Modeling and Control of Infectious Diseases in the Host ― With Matlab and R

Modeling and Control of Infectious Diseases in the Host: With MATLAB and R aims to provide the adequate background between modeling and biology to bring a holistic understanding of health and disease, provide quantitative decision making to influence the discovery and development of drugs, and propose new computational algorithms to overcome the challenges of systems medicine. This book presents recent modeling advances in different viral infections, dissecting detailed contributions of key players to severe viral infections as well as their respective interactions, which is crucial for developing prophylactic and therapeutic strategies. By combining tailored in vivo experiments and mathematical modelling approaches, this book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections: HIV, influenza, and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained with its corresponding programming code using the software MATLAB and R.

• Multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases
• PK/PD modelling and simulation approach to improved efficiency and decision-making at preclinical development phases
• Control theoretic approach to schedule drug treatments