Heterochronic Parabiosis: Anti-Aging Plasma Exchange

◎The first book in the world detailing the development history and clinical application of plasma exchange in solving aging problems.
◎Heterochronic Parabiosis is science, not medical.
◎If you are struggling with aging problems, this book will help you understand the root cause of the problems.


◎代理經銷：白象文化
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Fu-shih Pan, M.D., Ph.D.

Fushih Pan M.D., Ph.D. is not only the only practicing American Boarded Plastic Surgeon but also a well-known pioneer in regenerative medicine in Asia.
Dr. Pan began to isolate ADSC (i.e. Adipose-Derived Stem Cells) from the fat of liposuction and re-injected them to rejuvenate facial skin and hair follicles since 2001.
In 2003, Dr. Pan established Lotusbio Technology Ltd. to translate his ADSC technologies into the skin and hair care industry. The anti-aging facial serum allowed him to win First Place in Global Launchpad: Beijing in 2012.
Since 2015, Dr. Pan became interested in translating the heterochronic parabiosis experimental technologies into clinical practice for the treatment of aging-related diseases and conditions.
He set up a transfusion center in Cambodia to study the unique components in the young plasma. Based on this, he was able to create a chemical-defined formulation to simulate the beneficial effects of young plasma.
In order to simulate the actual effect of in vivo heterochronic parabiosis, Dr. Pan also developed a mathematical model for heterochronic parabiosis which allows him to calculate and optimize optimal dosage and intervals of intermittent plasma exchange for the individual patient.
Dr. Pan received his Ph.D. in Chemistry in 1986 and MD in 1989 both from the University of Chicago. After completed his training in Plastic and Reconstructive Surgery at the University of Chicago Medical Center, he became the Craniofacial Fellow in the Children’s Hospital of Philadelphia and Lecturer in the Department of Surgery at the University of Pennsylvania.

I am pleased to have the opportunity to recommend this book which brings valuable pieces of information for the benefit of mankind.

I met Dr. Pan on a casual occasion through the introduction of a friend. Dr. Pan is an M.D. and Ph.D. in Chemistry, a reputable plastic surgeon, and a scientist. He has more than 40 years of experience in research and more than 30 years of experience in clinical medicine.

After I took charge of the Wan Hai Lines, I became a firm believer in “Health is Wealth” and have been receiving various anti-aging therapies*. When Dr. Pan explained the science behind heterochronic parabiosis, I immediately became interested and decided to receive the treatment. After only a few sessions, I felt my energy level had improved, the dark shadow of the skin around my toes resolved, and the pigmentation of my face had lightened up. My friends also noticed the changes in my appearance for which I have received many compliments. Since then I have become a great supporter of the plasma exchange program based on the principle of heterochronic parabiosis.

The most unique aspect of the book is that it is organized by a series of questions. Dr. Pan used these questions to guide the readers to explore the vast amount of information in the rapidly growing field of anti-aging medicine. If you read the book carefully, you will understand how scientists are approaching questions by asking one after another one of the questions, followed by carefully designed experiments and analysis of data collected, to find the answer.

After I finished reading this book, I realized that heterochronic parabiosis is more than just an emerging anti-aging medical treatment, it is a science that is based on rigorous scientific principles as compared to medicine which is sometimes more of an art. Just like adding water to a cup of espresso will make it look and tastes lighter, is a science. Heterochronic parabiosis is a technology that makes the blood younger, when the blood becomes younger, the function of the cell will improve, and the aging phenomena are reversed.

If you are interested in the science of aging or anti-aging or want to delay the aging process of your body or improve aging-related diseases or are merely interested in the clinical application of the heterochronic parabiosis technology, I would recommend this book to you without any hesitation.

Dr. Ching-Chih Chen**

Group Chairman
Wan Hai Lines Ltd.


** Dr. Ching-Chih Chen is a B.S. in Physics and a Ph.D. in Economics from the Massachusetts Institute of Technology. He was a Professor in Economics at National Taiwan University and a consultant to the Ministry of Finance, Taiwan. He was the President of Wan Hai Lines Ltd. from 1969-1989 and Chairman from 1989-2008, during which he successfully built the company to become one of the largest players in the container shipping industry worldwide.

* Dr. Ching-Chih Chen has received the La Prairie Therapy annually from 1991 till 2000 for 9 consecutive years. He also had been to Morishita Clinic in Nagoya, Japan for placenta tissue therapy 3-4 times a year for 19 years. He began a modified version of intermittent fasting in 2019.

To live and look young forever has been the dream of mankind. Now, for the first time in history, the secret of aging and the method to reverse it has been revealed scientifically red

About 100 hundred years ago, scientists performed an experiment called heterochronic parabiosis to successfully reverse the aging phenomena of old animals in the laboratory.

