Microglia in Health and Disease

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Eve Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents.

To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

The General Setting
1. Introduction
Amanda Sierra and Marie-Eve Tremblay
2. Historical Context
Payam Rezaie and Uwe-Karsten Hanisch
3. Microglial Physiology
Jyoti J. Watters and Jennifer M. Pocock
4. Lessons from in vivo Imaging
Dimitrios Davalos and Martin Fuhrmann
5. Roles in Immune Responses
Richa Hanamsagar, Sandra M. Cardona, Tammy Kielian, and Astrid E. Cardona
6. Neuroprotection Versus Neurotoxicity
Knut Biber and Michelle L. Block

What Is on Stage
The New Roles
7. Developmental Neuronal Elimination
Jose L. Marin-Teva, Julio Navascues, Ana Sierra, and Michel Mallat

8. Developmental Angiogenesis, Myelination and Astrogliogenesis
G. Jean Harry and Lorena Pont-Lezica
9. Developing and Mature Synapses
Marie-Eve Tremblay, Rosa C. Paolicelli, Beth Stevens, Hiroaki Wake, and Alain Bessis
10. Adult Neurogenesis, Learning and Memory
Amanda Sierra and Marie-Eve Tremblay

11. Neuropathic Pain
Jessica K. Alexander, Simon Beggs, and Michael W. Salter

12. Drug Addiction
Xiaohui Wang, Thomas A. Cochran, Mark R. Hutchinson, Hang Yin, and Linda R. Watkins
13. Aging
Rommy von Bernhardi, Betsi Flores, and Hiroshi Nakanishi

Their Pathological Implications
CONDITIONS IMPACTING ON THE QUALITY OF LIFE
14. Neurodevelopmental and Neuropsychiatric Disorders
Akira Monji, Izumi Maezawa, Yoshito Mizoguchi, Takahiro A. Kato, and Lee-Way Jin
15. Human Immunodeficiency Virus
Daniel F. Marker, Shao-Ming Lu, and Harris A. Gelbard
16. Multiple Sclerosis
Yoshifumi Sonobe and Akio Suzumura
LEADING CAUSES OF DEATH
17. Ischemia and Stroke
Raffaela Cipriani, Maria Domerq, and Carlos Matute

18. Neurodegenerative Diseases
Diego Gomez-Nicola and Hugh Perry

19. Spinal Cord and Brain Trauma
Samuel David and Phillip G. Popovich