商品簡介
This unique volume provides interdisciplinary coverage of the mechanistic perspective of neurotoxicity that focuses on the site of action of known neurotoxins. It provides the reader with an insight into the common characteristics of neurotoxin action on the nervous system and examines sites of action at three levels of complexity: molecular, cellular, and brain, which will allow the development of more specific therapeutic and pharmacological rationales for treatment in the future. Site-Selective Neurotoxicity contains useful information for graduate students and academic and industrial researchers in the fields of toxicology, pharmacology, neurosciences and medicine.
Contents
Part 1. Introduction 1. Principles of Neurotoxicology Hugh A. Tilson and G. Jean Harry 2. Site-Selective Action William Slikker Jr. Part 2. Molecular-Specific Actions 3. Targets of Free Radical Toxicity Terry C. Pellmar 4. Neurotrophic Factors and Synaptic Plasticity in the Adult Hippocampus Clive R. Bramham, Elhoucine Messaoudi and Kjetil Bårdsen 5. Cholinergic Muscarinic Receptors as Targets for Neurotoxicity Lucio G. Costa 6. Nicotinic Acetylcholine Receptors, Beta-Adrenergic Receptors and Lung Cancer Hildegard M. Schuller 7. Molecular Neurotoxicology Implications of Acetylcholinesterase Inhibition David Glick, Michael Shapira and Hermona Soreq 8. Potassium Channels Christiane Mourre Part 3. Cellular-Selective Toxicity 9. Motor Neurons Morihiro Matsuda and Nakaba Sugimoto 10. The Cerebellar Granule Cell Theodore A. Sarafian 11. Purkinje Cells: A Significant Target for Neurotoxicity David S. Lester and Joseph P. Hanig 12. Neuronal Degeneration in the Forebrain Produced by Amphetamine, Methamphetamine and Fenfluramine John F. Bowyer and Steven L. Peterson 13. The Astrocyte Response to Neural Injury: A Review and Reconsideration of Key Features Alvin R. Little Jr. and James P. O'Callaghan Part 4. Tissue-Selective Toxicity 14. Detecting Neurotoxic Damage to the Circumventricular Organs (CVOs): Susceptible Brain Tissues Located Outside the Blood-Brain Barrier Andrew C. Scallet 15. Mechanisms of Peripheral Neurotoxicity Frederik A. de Wolff, Nicoline Treijtel and Marinus Vermeulen
