Molecular, Cellular, and Metabolic Fundamentals of Human Aging, provides researchers with an overview of the main aging mechanisms and physiology and how these can lead to age-related diseases and conditions. Topics covered include: DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. This book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.
Molecular, Cellular and Metabolic Fundamentals of Human Aging equips researchers with a foundational knowledge of aging at the basic biological level, and provides a detailed introduction to the relationship between aging and illness.
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