The Science of Broken HeartsDisaffected New York Physician Dr Hunter Newton lives alone at the old Spring Hill Inn, located in a forgotten part of Queens NY. Recently divorced, chronically depressed, and in danger of losing his license for caring too intensely for his patients, Hunter is one hopeless case short of a meltdown. Enter terminally ill Deanna Kovak, Hunter's first love and the soon-to-be-ex-wife of his old friend Robert, a Beverley Hills proctologist. British-born artist Deanna has acquired, over twenty childfree years in LA with Robert, the kind of Californian dippy-hippiness that makes Hunter's skin itch. Even so he welcomes his old flame to Spring Hill, not just as his patient, but also as his tenant, hoping to reawaken their old romance by persuading Deanna to sublet his late brother's apartment at the Inn.
Although Deanna has come to New York to conclude the unfinished business that is Hunter, she is side-tracked into an imaginary love affair with the ghost of Hunter's brother Gray. Inspired by the intense reaction this provokes in Hunter, who is drowning in guilt over his part in the death of his despised (and despicable) brother, Deanna conspires with Hunter's girlfriend Bernice, and his ex-wife Susan to lure Hunter to London, where he can be weaned off his prescription drug habit, cured of his many phobias and reacquainted with the decent human he used to be.