Genomes 4

The 4th edition of Genomes has been completely revised and updated to make it a thoroughly modern textbook about genomes and how they are investigated. As with the 3rd edition, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: bacteria, plants, and animals including humans and other hominids.

Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Genome sequencing and assembly methods have been totally revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression is truly genomic, concentrating on the genome-wide implications of DNA packaging, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology.

 Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.

Terry Brown is professor of Biomolecular Archaeology at Manchester University. As well as writing the previous editions of Genomes, he is the author of Introduction to Genetics: A Molecular Approach (Garland 2011) and 5 editions of DNA Cloning & Analysis (Wiley Blackwell). He is also an experienced teacher of genetics.