microbiologists, immunologists, pathologists, entomologists, biologists, and other researchers from the US, who update scientists, physicians, medical and veterinary students, public health professionals, epidemiologists, biocomputational scientists, and policy makers on recent knowledge about rickettsiae. Focusing on five of the six genera of Rickettsiales (excluding Wolbachia), they discuss the human disease manifestations, the evolution of treatment for infections, challenges for treatment and management, and treatment failures or persistent complaints; epidemiology and public health in the US, as well as the global impact; phylogeny and comparative genomics; the cell biology involved in host invasion; stages of intracellular infection; physiology and metabolism; innate immune response and inflammation in pathogenesis and protection; adaptive immune responses to infection and opportunities for vaccine development; persistence and antigenic variation; transmission; and improving genetic systems. Annotation c2012 Book News, Inc., Portland, OR (booknews.com)
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