The Metabolic Pathway Engineering Handbook ― Fundamentals

Biotechnology researchers offer an overview of constructing, redirecting, and manipulating cellular metabolism by altering endogenous and/or heterologous enzyme activities and levels in order to produce desired compounds through analysis or catalysis. This first volume looks at the basic processes of cellular metabolism, balances and reaction models, the bacterial transcriptional regulation of metabolism, modeling tools for metabolic engineering, and grooming appropriate hosts. Among specific topics are catabolism and metabolic fueling processes, growth nutrients and diversity, the regulation of secondary metabolism in bacteria, analyzing structure and flux in metabolic networks, Escherichia coli, filamentous fungi, and mammalian cells. A second volume covers tools and applications. Also sold packaged as a two volume set in a slipcase under the ISBN 978-0-8493-3923-3. Annotation c2009 Book News, Inc., Portland, OR (booknews.com)