商品簡介
Over the last decade, scientific and engineering interests have been shifting from conventional ion mobility spectrometry (IMS) to field asymmetric waveform ion mobility spectrometry (FAIMS). Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS explores this new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction.
The book relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It begins with the basics of ion diffusion and mobility in gases, covering the main attributes of conventional IMS that are relevant to all IMS approaches. Building on this foundation, the author reviews diverse high-field transport phenomena that underlie differential IMS. He discusses the conceptual implementation and first-principles optimization of FAIMS as a filtering technique, emphasizing the dependence of FAIMS performance metrics on instrumental parameters and properties of ion species. He also explores ion reactions in FAIMS caused by field heating and the effects of inhomogeneous electric field in curved FAIMS gaps.
Written by an accomplished scientist in the field, this state-of-the-art book supplies the foundation to understand the new technology of nonlinear IMS methods.
目次
Separation and Characterization of Molecules and Ions Using Gas-Phase TransportPhysical Foundation and Definitions Characterization of Molecules by Diffusion MeasurementsIMS: Ion Dynamics in IMS and Consequent General FeaturesRelating IMS Data to Molecular Structure
Fundamentals of High-Field Ion Mobility and Diffusion General Aspects of High-Field Ion Mobility: Standard and Nonstandard Effects Standard High-Field EffectClustering of Gas Molecules on Ions and Standard High-Field EffectNon-Blanc Phenomena in High-Field Ion Transport Vibrationally Inelastic CollisionsRotational Inelasticity and Collisional Alignment of Ions Dipole Alignment of Ions Unstable High-Field Mobility of Runaway Ions Summary and Significance for Differential IMS
Conceptual Implementation of Differential IMS and Separation Properties of FAIMS Strategy for Optimum Differential Ion Mobility SeparationsLimitations on the Differential IMS Paradigm That Shape FAIMS ApproachTrends of FAIMS Separation Parameters Separations in Heteromolecular MediaIon Transformations inside FAIMS and Effect on Separation Performance
Separation Performance of FAIMS and Its Control via Instrumental ParametersApproaches to Simulation of FAIMS OperationSeparation Properties in Homogeneous Electric FieldIon Focusing in Inhomogeneous Fields and Consequences for FAIMS Performance
Beyond FAIMS: New Concepts in Nonlinear Ion Mobility Spectrometry Ion Guidance and Trapping at Atmospheric Pressure Higher-Order Differential (HOD) IMS MethodsIon Mobility Spectrometry with Alignment of Dipole Direction (IMS-ADD)
Index
References appear at the end of each chapter.
