Principles of Cloning

Principles of Cloning is the first comprehensive review of animal cloning since the creation of the cloned sheep Dolly. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species-including mice, sheep, cattle, and non-mammals-is considered as well.

The contributing authors are the principal investigators on each of the animal species cloned to date and are expertly qualified to present the state-of-the-art information in their respective areas. Editors Cibelli, Lanza and West garnered worldwide spotlight late in 2001 when their company, Advanced Cell Technology, announced the successful engineering of the world's first cloned human embryo, and were featured in the US News & World Report December 2001 cover story, "The First Human Clone."

While the topics of cloning and stem cell use remain controversial, research continues on many promising and varied applications, including cell replacement through nuclear transfer (CRNT), therapeutic protein production by transgenic animals, and the cloning of endangered species.

• First and most comprehensive book on animal cloning
• Includes a broad array of information, from the early experiments in amphibia to the latest one in mammals
• Presents basic biological mechanisms on how cloning works and all their current and potential applications
• Offers cloning applications on basic biology, agriculture, biotechnology and medicine