商品簡介
Acetylcholine in Alzheimer's disease and Related Dementias surveys the current state of knowledge on the cholinergic system in rodents, primates, including humans. The authors discuss aging and AD from the system, cellular, molecular and genetic aspects. The book critically evaluates the role of the cholinergic system as it relates to the clinical symptoms, therapy and pathogenesis. It follows the history of the cholinergic hypothesis of memory and AD from the seventies/early eighties of the previous century to the current view of disease-modifying role. It promotes the idea that the organization of the cholinergic system and its purported homeostatic role may contribute to its higher vulnerability to amyloid pathology of AD. Finally, it discusses current trends of AD prevention from the functional medicine perspective.