What is heterochronic parabiosis?

In short, it is the use of materials (e.g., blood, tissue extracts, or stem cells) obtained from young organisms to make the old organism young again.

From 1904 to 1906 at the University of Chicago , Dr. Alexis Carrel was able to connect the vessels of an animal or its organ to another animal and kept it alive for weeks in time. By this technique, he was able to study the effect of aging and the mechanisms of other disease processes. This is the first time and the only experimental method to date where effects of aging reversal could be observed with naked eyes within days.

As a plastic surgeon with a practice focused on facelift procedures, I began to notice the loss of harmony in post-operative patients. As a result, I became very interested in regenerative medical technologies that might rejuvenate the facial appearance in a natural way.

Until the summer of 2012 when the work of Dr. Carrel was brought to my attention incidentally while I was competing in the Global Launch of The Booth Business School of the University of Chicago in Beijing. Based on the immortal theory of cells propose by Carrel, I was able to hypothesize that the blood plasma is like the culture media for the cells inside human body, if we can renew the plasma to a more youthful state, we might be able to reverse the aging process and extend the healthspan of human.

We were able to engineer a formulation to simulate the effect of heterochronic parabiosis in a clinical setting which was later supported by the pioneering work of Conboys’ and Dr. Dobri Kiprov in 2020.

Current protocol for our heterochronic plasma exchange is in three parts. All of the parts could be performed using one small single lumen intravenous catheter easily in an outpatient clinic setting.

During the past few years, we have performed these heterochronic plasma exchange procedures for hundreds of patients with various aging-related problems, such as: Adult-onset diabetes, Alzheimer’s disease, degenerative disc joint diseases, frailty, and for the prevention of local recurrence and metastasis of solid tumors. The expectancy of our patients was largely met as indicated by more than sixty percent of retention rate.

Finally, I sincerely wish the birth of this book will allow those who are interested in anti-aging technologies to gain further understanding of the developmental history, underlying mechanism, and potential clinical applications of anti-aging plasma exchange developed based on the heterochronic parabiosis experiment.


Fu-shih Pan, M.D., Ph.D.

FOREWORD
PREFACE
1. Why Is Anti-Aging Important?
2. How To Live To 100 Years Of Health Span?
3. How To Reverse The Aging Processes?
4. What Is Stem Cell ?
5. How To Improve Repair Capacity Of Stem Cell?
6. How Good Is The Effect Of Stem Cell Therapy?
7. Who Is Dr. Carrel?
8. What Is Heterochronic Parabiosis?
9. What Is Placenta Extract ?
10. How Did Heterochronic Parabiosis Get Back To The Centerstage Of Anti-Aging Research?
11. Where Are The Aging Reversal Factors In The Blood?
12. Who Is The Successor Of Dr. Carrel ?
13. Who Is Dr. Pan?
14. How Did Dr. Pan Returned To The Clan?
15. Can The Effect Of Heterochronic Parabiosis Happened For A Different Reason ?
16. What Should Be The Anti-Aging Treatment Be Re-Designed Based on The Current Understandings Of Heterochronic Parabiosis?
17. How To Detoxify Aging Plasma?
18. Where Are The Beneficial Factors For Stem Cell In The Blood?
19. What Are The Potential Sources Of Young Plasma ?
20. Why Is The Treatment Offered By Ambrosia Ineffective?
21. Why Is Phnom Penh Plasma Not Feasible?
22. How About Artificial Plasma?
23. Why Is Stem Cells Ineffective For Anti-Aging?
24. Since Stem Cell Transplantation Is Ineffective Systemically, Why Do We Still Do It?
25. How Many Stem Cells Should Be Implanted For The Best Result?
26. What Is Autophagy?
27. What Does Anti-Aging Medicine Look Like?
28. Is Heterochronic Parabiosis Scientifically Sound ?
29. Is Heterochronic Parabiosis Being Done Clinically?
30. Are There Any Clinical Cases In Heterochronic Parabiosis?
31. Are There Any Clinical Papers On Heterochronic Parabiosis?
32. What Is The Impact of AMBAR Trial?
33. Is Transplantation Of Stem Cells Necessary To Simulate Effects Of Heterochronic Parabiosis in Clinical Setting?
34. The 3 Steps Clinical Heterochronic Parabiosis Program.
35. Really? Trilogy Of Scientific Breakthrough
36. Pregnancy Is Heterochronic Parabiosis
37. The Future Of Heterochronic Parabiosis Technologies
38. References

1. Why Is Anti-Aging Important?

Since thousands of years ago, mankind had begun the pursuit of longevity and hoping to feel and look young forever. However, to the surprise of many, modern medical society did not pay much attention to aging-related problems until the late 20 century.

