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Preface...Table of Contents...Contributing Authors... Part I Introduction 1. On Framing the Research Question and Choosing the Appropriate Research DesignPatrick S. Parfrey and Pietro Ravani 2. Bias in Clinical ResearchSusan Stuckless and Patrick S. Parfrey 3. Definitions of Bias in Clinical ResearchGeoffrey Warden 4. Research Ethics for Clinical ResearchersJohn D. Harnett 5. Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics ResearchDaryl Pullman and Holly Etchegary Part II Longitudinal Studies
6. Longitudinal Studies 1: Determinants of RiskSean W. Murphy 7. Longitudinal Studies 2: Modeling Data using Multivariate AnalysisPietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey 8. Longitudinal Studies 3: Data Modeling using Standard Regression Models and ExtensionsPietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey 9. Longitudinal Studies 4: Matching Strategies to Evaluate RiskMatthew T. James 10. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic DiseaseNavdeep Tangri and Claudio Rigatto Part III Randomized Controlled Trials 11. Randomized Controlled Trials 1: DesignBryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey 12. Randomized Controlled Trials 2: Analysis Robert N. Foley and Patrick S. Parfrey 13. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes Michelle M. Richardson and Klemens B. Meyer 14. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life StudiesRobert N. Foley and Patrick S. Parfrey 15. Randomized Controlled Trials 5: Biomarkers and Surrogates/OutcomesClaudio Rigatto and Brendan J. Barrett 16. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort StudiesTom Greene 17. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect Patrick S. Parfrey Part IV Other Clinical Epidemiology Methods 18. Evaluation of Diagnostic TestsBrendan J. Barrett and John M. Fardy 19. Genetic Epidemiology of Complex PhenotypesDarren D. O'Rielly and Proton Rahman
20. Qualitative Research in Clinical EpidemiologyStephanie Thompson and Kara Schick-Makaroff Part V Methods in Evidence-Based Decision Making 21. Evidence Based Decision Making 1: Critical Appraisal Laurie K. Twells
22. Evidence Based Decision Making 2: Systematic Review and Meta-Analysis Aminu Bello, Ben Vandermeer, Natasha Wiebe, Amit X. Garg, and Marcello Tonelli
23. Evidence-Based Decision Making 3: Health Technology AssessmentDaria O'Reilly, Richard Audas, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree 24. Evidence-Based Decision Making 4: Clinical Practice Guidelines Tae Won Yi, Sine D