Two hundred years ago, the average lifespan of humans was only 40 years. At that time, people, in general, could not live long enough to experience the aging processes.

Due to the birth of modern medicine, within the next 100 years, the average lifespan experienced a rapid rise to 55 years, which was further extended by another 25 years to reach the current life expectancy of 80 years old during the past 100 years. If this trend were able to continue, at this speed of 20 to 30 years per 100 years, some scientists project that the human life span will eventually reach the 150 years mark. However, this is unlikely to be the case.

Let us examine the age of death of United States women over the past 85 years. From the figure, we can see that in 1933, there were 2 peaks in the curve. The first peak occurs at birth and the other peak occurs between 70 and 90 years of age. On the other hand, there was only one peak of the 2014 age of death curve between 85 and 95. This implies that the largest increase in the average life expectancy over the past 85 years occurs due to the decrease in mortality at birth (mostly due to the advances in obstetrics and neonatal care). If we eliminate the influences of this, the actual extension in average life span was less than 15 years over the last 80 years.

Furthermore, from the changes in the spread of the above age of death curve, we also observe that the distribution of the age of death narrowed significantly over the last 80 years. This seems to imply that most people will eventually die at the same age bracket, e.g., between the age 90 and 100 as the standard of medical care continues to improve in the future; rather than extending to 150 years old as some optimistic scientists might suggest. Should we be happy about the life extension phenomena? According to the WHO (World Health Organization), the profile of the disease for the causes of death was very different 100 years ago. At that time (in early 1900), the most prevalent diseases and cause of death were infectious, e.g., pneumonia, influenza, tuberculosis, and gastrointestinal diseases. Over the last century, the profile of causes of death has changed dramatically. Cardiovascular, malignant tumors (e.g., cancers), and chronic obstructive pulmonary disease become the top 3 causes of death in 2018. These changes are mostly due to the advances in three important advances in medicine, namely: anesthesiology, transfusion, and antibiotics.

As people can live to an older age, aging-related diseases also begin to surface. For illustrative purposes, let us take osteoporosis as an example. Assuming the osteoporosis will occur 10 years after menopause which on average occurs at age of 50. When the average life span is less than 50 years, only a few women can live to experience menopause and there will be very few women who can live to suffer from osteoporosis. When the average life span is between 50 and 60, there will be many people who can live to experience the menopausal symptoms, but still very few will contract the osteoporosis diseases. When the average life span passes 60, every woman will suddenly live to an old age, which allows them to experience both signs and symptoms of menopausal and osteoporosis. As a result, people will have a bone fracture from a fall and will crowd the hospital if the governing agency is not prepared ahead of time.

From the disease prevalence curve, we can observe that from the adult-onset Type 2 Diabetes to Cardiovascular disease, to neurodegenerative diseases, to cancer and even Covid-19, almost all of the disease incidence increases with age. The incidence of 9 out of the 10 most common diseases in developed countries, i.e., cancer, cardiovascular diseases, pneumonia, cerebrovascular incidence, diabetes, COPD, high blood pressure, nephritis, Chronic renal failure, and Cirrhosis, are in proportion to age.

Most of the citizens over the age of 65 are diagnosed with multiple diseases. According to a recent study in Taiwan (who has a complete medical history of her citizen under the National Health Service program), 50% of the senior were diagnosed with hypertension, 20% with Diabetes, 10% has hepatobiliary problems, and as high as 7% of this population has chronic renal diseases. This data suggests that most of the seniors are literally in the octant state of illness by definition, with further extension in life span, the length of suffering from the diseases also increases. It is estimated that the last 20% of our natural life span is accompanied by at least one or more chronic diseases and the unhealthy lifespan also increases steadily as the healthy life span increases.

In summary, due to the advances in medicine, the human lifespan has almost doubled over the past 200 years. However, this extension comes with the cost of increases in numerous chronic diseases and tremendous social economic burdens to society. Furthermore, it also created a vicious cycle of increases in unhealthy life span. At present, most of the seniors usually are of them are handicapped or bedridden, which greatly reduced the happiness that could have been achieved with the life span extension.

The general public and medical society should place a greater interest and effort to promote lifestyles in anti-aging and anti- chronic diseases. In contrary to the use of extreme therapies, e.g., respirators, ECMO (i.e., Extracorporeal Membrane Oxygenator), etc., to extend the unhealthy life span.

The goal of the next generation of medicine should be using preventive medicine or regenerative medicine to slow down or even reverse the effect of age (i.e., the aging processes) exerted in health, to maximize the length of healthspan, and preserve independent life until the very end of life.


以上內容節錄自《Heterochronic Parabiosis: Anti-Aging Plasma Exchange》Fu-shih Pan◎著．白象文化出版
更多精彩內容請見
http://www.pressstore.com.tw/freereading/9786267018729.pdf